Crystal structure of the c-fms kinase domain: applications and use of heterologous substitutions of kinase insert domains for crystallization

ABSTRACT

The present invention includes a crystal structure of the kinase domain of c-fms and a methodology to produce diffraction quality crystals of the c-fms kinase domain by heterologous substitution of the kinase insert domain. Also included in the invention is the structure of the c-fms kinase domain in liganded form for use in the discovery of inhibitors of c-fms for the treatment of diseases caused by inappropriate activity of c-fms. The present invention includes descriptions of the X-ray diffraction patterns of the crystals. The diffraction patterns allow the three dimensional structure of c-fms to be determined at atomic resolution so that ligand binding sites on can be identified and the interactions of ligands with amino acid residues can be modeled.

FIELD OF THE INVENTION

The present invention generally pertains to the fields of molecularbiology, protein crystallization, X-ray diffraction analysis,three-dimensional structural determination, molecular modeling andstructure based rational drug design. The present invention providescrystallized peptides of the c-fms kinase domain as well as descriptionsof the X-ray diffraction patterns. The X-ray diffraction patterns of thec-fms kinase domain crystals are of sufficient resolution so that thethree-dimensional structure can be determined at atomic resolution,ligand binding sites on c-fms can be identified, and the interactions ofligands with c-fms amino acid residues can be modeled.

The high resolution maps provided by the present invention and themodels prepared using such maps also permit the design of ligands whichcan function as active agents. Thus, the present invention hasapplications to the design of active agents which include, but are notlimited to, those that find use as inhibitors of c-fms for the treatmentof diseases caused by inappropriate activity of c-fms.

BACKGROUND

Protein kinases are enzymes that serve as key components of signaltransduction pathways by catalyzing the transfer of the terminalphosphate from ATP to the hydroxy group of tyrosine, serine andthreonine residues of proteins. As a consequence, protein kinaseinhibitors and substrates are valuable tools for assessing thephysiological consequences of protein kinase activation. Theoverexpression or inappropriate expression of normal or mutant proteinkinases in mammals has been demonstrated to play significant roles inthe development of many diseases, including cancer, diabetes andautoimmune diseases.

Protein kinases can be divided into two classes: those, whichpreferentially phosphorylate tyrosine residues (protein tyrosinekinases) and those, which preferentially phosphorylate serine and/orthreonine residues (protein serine/threonine kinases). Protein tyrosinekinases perform diverse functions ranging from stimulation of cellgrowth and differentiation to arrest of cell proliferation. They can beclassified as either receptor protein tyrosine kinases or intracellularprotein tyrosine kinases. The FMS or CSF-1-R protooncogene encodes themacrophage colony stimulating factor I receptor (or CSF-1-R or c-fms),which is the cell surface receptor for the colony stimulating factor I(CSF-1 or M-CSF) [1]. c-fms is part of the Platelet Derived GrowthFactor (“PDGF”) receptor family, which includes PDGFR, the stem cellfactor receptor (c-kit), c-fms, VEGFR-1 (flt-1) and VEGFR-2 (KDR).

Receptor Tyrosine Kinases (RTKs), such as c-fms, share a commonarchitecture by which an extracellular ligand-binding domain isconnected via a transmembrane segment to an intracellular catalyticdomain with intrinsic tyrosine kinase activity. Binding of the ligand tothe ligand-binding domain induces a conformational change, which leadsin most cases to receptor dimerization, autophosphorylation of thekinase domain or adjacent domains and activation of the kinase. Theactivated RTK in turn trans-phosphorylates specific tyrosine residues oftheir respective substrates, thus transmitting the signal further.Additional members of the RTK subfamilies include the epidermal growthfactor (“EGF”) family, (HER-1, HER-2/neu and HER-3 receptors), whichcode for oncogenes that have been have been linked to breast, colorectaland prostate cancers.

Insulin receptor (“IR”) and insulin-like growth factor I receptor(“IGF-1R”) are structurally and functionally related but exert distinctbiological effects. IGF-1R over-expression has been associated withbreast cancer. Fibroblast growth factor (“FGR”) receptors consist offour receptors, which are responsible for the production of bloodvessels, for limb outgrowth, and for the growth and differentiation ofnumerous cell types.

Mononuclear phagocyte colony-stimulating factor (CSF-1 or M-CSF) is apolypeptide growth factor, which stimulates the survival, proliferation,and differentiation of haematopoietic cells of the monocyte-macrophageseries. Multiple forms of soluble CSF-1 are produced by proteolyticcleavage of membrane-bound precursors, some of which are stablyexpressed at the cell surface [2].

Valuable insight into the signaling role of M-CSF and its receptor c-fmscomes from the M-CSF deficient mice strain (op/op) [3]. These miceexhibit a selective reduction of monocytes, osteoclasts and macrophagesin muscle, joints and other tissues. Furthermore these mice areosteoporotic and exhibit reduced fertility, but the incapability toproduce functional M-CSF appears not to be life threatening per se.op/op mice are resistant to collagen-induced arthritis and show areduced rate of mammary tumor progression into metastasis [4].

M-CSF has been shown to exacerbate collagen-induced arthritis in mousemodels an effect, which could be suppressed with M-CSF blockingantibodies [5]. In another study M-CSF and GM-CSF (granulocytemacrophage colony-stimulating factor) induced prolonged inflammation andrecruitment of macrophages in an mBSA induced arthritis model [6]. Thesestudies demonstrated that CSF-1 and GM-CSF can exacerbate and prolongthe histopathology of acute inflammatory arthritis and lend support tomonocytes/macrophages being a driving influence in the pathogenesis ofinflammatory arthritis. The data shown in these studies suggest thateither M-CSF or its cognate receptor c-fms are suitable targets fortreating arthritis or other macrophage induced inflammatory diseases.

In a recent study, expression of c-fms in various tumors was linked topoor survivability and increased tumor size [7]. M-CSF and c-fms havealso been shown to be expressed by carcinomas of the breast and otherepithelia of the female reproductive tract where activation of thereceptor by ligand produced either by the tumor cells or by stromalelements stimulates tumor cell invasion by a urokinase-dependentmechanism [8]. These results also support other preclinical findingsthat CSF-1R may be involved in local invasion and metastasis. Thus, thisreceptor may be an effective anti-cancer target.

Recent studies indicate that macrophages, infected with HIV-1 producehigh levels of M-CSF related specifically to HIV-1 and not other viralinfections. High levels of M-CSF appear to be important to sustain HIVreplication in vitro [9], a fact that is also corroborated by inhibitionof HIV-1 replication through M-CSF scavenging agents (anti-M-CSFmonoclonal or polyclonal Antibodies or soluble M-CSF receptors). Theseresults suggest that antagonists for the action of M-CSF may representnovel a strategy for inhibiting the spread of HIV-1.

Overview of the c-fms Structures

The structure of the c-fms kinase domain closely resembles other kinasedomain structures in the inactive form determined so far [12-14]. c-fmsis organized in a two-lobe structure (FIG. 1). The N-lobe, comprised of5 twisted β-sheets and a single α-helix-C is connected to the mostlyα-helical C-lobe by a hinge region. The N-lobe and hinge regions aremainly responsible for nucleotide or inhibitor binding and provide partof the catalytic residues, whereas the C-lobe is responsible forsubstrate binding and catalysis. Nucleotide or inhibitor binding takesplace in a deep cleft between the N- and C-lobe. Further importantstructural motifs are the glycine rich nucleotide binding loop (residues590-594), the activation loop (residues 796-825) and the catalytic loop(residues 776-783). The native c-fms kinase insert domain (residues680-751), which has been replaced by the FGFR kinase insert domain islocated between α-helix-D and α-helix-E and is mostly disordered.

Activation Loop

The activation loop in RTKs is an essential element for the regulationof the kinase activity. In RTKs the activation loop is approximately 22amino acids long and begins with a conserved Asp-Phe-Gly (DFG) motif andends with a tyrosine kinase conserved Pro [15]. Autophosphorylation oftyrosines present in the activation loop has been shown to be essentialfor stimulation of activity for RTKs. In the absence of phosphorylationthe activation loop is not properly positioned for catalysis andprevents binding of ATP. Phosphorylation events in the activation loopstabilize a conformation in which the activation loop is accessible tosubstrates and residues important for catalysis are positioned properly.Tyr809 is the single tyrosine present in the c-fms activation loop andis one of several that are phosphorylated in response to ligand binding.Tyr809 is bound in the active site in a manner very similar to that ofTyr1162 of the inactive form of IRK [13]. The phenol group of Tyr809forms hydrogen-bonding interactions with Asp778 and Arg782 of thecatalytic loop, which stabilize the inactive conformation of theactivation loop.

The effect of its phosphorylation on this critical residue in theactivation loop has been established by several mutagenesis studies. Forinstance a Tyr809Phe mutation prevents differentiation of macrophagecolony-stimulating factor (M-CSF)-dependent bone marrow macrophages intoosteoclasts [16]. In a rat cell line model Tyr809Gly abolished kinaseactivity and Tyr809Phe reduced kinase activity by 40-60% [17]. In aprevious study the same Tyr809Phe mutation was shown to retain activityas a tyrosine kinase in vitro and in vivo, was able to undergoCSF-1-dependent association with a phosphatidylinositol 3-kinase, andinduced expression of the protooncogenes c-fos and junB, underscoringits ability to trigger some of the known cellular responses to CSF-1[18]. On the other hand the mutated receptor failed to inducemitogenesis.

Juxtamembrane Domain

The c-fms juxtamembrane domain (JM-domain) corresponds to residues538-572 and contains two tyrosines (546 and 561). Tyr546 was shown to bea major autophosphorylation site and binds to a yet unidentified 55 kDaphosphoprotein [19]. A phosphopeptide modeled on the sequence of Tyr561and surrounding residues competed with the association of Fyn with c-fms[20]. Furthermore, mutational analysis demonstrated that this and othersequences were required for the efficient association of Src familykinases with activated c-fms in vivo.

Structurally, the JM-domain adopts a similar arrangement as the oneobserved in the recently determined flt3 kinase structure [21]. Residues548-552 are wedged between the catalytically important α-helix C and aβ-sheet like loop region (residues 772-776) just preceding the catalyticloop. Residues N-terminal to Val548 do not show any electron density andare disordered. Parts of the JM-domain (558-559 and 565-572) are alsodisordered; this is in contrast to the flt3 structure in which the wholeJM-domain was traced.

Another difference is the main anchoring point of the JM-domain to thebulk of the kinase domain. In c-fms Trp550 serves as the main anchor andis wedged deep into a cleft under α-helix C, whereas in flt3 theanchoring residue is Tyr572, which is located 2 residues upstream alongthe JM-domain. W550 sits in a hydrophobic pocket formed by (Ile636,Met637, Leu640, Ile646, Leu769, Cys774 and Ile794). It also forms a πface-to-edge interaction with His776. The backbone amid forms a hydrogenbond with one of the carboxyl atoms of Asp796, which is part of the DFGmotif and signifies the start of the activation loop. The backboneoxygen of Trp550 also forms another hydrogen bond with the side chainsof Arg777. The extended network of hydrophobic interactions and thebackbone hydrogen-bonding network keep W550 firmly seated in its place,a fact underscored by the significantly lower B-factors of Trp550 ascompared to its neighboring residues. Downstream of W550 a 3 residueantiparallel β-sheet like interaction between residues 551-553 and773-775 provides additional anchorage for the JM-domain. This structuralorganization is also similar to that adopted by the activation loop ofactivated Insulin Receptor Kinase (IRK-A) in complex with AMP-PNP [22].In IRK-A the activation loop is displaced from its inhibitory positionin the nucleotide-binding pocket and folds partly around thekinase-domain parallel to the interface between the N- and C-lobe.Residues 1153 and 1157 are also wedged under the α-helix C and form asimilar β-sheet like interaction as the c-fms JM-domain.

Kinase Insert Domain (KID)

The kinase insert domain is an additional loop region found in a subsetof RTKs, which is located between α-helix D and α-helix E. It can varyin length from a dozen to almost 100 residues. There are several reportsthat the KID is involved in downstream signaling of c-fms through themediation of protein-protein interactions. Deletion of the entire kinaseinsert domain completely abrogated signal transduction by the CSF-1receptor expressed in Rat-2 fibroblasts [23]. Mutation of either Tyr697or Tyr721 (Tyr699 and Tyr723 in human c-fms) compromised signaltransduction by c-fms and the receptor lost all ability to inducechanges in morphology or to increase cell growth rate in response toCSF-1. Early protein constructs, which utilized the full KID did notyield any crystals.

A need continues to exist for the development of modeling systems todesign and select potent, small molecules that are inhibitors of c-fmsfor the treatment of diseases caused by inappropriate activity of c-fms.

SUMMARY OF THE INVENTION

The present invention includes an isolated chimeric kinase receptorpolypeptide, wherein the polypeptide comprises an ATP binding pocketlinked to a substrate binding pocket by a kinase insert domain (KID),wherein the domain is heterologous to the ATP binding pocket or thesubstrate binding pocket. The invention also includes a crystalcomprising the chimeric kinase receptor polypeptide and a crystalcomprising a fragment of the chimeric kinase receptor polypeptide. Inone aspect of the invention, the ATP binding pocket and substratebinding pocket are c-fms. In a different aspect of the invention, theheterologous KID is selected from the group consisting of FGFR1, tie2and IRK.

In one aspect of the invention, the invention includes an isolatedchimeric kinase receptor polypeptide, wherein the chimeric polypeptidecomprises an amino acid sequence beginning at c-fms amino acid position538 and continuing through c-fms amino acid position 922 wherein thenative c-fms KID is replaced with a KID sequence comprising aheterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688, SEQ ID NO. 1. The invention also includes a crystalcomprising the polypeptide or a crystal comprising a fragment of thepolypeptide. In one embodiment, the heterologous KID is selected fromthe group consisting of FGFR1, tie2 and IRK. In another aspect of theinvention, the chimeric polypeptide has an amino acid sequence having atleast 95% amino acid sequence identity to a sequence selected from thegroup consisting of SEQ ID NO. 2 (FMS/FGFR1 chimera); SEQ ID NO. 4(FMS/tie chimera) and SEQ ID NO: 6 (FMS/irk chimera). The chimericpolypeptide or the chimeric kinase receptor polypeptide can be incrystalline form.

The invention also includes a crystal comprising a chimeric kinasereceptor polypeptide wherein the polypeptide comprises an ATP bindingpocket linked to a substrate binding pocket by a kinase insert domainwherein the domain is heterologous to the ATP binding pocket or thesubstrate binding pocket, or a fragment thereof, wherein the crystalcomprises a crystal structure defined by one or more structurecoordinates of c-fms amino acid residues Trp 550, Lys 586, Thr 587, Leu588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802 according to Tables 1,2 or 3 or similar structure coordinates for said amino acids comprisinga root mean square deviation of non-hydrogen atoms of less than about1.5 Å when superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or 3

In a different aspect the crystal comprises a chimeric kinase receptorpolypeptide wherein the polypeptide comprises an ATP binding pocketlinked to a substrate binding pocket by a kinase insert domain whereinthe domain is heterologous to the ATP binding pocket or the substratebinding pocket, or a fragment thereof, wherein the crystal comprises acrystal structure defined by one or more structure coordinates of c-fmsamino acid residues Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 or similarstructure coordinates for said amino acids comprising a root mean squaredeviation of non-hydrogen atoms of less than about 0.75 Å whensuperimposed on the non-hydrogen atom positions of the correspondingatomic coordinates of Tables 1, 2 or 3.

In a different aspect, the crystal comprises a chimeric kinase receptorpolypeptide wherein the polypeptide comprises an ATP binding pocketlinked to a substrate binding pocket by a kinase insert domain whereinthe domain is heterologous to the ATP binding pocket or the substratebinding pocket, or a fragment thereof, wherein the crystal comprises acrystal structure defined by one or more structure coordinates of c-fmsamino acid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe 797, Gly798, Leu 799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 orsimilar structure coordinates for said amino acids comprising a rootmean square deviation of non-hydrogen atoms of less than about 1.5 Åwhen superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or 3.

The invention also includes a crystal comprising a chimeric kinasereceptor polypeptide wherein the polypeptide comprises an ATP bindingpocket linked to a substrate binding pocket by a kinase insert domainwherein the domain is heterologous to the ATP binding pocket or thesubstrate binding pocket, or a fragment thereof, wherein the crystalcomprises a crystal structure defined by one or more structurecoordinates of c-fms amino acid residues Lys 586, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802 according toTables 1, 2 or 3 or similar structure coordinates for said amino acidscomprising a root mean square deviation of non-hydrogen atoms of lessthan about 0.75 Å when superimposed on the non-hydrogen atom positionsof the corresponding atomic coordinates of Tables 1, 2 or 3.

The invention also includes a crystal comprising a chimeric kinasereceptor polypeptide wherein the polypeptide comprises an ATP bindingpocket linked to a substrate binding pocket by a kinase insert domainwherein the domain is heterologous to the ATP binding pocket or thesubstrate binding pocket, or a fragment thereof, wherein the crystalcomprises a crystal structure defined by structure coordinates of c-fmsamino acid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu799, Ala 800, Arg 801 according to Tables 1, 2 or 3 or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 1.5 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or 3.

The invention also includes a crystal comprising a chimeric kinasereceptor polypeptide wherein the polypeptide comprises an ATP bindingpocket linked to a substrate binding pocket by a kinase insert domainwherein the domain is heterologus to the ATP binding pocket or thesubstrate binding pocket, or a fragment thereof, wherein the crystalcomprises a crystal structure defined by structure coordinates of c-fmsamino acid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu799, Ala 800, Arg 801 according to Tables 1, 2 or 3 or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 0.75 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or 3.

In another aspect of the invention, the invention comprises a crystalcomprising a chimeric kinase receptor polypeptide, wherein said chimericpolypeptide comprises an amino acid sequence beginning at c-fms aminoacid position 538 and continuing through c-fms amino acid position 922wherein the native c-fms KID is replaced with a KID sequence comprisinga heterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688, or a fragment of the chimeric kinase receptorpolypeptide, wherein said crystal comprises a crystal structure definedby one or more structure coordinates of c-fms amino acid residues Trp550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Val615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646, Val 647, Val 661, Thr663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn673, Arg 677, Cys 774, Ile 775, His 776, Arg 782, Asn 783, Leu 785, Ile794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp802 according to Tables 1, 2 or 3 or similar structure coordinates forsaid amino acids comprising a root mean square deviation of non-hydrogenatoms of less than about 1.5 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3.

In another aspect of the invention, the invention comprises a crystalcomprising a chimeric kinase receptor polypeptide, wherein said chimericpolypeptide comprises an amino acid sequence beginning at c-fms aminoacid position 538 and continuing through c-fms amino acid position 922wherein the native c-fms KID is replaced with a KID sequence comprisinga heterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688, or a fragment of the chimeric kinase receptorpolypeptide, wherein said crystal comprises a crystal structure definedby one or more structure coordinates of c-fms amino acid residues Trp550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Val615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646, Val 647, Val 661, Thr663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn673, Arg 677, Cys 774, Ile 775, His 776, Arg 782, Asn 783, Leu 785, Ile794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp802 according to Tables 1, 2 or 3 or similar structure coordinates forsaid amino acids comprising a root mean square deviation of non-hydrogenatoms of less than about 0.75 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3.

In another aspect of the invention, the invention comprises a crystalcomprising a chimeric kinase receptor polypeptide, wherein said chimericpolypeptide comprises an amino acid sequence beginning at c-fms aminoacid position 538 and continuing through c-fms amino acid position 922wherein the native c-fms KID is replaced with a KID sequence comprisinga heterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688, or a fragment of the chimeric kinase receptorpolypeptide, wherein said crystal comprises a crystal structure definedby one or more structure coordinates of c-fms amino acid residues Lys586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg677, Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg801, Asp 802 according to Tables 1, 2 or 3 or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 1.5 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or 3.

In another aspect of the invention, the invention comprises a crystalcomprising a chimeric kinase receptor polypeptide, wherein said chimericpolypeptide comprises an amino acid sequence beginning at c-fms aminoacid position 538 and continuing through c-fms amino acid position 922wherein the native c-fms KID is replaced with a KID sequence comprisinga heterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688, or a fragment of the chimeric kinase receptorpolypeptide, wherein said crystal comprises a crystal structure definedby one or more structure coordinates of c-fms amino acid residues Lys586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg677, Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg801, Asp 802 according to Tables 1, 2 or 3- or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 0.75 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or 3.

In another aspect of the invention, the invention comprises a crystalcomprising a chimeric kinase receptor polypeptide, wherein said chimericpolypeptide comprises an amino acid sequence beginning at c-fms aminoacid position 538 and continuing through c-fms amino acid position 922wherein the native c-fms KID is replaced with a KID sequence comprisinga heterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688, or a fragment of the chimeric kinase receptorpolypeptide, wherein said crystal comprises a crystal structure definedby structure coordinates of c-fms amino acid residues Lys 586, Leu 588,Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664,Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783,Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 according to Tables1, 2 or 3 or similar structure coordinates for said amino acidscomprising a root mean square deviation of non-hydrogen atoms of lessthan about 1.5 Å when superimposed on the non-hydrogen atom positions ofthe corresponding atomic coordinates of Tables 1, 2 or 3.

In another aspect of the invention, the invention comprises a crystalcomprising a chimeric kinase receptor polypeptide, wherein said chimericpolypeptide comprises an amino acid sequence beginning at c-fms aminoacid position 538 and continuing through c-fms amino acid position 922wherein the native c-fms KID is replaced with a KID sequence comprisinga heterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688, or a fragment of the chimeric kinase receptorpolypeptide, wherein said crystal comprises a crystal structure definedby structure coordinates of c-fms amino acid residues Lys 586, Leu 588,Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664,Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783,Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 according to Tables1, 2 or 3 or similar structure coordinates for said amino acidscomprising a root mean square deviation of non-hydrogen atoms of lessthan about 0.75 Å when superimposed on the non-hydrogen atom positionsof the corresponding atomic coordinates of Tables 1, 2 or 3.

In yet a different aspect, any of the crystals further comprise aligand, wherein the ligand is an ATP-binding pocket ligand. In oneembodiment, the ATP-binding pocket ligand is a small molecule inhibitor.

In one embodiment, small molecule inhibitor is an arylamide compound ora derivative thereof. In another embodiment, the small moleculeinhibitor is a quinolone compound or a derivative thereof. In apreferred embodiment, the arylamide compound is5-cyano-furan-2-carboxylic acid[5-hydroxymethyl-2-(4-methyl-piperidine-1-yl)-phenyl]-amide orderivative thereof. In another preferred embodiment, the quinolonecompound is6-Chloro-3-(3-methyl-isoxazol-5-yl)-4-phenyl-1H-quinolin-2-one or aderivative thereof.

In one aspect of the invention, the crystal-ligand complex has a spacegroup of R3. (Form I). In another aspect of the invention, thecrystal-ligand complex has a space group of sg=P2₁2₁2₁. (Form II). Inyet a different aspect, the crystal effectively diffracts X-rays fordetermination of atomic coordinates to a resolution of at least about1.9 Å (Form I). In another aspect, the crystal effectively diffractsX-rays for determination of atomic coordinates to a resolution of atleast about 3.0 Å (Form II).

Also included in the invention is a crystal comprising a unit cellhaving dimensions consisting of: a=81.07; b=81.07; c=144.67; alpha=90;beta=90; gamma=120. In one embodiment, the crystal comprises a unit cellhaving dimensions consisting of a=53.1; b=72.4; c=91.7; alpha=90;beta=90; gamma=90.

The invention also includes a crystal comprising a polypeptide whichcomprises a peptide having at least 95% amino acid sequence identity toSEQ ID NO. 2 (FMS/FGFR1 chimera); SEQ ID NO. 4 (FMS/tie chimera) or SEQID NO: 6 (FMS/irk chimera). In one embodiment, the crystal comprises apeptide having at least 95% sequence identity to SEQ ID NO. 2.

In one aspect, the crystal comprises SEQ ID NO: 2 comprising an atomicstructure characterized by the coordinates of Tables 1, 2 or 3. Inanother aspect the invention includes an isolated nucleic acid moleculeencoding any of the chimeric polypeptides or polypeptides disclosedabove, a vector comprising the nucleic acid, a host cell comprising thevector and a method of producing the polypeptide by culturing the hostcell.

Also included in the invention is a computer system comprising (a) adatabase containing information on the three dimensional structure of acrystal comprising a c-fms chimera, or a fragment or a target structuralmotif or derivative thereof, and a ligand, wherein the ligand is a smallmolecule inhibitor, stored on a computer readable storage medium; and,(b) a user interface to view the information.

In one aspect of the invention, the information comprises diffractiondata obtained from a crystal comprising SEQ ID NO: 2, 4 or 6. In anotheraspect, the information comprises an electron density map of a crystalform comprising SEQ ID NO: 2, 4 or 6. In yet a different aspect, theinformation comprises the structure coordinates of Tables 1, 2 or 3 orhomologous structure coordinates for the amino acids of SEQ ID NO: 2comprising a root mean square deviation of non-hydrogen atoms of lessthan about 1.5 Å when superimposed on the non-hydrogen atom positions ofthe corresponding atomic coordinates of Tables 1, 2 or 3. In oneembodiment, the information comprises structure coordinates for aminoacid residues of SEQ ID NO: 2 comprising a root mean square deviation ofnon-hydrogen atoms of less than about 0.75 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or 3.

In yet a different embodiment, the information comprises the structurecoordinates for one or more amino acid residues Trp 550, Lys 586, Thr587, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu633, Met 637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys774, Ile 775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802 according toTables 1, 2 or 3 or similar structure coordinates for said amino acidscomprising a root mean square deviation of non-hydrogen atoms of lessthan about 1.5 Å when superimposed on the non-hydrogen atom positions ofthe corresponding atomic coordinates of Tables 1, 2 or 3. In anotheraspect, the information further comprises the structure coordinates forone or more amino acid residues Trp 550, Lys 586, Thr 587, Leu 588, Gly589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly798, Leu 799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 orsimilar structure coordinates for said amino acids comprising a rootmean square deviation of non-hydrogen atoms of less than about 0.75 Åwhen superimposed on the non-hydrogen atom, positions of thecorresponding atomic coordinates of Tables 1, 2 or 3.

In a different aspect, the computer system comprises a crystal structuredefined by structure coordinates of one or more c-fms amino acidresidues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616,Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669,Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu 799,Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 or similarstructure coordinates for said amino acids comprising a root mean squaredeviation of non-hydrogen atoms of less than about 1.5 Å whensuperimposed on the non-hydrogen atom positions of the correspondingatomic coordinates of Tables 1, 2 or 3. In another aspect, the computersystem comprises a crystal structure defined by structure coordinates ofone or more c-fms amino acid residues Lys 586, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802 according toTables 1, 2 or 3 or similar structure coordinates for said amino acidscomprising a root mean square deviation of non-hydrogen atoms of lessthan about 0.75 Å when superimposed on the non-hydrogen atom positionsof the corresponding atomic coordinates of Tables 1, 2 or 3.

In yet a different aspect, the computer system comprises a crystalstructure defined by structure coordinates of c-fms amino acid residuesLys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647,Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670,Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801according to Tables 1, 2 or 3 or similar structure coordinates for saidamino acids comprising a root mean square deviation of non-hydrogenatoms of less than about 1.5 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3. In one embodiment, the computer system comprises a crystal structuredefined by structure coordinates of c-fms amino acid residues Lys 586,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663,Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782,Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 accordingto Tables 1, 2 or 3 or similar structure coordinates for said aminoacids comprising a root mean square deviation of non-hydrogen atoms ofless than about 0.75 Å when superimposed on the non-hydrogen atompositions of the corresponding atomic coordinates of Tables 1, 2 or 3.

The invention further includes a method of evaluating the potential ofan agent to associate with c-fms chimeric polypeptides comprising (a)exposing the c-fms chimera to the agent; and (b) detecting theassociation of the agent to one or more c-fms amino acid residuesselected from the group consisting of (i) Trp 550, Lys 586, Thr 587, Leu588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802; (ii) Lys 586, Leu 588,Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664,Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782,Leu 785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802;and, (iii) Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly669, Asp 670, Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala800, Arg 801 thereby evaluating the potential. The agent can be avirtual compound.

In addition, also included is a method of evaluating the potential of anagent to associate with the polypeptide, comprising: (a) exposing thepolypeptide to the agent; and (b) detecting the level of association ofthe agent to the polypeptide, thereby evaluating the potential of theagent to associate with the polypeptide; the agent can be a virtualcompound. In one aspect, step (a) comprises comparing the atomicstructure of the compound to the three dimensional structure of a c-fmschimeric polypeptide. In one embodiment, the comparing comprisesemploying a computational means to perform a fitting operation betweenthe compound and at least one binding site of a c-fms chimera.

In one embodiment, the binding site is defined by one or more structurecoordinates for amino acids Trp 550, Lys 586, Thr 587, Leu 588, Gly 589,Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640,Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667,Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776,Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798,Leu 799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 orsimilar structure coordinates for said amino acids of a c-fms chimeracomprising a root mean square deviation of non-hydrogen atoms of lessthan about 1.5 Å when superimposed on the non-hydrogen atom positions ofthe corresponding atomic coordinates of Tables 1, 2 or 3. In anotheraspect, the binding site is defined by one or more structure coordinatesfor amino acids Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596,Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646,Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668,Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782,Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799,Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 or similarstructure coordinates for said amino acids of a c-fms chimera comprisinga root mean square deviation of non-hydrogen atoms of less than about0.75 Å when superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or 3.

In one embodiment, the method of comprises a crystal structure definedby one or more structure coordinates of c-fms amino acid residues Lys586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647 Thr663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg677, Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg801, Asp 802 according to Tables 1, 2 or 3 or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 1.5 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or 3. In a different embodiment, the method comprises acrystal structure defined by one or more structure coordinates of c-fmsamino acid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe 797, Gly798, Leu 799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 orsimilar structure coordinates for said amino acids comprising a rootmean square deviation of non-hydrogen atoms of less than about 0.75 Åwhen superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or 3.

In yet a different embodiment, the method comprises a crystal structuredefined by structure coordinates of c-fms amino acid residues Lys 586,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663,Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782,Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 accordingto Tables 1, 2 or 3 or similar structure coordinates for said aminoacids comprising a root mean square deviation of non-hydrogen atoms ofless than about 1.5 Å when superimposed on the non-hydrogen atompositions of the corresponding atomic coordinates of Tables 1, 2 or 3.In another embodiment, the method comprises a crystal structure definedby structure coordinates of c-fms amino acid residues Lys 586, Leu 588,Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664,Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783,Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 according to Tables1, 2 or 3 or similar structure coordinates for said amino acidscomprising a root mean square deviation of non-hydrogen atoms of lessthan about 0.75 Å when superimposed on the non-hydrogen atom positionsof the corresponding atomic coordinates of Tables 1, 2 or 3. In adifferent aspect of the method, the agent is exposed to a crystallinec-fms chimera and the detecting of step (b) comprises determining thethree dimensional structure of the agent-c-fms chimera complex.

In a different aspect, the invention includes a method of identifying apotential agonist or antagonist against a c-fms chimera comprisingemploying the three dimensional structure of the c-fms chimeracocrystallized with a small molecule inhibitor to design or select apotential agonist or antagonist. In one embodiment, the threedimensional structure corresponds to the atomic structure characterizedby the coordinates of Tables 1, 2 or 3 or similar structure coordinatesfor said c-fms chimera comprising a root mean square deviation ofnon-hydrogen atoms of less than about 1.5 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or 3. In another embodiment, the method further comprisesthe steps of: (b) synthesizing the potential agonist or antagonist; and(c) contacting the potential agonist or antagonist with a chimeric c-fmspolypeptide.

The invention is also directed to a method of locating the attachmentsite of an inhibitor to a c-fms chimeric polypeptide, comprising (a)obtaining X-ray diffraction data for a crystal of a chimeric c-fmspolypeptide; (b) obtaining X-ray diffraction data for a complex of achimeric c-fms polypeptide and the inhibitor; (c) subtracting the X-raydiffraction data obtained in step (a) from the X-ray diffraction dataobtained in step (b) to obtain the difference in the X-ray diffractiondata; (d) obtaining phases that correspond to X-ray diffraction dataobtained in step (a); (e) utilizing the phases obtained in step (d) andthe difference in the X-ray diffraction data obtained in step (c) tocompute a difference Fourier image of the inhibitor; and (f) locatingthe attachment site of the inhibitor based on the computations obtainedin step (e).

In a different aspect, the invention is directed to a method ofobtaining a modified inhibitor comprising (a) obtaining a crystalcomprising a chimeric c-fms polypeptide and an inhibitor; (b) obtainingthe atomic coordinates of the crystal; (c) using the atomic coordinatesand one or more molecular modeling techniques to determine how to modifythe interaction of the inhibitor with the chimeric c-fms polypeptide;and (d) modifying the inhibitor based on the determinations obtained instep (c) to produce a modified inhibitor.

In one embodiment, the crystal comprises a peptide selected from thegroup consisting of: a peptide having SEQ ID NO: 2; a peptide having SEQID NO: 4 and a peptide having SEQ ID NO: 6. In another embodiment, theone or more molecular modeling techniques are selected from the groupconsisting of graphic molecular modeling and computational chemistry. Inone embodiment, step (b) comprises detecting the interaction of theinhibitor to one or more amino acid residues selected from the groupconsisting of (i) Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596,Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646,Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668,Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782,Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799,Ala 800, Arg 801, Asp 802; (ii) Lys 586, Leu 588, Gly 589, Val 596, Glu598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802; and, (iii) Lys 586,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663,Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782,Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801. In oneembodiment of the method, an inhibitor of a chimeric c-fms polypeptideis identified.

The invention further includes an isolated protein fragment comprising abinding pocket or active site defined by one or more structurecoordinates of chimeric c-fms amino acid residues selected from thegroup consisting of (i) Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu799, Ala 800, Arg 801, Asp 802; (ii) Lys 586, Leu 588, Gly 589, Val 596,Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666,Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796,Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802; and, (iii) Lys586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg782, Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801. Theinvention also includes a fragment linked to a solid support, anisolated nucleic acid molecule encoding the fragment, a vectorcomprising the nucleic acid molecule, a host cell comprising the vector,and, a method of producing a protein fragment comprising culturing thehost cell under conditions in which the fragment is expressed.

The invention also includes a method of screening for an agent thatassociates with a chimeric c-fms polypeptide, comprising (a) exposing aprotein molecule fragment to the agent; and (b) detecting the level ofassociation of the agent to the fragment. Also included in the inventionis a kit comprising the protein molecule fragment.

In another aspect of the invention, the invention is directed to amethod for the production of a crystal complex comprising a chimericc-fms chimeric polypeptide-ligand comprising (a) contacting the chimericc-fms polypeptide with the ligand in a suitable solution and, (b)crystallizing the resulting complex of chimeric c-fms polypeptide-ligandfrom the solution. In one embodiment, the invention includes a methodfor the production of a crystal comprising crystallizing a peptidecomprising a sequence selected from the group consisting of SEQ ID NO:2, 4 or 6 with a potential inhibitor. In another embodiment, the methodfurther comprises contacting the crystalline chimeric c-fmspolypeptide-ligand complex with another ligand in a suitable solution toreplace the bound ligand.

The invention also includes methods or identifying a potential inhibitorof a chimeric c-fms polypeptide comprising (a) using a three dimensionalstructure of a chimeric c-fms polypeptide as defined by atomiccoordinates according to Tables 1, 2 or 3 or similar structurecoordinates for the amino acids of a c-fms chimera comprising a rootmean square deviation of non-hydrogen atoms of less than about 1.5 Åwhen superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or 3; (b) replacing oneor more chimeric c-fms polypeptide amino acids selected from the groupconsisting of (i) Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596,Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646,Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668,Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782,Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799,Ala 800, Arg 801, Asp 802; (ii) Lys 586, Leu 588, Gly 589, Val 596, Glu598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802; and, (iii) Lys 586,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663,Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782,Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 in thethree-dimensional structure with a different amino acid to produce amodified three-dimensional structure; and, (c) using the modifiedthree-dimensional structure to design or select the potential inhibitor.In one aspect, the method further comprises d) synthesizing saidpotential inhibitor. In a different aspect, the method further comprisese) contacting said potential inhibitor with said modified chimeric c-fmspolypeptide in the presence of a ligand to test the ability of saidpotential inhibitor to inhibit a chimeric c-fms polypeptide or saidmodified chimeric c-fms polypeptide; and the inhibitor identified. Inone embodiment, the replacing of one or more amino acid residues furthercomprises replacing SEQ ID NO: 2 amino acid residues selected from thegroup consisting of Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu799, Ala 800, Arg 801. In yet a different aspect, the potentialinhibitor is selected from a database. In another aspect, the potentialinhibitor is designed de novo. In one embodiment, the potentialinhibitor is designed from a known inhibitor. In yet a differentembodiment, the step of employing said modified three-dimensionalstructure to design or select said potential inhibitor comprises thesteps of: (a) identifying chemical entities or fragments capable ofassociating with a modified chimeric c-fms polypeptide; and (b)assembling the identified chemical entities or fragments into a singlemolecule to provide the structure of said potential inhibitor. In oneaspect, the potential inhibitor is a competitive inhibitor. In adifferent aspect, the potential inhibitor is a non-competitive oruncompetitive inhibitor. In one embodiment, the potential inhibitor isan irreversible inhibitor.

The present invention includes methods of producing and usingthree-dimensional structure information derived from c-fms and c-fmschimeric polypeptides and inhibitory compounds which form a complex withc-fms and c-fms chimeric polypeptides and prevent c-fms and c-fmschimeras from interacting with their naturally occurring ligand orligands. The present invention also includes specific crystallization toobtain crystals of the c-fms-ligand (inhibitor) complex. The crystalsare subsequently used to obtain a 3-dimensional structure of the complexusing X-ray crystallography (or NMR) and the obtained data is used forrational drug discovery design with the aim to improve the complexformation between c-fms and its chimeras and the inhibitor, and, also toimprove the inhibition of the binding of c-fms ligands. In thisinvention the KID was replaced by the shorter KID derived from the FGFR1receptor [24]. Additional constructs also include c-fms chimeras derivedfrom replacing the native KID with the KID of tie2 or IRK.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1 A and B. Ribbons representation of the overall fold of c-fmscomplexed with arylamide 1183648 (A) or quinolone 793693 (B) compounds.The secondary structure elements are coded in magenta (α-helices) oryellow (β-sheets). The positions of the termini are indicated by N andC, respectively. Important structural elements are color-coded:nucleotide binding loop (blue), activation loop (red), catalytic loop(green), hinge region (salmon) and kinase insert domain (KID) (cyan).Disordered regions are approximated by dotted lines. Figure created inPyMol [25].

FIGS. 2A and B. Combined ribbons and ball-and-stick representation ofthe c-fms binding pocket complexed with arylamide 1183648 (A) orquinolone 793693 (B) compounds. Color coding is the same as in FIG. 1.The ribbons representation for the hinge region was omitted and replacedwith a complete ball-and-stick representation of the relevant aminoacids. Figure created in PyMol [25].

FIG. 3. Nucleotide sequence of the cfms-FGFR1 chimera beginning at Tyr538 of c-fms (SEQ ID NO: 1).

FIG. 4. Amino acid sequence of the c-FMS-FGFR1 chimera (SEQ ID NO: 2).

FIG. 5. Nucleotide sequence of the cfms-TIE2 chimera beginning at Tyr538 of c-fms (SEQ ID NO: 3).

FIG. 6. Amino acid sequence of the c-FMS-TIE2 chimera (SEQ ID NO: 4).

FIG. 7. Nucleotide sequence of the c-FMs-irk chimera (SEQ ID NO: 5)

FIG. 8. Amino acid sequence of the c-FMS-irk chimera (SEQ ID NO: 6)

FIG. 9. Nucleotide sequence of wild-type c-fms (SEQ ID NO: 7)

FIG. 10. Amino acid sequence of wild-type c-fms (SEQ ID NO: 8)

FIG. 11. FIG. 11 describes the construct design process exemplified forthe c-fms-FGFR1-chimera.

DETAILED DESCRIPTION OF THE INVENTION

Definitions

As is generally the case in biotechnology and chemistry, the descriptionof the present invention has required the use of a number of terms ofart. Although it is not practical to do so exhaustively, definitions forsome of these terms are provided here for ease of reference. Unlessdefined otherwise, all technical and scientific terms used herein havethe same meaning as commonly understood by one of ordinary skill in theart to which this invention belongs. Definitions for other terms alsoappear elsewhere herein. However, the definitions provided here andelsewhere herein should always be considered in determining the intendedscope and meaning of the defined terms. Although any methods andmaterials similar or equivalent to those described herein can be used inthe practice of the present invention, the preferred methods andmaterials are described.

As used herein, the term “atomic coordinates” or “structure coordinates”refers to mathematical coordinates that describe the positions of atomsin crystals of c-fms chimeras in Protein Data Bank (PDB) format,including X, Y, Z and B, for each atom. The diffraction data obtainedfrom the crystals are used to calculate an electron density map of therepeating unit of the crystal. The electron density maps may be used toestablish the positions (i.e., coordinates X, Y and Z) of the individualatoms within the crystal. Those of skill in the art understand that aset of structure coordinates determined by X-ray crystallography is notwithout standard error. For the purpose of this invention, any set ofstructure coordinates for c-fms chimeras from any source having a rootmean square deviation of non-hydrogen atoms of less than about 1.5 Åwhen superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or 3 are consideredsubstantially identical or homologous. In a preferred embodiment, anyset of structure coordinates for c-fms chimeras from any source having aroot mean square deviation of non-hydrogen atoms of less than about 0.75Å when superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or 3 are consideredsubstantially identical or homologous.

As used herein, the term “unit cell” means the fundamental portion of acrystal structure that is repeated infinitely by translation in threedimensions. A unit cell is characterized by three vectors a, b, and c,not located in one plane, which form the edges of a parallelepiped.Angles alpha, beta and gamma define the angles between the vectors:angle alpha is the angle between vectors b and c; angle beta is theangle between vectors a and c; and angle gamma is the angle betweenvectors a and b. The entire volume of a crystal can be constructed byregular assembly of unit cells. Each unit cell comprises a completerepresentation of the unit of pattern, the repetition of which builds upthe crystal. See, for example, U.S. Appl. No. 2004/0002145.

As used herein, the term “asymmetric unit” (ASU) means part of asymmetric object, which by itself does not posses any symmetry and fromwhich the whole unit cell is built up by the application of symmetryoperations of its point group. See, for example, U.S. Appl. No.2004/0002145.

As used herein, the term “space group” means a group or array ofoperations consistent with an infinitely extended regularly repeatingpattern. It is the symmetry of a three-dimensional structure, or thearrangement of symmetry elements of a crystal. There are 230 space groupsymmetries possible; however, there are only 65 space group symmetriesavailable for biological structures. See, for example, U.S. Appl. No.2004/0002145.

The term “atom type” refers to the chemical element whose coordinatesare measured. For instance, the first letter in a column in Table 1identifies the element.

The terms “X,” “Y” and “Z” refer to the crystallographically-definedatomic position of the element measured with respect to the chosencrystallographic origin. The term “B” refers to a thermal factor thatmeasures the mean variation of an atom's position with respect to itsaverage position.

As used herein, the term “crystal” refers to any three-dimensionalordered array of molecules that diffracts X-rays.

As used herein, the term “carrier” in a composition refers to a diluent,adjuvant, excipient, or vehicle with which the product is mixed.

As used herein, the term “composition” refers to the combining ofdistinct elements or ingredients to form a whole. A compositioncomprises more than one element or ingredient. For the purposes of thisinvention, a composition will often, but not always, comprise a carrier.

As used herein, the term “SAR,” an abbreviation for Structure-ActivityRelationships, collectively refers to the structure-activity/structureproperty relationships pertaining to the relationship(s) between acompound's activity/properties and its chemical structure.

As used herein, the term “molecular structure” refers to the threedimensional arrangement of molecules of a particular compound or complexof molecules (e.g., the three dimensional structure of a c-fms chimeraand ligands that interact with the c-fms chimera).

As used herein, the term “molecular modeling” refers to the use ofcomputational methods, preferably computer assisted methods, to drawrealistic models of what molecules look like and to make predictionsabout structure activity relationships of ligands. The methods used inmolecular modeling range from molecular graphics to computationalchemistry.

As used herein, the term “molecular model” refers to the threedimensional arrangement of the atoms of a molecule connected by covalentbonds or the three dimensional arrangement of the atoms of a complexcomprising more than one molecule, e.g., a protein-ligand complex.

As used herein, the term “molecular graphics” refers to 3Drepresentations of the molecules, for instance, a 3D representationproduced using computer assisted computational methods.

As used herein, the term “computational chemistry” refers tocalculations of the physical and chemical properties of the molecules.

As used herein, the term “molecular replacement” refers to a method thatinvolves generating a preliminary model of a crystal of whosecoordinates are unknown, by orienting and positioning the said atomiccoordinates described in the present invention so as best to account forthe observed diffraction pattern of the unknown crystal. Phases can thenbe calculated from this model and combined with the observed amplitudesto give an approximate Fourier synthesis of the structure whosecoordinates are unknown. (Rossmann, M. G., ed., “The MolecularReplacement Method,” Gordon & Breach, New York, 1972).

As used herein, the term “homolog” refers to the protein molecule or thenucleic acid molecule which encodes the protein, or a functional domainfrom said protein from a first source having at least about 30%, 40% or50% sequence identity, or at least about 60%, 70% or 75% sequenceidentity, or at least about 80% sequence identity, or more preferably atleast about 85% sequence identity, or even more preferably at leastabout 90% sequence identity, and most preferably at least about 95%, 97%or 99% amino acid or nucleotide sequence identity, with the protein,encoding nucleic acid molecule or any functional domain thereof, from asecond source. The second source may be a version of the molecule fromthe first source that has been genetically altered by any availablemeans to change the primary amino acid or nucleotide sequence or may befrom the same or a different species than that of the first source.

As used herein, the term “active site” refers to regions on a protein ora structural motif of a protein that are directly involved in thefunction or activity of the c-fms chimera or c-fms protein.

As used herein, the terms “binding site” or “binding pocket” refer to aregion of a protein or a molecular complex comprising the protein orpolypeptide that, as a result of the primary amino acid sequence of theprotein and/or its three-dimensional shape, favorably associates withanother chemical entity or compound including ligands or inhibitors.

For the purpose of this invention, any active site, binding site orbinding pocket defined by a set of structure coordinates for a proteinor for a homolog of a protein from any source having a root mean squaredeviation of non-hydrogen atoms of less than about 1.5 Å whensuperimposed on the non-hydrogen atom positions of the correspondingatomic coordinates of Tables 1, 2 or 3 are considered substantiallyidentical or homologous. In a more preferred embodiment, any set ofstructure coordinates for a protein or a homolog of a protein from anysource having a root mean square deviation of non-hydrogen atoms of lessthan about 0.75 Å when superimposed on the non-hydrogen atom positionsof the corresponding atomic coordinates of Tables 1, 2 or 3 areconsidered substantially identical or homologous.

The term “root mean square deviation” means the square root of thearithmetic mean of the squares of the deviations from the mean.

As used herein, the term “amino acids” refers to the L-isomers of thenaturally occurring amino acids. The naturally occurring amino acids areglycine, alanine, valine, leucine, isoleucine, serine, methionine,threonine, phenylalanine, tyrosine, tryptophan, cysteine, proline,histidine, aspartic acid, asparagine, glutamic acid, glutamine,γ-carboxylglutamic acid, arginine, ornithine, and lysine. Unlessspecifically indicated, all amino acids are referred to in thisapplication are in the L-form.

As used herein, the term “nonnatural amino acids” refers to amino acidsthat are not naturally found in proteins. For example, selenomethionine.

As used herein, the term “positively charged amino acid” includes anyamino acids having a positively charged side chain under normalphysiological conditions. Examples of positively charged naturallyoccurring amino acids are arginine, lysine, and histidine.

As used herein, the term “negatively charged amino acid” includes anyamino acids having a negatively charged side chains under normalphysiological conditions. Examples of negatively charged naturallyoccurring amino acids are aspartic acid and glutamic acid.

As used herein, the term “hydrophobic amino acid” includes any aminoacids having an uncharged, nonpolar side chain that is relativelyinsoluble in water. Examples of naturally occurring hydrophobic aminoacids are alanine, leucine, isoleucine, valine, proline, phenylalanine,tryptophan, and methionine.

As used herein, the term “hydrophilic amino acid” refers to any aminoacids having an uncharged, polar side chain that is relatively solublein water. Examples of naturally occurring hydrophilic amino acids areserine, threonine, tyrosine, asparagine, glutamine and cysteine.

As used herein, the term “hydrogen bond” refers to two hydrophilic atoms(either O or N), which share a hydrogen that is covalently bonded toonly one atom, while interacting with the other.

As used herein, the term “hydrophobic interaction” refers tointeractions made by two hydrophobic residues or atoms (such as C).

As used herein, the term “conjugated system” refers to more than twodouble bonds are adjacent to each other, in which electrons arecompletely delocalized with the entire system. This also includesaromatic residues.

As used herein, the term “aromatic residue” refers to amino acids withside chains having a delocalized conjugated system. Examples of aromaticresidues are phenylalanine, tryptophan, and tyrosine.

As used herein, the terms “c-fms chimera,” “c-fms chimeric polypeptide”and “c-fms chimeric protein” are used interchangeably unless a differentmeaning is specifically indicated otherwise. When a different meaning isintended, such will be clear from the text. The term “c-fms,” “c-fmsprotein” and “c-fms polypeptide” may refer to either the chimeric ornon-chimeric c-fms. When a different meaning is intended, such will beclear from the text.

As used herein, the term “inhibitor” or “potential inhibitor” means asubstance that is believed to interact with another moiety, for examplea given ligand that is believed to interact to at least partiallyinhibit the activity of a complete c-fms or a chimeric c-fmspolypeptide, or fragment of either, and which can be subsequentlyevaluated for such an interaction and inhibititory effect.Representative candidate compounds or substrates include drugs and othertherapeutic agents, carcinogens and environmental pollutants, naturalproducts and extracts, as well as steroids, fatty acids andprostaglandins. Other examples of potential inhibitors that can beinvestigated using the methods of the present invention include, but arenot restricted to, agonists and antagonists of c-fms, a chimeric c-fmspolypeptide, toxins and venoms, viral epitopes, hormones, hormonereceptors, peptides, enzymes, enzyme substrates, co-factors, lectins,sugars, oligonucleotides or nucleic acids, oligosaccharides, proteins,small molecules and monoclonal antibodies. See, for example, U.S. PatentAppl. No. 20040002145.

As used herein, the phrase “inhibiting the binding” refers to preventingor reducing the direct or indirect association of one or more molecules,peptides, proteins, enzymes, or receptors, or preventing or reducing thenormal activity of one or more molecules, peptides, proteins, enzymes orreceptors, e.g., preventing or reducing the direct or indirectassociation with c-fms chimeric polypeptides.

As used herein, the term “competitive inhibitor” refers to inhibitorsthat bind to c-fms chimeras at the same sites as its binding partner(s),thus directly competing with them. Competitive inhibition may, in someinstances, be reversed completely by increasing the substrateconcentration.

As used herein, the term “uncompetitive inhibitor” refers to one thatinhibits the functional activity of a c-fms chimera by binding to adifferent site than does its substrate(s).

As used herein, the term “non-competitive inhibitor” refers to one thatcan bind to either the free or bound form of a c-fms chimera.

As used herein the term “irreversible” or “covalent” inhibitor refers toone that inhibits a c-fms chimera by forming a covalent bond with thechimera and either inhibiting the enzyme by excluding its substrate orcausing a permanent reorientation of catalytic residues thus renderingthe enzyme inactive. Those of skill in the art may identify inhibitorsas competitive, uncompetitive, or non-competitive by computer fittingenzyme kinetic data using standard methods. See, for example, Segel, I.H., Enzyme Kinetics, J. Willey & Sons, (1975). Examples of irreversibleinhibition are found, for example, in U.S. Pat. Nos. 6,153,617;6,127,374; 5,4981,616; 5,298,508 and 5,082,964.

As used herein, the term “R or S-isomer” refers to two possiblestereroisomers of a chiral carbon according to the Cahn-Ingold-Prelogsystem adopted by International Union of Pure and Applied Chemistry(IUPAC). Each group attached to the chiral carbon is first assigned to apreference or priority a, b, c or d on the basis of the atomic number ofthe atom that is directly attached to the chiral carbon. The group withthe highest atomic number is given the highest preference a, the groupwith next highest atomic number is given the next highest preference b;and so on. The group with the lowest preference (d) is then directedaway from the viewer. If the trace of a path from a to b to c is counterclockwise, the isomer is designated (S); in the opposite direction,clockwise, the isomer is designated (R).

As used herein, the term “ligand” refers to any molecule, or chemicalentity which binds with or to a c-fms chimera, a subunit of a c-fmschimera, a domain of c-fms chimera, a target structual motif of a c-fmschimera or a fragment of a c-fms chimera. Thus, ligands include, but arenot limited to, small molecule inhibitors, for example.

The term “soaking in a ligand” or “soaking a ligand” or “soaking” in thecontext of protein crystallography/structure based drug design refers toa process by which a ligand is brought in contact with and preferablybound to a protein present in crystalline form through diffusion of theligand through the crystalline matrix. In a typical application acrystal of the protein of interest is placed in a stabilization solutionfor a certain period of time (hours or days) in which a molar excess ofligand of interest has been at least partially solubilized. Typicallythe protein is present in unliganded form to facilitate ligand bindingbut could also be present in complex with a weaker or equally strongligand as the one one seeks to replace. If the binding affinity of theligand is high enough and the ligand-binding-site is unobstructed theligand will bind to the crystalline protein thus enabling the3-dimensional structure of the protein-ligand complex to be determinedby X-ray crystallography.

As used herein, the term “small molecule inhibitor” refers to compoundsuseful in the present invention having measurable or inhibitingactivity. In addition to small organic molecules, peptides, antibodies,cyclic peptides and peptidomimetics are contemplated as being useful inthe disclosed methods. Preferred inhibitors are small molecules,preferably less than 700 Daltons, and more preferably less than 450Daltons.

As used herein, the terms “bind,” “binding,” “bond,” or “bonded” whenused in reference to the association of atoms, molecules, or chemicalgroups, refer to any physical contact or association of two or moreatoms, molecules, or chemical groups.

As used herein, the terms “covalent bond” or “valence bond” refer to achemical bond between two atoms in a molecule created by the sharing ofelectrons, usually in pairs, by the bonded atoms.

As used herein, “noncovalent bond” refers to an interaction betweenatoms and/or molecules that does not involve the formation of a covalentbond between them.

As used herein, the term “native protein” refers to a protein comprisingan amino acid sequence identical to that of a protein isolated from itsnatural source or organism.

SPECIFIC EMBODIMENTS Detailed Embodiments

Included in this invention is a substitution of the native kinase insertdomain of c-fms, which due to its structural bulk and potentialdisorder, prevents crystallization of the native protein. The inventionalso includes a method for replacing the native kinase insert domainwith shorter kinase insert domains from the FGF receptor kinase, thetie-2 kinase and the insulin receptor kinase, and obtaining crystals ofa c-fms-chimeric protein.

A. Modeling the Three-Dimensional Structure of the c-fms ChimericProtein

The atomic coordinate data provided in Tables 1, 2 or 3 or thecoordinate data derived from homologous proteins may be used to build athree-dimensional model of a c-fms chimeric protein. Any availablecomputational methods may be used to build the three dimensional model.As a starting point, the X-ray diffraction pattern obtained from theassemblage of the molecules or atoms in a crystalline version of a c-fmschimera or a c-fms chimeric homolog can be used to build an electrondensity map using tools well known to those skilled in the art ofcrystallography and X-ray diffraction techniques. Additional phaseinformation extracted either from the diffraction data and available inthe published literature and/or from supplementing experiments may thenused to complete the reconstruction.

For basic concepts and procedures of collecting, analyzing, andutilizing X-ray diffraction data for the construction of electrondensities see, for example, Campbellet al., 1984, BiologicalSpectroscopy, The Benjamin/Cummings Publishing Co., Inc., Menlo Park,Calif.; Cantor et al., 1980, Biophysical Chemistry, Part II: Techniquesfor the study of biological structure and function, W.H. Freeman andCo., San Francisco, Calif.; A. T. Brunger, 1993, X-Flor Version 3.1: Asystem for X-ray crystallography and NMR, Yale Univ. Pr., New Haven,Conn.; M. M. Woolfson, 1997, An Introduction to X-ray Crystallography,Cambridge Univ. Pr., Cambridge, UK; J. Drenth, 1999, Principles ofProtein X-ray Crystallography (Springer Advanced Texts in Chemistry),Springer Verlag; Berlin; Tsirelson et al., 1996, Electron Density andBonding in Crystals: Principles, Theory and X-ray DiffractionExperiments in Solid State Physics and Chemistry, Inst. of Physics Pub.;U.S. Pat. No. 5,942,428; U.S. Pat. No. 6,037,117; U.S. Pat. No.5,200,910 and U.S. Pat. No. 5,365,456 (“Method for Modeling the ElectronDensity of a Crystal”), each of which is herein specificallyincorporated by reference in their entirety.

For basic information on molecular modeling, see, for example, M.Schlecht, Molecular Modeling on the PC, 1998, John Wiley & Sons; Gans etal., Fundamental Principals of Molecular Modeling, 1996, Plenum Pub.Corp.; N. C. Cohen (editor), Guidebook on Molecular Modeling in DrugDesign, 1996, Academic Press; and W. B. Smith, Introduction toTheoretical Organic Chemistry and Molecular Modeling, 1996. U.S. patentswhich provide detailed information on molecular modeling include U.S.Pat. Nos. 6,093,573; 6,080,576; 6,075,014; 6,075,123; 6,071,700;5,994,503; 5,612,894; 5,583,973; 5,030,103; 4,906,122; and 4,812,12,each of which are incorporated by reference herein in their entirety.

B. Methods of Using the Atomic Coordinates to Identify and DesignLigands of Interest

The atomic coordinates of the invention, such as those described inTables 1, 2 or 3 or coordinates substantially identical to or homologousto those of Tables 1, 2 or 3 may be used with any available methods toprepare three dimensional models of c-fms chimeras as well as toidentify and design ligands, inhibitors or antagonists or agonistmolecules.

For instance, three-dimensional modeling may be performed using theexperimentally determined coordinates derived from X-ray diffractionpatterns, such as those in Tables 1, 2 or 3, for example, wherein suchmodeling includes, but is not limited to, drawing pictures of the actualstructures, building physical models of the actual structures, anddetermining the structures of related subunits and /ligand andsubunit/ligand complexes using the coordinates. Such molecular modelingcan utilize known X-ray diffraction molecular modeling algorithms ormolecular modeling software to generate atomic coordinates correspondingto the three-dimensional structure of c-fms chimeras.

As described above, molecular modeling involves the use of computationalmethods, preferably computer assisted methods, to build realistic modelsof molecules that are identifiably related in sequence to the knowncrystal structure. It also involves modeling new small moleculeinhibitors bound to c-fms chimeras starting with the structures of c-fmschimeras alone or complexed with known ligands or inhibitors. Themethods utilized in ligand modeling range from molecular graphics (i.e.,3D representations) to computational chemistry (i.e., calculations ofthe physical and chemical properties) to make predictions about thebinding of ligands or activities of ligands; to design new ligands; andto predict novel molecules, including ligands such as drugs, forchemical synthesis, collectively referred to as rational drug design.

One approach to rational drug design is to search for known molecularstructures that might bind to an active site. Using molecular modeling,rational drug design programs can look at a range of different molecularstructures of drugs that may fit into the active site of an enzyme orprotein, and by moving them in a three-dimensional environment it can bedecided which structures actually fit the site well. See, also, forexample, data in Tables 1, 2 or 3. An alternate but related rationaldrug design approach starts with the known structure of a complex with asmall molecule ligand and models modifications of that small molecule inan effort to make additional favorable interactions with c-fms chimerasand c-fms proteins.

The present invention includes the use of molecular and computermodeling techniques to design and select ligands, such as small moleculeagonists or antagonists or other therapeutic agents that interact withc-fms chimeras as proteins. Such agents include, but are not limited toarylamides and quinolones and derivatives thereof. For example, theinvention as herein described includes the design of ligands that act aspartial or complete inhibitors of at least one function by binding toall, or a portion of, the active sites or other regions of c-fmschimeras or proteins.

This invention also includes the design of compounds that act asuncompetitive inhibitors of at least one function of c-fms chimeras orproteins. These inhibitors may bind to all, or a portion of, the activesites or other regions of the chimeras or proteins already bound to aligand and may be more potent and less non-specific than competitiveinhibitors that compete for active sites. Similarly, non-competitiveinhibitors that bind to and inhibit at least one function of c-fmschimeras or proteins whether or not it is bound to another chemicalentity, such as a natural ligand, for example, may be designed using theatomic coordinates of the chimeras or complexes comprising the chimerasof this invention.

The atomic coordinates of the present invention also provide the neededinformation to probe a crystal of a c-fms chimera with moleculescomposed of a variety of different chemical features to determineoptimal sites for interaction between candidate inhibitors and/oractivators and c-fms chimeras. For example, high resolution X-raydiffraction data collected from crystals saturated with solvent allowsthe determination of where each type of solvent molecule sticks. Smallmolecules that bind to those sites can then be designed and synthesizedand tested for their inhibitory activity (Travis, J., Science 262:1374(1993)).

The present invention also includes methods for computationallyscreening small molecule databases and libraries for chemical entities,agents, ligands, or compounds that can bind in whole, or in part, toc-fms chimeras. In this screening, the quality of fit of such entitiesor compounds to the binding site or sites may be judged either by shapecomplementarity or by estimated interaction energy (Meng, E. C. et al.,J. Comp. Chem. 13:505-524 (1992)).

The design of compounds that bind to, promote or inhibit the functionalactivity of c-fms proteins and/or chimeras according to this inventiongenerally involves consideration of two factors. First, the compoundmust be capable of physically and structurally associating with thec-fms protein and/or c-fms chimera. Non-covalent molecular interactionsimportant in the association of the c-fms protein with the compoundinclude hydrogen bonding, van der Waals and hydrophobic interactions.Second, the compound must be able to assume a conformation that allowsit to associate with a c-fms protein and/or chimera. Although certainportions of the compound may not directly participate in the associationwith c-fms, those portions may still influence the overall conformationof the molecule. This, in turn, may have a significant impact on bindingaffinities, therapeutic efficacy, drug-like qualities and potency. Suchconformational requirements include the overall three-dimensionalstructure and orientation of the chemical entity or compound in relationto all or a portion of the active site or other region of c-fms, or thespacing between functional groups of a compound comprising severalchemical entities that directly interact with c-fms.

The potential, predicted, inhibitory agonist, antagonist or bindingeffect of a ligand or other compound on a c-fms protein may be analyzedprior to its actual synthesis and testing by the use of computermodeling techniques. If the theoretical structure of the given compoundsuggests insufficient interaction and association between it and thec-fms protein, synthesis and testing of the compound may be obviated.However, if computer modeling indicates a strong interaction, themolecule may then be synthesized and tested for its ability to interactwith c-fms. In this manner, synthesis of inoperative compounds may beavoided. In some cases, inactive compounds are synthesized predicted onmodeling and then tested to develop a SAR (structure-activityrelationship) for compounds interacting with a specific region of ac-fms protein.

One skilled in the art may use one of several methods to screen chemicalentities fragments, compounds, or agents for their ability to associatewith a c-fms protein and more particularly with the individual bindingpockets or active sites of the c-fms protein. This process may begin byvisual inspection of, for example, the active site based on the atomiccoordinates of the chimeric protein or the chimeric protein complexedwith a ligand. Selected chemical entities, compounds, or agents may thenbe positioned in a variety of orientations, or docked within anindividual binding pocket of the chimeric c-fms protein. Docking may beaccomplished using software-such as Quanta and Sybyl, followed by energyminimization and molecular dynamics with standard molecular mechanicsforcefields, such as CHARMM and AMBER.

Specialized computer programs may also assist in the process ofselecting chemical entities. These include but are not limited to: GRID(Goodford, P. J., “A Computational Procedure for DeterminingEnergetically Favorable Binding Sites on Biologically ImportantMacromolecules,” J. Med. Chem. 28:849-857 (1985), available from OxfordUniversity, Oxford, UK); MCSS (Miranker, A. and M. Karplus,“Functionality Maps of Binding Sites: A Multiple Copy SimultaneousSearch Method.” Proteins: Structure, Function and Genetics 11: 29-34(1991), available from Molecular Simulations, Burlington, Mass.);AUTODOCK (Goodsell, D. S. and A. J. Olsen, “Automated Docking ofSubstrates to Proteins by Simulated Annealing” Proteins: Structure.Function, and Genetics 8:195-202 (1990), available from Scripps ResearchInstitute, La Jolla, Calif.); DOCK (Kuntz, I. D. et al., “A GeometricApproach to Macromolecule-Ligand Interactions,” J. Mol. Biol.161:269-288 (1982), available from University of California, SanFrancisco, Calif.); Gold (Jones, G. et al., “Development and validationof a genetic algorithm for flexible docking.” J. Mol. Biol. 267: 727-748(1997)); Glide (Halgren, T. A. et al., “Glide: a new approach for rapid,accurate docking and scoring. 2. Enrichment factors in databasescreening.” J Med Chem, 47:1750-1759 (2004), Friesner, R. A. et al.,“Glide: a new approach for rapid, accurate docking and scoring. 1.Method and assessment of docking accuracy.” J Med Chem, 47:1739-1749(2004)); FlexX (Rarey, M. et al., “A fast flexible docking method usingan incremental construction algorithm.” J. Mol. Biol. 261: 470-489(1996)); and ICM (Abagyan, R. A. and Totrov, M. M., J. Mol. Biol. 235:983-1002 (1994)).

The use of software such as GRID, a program that determines probableinteraction sites between probes with various functional groupcharacteristics and the macromolecular surface, is used to analyze thesurface sites to determine structures of similar inhibiting proteins orcompounds. The GRID calculations, with suitable inhibiting groups onmolecules (e.g., protonated primary amines) as the probe, are used toidentify potential hotspots around accessible positions at suitableenergy contour levels. The program DOCK may be used to analyze an activesite or ligand binding site and suggest ligands with complementarysteric properties. See also, See, also, Kellenberger, P. N et al.,“Recovering the true targets of specific ligands by virtual screening ofthe protein data bank,” Proteins 54(4):671-80 (2004); Oldfield, T.,“Applications for macromolecular map interpretation: X-AUTOFIT,X-POWERFIT, X-BUILD, X-LIGAND, and X-SOLVATE,” Methods Enzymol.374:271-300 (2003); Richardson, J. S. et al., “New tools and data forimproving structures, using all-atom contacts,” Methods Enzymol. 374:385-412 (2003); Terwilliger, T. C., “Improving macromolecular atomicmodels at moderate resolution by automated iterative model building,statistical density modification and refinement,” Acta Crystallogr DBiol Crystallogr. 59(Pt 7): 1174-82 (2003); Toerger, T. C. andSacchettini, J. C., “TEXTAL system: artificial intelligence techniquesfor automated protein model building,” Methods Enzymol. 374:244-70(2003); von Grotthuss, M. et al., “Predicting protein structuresaccurately,” Science 304(5677):1597-9 (2004); Rajakiannan, V. et al.,“The use of ACORN in solving a 39.5 kDa macromolecule with 1.9 Åresolution laboratory source data,” J Synchrotron Radiat. 11(Pt4):358-62 (2004); Claude, J. B. et al., “CaspR: a web server forautomated molecular replacement using homology modelling,” Nucleic AcidsRes. 32(Web Server issue):W606-9 (2004); Suhre, K. and Sanejouand, Y.H., “ElNemo: a normal mode web server for protein movement analysis andthe generation of templates for molecular replacement,” Nucleic AcidsRes. 32(Web Server issue):W610-4 (2004).

Once suitable chemical entities, compounds, or agents have beenselected, they can be assembled into a single ligand or compound orinhibitor or activator. Assembly may proceed by visual inspection of therelationship of the fragments to each other on the three-dimensionalimage. This may be followed by manual model building using software suchas Quanta or Sybyl.

Useful programs to aid in connecting the individual chemical entities,compounds, or agents include but are not limited to: CAVEAT (Bartlett,P. A. et al., “CAVEAT: A Program to Facilitate the Structure-DerivedDesign of Biologically Active Molecules.” In Molecular Recognition inChemical and Biological, Problems, Special Pub., Royal Chem. Soc., 78,pp. 82-196 (1989)); 3D Database systems such as MACCS-3D (MDLInformation Systems, San Leandro, C A and Martin, Y. C., “3D DatabaseSearching in Drug Design,” J. Med. Chem. 35: 2145-2154 (1992); and HOOK(available from Molecular Simulations, Burlington, Mass.).

Several methodologies for searching three-dimensional databases to testpharmacophore hypotheses and select compounds for screening areavailable. These include the program CAVEAT (Bacon et al., J. Mol. Biol.225:849-858 (1992)). For instance, CAVEAT uses databases of cycliccompounds which can act as “spacers” to connect any number of chemicalfragments already positioned in the active site. This allows one skilledin the art to quickly generate hundreds of possible ways to connect thefragments already known or suspected to be necessary for tight binding.

Instead of proceeding to build an inhibitor activator, agonist orantagonist of a c-fms chimeric protein in a step-wise fashion onechemical entity at a time as described above, such compounds may bedesigned as a whole or “de novo” using either an empty active site oroptionally including some portion(s) of a known molecules. These methodsinclude: LUDI (Bohm, H.-J., “The Computer Program LUDI: A New Method forthe De Novo Design of Enzyme Inhibitors”, J. Comp. Aid. Molec. Design,6, pp. 61-78 (1992), available from Biosym Technologies, San Diego,Calif.); LEGEND (Nishibata, Y. and A. Itai, Tetrahedron 47:8985 (1991),available from Molecular Simulations, Burlington, Mass.); and LeapFrog(available from Tripos Associates, St. Louis, Mo.).

For instance, the program LUDI can determine a list of interaction sitesinto which to place both hydrogen bonding and hydrophobic fragments.LUDI then uses a library of linkers to connect up to four differentinteraction sites into fragments. Then smaller “bridging” groups such as—CH2— and —COO— are used to connect these fragments. For example, forthe enzyme DHFR, the placements of key functional groups in thewell-known inhibitor methotrexate were reproduced by LUDI. See also,Rotstein and Murcko, J. Med. Chem. 36: 1700-1710 (1992).

Other molecular modeling techniques may also be employed in accordancewith this invention. See, e.g., Cohen, N. C. et al., “Molecular ModelingSoftware and Methods for Medicinal Chemistry, J. Med. Chem. 33:883-894(1990). See also, Navia, M. A. and M. A. Murcko, “The Use of StructuralInformation in Drug Design,” Current Opinions in Structural Biology, 2,pp. 202-210 (1992).

Once a compound has been designed or selected by the above methods, theaffinity with which that compound may bind or associate with a c-fmsprotein may be tested and optimized by computational evaluation and/orby testing biological activity after synthesizing the compound.Inhibitors or compounds may interact with c-fms in more than oneconformation that is similar in overall binding energy. In those cases,the deformation energy of binding is taken to be the difference betweenthe energy of the free compound and the average energy of theconformations observed when the compound binds to a c-fms protein.

A compound designed or selected as binding or associating with c-fms maybe further computationally optimized so that in its bound state it wouldpreferably lack repulsive electrostatic interaction with the protein.Such non-complementary (e.g., electrostatic) interactions includerepulsive charge-charge, dipole-dipole and charge-dipole interactions.Specifically, the sum of all electrostatic interactions between theinhibitor and the chimera when the inhibitor is bound, preferably make aneutral or favorable contribution to the enthalpy of binding. Weakbinding compounds will also be designed by these methods so as todetermine SAR.

Specific computer software is available in the art to evaluate compounddeformation energy and electrostatic interaction. Examples of programsdesigned for such uses include: Gaussian 92, revision C (M. J. Frisch,Gaussian, Inc., Pittsburgh, Pa., COPYRGT 1992); AMBER, version 4.0 (P.A. Kollman, University of California at San Francisco, COPYRGT 1994);QUANTA/CHARMM (Molecular Simulations, Inc., Burlington, Mass. COPYRGT1994); Insight II/Discover (Biosysm Technologies Inc., San Diego, Calif.COPYRGT. 1994); and Delphi (A. Nicholls and B. Honig “A rapid finitedifference algorithm, utilizing successive over-relaxation to solve thePoisson-Boltzman equation” J. Comp. Chem. 12: 435-445 (1991), M. K.Gilson and B. Honig. “Calculation of the total electrostatic energy of amacromolecular system: Solvation energies, binding energies andconformation analysis” Proteins 4: 7-18 (1988), M. K. Gilson et al.,“Calculating the electrostatic potential of molecules in solution:Method and error assessment” J Comp. Chem 9: 327-335 (1987)). Otherhardware systems and software packages will be known to those skilled inthe art.

Once a compound that associates with the c-fms chimera and/or c-fmsprotein has been optimally selected or designed, as described above,substitutions may then be made in some of its atoms or side groups inorder to improve or modify its binding properties. Generally, initialsubstitutions are conservative, i.e., the replacement group will haveapproximately the same size, shape, hydrophobicity and charge as theoriginal group. It should, of course, be understood that componentsknown in the art to alter conformation may be avoided. Such substitutedchemical compounds may then be analyzed for efficiency of fit to a c-fmschimera by the same computer methods described in detail, above.

C. Use of Homology Structure Modeling to Design Ligands with ModulatedBinding or Activity to c-fms Proteins

The present invention includes the use of the atomic coordinates andstructures of c-fms chimeric proteins and/or c-fms chimeric proteininhibitor complexes. The structure of a complex between the chimera andthe starting compound can be used to guide the modification of thatcompound to produce new compounds that have other desirable propertiesfor applicable industrial and other uses (e.g., as pharmaceuticals),such as chemical stability, solubility or membrane permeability(Lipinski et al., Adv. Drug Deliv. Rev. 23:3 (1997)).

Binding compounds, agonists, antagonists and such that are known in theart include but are not limited to arylamides and quinolones. Suchcompounds can be diffused into or soaked with the stabilized crystals ofa c-fms chimera to form a complex for collecting X-ray diffraction data.Alternatively, other compounds, known and unknown in the art, can becocrystallized with the c-fms chimera by mixing the compound with thechimera before precipitation.

To produce custom high affinity and very specific compounds, thestructure of a c-fms chimera can be compared to the structure of aselected non-targeted molecule and a hybrid constructed by changing thestructure of residues at the binding site for a ligand for the residuesat the same positions of the non-target molecule. The process wherebythis modeling is achieved is referred to as homology structure modeling.This is done computationally by removing the side chains from themolecule or target of known structure and replacing them with the sidechains of the non-targeted structure put in sterically plausiblepositions. In this way it can be understood how the shapes of the activesite cavities of the targeted and non-targeted molecules differ. Thisprocess, therefore, provides information concerning how a bound ligandcan be chemically altered in order to produce compounds that will bindtightly and specifically to the desired target but will simultaneouslybe sterically prevented from binding to the non-targeted molecule.Likewise, knowledge of portions of the bound ligands that are facing tothe solvent would allow introduction of other functional groups foradditional pharmaceutical purposes. The use of homology structuremodeling to design molecules (ligands) that bind more tightly to thetarget enzyme than to the non-target enzyme has wide spreadapplicability.

D. High Throughput Assays

Any high throughput screening may be utilized to test new compoundswhich are identified or designed for their ability to interact withc-fms. For general information on high-throughput screening see, forexample, Devlin, 1998, High Throughput Screening, Marcel Dekker; andU.S. Pat. No. 5,763,263. High throughput assays utilize one or moredifferent assay techniques including, but not limited to, thosedescribed below.

Immunodiagnostics and Immunoassays. These are a group of techniques usedfor the measurement of specific biochemical substances, commonly at lowconcentrations in complex mixtures such as biological fluids, thatdepend upon the specificity and high affinity shown by suitably preparedand selected antibodies for their complementary antigens. A substance tobe measured must, of necessity, be antigenic—either an immunogenicmacromolecule or a haptenic small molecule. To each sample a known,limited amount of specific antibody is added and the fraction of theantigen combining with it, often expressed as the bound:free ratio, isestimated, using as indicator a form of the antigen labeled withradioisotope (radioimmunoassay), fluorescent molecule(fluoroimmunoassay), stable free radical (spin immunoassay), enzyme(enzyme immunoassay), or other readily distinguishable label.

Antibodies can be labeled in various ways, including: enzyme-linkedimmunosorbent assay (ELISA); radioimmuno assay (RIA); fluorescentimmunoassay (FIA); chemiluminescent immunoassay (CLIA); and labeling theantibody with colloidal gold particles (immunogold). Common assayformats include the sandwich assay, competitive or competition assay,latex agglutination assay, homogeneous assay, microtitre plate formatand the microparticle-based assay.

Enzyme-linked immunosorbent assay (ELISA). ELISA is an immunochemicaltechnique that avoids the hazards of radiochemicals and the expense offluorescence detection systems. Instead, the assay uses enzymes asindicators. ELISA is a form of quantitative immunoassay based on the useof antibodies (or antigens) that are linked to an insoluble carriersurface, which is then used to “capture” the relevant antigen (orantibody) in the test solution. The antigen-antibody complex is thendetected by measuring the activity of an appropriate enzyme that hadpreviously been covalently attached to the antigen (or antibody).

For information on ELISA techniques, see, for example, Crowther, (1995)ELISA—Theory and Practice (Methods in Molecular Biology), Humana Press;Challacombe & Kemeny, (1998) ELISA and Other Solid PhaseImmunoassays—Theoretical and Practical Aspects, John Wiley; Kemeny,(1991) A Practical Guide to ELISA, Pergamon Press; Ishikawa, (1991)Ultrasensitive and Rapid Enzyme Immunoassay (Laboratory Techniques inBiochemistry and Molecular Biology) Elsevier.

Colorimetric Assays for Enzymes. Colorimetry is any method ofquantitative chemical analysis in which the concentration or amount of acompound is determined by comparing the color produced by the reactionof a reagent with both standard and test amounts of the compound, oftenusing a colorimeter. A colorimeter is a device for measuring colorintensity or differences in color intensity, either visually orphotoelectrically.

Standard calorimetric assays of beta-galactosidase enzymatic activityare well known to those skilled in the art (see, for example, Norton etal., Mol. Cell. Biol. 5:281-290 (1985)). A calorimetric assay can beperformed on whole cell lysates using O-nitrophenyl-beta-D-galactopyranoside (ONPG, Sigma) as the substrate in a standardcolorimetric beta-galactosidase assay (Sambrook et al., (1989) MolecularCloning—A Laboratory Manual, Cold Spring Harbor Laboratory Press).Automated calorimetric assays are also available for the detection ofbeta-galactosidase activity, as described in U.S. Pat. No. 5,733,720.

Immunofluorescence Assays. Immunofluorescence or immunofluorescencemicroscopy is a technique in which an antigen or antibody is madefluorescent by conjugation to a fluorescent dye and then allowed toreact with the complementary antibody or antigen in a tissue section orsmear. The location of the antigen or antibody can then be determined byobserving the fluorescence by microscopy under ultraviolet light.

For general information on immunofluorescent techniques, see, forexample, Knapp et al., (1978) Immunofluorescence and Related StainingTechniques, Elsevier; Allan, (1999) Protein Localization by FluorescentMicroscopy—A Practical Approach (The Practical Approach Series) OxfordUniversity Press; Caul, (1993) Immunofluorescence Antigen DetectionTechniques in Diagnostic Microbiology, Cambridge University Press. Fordetailed explanations of immunofluorescent techniques applicable to thepresent invention, see U.S. Pat. No. 5,912,176; U.S. Pat. No. 5,869,264;U.S. Pat. No. 5,866,319; and U.S. Pat. No. 5,861,259.

E. Databases and Computer Systems

An amino acid sequence or nucleotide sequence of a c-fms chimera and/orX-ray diffraction data, useful for computer molecular modeling of ac-fms chimera or a portion thereof, can be “provided” in a variety ofmediums to facilitate use thereof. As used herein, “provided” refers toa manufacture, which contains, for example, an amino acid sequence ornucleotide sequence and/or atomic coordinates derived from X-raydiffraction data of the present invention, e.g., an amino acid ornucleotide sequence of a c-fms chimera, a representative fragmentthereof, or a homologue thereof. Such a product provides the amino acidsequence and/or X-ray diffraction data in a form which allows a skilledartisan to analyze and molecular model the three-dimensional structureof a c-fms chimera or related molecules, including a subdomain thereof.

In one application of this embodiment, databases comprising datapertaining to a c-fms chimera, or at least one subdomain thereof, aminoacid and nucleic acid sequence and/or X-ray diffraction data of thepresent invention is recorded on computer readable medium. As usedherein, “computer readable medium” refers to any medium which can beread and accessed directly by a computer. Such media include, but arenot limited to: magnetic storage media, such as floppy discs, hard discstorage media, and magnetic tape; optical storage media such as opticaldiscs or CD-ROM; electrical storage media such as RAM and ROM; andhybrids of these categories such as magnetic/optical storage media. Askilled artisan can readily appreciate how any of the presently knowncomputer readable media can be used to create a manufacture comprisingcomputer readable medium having recorded thereon an amino acid sequenceand/or X-ray diffraction data of the present invention.

As used herein, “recorded” refers to a process for storing informationon computer readable media. A skilled artisan can readily adopt any ofthe presently known methods for recording information on computerreadable media to generate manufactures comprising an amino acidsequence and/or atomic coordinate/X-ray diffraction data information ofthe present invention.

A variety of data storage structures are available to a skilled artisanfor creating a computer readable medium having recorded thereon an aminoacid sequence and/or atomic coordinate/X-ray diffraction data of thepresent invention. The choice of the data storage structure willgenerally be based on the means chosen to access the stored information.In addition, a variety of data processor programs and formats can beused to store the sequence and X-ray data information of the presentinvention on computer readable media. The sequence information can berepresented in a word processing text file, formatted incommercially-available software such as WordPerfect and MICROSOFT Word,or represented in the form of an ASCII file, stored in a databaseapplication, such as DB2, Sybase, Oracle, or the like. A skilled artisancan readily adapt any number of dataprocessor structuring formats (e.g.,text file or database) in order to obtain computer readable media havingrecorded thereon the information of the present invention.

By providing computer readable media having sequence and/or atomiccoordinates based on X-ray diffraction data, a skilled artisan canroutinely access the sequence and atomic coordinate or X-ray diffractiondata to model, for instance, a related molecule, a subdomain, mimetic,or a ligand thereof. Computer algorithms are publicly and commerciallyavailable which allow a skilled artisan to access this data provided ina computer readable medium and analyze it for molecular modeling and/orRDD (rational drug design). See, e.g., Biotechnology Software Directory,MaryAnn Liebert Publ., New York (1995).

The present invention further provides systems, particularlycomputer-based systems, which contain the sequence, structure, and/ordiffraction data described herein. Such systems are designed to dostructure determination and RDD for a c-fms chimera or at least onesubdomain thereof. Non-limiting examples are microcomputer workstationsavailable from Silicon Graphics Incorporated and Sun Microsystemsrunning UNIX based, Windows or IBM OS/2 operating systems.

As used herein, “a computer-based system” refers to the hardware means,software means, and data storage means used to analyze the sequence,structure, and/or X-ray diffraction data of the present invention. Theminimum hardware means of the computer-based systems of the presentinvention comprises a central processing unit (CPU), input means, outputmeans, and data storage means. A skilled artisan can readily appreciatewhich of the currently available computer-based systems are suitable foruse in the present invention. A visualization device, such as a monitor,is optionally provided to visualize structure data.

As stated above, the computer-based systems of the present inventioncomprise a data storage means having stored therein sequence, structure,and/or atomic coordinate/X-ray diffraction data of the present inventionand the necessary hardware means and software means for supporting andimplementing an analysis means. As used herein, “data storage means”refers to memory which can store sequence, structure, or atomiccoordinate/X-ray diffraction data of the present invention, or a memoryaccess means which can access manufactures having recorded thereon thesequence or X-ray data of the present invention.

As used herein, “search means” or “analysis means” refers to one or moreprograms which are implemented on the computer-based system to compare atarget sequence or target structural motif with the sequence, structure,or X-ray data stored within the data storage means. Search means areused, for instance, to identify fragments or regions of a protein orpolypeptide which match a particular target sequence or target motif. Avariety of known algorithms are disclosed publicly and a variety ofcommercially available software for conducting search means are and canbe used in the computer-based systems of the present invention. Askilled artisan can readily recognize that any one of the availablealgorithms or implementing software packages for conducting computeranalyses can be adapted for use in the present computer-based systems.

As used herein, “a target structural motif,” or “target motif,” refersto any rationally selected sequence or combination of sequences in whichthe sequence(s) are chosen based on a three-dimensional configuration orelectron density map which is formed upon the folding of the targetmotif. There are a variety of target motifs known in the art. Proteintarget motifs include, but are not limited to, enzymatic active sites,inhibitor binding sites, structural subdomains, epitopes, functionaldomains and signal sequences. Similar motifs are known for RNA. Avariety of structural formats for the input and output means can be usedto input and output the information in the computer-based systems of thepresent invention.

A variety of comparing means can be used to compare a target sequence ortarget motif with the data described herein to identify structuralmotifs or electron density maps derived in part from the atomiccoordinate/X-ray diffraction data. A skilled artisan can readilyrecognize that any one of the publicly available computer modelingprograms can be used as the search means for the computer-based systemsof the present invention.

F. Target Molecule Fragments and Portions

Fragments of c-fms, for instance fragments comprising active sitesdefined by two or more amino acids selected from the group consistingof: Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646, Val 647, Val661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782, Asn 783, Leu785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg801, Asp 802 may be prepared by any available means including syntheticor recombinant means. Such fragments may then be used in the assays asdescribed above, for instance, high through put assays to detectinteractions between prospective agents and the active site within thefragment.

For recombinant expression or production of the fragments of theinvention, nucleic acid molecules encoding the fragment may be prepared.As used herein, “nucleic acid” is defined as RNA or DNA that encodes aprotein or peptide as defined above, or is complementary to nucleic acidsequence encoding such peptides, or hybridizes to such nucleic acid andremains stably bound to it under appropriate stringency conditions.

Nucleic acid molecules encoding fragments of the invention may differ insequence because of the degeneracy in the genetic code or may differ insequence as they encode proteins or protein fragments that differ inamino acid sequence. Homology or sequence identity between two or moresuch nucleic acid molecules is determined by BLAST (Basic LocalAlignment Search Tool) analysis using the algorithm employed by theprograms blastp, blastn, blastx, tblastn and tblastx (Karlin et al.,Proc. Natl. Acad. Sci. USA 87:2264-2268 (1990) and Altschul et al., J.Mol. Evol. 36:290-300 (1993), fully incorporated by reference) which aretailored for sequence similarity searching.

The approach used by the BLAST program is to first consider similarsegments between a query sequence and a database sequence, then toevaluate the statistical significance of all matches that are identifiedand finally to summarize only those matches which satisfy a preselectedthreshold of significance. For a discussion of basic issues insimilarity searching of sequence databases, see Altschul et al. (Nat.Genet. 6, 119-129 (1994)) which is fully incorporated by reference. Thesearch parameters for histogram, descriptions, alignments, expect (i.e.,the statistical significance threshold for reporting matches againstdatabase sequences), cutoff, matrix and filter are at the defaultsettings. The default scoring matrix used by blastp, blastx, tblastn,and tblastx is the BLOSUM62 matrix (Henikoff et al., Proc. Natl. Acad.Sci. USA 89:10915-10919 (1992), fully incorporated by reference). Fourblastn parameters were adjusted as follows: Q=10 (gap creation penalty);R=10 (gap extension penalty); wink=1 (generates word hits at everywink^(th) position along the query); and gapw=16 (sets the window widthwithin which gapped alignments are generated). The equivalent Blastpparameter settings were Q=9; R=2; wink=1; and gapw=32. A Bestfitcomparison between sequences, available in the GCG package version 10.0,uses DNA parameters GAP=50 (gap creation penalty) and LEN=3 (gapextension penalty) and the equivalent settings in protein comparisonsare GAP=8 and LEN=2.

“Stringent conditions” are those that (1) employ low ionic strength andhigh temperature for washing, for example, 0.015 M NaCl/0.0015 M sodiumcitrate/0.1% SDS at 50° C. or (2) employ during hybridization adenaturing agent such as formamide, for example, 50% formamide with 0.1%bovine serum albumin/0.1% Ficoll/0.1% polyvinylpyrrolidone/50 mM, sodiumphosphate buffer at pH 6.5 with 750 mM NaCl, 75 mM sodium citrate at 42°C. Another example is use of 50% formamide, 5×SSC, 50 mM sodiumphosphate (pH 6.8), 0.1% sodium pyrophosphate, 5× Denhardt's solution,sonicated salmon sperm DNA (50 mg/ml), 0.1% SDS and 10% dextran sulfateat 42° C., with washes at 42° C. in 0.2×SSC and 0.1% SDS. A skilledartisan can readily determine and vary the stringency conditionsappropriately to obtain a clear and detectable hybridization signal.

As used herein, a nucleic acid molecule is said to be “isolated” whenthe nucleic acid molecule is substantially separated from contaminantnucleic acid encoding other polypeptides from the source of nucleicacid.

The encoding nucleic acid molecules of the present invention (i.e.,synthetic oligonucleotides) and those that are used as probes orspecific primers for polymerase chain reaction (PCR) or to synthesizegene sequences encoding proteins of the invention can easily besynthesized by chemical techniques, for example, the phosphotriestermethod of Matteucci et al. (J. Am. Chem. Soc. 103: 185-3191 (1981)) orusing automated synthesis methods. In addition, larger DNA segments canreadily be prepared by well known methods, such as synthesis of a groupof oligonucleotides that define various modular segments of the gene,followed by ligation of oligonucleotides to build the complete modifiedgene.

The encoding nucleic acid molecules of the present invention may furtherbe modified so as to contain a detectable label for diagnostic and probepurposes. A variety of such labels are known in the art and can readilybe employed with the encoding molecules herein described. Suitablelabels include, but are not limited to, biotin, radiolabeled nucleotidesand the like. A skilled artisan can employ any of the art-known labelsto obtain a labeled encoding nucleic acid molecule.

The present invention further provides recombinant DNA molecules (rDNA)that contain a coding sequence for a protein fragment as describedabove. As used herein, a rDNA molecule is a DNA molecule that has beensubjected to molecular manipulation. Methods for generating rDNAmolecules are well known in the art, for example, see Sambrook et al.,Molecular Cloning—A Laboratory Manual, Cold Spring Harbor LaboratoryPress (1989). In the preferred rDNA molecules, a coding DNA sequence isoperably linked to expression control sequences and/or vector sequences.

The choice of vector and expression control sequences to which one ofthe protein encoding sequences of the present invention is operablylinked depends directly, as is well known in the art, on the functionalproperties desired (e.g., protein expression, and the host cell to betransformed). A vector of the present invention may be capable ofdirecting the replication or insertion into the host chromosome, andpreferably also expression, of the structural gene included in the rDNAmolecule.

Expression control elements that are used for regulating the expressionof an operably linked protein encoding sequence are known in the art andinclude, but are not limited to, inducible promoters, constitutivepromoters, secretion signals, and other regulatory elements. Preferably,the inducible promoter is readily controlled, such as being responsiveto a nutrient in the host cell's medium.

The present invention further provides host cells transformed with anucleic acid molecule that encodes a protein, polypeptide, or fragmentof a protein or polypeptide of the present invention. The host cell canbe either prokaryotic or eukaryotic. Eukaryotic cells useful forexpression of a protein of the invention are not limited, so long as thecell line is compatible with cell culture methods and compatible withthe propagation of the expression vector and expression of the geneproduct. Preferred eukaryotic host cells include, but are not limitedto, yeast, insect and mammalian cells, preferably vertebrate cells suchas those from a mouse, rat, monkey or human cell line. Preferredeukaryotic host cells include Chinese hamster ovary (CHO) cellsavailable from the ATCC as CCL61, NIH Swiss mouse embryo cells NIH-3T3available from the ATCC as CRL1658, baby hamster kidney cells (BHK), andthe like eukaryotic tissue culture cell lines.

Transformed host cells of the invention may be cultured under conditionsthat allow the production of the recombinant protein. Optionally therecombinant protein is isolated from the medium or from the cells;recovery and purification of the protein may not be necessary in someinstances where some impurities may be tolerated.

Kits may also be prepared with any of the above described nucleic acidmolecules, protein fragments, vector and/or host cells optionallypackaged with the reagents needed for a specific assay, such as thosedescribed above. In such kits, the protein fragments or other reagentsmay be attached to a solid support, such as glass or plastic beads.

G. Integrated Procedures Which Utilize the Present Invention

Molecular modeling is provided by the present invention for rationaldrug design (RDD) of mimetics and ligands of a c-fms chimera. Asdescribed above, the drug design paradigm uses computer modelingprograms to determine potential mimetics and ligands of a c-fms chimerawhich are expected to interact with sites on the protein. The potentialmimetics or ligands are then screened for activity and/or binding and/orinteraction with the c-fms protein. For c-fms-related mimetics orligands, screening methods can be selected from assays for at least onebiological activity of c-fms, e.g., such as phosphorylation, accordingto known method steps. See, for example, U.S. Appl. No. 2004/0002145 A1.

Thus, the tools and methodologies provided by the present invention maybe used in procedures for identifying and designing ligands which bindin desirable ways with the target, a c-fms protein. Such proceduresutilize an iterative process whereby ligands are synthesized, tested andcharacterized. New ligands can be designed based on the informationgained in the testing and characterization of the initial ligands andthen such newly identified ligands can themselves be tested andcharacterized. This series of processes may be repeated as many times asnecessary to obtain ligands with the desirable binding properties.

The following steps serve as an example of the overall procedure:

1. A biological activity of a target is selected.

2. A ligand is identified that appears to be in some way associated withthe chosen biological activity (e.g., the ligand may be an inhibitor ofa known activity). The activity of the ligand may be tested by in vivoand/or in vitro methods.

A ligand of the present invention can be, but is not limited to, atleast one selected from a lipid, a nucleic acid, a compound, a protein,an element, an antibody, a saccharide, an isotope, a carbohydrate, animaging agent, a lipoprotein, a glycoprotein, an enzyme, a detectableprobe, and antibody or fragment thereof, or any combination thereof,which can be detectably labeled as for labeling antibodies. Such labelsinclude, but are not limited to, enzymatic labels, radioisotope orradioactive compounds or elements, fluorescent compounds or metals,chemiluminescent compounds and bioluminescent compounds. Alternatively,any other known diagnostic or therapeutic agent can be used in a methodof the invention. Suitable compounds are then tested for activities inrelationship to the target.

Complexes between a c-fms chimera and ligands are made either byco-crystallization or more commonly by diffusing the small moleculeligand into the crystal. X-ray diffraction data from the complex crystalare measured and a difference electron density map is calculated. Thisprocess provides the precise location of the bound ligand on the targetmolecule. The difference Fourier is calculated using measureddiffraction amplitudes and the phases of these reflections calculatedfrom the coordinates.

3. Using the methods of the present invention, X-ray crystallography isutilized to create electron density maps and/or molecular models of theinteraction of the ligand with the target molecule.

The entry of the coordinates of the target into the computer programsdiscussed above results in the calculation of the most probablestructure of the macromolecule. These structures are combined andrefined by additional calculations using such programs to determine theprobable or actual three-dimensional structure of the target includingpotential or actual active or binding sites of ligands. Such molecularmodeling (and related) programs useful for rational drug design ofligands or mimetics, are also provided by the present invention.

4. The electron density maps and/or molecular models obtained in Step 3are compared to the electron density maps and/or molecular models of anon-ligand containing target and the observed/calculated differences areused to specifically locate the binding of the ligand on the target orsubunit.

5. Modeling tools, such as computational chemistry and computermodeling, are used to adjust or modify the structure of the ligand sothat it can make additional or different interactions with the target.

The ligand design uses computer modeling programs which calculate howdifferent molecules interact with the various sites of a target. Thisprocedure determines potential ligands or mimetics of the ligand(s).

The ligand design uses computer modeling programs which calculate howdifferent molecules interact with the various sites of the target,subunit, or a fragment thereof. Thus, this procedure determinespotential ligands or ligand mimetics.

6. The newly designed ligand from Step 5 can be tested for itsbiological activity using appropriate in vivo or in vitro tests,including the high throughput screening methods discussed above.

The potential ligands or mimetics are then screened for activityrelating to a c-fms chimera, c-fms protein, or at least a fragmentthereof. Such screening methods are selected from assays for at leastone biological activity of the native target.

The resulting ligands or mimetics, provided by methods of the presentinvention, are useful for treating, screening or preventing diseases inanimals, such as mammals (including humans) and birds.

7. Of course, each of the above steps can be modified as desired bythose of skill in the art so as to refine the procedure for theparticular goal in mind. Also, additional X-ray diffraction data may becollected on c-fms chimeric proteins, c-fms chimeric proteins/ligandcomplexes, structural target motifs and subunit/ligand complexes at anystep or phase of the procedure. Such additional diffraction data can beused to reconstruct electron density maps and molecular models which mayfurther assist in the design and selection of ligands with the desirablebinding attributes.

It is to be understood that the present invention is considered toinclude stereoisomers as well as optical isomers, e.g., mixtures ofenantiomers as well as individual enantiomers and diastereomers, whicharise as a consequence of structural asymmetry in selected compounds,ligands or mimetics of the present series.

Some of the compounds or agents disclosed or discovered by the methodsherein may contain one or more asymmetric centers and thus give rise toenantiomers, diastereomers, and other stereoisomeric forms. The presentinvention is also meant to encompass all such possible forms as well astheir racemic and resolved forms and mixtures thereof. When thecompounds described or discovered herein contain olefinic double bondsor other centers of geometric asymmetry, and unless otherwise specified,it is intended to include both E and Z geometric isomers. All tautomersare intended to be encompassed by the present invention as well.

As used herein, the term “stereoisomers” is a general term for allisomers of individual molecules that differ only in the orientation oftheir atoms in space. It includes enantiomers and isomers of compoundswith more than one chiral center that are not mirror images of oneanother (diastereomers).

As used herein, the term “chiral center” refers to to a carbon atom towhich four different groups are attached.

As used herein, the term “enantiomer” or “enantiomeric” refers to amolecule that is nonsuperimposable on its mirror image and henceoptically active wherein the enantiomer rotates the plane of polarizedlight in one direction and its mirror image rotates the plane ofpolarized light in the opposite direction.

As used herein, the term “racemic” refers to a mixture of equal parts ofenantiomers and which is optically active.

As used herein, the term “resolution” refers to the separation orconcentration or depletion of one of the two enantiomeric forms of amolecule. In the context of this application, the term “resolution” alsorefers to the amount of detail which can be resolved by the diffractionexperiment. Or in other terms, since the inherent disorder of a proteincrystal diffraction pattern fades away at some diffraction angleθ_(max), the corresponding distance d_(min) of the reciprocal latticesis deterimined by Bragg's law.$d_{\min} = \frac{\lambda}{2\sin\quad\theta_{\max}}$In practice in protein crystallography it is usual to quote the nominalresolution of a protein electron density in terms of d_(min), theminimum lattice distance to which data is included in the calculation ofthe map.

Without further description, it is believed that one of ordinary skillin the art can, using the preceding description and the followingillustrative examples, make and utilize the compounds of the presentinvention and practice the claimed methods. The following workingexamples therefore, specifically point out preferred embodiments of thepresent invention, and are not to be construed as limiting in any waythe remainder of the disclosure.

EXAMPLES Example 1 Cloning of c-FMS-FGFR1 Chimera 538-922

All constructs begin at amino acid 538 of FMS and end at amino acid 922of FMS. Chimeras were created by replacing FMS KID with KID sequencesfrom RTK's known to be structured, like tie2 and irk. Chimeras are basedon structure prediction and sequence alignment.

c-fms fragments from amino acids 922-678 and 753-922 were generated byPCR using a c-fms construct derived by RT-PCR from THP-1 cells. Forcloning purposes, a Sal I site was included on the 5′ side of the922-678 PCR product and a stop codon followed by a Not I site wasincluded on the 3′ end of the 753-922 PCR product. The FGFR1 kinaseinsert domain was generated by annealing 2 synthesized oligonucleotidescorresponding to amino acids 671-679 of c-fms, followed by amino acids577-617 of FGFR1 and ending with amino acids 753-760 of c-fms. To obtainthe chimera, overlapping PCR was performed using the FMS PCR fragments922-678 and 753-922 and the annealed synthesized FGFR1 kinase insertdomain oligonucleotides as a template. The final PCR product wassubcloned into pCRII (Invitrogen) and the sequence was confirmed. Forexpression in SF9 cells, a recombinant baculovirus was generated bysubcloning the FMS-FGFR1 chimera into a modified Invitrogen GATEWAYpDEST8 vector, and following the protocol for Baculovirus Expressionaccording to the Bac-to-Bac manual. Other chimeras were generated in asimilar manner by using synthetic oligonucleotides corresponding to theKID of TIE2 or IR. FIG. 11 shows the Kinase insert domain replaced byFGFR1 KID.

Example 2 Protein Purification

Frozen cells were thawed and resuspended in 50 mM NaKPO₄ pH 7.5, 200 mMNaCl, 5% Glycerol, 1 mM Glutathione, 5 mM Imidazole, 1× CompleteEDTA-free protease inhibitor cocktail (Roche) (Buffer A). Thawed cellswere dounce homogenized, mechanically lysed with an Emulsiflex-C5(Avestin) at 10,000-15,000 psi and centrifuged at 40,000×g (16,000 rpm)for 1 hour to remove insoluble material. The supernatant was filteredthrough a 0.45 μm vacuum filter and incubated with a BD Talon metalaffinity resin (BD Biosciences Clontech) overnight at 4° C. After 20column volumes washes with buffer A containing 10 mM Imidazole, c-fmswas eluted using a 10 column volume linear gradient from 10 mM to 200 mMImidazole in buffer A. Fractions containing c-fms, as assayed bySDS-PAGE, were pooled and combined with 0.2 Units of TEV Protease(Invitrogen)/μg of c-fms to remove the histidine tag. The reaction wasdialyzed overnight against 50 mM NaKPO₄ pH 7.5, 200 mM NaCl, 5%Glycerol, 2 mM Glutathione and was then incubated with a BD Talon metalaffinity resin for two hours to remove TEV protease. Purified c-fms wasthen filtered through a 0.2 μm filter, concentrated and further purifiedon size exclusion column (Superdex 200 HR 10/30, Amersham Biosciences).The buffer used for gel filtration was 50 mM HEPES pH 7.5, 200 mM NaCl,5 mM Glutathione, 3% Glycerol. Fractions containing c-fms were pooled,passed through a 0.1 μm vacuum filter, incubated with a compound for 2hours and concentrated to a final concentration of 7 to 11 mg/ml.

Example 3 Enzymatic Assays

(a) An autophosphorylation, fluorescence polarization competitionimmunoassay was used for compounds with IC₅₀'s >10 nM. The assay wasperformed in black 96-well micro plates (UL BioSystems). The assaybuffer used was 100 mM HEPES, pH 7.5, 1 mM DTT, 0.01% (v/v) Tween-20.Compounds were diluted in assay-buffer containing 4% DMSO just prior tothe assay. To each well, 5 μl of compound were added followed by theaddition of 3 μl of a mix containing 33 nM c-fms (3DP) and 16.7 mM MgCl₂(Sigma) in assay buffer. The kinase reaction was initiated by adding 2μl of 5 mM ATP (Sigma) in assay buffer. The final concentrations in theassay were 10 nM c-fms, 1 mM ATP, 5 mM MgCl₂, 2% DMSO. Control reactionswere ran in each plate: in positive and negative control wells, assaybuffer (made 4% in DMSO) was substituted for the compound; in addition,positive control wells received 1.2 μl of 50 mM EDTA.

The plates were covered and incubated at room temperature for 45 min. Atthe end of the incubation, the reaction was quenched with 1.2 μl of 50mM EDTA (EDTA was not added to the positive control wells at this point;see above). Following a 5-min incubation, each well received 10 μl of a1:1:3 mixture of anti-phosphotyrosine antibody, 10X, PTK green tracer,10X (vortexed), FP dilution buffer, respectively (all from PanVera, cat.# P2837). The plate was covered, incubated for 30 min at roomtemperature and the fluorescence polarization was read on the Analyst.The instrument settings were: 485 nm excitation filter; 530 nm emissionfilter; Z height: middle of well; G factor: 0.93. Under theseconditions, the fluorescence polarization values for positive andnegative controls were ˜300 and ˜150, respectively, and were used todefine the 100% and 0% inhibition of the c-fms reaction. The IC₅₀ valuesreported are the averages of three independent measurements.

(b) A peptide phosphorylation, fluorescence polarization competitionimmunoassay was used for compounds with IC₅₀'s <10 nM. The assay wasperformed in black 96-well micro plates. The assay buffer used was 100mM HEPES, pH 7.5, 1 mM DTT, 0.01% (v/v) Tween-20. Compounds were dilutedin assay buffer containing 4% DMSO just prior to the assay. To eachwell, 5 μl of compound were added followed by the addition of 2 μl of amix containing 5 nM c-fms and 25 mM MgCl₂ in assay buffer. 2 μl of 1540μM peptide SYEGNSYTFIDPTQ (AnaSpec) were subsequently added. The kinasereaction was initiated by adding 1 μl of 10 mM ATP in assay buffer. Thefinal concentrations in the assay were 1 nM c-fms, 308 μM peptide, 1 mMATP, 5 mM MgCl₂, 2% DMSO. Control reactions were ran in each plate: inpositive and negative control wells, assay buffer (made 4% in DMSO) wassubstituted for the compound; in addition, positive control wellsreceived 1.2 μl of 50 mM EDTA. The plates were covered and incubated atroom temperature for 80 min. Quenching of the reaction and detection ofproduct formation were performed as described in (a). Fluorescencepolarization values for positive and negative controls were ˜290 and˜160, respectively, and were used to define the 100% and 0% inhibitionof the c-fms reaction.

Example 4 Crystallographic Detail

Crystallization and Structure Determination

In a typical crystallization experiment 1-2 μl of c-fms proteincomplexed with the lead compounds and concentrated to 7-10 mg/ml wasmixed in a 1:1 ratio with well solution (15-28% PEG 3350, 100 mMSodium-Acetate pH 5.0-5.6, 200 mM Li₂SO₄, 5 mM DTT, 0-3% glycerol) andplaced on a glass cover slip. The cover slip was inverted and sealedover a reservoir of 500-1000 μl of well solution and incubated at 22° C.Crystals usually appeared over night. In most cases μ-seeding with aseed stock obtained from one of the lead compounds was used to inducecrystallization. Crystals were harvested with a nylon loop, placed forless than 10 seconds in cryo-solution (27% PEG 3350, 100 mM.Sodium-Acetate pH 5.5, 200 mM Li₂SO₄, 5 mM DTT, 10% glycerol) and frozenby immersion in liquid nitrogen. Data were collected at 100K on a BrukerAXS MO6XCE rotating anode and a SMART 6000 CCD detector or at theIMCA-CAT ID-17 beamline at the Argonne National Laboratory. Thediffraction data was processed with the Bruker Proteum suite or the HKLsuite (Denzo/Scalepack) The initial c-fms structure was solved bymolecular replacement using the FGFR crystal structure as a search modelin CNX. Structure refinement and model building was carried outaccording to standard protocols using CNX [10] and O [11].

Crystal form I was obtained with the following characteristics: a=81.07,b=81.07, c=144.67, α=90, β=90, γ=120, sg=R3, diffraction limit 1.9 Å(synchrotron), one molecule/ASU. Crystal form II was obtained with thefollowing characteristics: a=53.1, b=72.4, c=91.7, α=90, β=90, γ=90,sg=P2₁2₁2₁, diffraction limit 3 Å (synchrotron), one molecule/asymmetricunit.

A highly preferred crystal structure is a crystal structure defined bystructure coordinates of c-fms amino acids Trp 550, Lys 586, Thr 587,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633,Met 637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665,Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774,Ile 775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796,Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802.

A preferred crystal structure is a crystal structure defined bystructure coordinates of c-fms amino acid residues Lys 586, Leu 588, Gly589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802.

Another crystal structure of the invention is defined by structurecoordinates of c-fms amino acid residues Lys 586, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp796, Phe 797, Leu 799, Ala 800, Arg 801.

Ligands of c-fms

Binding Mode of the Arylamide Series

The inhibitor of the arylamide series occupies the nucleotide-bindingpocket, located between the N-domain and the C-domain. The carbonyloxygen of the amide bond forms a hydrogen bond with the amide-N ofCys666 in the hinge-region. The five-membered ring together with thecyano-group occupies the adenine pocket. A π-π stacking interaction isformed with Phe797 of the DFG motif. Other van der waals interactionsare mediated by the surrounding hydrophobic pocket formed by Val596,Ala614, Lys616, Val647, Thr663, Leu785 and Ala800. Theortho-methyl-piperidine ring is located in the sugar pocket. Arg801forms the bottom of that pocket and Asn783 and Gly589 are flanking thepiperidine ring on either side. The methoxy-aryl ring projects into thesolvent area and interacts with part of the solvent interface residues,mainly Leu588 and Gly669. A weak hydrogen bonding interaction betweenmethyl-hydroxy group and the phenol-hydroxy group of Tyr665 can beobserved as well. A general description of the acrylamide series is setforth, below.

Binding Mode of Quinolone Series

The quinolone also occupies the nucleotide-binding pocket, with thechloro-aryl ring located in the adenine pocket. Both the amide oxygenand nitrogen form hydrogen-bonding interactions with the backbone of thehinge residues Cys666 and Glu664. The remainder of the interactions ismainly of hydrophobic nature and involves residues of the solventinterface and the sugar pocket (Leu588, Gly589, Leu596, Gly669, Asp670,Leu785, Phe797, Ala800, Arg801). A general description of the quinoloneseries is set forth below.

Specific ligands used in this invention: TABLE 1 Coordinates of c-FMS(FGF-chimera) in complex with 1183648 (Arylamide) 1183648 ArylamideSeries

793693 Quinolone Series

REMARK c-fins (538-922, FGF chimera) complexed with 1183648 REMARKrefinement resolution: 500.0-1.9 A REMARK starting r = 0.2455 free_r =0.2709 REMARK final r = 0.2382 free_r = 0.2634 CRYST1 81.070 81.070144.670 90.00 90.00 120.00 R 3 REMARK Written by CMX VERSION: 2000.12ATOM 1 GB VAL A 548 11.165 23.567 −9.796 1.00 46.87 A C ATOM 2 CG1 VAL A548 10.117 22.545 −10.233 1.00 48.46 A C ATOM 3 CG2 VAL A 548 11.50724.515 −10.930 1.00 47.89 A C ATOM 4 C VAL A 548 10.853 23.525 −7.3181.00 44.87 A C ATOM 5 O VAL A 548 10.292 23.832 −6.266 1.00 46.87 A OATOM 6 N VAL A 548 11.394 25.649 −8.429 1.00 47.54 A N ATOM 7 CA VAL A548 10.652 24.363 −8.578 1.00 46.32 A C ATOM 8 N ARG A 549 11.665 22.476−7.423 1.00 42.02 A N ATOM 9 CA ARG A 549 11.938 21.604 −6.285 1.0037.85 A C ATOM 10 CB ARG A 549 11.190 20.275 −6.452 1.00 41.18 A C ATOM11 CG ARG A 549 9.696 20.418 −6.734 1.00 46.48 A C ATOM 12 CD ARG A 5498.961 21.106 −5.591 1.00 49.39 A C ATOM 13 NE ARG A 549 7.583 21.443−5.947 1.00 53.70 A N ATOM 14 CZ ARG A 549 6.645 20.553 −6.263 1.0054.90 A C ATOM 15 NH1 ARG A 549 6.924 19.256 −6.273 1.00 55.44 A N ATOM16 NH2 ARG A 549 5.421 20.961 −6.565 1.00 54.85 A N ATOM 17 C ARG A 54913.435 21.329 −6.157 1.00 33.97 A C ATOM 18 O ARG A 549 14.173 21.380−7.145 1.00 30.81 A O ATOM 19 N TRP A 550 13.880 21.052 −4.933 1.0029.62 A N ATOM 20 CA TRP A 550 15.283 20.740 −4.666 1.00 28.56 A C ATOM21 CB TRP A 550 15.504 20.519 −3.171 1.00 26.01 A C ATOM 22 CG TRP A 55015.550 21.786 −2.386 1.00 25.25 A C ATOM 23 CD2 TRP A 550 16.091 21.955−1.074 1.00 23.72 A C ATOM 24 CE2 TRP A 550 15.908 23.307 −0.717 1.0022.59 A C ATOM 25 CE3 TRP A 550 16.713 21.090 −0.163 1.00 24.79 A C ATOM26 CD1 TRP A 550 15.069 23.012 −2.768 1.00 24.22 A C ATOM 27 NE1 TRP A550 15.283 23.930 −1.765 1.00 22.76 A N ATOM 28 CZ2 TRP A 550 16.32823.821 0.515 1.00 21.82 A C ATOM 29 CZ3 TRP A 550 17.128 21.602 1.0681.00 24.34 A C ATOM 30 CH2 TRP A 550 16.932 22.955 1.391 1.00 22.28 A CATOM 31 C TRP A 550 15.657 19.475 −5.410 1.00 29.29 A C ATOM 32 O TRP A550 14.826 18.589 −5.571 1.00 28.55 A O ATOM 33 N LYS A 551 16.91019.386 −5.843 1.00 30.00 A N ATOM 34 CA LYS A 551 17.365 18.224 −6.5901.00 33.37 A C ATOM 35 CB LYS A 551 16.932 18.370 −8.052 1.00 35.38 A CATOM 36 CG LYS A 551 17.405 17.253 −8.976 1.00 39.80 A C ATOM 37 CD LYSA 551 16.825 17.431 −10.367 1.00 42.63 A C ATOM 38 CE LYS A 551 17.25616.315 −11.302 1.00 44.35 A C ATOM 39 NZ LYS A 551 16.549 16.416 −12.6051.00 48.76 A N ATOM 40 C LYS A 551 18.875 18.013 −6.523 1.00 32.42 A CATOM 41 O LYS A 551 19.655 18.962 −6.622 1.00 32.55 A O ATOM 42 N ILE A552 19.282 16.760 −6.352 1.00 33.95 A N ATOM 43 CA ILE A 552 20.69716.424 −6.305 1.00 35.46 A C ATOM 44 CB ILE A 552 20.953 15.123 −5.5031.00 35.03 A C ATOM 45 CG2 ILE A 552 22.436 14.785 −5.526 1.00 34.39 A CATOM 46 CG1 ILE A 552 20.460 15.285 −4.059 1.00 35.72 A C ATOM 47 CD1ILE A 552 21.162 16.378 −3.276 1.00 34.12 A C ATOM 48 C ILE A 552 21.16716.214 −7.742 1.00 37.59 A C ATOM 49 O ILE A 552 20.582 15.425 −8.4811.00 37.74 A O ATOM 50 N ILE A 553 22.214 16.932 −8.134 1.00 39.45 A NATOM 51 CA ILE A 553 22.763 16.820 −9.479 1.00 42.83 A C ATOM 52 CB ILEA 553 22.910 18.202 −10.134 1.00 43.54 A C ATOM 53 CG2 ILE A 553 21.54718.887 −10.204 1.00 44.16 A C ATOM 54 CG1 ILE A 553 23.894 19.054 −9.3311.00 44.09 A C ATOM 55 CD1 ILE A 553 24.230 20.373 −9.976 1.00 46.56 A CATOM 56 C ILE A 553 24.134 16.144 −9.426 1.00 45.11 A C ATOM 57 O ILE A553 24.637 15.843 −8.347 1.00 43.96 A O ATOM 58 N GLU A 554 24.74015.921 −10.589 1.00 48.95 A N ATOM 59 CA GLU A 554 26.039 15.255 −10.6581.00 53.03 A C ATOM 60 CB GLU A 554 26.065 14.318 −11.868 1.00 55.27 A CATOM 61 CG GLU A 554 24.945 13.294 −11.868 1.00 57.79 A C ATOM 62 CD GLUA 554 25.028 12.331 −13.036 1.00 59.93 A C ATOM 63 OE1 GLU A 554 25.01912.793 −14.198 1.00 61.39 A O ATOM 64 OE2 GLU A 554 25.098 11.108−12.790 1.00 61.06 A O ATOM 65 C GLU A 554 27.267 16.169 −10.697 1.0055.01 A C ATOM 66 O GLU A 554 27.377 17.039 −11.558 1.00 55.58 A O ATOM67 N SER A 555 28.182 15.943 −9.754 1.00 57.81 A N ATOM 68 CA SER A 55529.443 16.683 −9.615 1.00 61.03 A C ATOM 69 GB SER A 555 30.467 16.151−10.620 1.00 61.30 A C ATOM 70 OG SER A 555 31.014 14.925 −10.176 1.0063.33 A O ATOM 71 C SER A 555 29.456 18.210 −9.673 1.00 62.83 A C ATOM72 O SER A 555 28.832 18.826 −10.539 1.00 64.30 A O ATOM 73 N TYR A 55630.201 18.804 −8.741 1.00 64.60 A N ATOM 74 CA TYR A 556 30.358 20.255−8.646 1.00 66.35 A C ATOM 75 CB TYR A 556 29.013 20.938 −8.343 1.0067.32 A C ATOM 76 CG TYR A 556 29.133 22.442 −8.231 1.00 68.68 A C ATOM77 CD1 TYR A 556 29.739 23.185 −9.245 1.00 69.26 A C ATOM 78 CE1 TYR A556 29.938 24.555 −9.113 1.00 69.44 A C ATOM 79 CD2 TYR A 556 28.71923.114 −7.078 1.00 68.99 A C ATOM 80 CE2 TYR A 556 28.914 24.489 −6.9381.00 69.55 A C ATOM 81 CZ TYR A 556 29.524 25.201 −7.960 1.00 69.54 A CATOM 82 OH TYR A 556 29.723 26.557 −7.833 1.00 70.57 A O ATOM 83 C TYR A556 31.407 20.656 −7.593 1.00 66.71 A C ATOM 84 O TYR A 556 32.45120.010 −7.474 1.00 66.92 A O ATOM 85 N GLU A 557 31.121 21.716 −6.8371.00 66.87 A N ATOM 86 CA GLU A 557 32.017 22.249 −5.814 1.00 67.02 A CATOM 87 CB GLU A 557 31.976 21.382 −4.553 1.00 66.49 A C ATOM 88 CG GLUA 557 30.717 21.567 −3.721 1.00 65.18 A C ATOM 89 CD GLU A 557 30.66522.918 −3.023 1.00 64.82 A C ATOM 90 OE1 GLU A 557 31.463 23.140 −2.0861.00 62.98 A O ATOM 91 OE2 GLU A 557 29.826 23.758 −3.415 1.00 64.85 A OATOM 92 C GLU A 557 33.449 22.369 −6.317 1.00 67.59 A C ATOM 93 O GLU A557 33.798 23.344 −6.986 1.00 68.31 A O ATOM 94 N SER A 560 31.02318.654 −4.540 1.00 49.29 A N ATOM 95 CA SER A 560 31.861 17.507 −4.2111.00 47.58 A C ATOM 96 GB SER A 560 31.617 17.077 −2.765 1.00 49.09 A CATOM 97 OG SER A 560 32.464 15.999 −2.405 1.00 52.73 A O ATOM 98 C SER A560 31.543 16.355 −5.160 1.00 45.63 A C ATOM 99 O SER A 560 31.30916.574 −6.348 1.00 46.90 A O ATOM 100 N TYR A 561 31.526 15.132 −4.6401.00 43.44 A N ATOM 101 CA TYR A 561 31.237 13.972 −5.477 1.00 40.83 A CATOM 102 CB TYR A 561 32.342 12.921 −5.336 1.00 38.21 A C ATOM 103 CGTYR A 561 32.374 11.927 −6.474 1.00 36.42 A C ATOM 104 CD1 TYR A 56133.156 12.161 −7.610 1.00 35.20 A C ATOM 105 CE1 TYR A 561 33.169 11.259−8.670 1.00 33.53 A C ATOM 106 CD2 TYR A 561 31.605 10.767 −6.432 1.0034.66 A C ATOM 107 CE2 TYR A 561 31.607 9.863 −7.486 1.00 32.90 A C ATOM108 CZ TYR A 561 32.390 10.113 −8.599 1.00 31.59 A C ATOM 109 OH TYR A561 32.402 9.215 −9.635 1.00 34.61 A O ATOM 110 C TYR A 561 29.89613.351 −5.103 1.00 40.32 A C ATOM 111 O TYR A 561 29.597 13.156 −3.9241.00 41.32 A O ATOM 112 N THR A 562 29.088 13.054 −6.114 1.00 38.96 A NATOM 113 CA THR A 562 27.782 12.442 −5.900 1.00 39.31 A C ATOM 114 CBTHR A 562 26.709 13.046 −6.841 1.00 40.36 A C ATOM 115 OG1 THR A 56226.538 14.441 −6.552 1.00 41.37 A O ATOM 116 CG2 THR A 562 25.375 12.329−6.658 1.00 41.13 A C ATOM 117 C THR A 562 27.876 10.940 −6.167 1.0038.15 A C ATOM 118 O THR A 562 27.992 10.520 −7.310 1.00 36.90 A O ATOM119 N PHE A 563 27.828 10.138 −5.108 1.00 38.25 A N ATOM 120 CA PHE A563 27.904 8.686 −5.246 1.00 38.94 A C ATOM 121 CB PHE A 563 28.5618.059 −4.014 1.00 37.40 A C ATOM 122 CG PHE A 563 30.024 8.376 −3.8741.00 37.56 A C ATOM 123 CD1 PHE A 563 30.444 9.509 −3.188 1.00 36.54 A CATOM 124 CD2 PHE A 563 30.982 7.537 −4.439 1.00 37.87 A C ATOM 125 CE1PHE A 563 31.803 9.805 −3.062 1.00 37.79 A C ATOM 126 CE2 PHE A 56332.342 7.823 −4.322 1.00 36.75 A C ATOM 127 CZ PHE A 563 32.753 8.958−3.632 1.00 37.32 A C ATOM 128 C PHE A 563 26.528 8.063 −5.447 1.0039.38 A C ATOM 129 O PHE A 563 26.370 7.111 −6.219 1.00 39.09 A O ATOM130 N ILE A 564 25.539 8.601 −4.742 1.00 40.69 A N ATOM 131 CA ILE A 56424.170 8.112 −4.831 1.00 41.77 A C ATOM 132 CB ILE A 564 23.702 7.503−3.490 1.00 42.05 A C ATOM 133 CG2 ILE A 564 24.395 6.184 −3.250 1.0043.03 A C ATOM 134 CG1 ILE A 564 23.986 8.477 −2.344 1.00 42.97 A C ATOM135 CD1 ILE A 564 23.578 7.955 −0.974 1.00 43.33 A C ATOM 136 C ILE A564 23.231 9.254 −5.205 1.00 43.18 A C ATOM 137 O ILE A 564 23.075 9.570−6.385 1.00 44.14 A O ATOM 138 N GLU A 573 14.255 3.524 7.607 1.00 51.06A N ATOM 139 CA GLU A 573 12.990 4.014 8.131 1.00 48.88 A C ATOM 140 CBGLU A 573 11.937 2.909 8.066 1.00 50.91 A C ATOM 141 CG GLU A 573 10.6383.365 7.428 1.00 54.45 A C ATOM 142 CD GLU A 573 9.700 2.220 7.137 1.0054.34 A C ATOM 143 OE1 GLU A 573 9.200 1.602 8.101 1.00 57.46 A O ATOM144 OE2 GLU A 573 9.469 1.936 5.944 1.00 54.86 A O ATOM 145 C GLU A 57313.158 4.505 9.566 1.00 47.33 A C ATOM 146 O GLU A 573 12.230 4.44810.378 1.00 45.02 A O ATOM 147 N LYS A 574 14.358 4.992 9.862 1.00 45.22A N ATOM 148 CA LYS A 574 14.683 5.512 11.181 1.00 43.34 A C ATOM 149 CBLYS A 574 16.175 5.839 11.256 1.00 45.54 A C ATOM 150 CG LYS A 57416.626 6.882 10.231 1.00 48.43 A C ATOM 151 CD LYS A 574 18.138 7.07910.253 1.00 50.08 A C ATOM 152 CE LYS A 574 18.584 8.056 9.177 1.0050.70 A C ATOM 153 NZ LYS A 574 20.071 8.155 9.084 1.00 52.42 A N ATOM154 C LYS A 574 13.872 6.775 11.436 1.00 40.84 A C ATOM 155 O LYS A 57413.698 7.192 12.581 1.00 38.62 A O ATOM 156 N TRP A 575 13.378 7.37910.358 1.00 37.54 A N ATOM 157 CA TRP A 575 12.597 8.607 10.458 1.0035.85 A C ATOM 158 CB TRP A 575 12.668 9.390 9.142 1.00 35.33 A C ATOM159 CG TRP A 575 14.044 9.829 8.789 1.00 33.45 A C ATOM 160 CD2 TRP A575 14.756 10.924 9.364 1.00 33.42 A C ATOM 161 CE2 TRP A 575 16.03410.955 8.760 1.00 33.47 A C ATOM 162 CE3 TRP A 575 14.440 11.884 10.3341.00 33.14 A C ATOM 163 CD1 TRP A 575 14.890 9.252 7.884 1.00 34.38 A CATOM 164 NE1 TRP A 575 16.089 9.924 7.861 1.00 33.20 A N ATOM 165 CZ2TRP A 575 16.996 11.911 9.095 1.00 34.42 A C ATOM 166 CZ3 TRP A 57515.397 12.834 10.667 1.00 33.68 A C ATOM 167 CH2 TRP A 575 16.660 12.84010.047 1.00 33.09 A C ATOM 168 C TRP A 575 11.135 8.392 10.816 1.0034.58 A C ATOM 169 O TRP A 575 10.419 9.352 11.078 1.00 35.64 A O ATOM170 N GLU A 576 10.688 7.140 10.830 1.00 33.31 A N ATOM 171 CA GLU A 5769.291 6.848 11.129 1.00 34.26 A C ATOM 172 CB GLU A 576 9.036 5.34111.030 1.00 33.19 A C ATOM 173 CG GLU A 576 7.577 4.961 10.804 1.0035.33 A C ATOM 174 CD GLU A 576 6.969 5.627 9.571 1.00 36.95 A C ATOM175 OE1 GLU A 576 7.710 5.905 8.606 1.00 34.78 A O ATOM 176 OE2 GLU A576 5.739 5.855 9.566 1.00 37.14 A O ATOM 177 C GLU A 576 8.859 7.36412.496 1.00 34.78 A C ATOM 178 O GLU A 576 9.556 7.177 13.493 1.00 34.79A O ATOM 179 N PHE A 577 7.704 8.025 12.522 1.00 34.65 A N ATOM 180 CAPHE A 577 7.137 8.587 13.747 1.00 35.89 A C ATOM 181 CB PHE A 577 7.32410.112 13.743 1.00 35.50 A C ATOM 182 CG PHE A 577 6.915 10.786 15.0261.00 38.52 A C ATOM 183 CD1 PHE A 577 7.692 10.660 16.173 1.00 39.23 A CATOM 184 CD2 PHE A 577 5.754 11.551 15.086 1.00 39.04 A C ATOM 185 CE1PHE A 577 7.319 11.288 17.359 1.00 40.42 A C ATOM 186 CE2 PHE A 5775.371 12.183 16.269 1.00 40.12 A C ATOM 187 CZ PHE A 577 6.157 12.05217.405 1.00 39.09 A C ATOM 188 C PHE A 577 5.646 8.232 13.775 1.00 35.65A C ATOM 189 O PHE A 577 5.001 8.178 12.729 1.00 34.99 A O ATOM 190 NPRO A 578 5.082 7.966 14.969 1.00 37.40 A N ATOM 191 CD PRO A 578 5.7547.831 16.272 1.00 37.91 A C ATOM 192 CA PRO A 578 3.659 7.620 15.0821.00 39.09 A C ATOM 193 CB PRO A 578 3.517 7.172 16.540 1.00 39.23 A CATOM 194 CG PRO A 578 4.919 6.779 16.939 1.00 39.86 A C ATOM 195 C PRO A578 2.776 8.828 14.781 1.00 39.55 A C ATOM 196 O PRO A 578 2.877 9.85415.454 1.00 39.44 A O ATOM 197 N ARG A 579 1.906 8.716 13.783 1.00 40.97A N ATOM 198 CA ARG A 579 1.044 9.842 13.441 1.00 43.14 A C ATOM 199 CBARG A 579 0.279 9.569 12.142 1.00 44.41 A C ATOM 200 CG ARG A 579 0.7708.473 12.218 1.00 43.56 A C ATOM 201 CD ARG A 579 −1.421 8.287 10.8541.00 43.26 A C ATOM 202 NE AEG A 579 −0.452 7.843 9.854 1.00 41.26 A NATOM 203 CZ ARG A 579 −0.279 8.419 8.668 1.00 40.59 A C ATOM 204 NH1 ARGA 579 −1.009 9.472 8.322 1.00 38.73 A N ATOM 205 NH2 ARG A 579 0.6307.944 7.828 1.00 38.95 A N ATOM 206 C ARG A 579 0.066 10.194 14.558 1.0044.85 A C ATOM 207 O ARG A 579 −0.367 11.339 14.668 1.00 44.89 A O ATOM208 N ASN A 580 −0.282 9.216 15.390 1.00 46.52 A N ATOM 209 CA ASN A 580−1.210 9.478 16.485 1.00 47.33 A C ATOM 210 CB ASN A 580 −1.707 8.16117.098 1.00 49.83 A C ATOM 211 CG ASN A 580 −0.578 7.283 17.597 1.0051.93 A C ATOM 212 OD1 ASN A 580 0.141 7.644 18.527 1.00 52.98 A O ATOM213 ND2 ASN A 580 −0.417 6.119 16.974 1.00 54.36 A N ATOM 214 C ASN A580 −0.545 10.350 17.548 1.00 47.28 A C ATOM 215 O ASN A 580 −1.21510.901 18.425 1.00 47.53 A O ATOM 216 N ASN A 581 0.776 10.474 17.4571.00 46.66 A N ATOM 217 CA ASN A 581 1.547 11.298 18.385 1.00 46.34 A CATOM 218 CB ASN A 581 2.928 10.684 18.622 1.00 46.38 A C ATOM 219 CG ASNA 581 2.909 9.601 19.680 1.00 48.64 A C ATOM 220 OD1 ASN A 581 1.9588.828 19.777 1.00 49.08 A O ATOM 221 ND2 ASN A 581 3.967 9.535 20.4761.00 49.59 A N ATOM 222 C ASN A 581 1.697 12.696 17.799 1.00 45.48 A CATOM 223 O ASN A 581 2.598 13.448 18.163 1.00 45.18 A O ATOM 224 N LEU A582 0.790 13.030 16.889 1.00 46.64 A N ATOM 225 CA LEU A 582 0.78814.320 16.213 1.00 47.46 A C ATOM 226 CB LEU A 582 1.021 14.099 14.7161.00 47.46 A C ATOM 227 CG LEU A 582 2.089 14.897 13.968 1.00 47.95 A CATOM 228 CD1 LEU A 582 3.427 14.798 14.684 1.00 47.18 A C ATOM 229 CD2LEU A 582 2.196 14.353 12.553 1.00 46.30 A C ATOM 230 C LEU A 582 −0.55215.027 16.417 1.00 47.70 A C ATOM 231 O LEU A 582 −1.611 14.442 16.1811.00 48.34 A O ATOM 232 N GLN A 583 −0.509 16.279 16.863 1.00 47.09 A NATOM 233 CA GLN A 583 −1.730 17.050 17.061 1.00 47.88 A C ATOM 234 CBGLN A 583 −1.826 17.565 18.501 1.00 50.09 A C ATOM 235 CG GLN A 583−3.178 18.186 18.834 1.00 52.33 A C ATOM 236 CD GLN A 583 −3.248 18.73820.246 1.00 54.36 A C ATOM 237 OE1 GLN A 583 −4.308 19.165 20.702 1.0057.10 A O ATOM 238 NE2 GLN A 583 −2.119 18.738 20.943 1.00 55.40 A NATOM 239 C GLN A 583 −1.694 18.222 16.089 1.00 47.05 A C ATOM 240 O GLNA 583 −0.955 19.183 16.289 1.00 46.70 A O ATOM 241 N PHE A 584 −2.49518.131 15.035 1.00 47.31 A N ATOM 242 CA PHE A 584 −2.543 19.160 14.0061.00 47.73 A C ATOM 243 CB PHE A 584 −3.227 18.603 12.757 1.00 50.38 A CATOM 244 CG PHE A 584 −2.416 17.561 12.039 1.00 53.03 A C ATOM 245 CD1PHE A 584 −1.697 16.604 12.752 1.00 55.45 A C ATOM 246 CD2 PHE A 584−2.389 17.518 10.652 1.00 53.61 A C ATOM 247 CE1 PHE A 584 −0.965 15.62112.094 1.00 54.55 A C ATOM 248 CE2 PHE A 584 −1.660 16.538 9.988 1.0054.81 A C ATOM 249 CZ PHE A 584 −0.948 15.587 10.711 1.00 54.82 A C ATOM250 C PHE A 584 −3.204 20.470 14.412 1.00 46.10 A C ATOM 251 O PHE A 584−4.168 20.496 15.181 1.00 45.13 A O ATOM 252 N GLY A 585 −2.661 21.55813.872 1.00 44.07 A N ATOM 253 CA GLY A 585 −3.173 22.883 14.151 1.0041.49 A C ATOM 254 C GLY A 585 −3.616 23.565 12.874 1.00 40.71 A C ATOM255 O GLY A 585 −4.151 22.921 11.970 1.00 40.08 A O ATOM 256 N LYS A 586−3.381 24.870 12.788 1.00 40.07 A N ATOM 257 CA LYS A 586 −3.777 25.63811.613 1.00 40.54 A C ATOM 258 CB LYS A 586 −3.736 27.137 11.917 1.0041.93 A C ATOM 259 CG LYS A 586 −2.326 27.697 12.074 1.00 45.59 A C ATOM260 CD LYS A 586 −2.339 29.221 12.134 1.00 47.83 A C ATOM 261 CE LYS A586 −0.933 29.794 12.215 1.00 50.42 A C ATOM 262 NZ LYS A 586 −0.24129.413 13.477 1.00 50.82 A N ATOM 263 C LYS A 586 −2.904 25.372 10.3931.00 38.79 A C ATOM 264 O LYS A 586 −1.740 24.986 10.510 1.00 37.58 A OATOM 265 N THR A 587 −3.486 25.586 9.219 1.00 38.30 A N ATOM 266 CA THRA 587 −2.777 25.417 7.964 1.00 37.40 A C ATOM 267 CB THR A 587 −3.76225.253 6.797 1.00 38.08 A C ATOM 268 OG1 THR A 587 −4.560 24.082 7.0141.00 36.18 A O ATOM 269 CG2 THR A 587 −3.010 25.123 5.473 1.00 37.14 A CATOM 270 C THR A 587 −1.942 26.680 7.754 1.00 36.74 A C ATOM 271 O THR A587 −2.435 27.788 7.939 1.00 36.53 A O ATOM 272 N LEU A 588 −0.67826.506 7.378 1.00 36.11 A N ATOM 273 CA LEU A 588 0.233 27.630 7.1601.00 35.14 A C ATOM 274 CB LEU A 588 1.650 27.218 7.540 1.00 35.05 A CATOM 275 CG LEU A 588 1.792 26.730 8.984 1.00 35.11 A C ATOM 276 CD1 LEUA 588 3.142 26.057 9.173 1.00 32.99 A C ATOM 277 CD2 LEU A 588 1.62527.910 9.944 1.00 36.00 A C ATOM 278 C LEU A 588 0.211 28.110 5.717 1.0035.47 A C ATOM 279 O LEU A 588 0.338 29.306 5.443 1.00 36.82 A O ATOM280 N GLY A 589 0.050 27.168 4.798 1.00 34.05 A N ATOM 281 CA GLY A 5890.009 27.503 3.392 1.00 33.07 A C ATOM 282 C GLY A 589 −0.331 26.2622.599 1.00 34.05 A C ATOM 283 O GLY A 589 −0.278 25.147 3.125 1.00 35.75A O ATOM 284 N ALA A 590 −0.677 26.448 1.334 1.00 34.26 A N ATOM 285 CAALA A 590 −1.025 25.327 0.480 1.00 35.08 A C ATOM 286 CB ALA A 590−2.458 24.881 0.760 1.00 35.99 A C ATOM 287 C ALA A 590 −0.876 25.694−0.983 1.00 37.94 A C ATOM 288 O ALA A 590 −0.955 26.867 −1.353 1.0038.44 A O ATOM 289 N GLY A 591 −0.652 24.674 −1.806 1.00 39.30 A N ATOM290 CA GLY A 591 −0.508 24.870 −3.234 1.00 40.01 A C ATOM 291 C GLY A591 −1.530 24.016 −3.955 1.00 39.30 A C ATOM 292 O GLY A 591 −2.46323.506 −3.338 1.00 39.01 A O ATOM 293 N ALA A 592 −1.344 23.846 −5.2571.00 41.36 A N ATOM 294 CA ALA A 592 −2.261 23.061 −6.070 1.00 42.29 A CATOM 295 CB ALA A 592 −1.834 23.124 −7.526 1.00 40.91 A C ATOM 296 C ALAA 592 −2.381 21.603 −5.633 1.00 44.01 A C ATOM 297 O ALA A 592 −3.47021.033 −5.654 1.00 44.46 A O ATOM 298 N PHE A 593 −1.275 21.002 −5.2171.00 45.09 A N ATOM 299 CA PHE A 593 −1.322 19.599 −4.830 1.00 46.88 A CATOM 300 CB PHE A 593 −0.619 18.771 −5.907 1.00 49.57 A C ATOM 301 CGPHE A 593 −1.259 18.887 −7.263 1.00 52.95 A C ATOM 302 CD1 PHE A 593−0.491 19.157 −81.393 1.00 53.94 A C ATOM 303 CD2 PHE A 593 −2.63318.725 −7.412 1.00 54.24 A C ATOM 304 CE1 PHE A 593 −1.082 19.265 −9.6511.00 54.02 A C ATOM 305 CE2 PHE A 593 −3.234 18.832 −81.664 1.00 55.12 AC ATOM 306 CZ PHE A 593 −2.456 19.102 −9.786 1.00 55.59 A C ATOM 307 CPHE A 593 −0.782 19.235 −3.451 1.00 45.57 A C ATOM 308 O PHE A 593−0.587 18.057 −3.152 1.00 46.97 A O ATOM 309 N GLY A 594 −0.560 20.232−2.602 1.00 43.26 A N ATOM 310 CA GLY A 594 −0.061 19.944 −1.271 1.0040.32 A C ATOM 311 C GLY A 594 −0.270 21.087 −0.301 1.00 38.53 A C ATOM312 O GLY A 594 −0.659 22.186 −0.698 1.00 37.40 A O ATOM 313 N LYS A 595−0.015 20.831 0.977 1.00 35.98 A N ATOM 314 CA LYS A 595 −0.169 21.8581.998 1.00 35.80 A C ATOM 315 CB LYS A 595 −1.641 21.981 2.413 1.0039.51 A C ATOM 316 CG LYS A 595 −2.189 20.797 3.197 1.00 40.62 A C ATOM317 CD LYS A 595 −3.701 20.919 3.360 1.00 44.05 A C ATOM 318 CE LYS A595 −4.264 19.834 4.266 1.00 46.20 A C ATOM 319 NZ LYS A 595 −3.82620.010 5.678 1.00 48.21 A N ATOM 320 C LYS A 595 0.681 21.540 3.215 1.0034.45 A C ATOM 321 O LYS A 595 1.042 20.388 3.438 1.00 34.47 A O ATOM322 N VAL A 596 1.016 22.569 3.988 1.00 33.39 A N ATOM 323 CA VAL A 5961.807 22.386 5.199 1.00 33.19 A C ATOM 324 CB VAL A 596 3.187 23.1105.123 1.00 33.40 A C ATOM 325 CG1 VAL A 596 3.002 24.596 4.842 1.0032.61 A C ATOM 326 CG2 VAL A 596 3.939 22.922 6.432 1.00 32.89 A C ATOM327 C VAL A 596 1.015 22.938 6.372 1.00 34.53 A C ATOM 328 O VAL A 5960.429 24.018 6.283 1.00 35.62 A O ATOM 329 N VAL A 597 0.986 22.1897.469 1.00 35.15 A N ATOM 330 CA VAL A 597 0.249 22.611 8.650 1.00 36.74A C ATOM 331 CB VAL A 597 −0.964 21.687 8.925 1.00 36.15 A C ATOM 332CG1 VAL A 597 −1.814 21.543 7.674 1.00 35.98 A C ATOM 333 CG2 VAL A 597−0.481 20.328 9.408 1.00 38.07 A C ATOM 334 C VAL A 597 1.125 22.6029.889 1.00 36.22 A C ATOM 335 O VAL A 597 2.092 21.847 9.979 1.00 37.18A O ATOM 336 N GLU A 598 0.777 23.457 10.842 1.00 37.77 A N ATOM 337 CAGLU A 598 1.501 23.539 12.099 1.00 38.02 A C ATOM 338 CB GLU A 598 1.30024.914 12.733 1.00 41.15 A C ATOM 339 CG GLU A 598 1.869 25.053 14.1301.00 44.89 A C ATOM 340 CD GLU A 598 1.611 26.428 14.716 1.00 48.46 A CATOM 341 OE1 GLU A 598 0.481 26.940 14.557 1.00 51.03 A O ATOM 342 OE2GLU A 598 2.531 26.995 15.341 1.00 49.97 A O ATOM 343 C GLU A 598 0.91522.455 12.991 1.00 39.95 A C ATOM 344 O GLU A 598 −0.298 22.228 12.9851.00 39.64 A O ATOM 345 N ALA A 599 1.771 21.781 13.749 1.00 40.04 A NATOM 346 CA ALA A 599 1.308 20.717 14.622 1.00 42.50 A C ATOM 347 CB ALAA 599 1.184 19.415 13.832 1.00 40.30 A C ATOM 348 C ALA A 599 2.24120.516 15.800 1.00 43.18 A C ATOM 349 O ALA A 599 3.380 20.983 15.7921.00 43.96 A O ATOM 350 N THR A 600 1.741 19.823 16.818 1.00 44.62 A NATOM 351 CA THR A 600 2.524 19.523 18.008 1.00 43.92 A C ATOM 352 CB THRA 600 1.733 19.824 19.306 1.00 45.49 A C ATOM 353 OG1 THR A 600 1.31421.195 19.317 1.00 45.84 A O ATOM 354 CG2 THR A 600 2.598 19.554 20.5251.00 43.01 A C ATOM 355 C THR A 600 2.848 18.033 17.978 1.00 44.17 A CATOM 356 O THR A 600 1.956 17.208 17.803 1.00 44.96 A O ATOM 357 N ALA A601 4.123 17.691 18.136 1.00 44.61 A N ATOM 358 CA ALA A 601 4.54616.294 18.132 1.00 46.30 A C ATOM 359 CB ALA A 601 5.691 16.091 17.1451.00 46.07 A C ATOM 360 C ALA A 601 4.990 15.905 19.535 1.00 47.25 A CATOM 361 O ALA A 601 5.819 16.587 20.141 1.00 47.52 A O ATOM 362 N PHE A602 4.444 14.808 20.050 1.00 47.57 A N ATOM 363 CA PHE A 602 4.78814.355 21.393 1.00 47.95 A C ATOM 364 CB PHE A 602 3.523 13.938 22.1531.00 46.66 A C ATOM 365 CG PHE A 602 2.417 14.954 22.094 1.00 45.97 A CATOM 366 CD1 PHE A 602 1.493 14.935 21.055 1.00 45.11 A C ATOM 367 CD2PHE A 602 2.306 15.940 23.071 1.00 45.23 A C ATOM 368 CE1 PHE A 6020.472 15.882 20.989 1.00 45.31 A C ATOM 369 CE2 PHE A 602 1.289 16.89223.014 1.00 45.31 A C ATOM 370 CZ PHE A 602 0.371 16.863 21.972 1.0044.91 A C ATOM 371 C PHE A 602 5.781 13.199 21.374 1.00 47.96 A C ATOM372 O PHE A 602 5.513 12.143 20.803 1.00 48.72 A O ATOM 373 N GLY A 6036.928 13.407 22.012 1.00 48.76 A N ATOM 374 CA GLY A 603 7.944 12.37422.055 1.00 49.43 A C ATOM 375 C GLY A 603 8.622 12.206 20.709 1.0050.41 A C ATOM 376 O GLY A 603 8.557 11.135 20.104 1.00 50.27 A O ATOM377 N LEU A 604 9.273 13.267 20.241 1.00 50.77 A N ATOM 378 CA LEU A 6049.961 13.236 18.954 1.00 52.26 A C ATOM 379 CB LEU A 604 9.449 14.37218.057 1.00 52.68 A C ATOM 380 CG LEU A 604 9.776 14.349 16.557 1.0053.44 A C ATOM 381 CD1 LEU A 604 9.064 15.512 15.874 1.00 53.80 A C ATOM382 CD2 LEU A 604 11.272 14.441 16.333 1.00 53.47 A C ATOM 383 C LEU A604 11.463 13.375 19.156 1.00 52.36 A C ATOM 384 O LEU A 604 11.92214.269 19.868 1.00 52.30 A O ATOM 385 N GLY A 605 12.224 12.487 18.5241.00 53.62 A N ATOM 386 CA GLY A 605 13.669 12.535 18.643 1.00 55.92 A CATOM 387 C GLY A 605 14.183 11.789 19.858 1.00 57.76 A C ATOM 388 O GLYA 605 13.411 11.167 20.588 1.00 57.37 A O ATOM 389 N LYS A 606 15.49111.856 20.079 1.00 60.19 A N ATOM 390 CA LYS A 606 16.112 11.178 21.2091.00 62.68 A C ATOM 391 CB LYS A 606 17.618 11.037 20.969 1.00 63.52 A CATOM 392 CG LYS A 606 18.189 9.666 21.331 1.00 65.35 A C ATOM 393 CD LYSA 606 18.010 9.330 22.807 1.00 66.31 A C ATOM 394 CE LYS A 606 18.80410.275 23.703 1.00 67.06 A C ATOM 395 NZ LYS A 606 18.564 10.002 25.1521.00 65.76 A N ATOM 396 C LYS A 606 15.861 11.946 22.506 1.00 63.77 A CATOM 397 O LYS A 606 16.037 11.409 23.599 1.00 64.44 A O ATOM 398 N GLUA 607 15.444 13.202 22.377 1.00 64.49 A N ATOM 399 CA GLU A 607 15.16814.042 23.538 1.00 65.19 A C ATOM 400 CB GLU A 607 15.553 15.494 23.2381.00 66.00 A C ATOM 401 CG GLU A 607 17.046 15.705 23.041 1.00 67.13 A CATOM 402 CD GLU A 607 17.852 15.285 24.257 1.00 68.09 A C ATOM 403 OE1GLU A 607 17.654 15.883 25.336 1.00 68.20 A O ATOM 404 OE2 GLU A 60718.681 14.356 24.136 1.00 68.54 A O ATOM 405 C GLU A 607 13.703 13.97323.965 1.00 65.19 A C ATOM 406 O GLU A 607 13.310 14.582 24.961 1.0065.12 A O ATOM 407 N ASP A 608 12.903 13.226 23.208 1.00 64.95 A N ATOM408 CA ASP A 608 11.482 13.063 23.501 1.00 64.78 A C ATOM 409 CB ASP A608 11.302 12.179 24.740 1.00 66.39 A C ATOM 410 CG ASP A 608 11.86810.785 24.548 1.00 67.46 A C ATOM 411 OD1 ASP A 608 11.756 9.960 25.4791.00 68.46 A O ATOM 412 OD2 ASP A 608 12.426 10.511 23.465 1.00 69.08 AO ATOM 413 C ASP A 608 10.786 14.403 23.722 1.00 64.02 A C ATOM 414 OASP A 608 9.998 14.559 24.655 1.00 63.43 A O ATOM 415 N ALA A 609 11.07415.366 22.855 1.00 62.73 A N ATOM 416 CA ALA A 609 10.481 16.691 22.9671.00 61.09 A C ATOM 417 CB ALA A 609 11.277 17.688 22.132 1.00 61.62 A CATOM 418 C ALA A 609 9.020 16.697 22.533 1.00 60.38 A C ATOM 419 O ALA A609 8.545 15.765 21.883 1.00 60.12 A O ATOM 420 N VAL A 610 8.314 17.76022.905 1.00 58.44 A N ATOM 421 CA VAL A 610 6.909 17.927 22.559 1.0057.44 A C ATOM 422 CB VAL A 610 6.066 18.195 23.827 1.00 57.02 A C ATOM423 CG1 VAL A 610 4.599 18.328 23.470 1.00 56.89 A C ATOM 424 CG2 VAL A610 6.269 17.060 24.821 1.00 56.92 A C ATOM 425 C VAL A 610 6.808 19.11521.601 1.00 56.74 A C ATOM 426 O VAL A 610 5.720 19.555 21.227 1.0057.00 A O ATOM 427 N LEU A 611 7.975 19.610 21.203 1.00 55.57 A N ATOM428 CA LEU A 611 8.107 20.744 20.297 1.00 52.67 A C ATOM 429 CB LEU A611 9.480 20.700 19.619 1.00 55.04 A C ATOM 430 CG LEU A 611 9.97519.331 19.134 1.00 55.70 A C ATOM 431 CD1 LEU A 611 8.909 18.641 18.3011.00 55.90 A C ATOM 432 CD2 LEU A 611 11.251 19.517 18.328 1.00 56.99 AC ATOM 433 C LEU A 611 7.038 20.900 19.225 1.00 50.88 A C ATOM 434 O LEUA 611 6.365 19.944 18.834 1.00 49.85 A O ATOM 435 N LYS A 612 6.89722.134 18.755 1.00 47.99 A N ATOM 436 CA LYS A 612 5.949 22.461 17.7041.00 45.40 A C ATOM 437 CB LYS A 612 5.578 23.942 17.782 1.00 47.84 A CATOM 438 CG LYS A 612 4.305 24.304 17.053 1.00 50.82 A C ATOM 439 CD LYSA 612 3.826 25.682 17.481 1.00 53.52 A C ATOM 440 CE LYS A 612 2.33525.669 17.788 1.00 56.32 A C ATOM 441 NZ LYS A 612 1.835 27.026 18.1431.00 57.98 A N ATOM 442 C LYS A 612 6.704 22.164 16.412 1.00 41.45 A CATOM 443 O LYS A 612 7.908 22.393 16.335 1.00 39.69 A O ATOM 444 N VAL A613 6.008 21.647 15.408 1.00 39.42 A N ATOM 445 CA VAL A 613 6.65121.304 14.148 1.00 35.63 A C ATOM 446 CB VAL A 613 7.005 19.794 14.0911.00 34.92 A C ATOM 447 CG1 VAL A 613 8.071 19.464 15.115 1.00 34.86 A CATOM 448 CG2 VAL A 613 5.757 18.960 14.335 1.00 35.32 A C ATOM 449 C VALA 613 5.779 21.621 12.950 1.00 34.73 A C ATOM 450 O VAL A 613 4.62622.026 13.092 1.00 33.73 A O ATOM 451 N ALA A 614 6.340 21.431 11.7611.00 32.99 A N ATOM 452 CA ALA A 614 5.597 21.671 10.533 1.00 32.60 A CATOM 453 CB ALA A 614 6.383 22.584 9.614 1.00 30.37 A C ATOM 454 C ALA A614 5.367 20.317 9.873 1.00 32.30 A C ATOM 455 O ALA A 614 6.269 19.4799.832 1.00 32.96 A O ATOM 456 N VAL A 615 4.156 20.101 9.373 1.00 31.44A N ATOM 457 CA VAL A 615 3.822 18.837 8.730 1.00 30.85 A C ATOM 458 CBVAL A 615 2.754 18.062 9.553 1.00 30.95 A C ATOM 459 CG1 VAL A 615 2.45316.715 8.901 1.00 30.88 A C ATOM 460 CG2 VAL A 615 3.250 17.854 10.9691.00 29.81 A C ATOM 461 C VAL A 615 3.321 19.063 7.311 1.00 30.31 A CATOM 462 O VAL A 615 2.290 19.705 7.099 1.00 30.36 A O ATOM 463 N LYS A616 4.078 18.550 6.342 1.00 29.30 A N ATOM 464 CA LYS A 616 3.733 18.6724.930 1.00 32.42 A C ATOM 465 CB LYS A 616 5.003 18.775 4.073 1.00 33.22A C ATOM 466 CG LYS A 616 6.037 19.740 4.620 1.00 37.03 A C ATOM 467 CDLYS A 616 7.297 19.792 3.769 1.00 39.55 A C ATOM 468 CE LYS A 616 8.37220.599 4.478 1.00 39.35 A C ATOM 469 NZ LYS A 616 9.538 20.889 3.6111.00 46.23 A N ATOM 470 C LYS A 616 2.957 17.425 4.522 1.00 33.00 A CATOM 471 O LYS A 616 3.294 16.318 4.938 1.00 32.17 A O ATOM 472 N MET A617 1.930 17.613 3.700 1.00 33.20 A N ATOM 473 CA MET A 617 1.098 16.5093.235 1.00 35.19 A C ATOM 474 CB MET A 617 0.010 16.215 4.269 1.00 36.09A C ATOM 475 CG MET A 617 −0.920 17.396 4.512 1.00 38.89 A C ATOM 476 SDMET A 617 −1.951 17.179 5.964 1.00 41.81 A S ATOM 477 CE MET A 617−0.859 17.755 7.191 1.00 40.42 A C ATOM 478 C MET A 617 0.452 16.8681.902 1.00 35.81 A C ATOM 479 O MET A 617 0.390 18.035 1.529 1.00 34.69A O ATOM 480 N LEU A 618 −0.026 15.858 1.186 1.00 38.40 A N ATOM 481 CALEU A 618 −0.669 16.077 −0.102 1.00 42.31 A C ATOM 482 CB LEU A 618−0.519 14.833 −0.975 1.00 42.77 A C ATOM 483 CG LEU A 618 0.928 14.407−1.242 1.00 44.34 A C ATOM 484 CD1 LEU A 618 0.949 13.070 −1.962 1.0044.42 A C ATOM 485 CD2 LEU A 618 1.628 15.476 −2.060 1.00 44.18 A C ATOM486 C LEU A 618 −2.150 16.404 0.073 1.00 44.15 A C ATOM 487 O LEU A 618−2.719 16.203 1.150 1.00 44.39 A O ATOM 488 N LYS A 619 −2.760 16.930−0.986 1.00 46.55 A N ATOM 489 CA LYS A 619 −4.177 17.266 −0.973 1.0049.19 A C ATOM 490 CB LYS A 619 −4.423 18.646 −1.596 1.00 50.25 A C ATOM491 CG LYS A 619 −4.101 19.820 −0.678 1.00 51.84 A C ATOM 492 CD LYS A619 −4.637 21.133 −1.240 1.00 53.72 A C ATOM 493 CE LYS A 619 −4.48122.272 −0.239 1.00 53.16 A C ATOM 494 NZ LYS A 619 −5.126 23.532 −0.7161.00 54.94 A N ATOM 495 C LYS A 619 −4.945 16.207 −1.755 1.00 51.05 A CATOM 496 O LYS A 619 −4.348 15.335 −2.388 1.00 50.59 A O ATOM 497 N SERA 620 −6.271 16.294 −1.713 1.00 53.46 A N ATOM 498 CA SER A 620 −7.13715.345 −2.408 1.00 55.58 A C ATOM 499 CB SER A 620 −8.604 15.677 −2.1171.00 55.37 A C ATOM 500 OG SER A 620 8.848 15.726 −0.722 1.00 56.91 A OATOM 501 C SER A 620 6.914 15.343 −3.917 1.00 56.82 A C ATOM 502 O SER A620 −7.111 14.326 −4.583 1.00 56.85 A O ATOM 503 N THR A 621 −6.49816.486 −4.449 1.00 58.76 A N ATOM 504 CA THR A 621 −6.271 16.635 −5.8831.00 61.23 A C ATOM 505 CB THR A 621 −6.330 18.126 −6.289 1.00 61.84 A CATOM 506 OG1 THR A 621 −7.430 18.760 −5.625 1.00 62.57 A O ATOM 507 CG2THR A 621 −6.525 18.266 −7.794 1.00 62.34 A C ATOM 508 C THR A 621−4.932 16.059 −6.342 1.00 62.19 A C ATOM 509 O THR A 621 −4.548 16.223−7.498 1.00 62.92 A O ATOM 510 N ALA A 622 −4.228 15.375 −5.445 1.0063.47 A N ATOM 511 CA ALA A 622 −2.927 14.800 −5.782 1.00 64.25 A C ATOM512 CB ALA A 622 −1.956 15.010 −4.624 1.00 64.52 A C ATOM 513 C ALA A622 −2.992 13.319 −6.140 1.00 65.13 A C ATOM 514 O ALA A 622 −3.80712.572 −5.599 1.00 65.10 A O ATOM 515 N HIS A 623 −2.119 12.902 −7.0541.00 66.01 A N ATOM 516 CA HIS A 623 −2.055 11.508 −7.486 1.00 67.66 A CATOM 517 CB HIS A 623 −2.491 11.378 −8.949 1.00 69.58 A C ATOM 518 CGHIS A 623 −3.953 11.115 −9.121 1.00 71.78 A C ATOM 519 CD2 HIS A 623−4.915 11.809 −9.776 1.00 72.43 A C ATOM 520 ND1 HIS A 623 −4.577 10.010−8.583 1.00 72.69 A N ATOM 521 CE1 HIS A 623 −5.860 10.033 −8.898 1.0073.42 A C ATOM 522 NE2 HIS A 623 −6.091 11.115 −9.622 1.00 73.70 A NATOM 523 C HIS A 623 −0.658 10.921 −7.319 1.00 67.21 A C ATOM 524 O HISA 623 0.169 11.460 −6.585 1.00 66.93 A O ATOM 525 N ALA A 624 −0.4079.811 −8.007 1.00 66.82 A N ATOM 526 CA ALA A 624 0.881 9.129 −7.9461.00 66.51 A C ATOM 527 CB ALA A 624 0.964 8.082 −9.052 1.00 66.37 A CATOM 528 C ALA A 624 2.055 10.097 −8.058 1.00 66.01 A C ATOM 529 O ALA A624 2.837 10.244 −7.122 1.00 66.23 A O ATOM 530 N ASP A 625 2.168 10.751−9.211 1.00 65.20 A N ATOM 531 CA ASP A 625 3.245 11.704 −9.470 1.0064.04 A C ATOM 532 CB ASP A 625 2.921 12.522 −10.721 1.00 65.31 A C ATOM533 CG ASP A 625 2.650 11.651 −11.931 1.00 66.37 A C ATOM 534 OD1 ASP A625 2.287 12.202 −12.991 1.00 67.06 A O ATOM 535 OD2 ASP A 625 2.80210.416 −11.822 1.00 67.63 A O ATOM 536 C ASP A 625 3.478 12.648 −8.2941.00 62.48 A C ATOM 537 O ASP A 625 4.620 12.943 −7.937 1.00 61.99 A OATOM 538 N GLU A 626 2.387 13.122 −7.701 1.00 60.47 A N ATOM 539 CA GLUA 626 2.458 14.034 −6.565 1.00 58.18 A C ATOM 540 CB GLU A 626 1.05614.522 −6.192 1.00 58.94 A C ATOM 541 CG GLU A 626 0.183 14.882 −7.3781.00 60.04 A C ATOM 542 CD GLU A 626 0.852 15.858 −8.312 1.00 60.48 A CATOM 543 OE1 GLU A 626 1.241 16.948 −7.848 1.00 61.70 A O ATOM 544 OE2GLU A 626 0.991 15.536 −9.510 1.00 61.36 A O ATOM 545 C GLU A 626 3.07413.323 −5.364 1.00 55.66 A C ATOM 546 O GLU A 626 3.983 13.844 −4.7191.00 54.16 A O ATOM 547 N LYS A 627 2.562 12.131 −5.077 1.00 52.99 A NATOM 548 CA LYS A 627 3.034 11.324 −3.959 1.00 51.38 A C ATOM 549 CB LYSA 627 2.236 10.020 −3.877 1.00 51.94 A C ATOM 550 CG LYS A 627 0.75410.213 −3.601 1.00 54.04 A C ATOM 551 CD LYS A 627 0.035 8.879 −3.4741.00 55.76 A C ATOM 552 CE LYS A 627 −1.425 9.068 −3.094 1.00 56.04 A CATOM 553 NZ LYS A 627 −2.164 9.867 −4.106 1.00 56.84 A N ATOM 554 C LYSA 627 4.518 11.007 −4.081 1.00 49.13 A C ATOM 555 O LYS A 627 5.23110.956 −3.081 1.00 46.60 A O ATOM 556 N GLU A 628 4.978 10.789 −5.3091.00 48.11 A N ATOM 557 CA GLU A 628 6.383 10.484 −5.544 1.00 47.77 A CATOM 558 CB GLU A 628 6.598 10.040 −6.997 1.00 50.42 A C ATOM 559 CG GLUA 628 6.044 8.654 −7.300 1.00 54.62 A C ATOM 560 CD GLU A 628 6.2428.237 −8.748 1.00 58.25 A C ATOM 561 OE1 GLU A 628 7.386 8.331 −9.2461.00 60.00 A O ATOM 562 OE2 GLU A 628 5.255 7.806 −9.386 1.00 59.90 A OATOM 563 C GLU A 628 7.260 11.691 −5.227 1.00 45.63 A C ATOM 564 O GLU A628 8.309 11.554 −4.597 1.00 45.97 A O ATOM 565 N ALA A 629 6.823 12.872−5.657 1.00 42.99 A N ATOM 566 CA ALA A 629 7.574 14.099 −5.409 1.0040.68 A C ATOM 567 CB ALA A 629 6.858 15.294 −6.042 1.00 42.09 A C ATOM568 C ALA A 629 7.759 14.332 −3.911 1.00 38.22 A C ATOM 569 O ALA A 6298.815 14.798 −3.474 1.00 37.70 A O ATOM 570 N LEU A 630 6.734 14.016−3.126 1.00 34.33 A N ATOM 571 CA LEU A 630 6.815 14.197 −1.679 1.0033.68 A C ATOM 572 CB LEU A 630 5.442 13.998 −1.033 1.00 33.94 A C ATOM573 CG LEU A 630 5.355 14.290 0.467 1.00 33.78 A C ATOM 574 OD1 LEU A630 5.812 15.716 0.749 1.00 33.38 A C ATOM 575 CD2 LEU A 630 3.92514.078 0.938 1.00 36.00 A C ATOM 576 C LEU A 630 7.817 13.206 −1.0831.00 32.83 A C ATOM 577 O LEU A 630 8.607 13.556 −0.207 1.00 31.87 A OATOM 578 N MET A 631 7.781 11.970 −1.569 1.00 32.86 A N ATOM 579 CA META 631 8.699 10.941 −1.097 1.00 32.19 A C ATOM 580 CB MET A 631 8.3069.570 −1.659 1.00 33.41 A C ATOM 581 CG MET A 631 7.084 8.940 −1.0031.00 35.18 A C ATOM 582 SD MET A 631 7.240 8.744 0.797 1.00 38.35 A SATOM 583 CE MET A 631 8.831 7.916 0.934 1.00 35.95 A C ATOM 584 C MET A631 10.123 11.290 −1.526 1.00 32.73 A C ATOM 585 O MET A 631 11.07211.044 −0.790 1.00 33.91 A O ATOM 586 N SER A 632 10.264 11.870 −2.7161.00 32.45 A N ATOM 587 CA SER A 632 11.578 12.264 −3.215 1.00 33.43 A CATOM 588 CB SER A 632 11.489 12.734 −4.672 1.00 33.95 A C ATOM 589 OGSER A 632 11.235 11.645 −5.541 1.00 39.34 A O ATOM 590 C SER A 63212.178 13.373 −2.356 1.00 32.55 A C ATOM 591 O SER A 632 13.381 13.381−2.092 1.00 32.51 A O ATOM 592 N GLU A 633 11.345 14.313 −1.923 1.0033.05 A N ATOM 593 CA GLU A 633 11.838 15.396 −1.082 1.00 32.69 A C ATOM594 CB GLU A 633 10.739 16.433 −0.832 1.00 35.18 A C ATOM 595 CG GLU A633 11.219 17.650 −0.046 1.00 38.91 A C ATOM 596 CD GLU A 633 10.08718.571 0.358 1.00 41.03 A C ATOM 597 OE1 GLU A 633 9.216 18.842 −0.4921.00 41.88 A O ATOM 598 OE2 GLU A 633 10.074 19.030 1.522 1.00 43.76 A OATOM 599 C GLU A 633 12.270 14.784 0.245 1.00 31.23 A C ATOM 600 O GLU A633 13.307 15.145 0.811 1.00 29.89 A O ATOM 601 N LEU A 634 11.46013.849 0.730 1.00 29.69 A N ATOM 602 CA LEU A 634 11.730 13.166 1.9891.00 31.05 A C ATOM 603 CB LEU A 634 10.661 12.103 2.247 1.00 32.88 A CATOM 604 CG LEU A 634 10.248 11.777 3.685 1.00 34.71 A C ATOM 605 CD1LEU A 634 9.460 10.467 3.674 1.00 31.29 A C ATOM 606 CD2 LEU A 63411.454 11.667 4.591 1.00 32.79 A C ATOM 607 C LEU A 634 13.098 12.4951.894 1.00 30.54 A C ATOM 608 O LEU A 634 13.926 12.606 2.798 1.00 30.33A O ATOM 609 N LYS A 635 13.326 11.810 0.778 1.00 31.01 A N ATOM 610 CALYS A 635 14.583 11.110 0.543 1.00 31.88 A C ATOM 611 CB LYS A 63514.476 10.270 −0.731 1.00 32.92 A C ATOM 612 CG LYS A 635 13.453 9.143−0.638 1.00 34.16 A C ATOM 613 CD LYS A 635 13.221 8.488 −1.988 1.0036.67 A C ATOM 614 CE LYS A 635 12.230 7.332 −1.889 1.00 38.08 A C ATOM615 NZ LYS A 635 11.850 6.801 −3.234 1.00 37.93 A N ATOM 616 C LYS A 63515.776 12.061 0.453 1.00 30.50 A C ATOM 617 O LYS A 635 16.845 11.7610.970 1.00 29.89 A O ATOM 618 N ILE A 636 15.596 13.204 −0.200 1.0030.73 A N ATOM 619 CA ILE A 636 16.681 14.179 −0.321 1.00 31.50 A C ATOM620 CB ILE A 636 16.277 15.369 −1.230 1.00 31.60 A C ATOM 621 CG2 ILE A636 17.237 16.543 −1.030 1.00 32.33 A C ATOM 622 CG1 ILE A 636 16.25414.915 −2.690 1.00 32.86 A C ATOM 623 CD1 ILE A 636 15.765 15.968 −3.6651.00 33.04 A C ATOM 624 C ILE A 636 17.068 14.721 1.047 1.00 30.67 A CATOM 625 O ILE A 636 18.249 14.766 1.402 1.00 30.22 A O ATOM 626 N MET A637 16.062 15.126 1.815 1.00 30.60 A N ATOM 627 CA MET A 637 16.29315.677 3.139 1.00 31.79 A C ATOM 628 CB MET A 637 14.973 16.165 3.7451.00 30.60 A C ATOM 629 CG MET A 637 14.345 17.341 2.986 1.00 31.95 A CATOM 630 SD MET A 637 15.555 18.656 2.640 1.00 33.78 A S ATOM 631 CE META 637 15.838 19.299 4.301 1.00 30.32 A C ATOM 632 C MET A 637 16.95914.663 4.065 1.00 31.88 A C ATOM 633 O MET A 637 17.810 15.030 4.8731.00 32.59 A O ATOM 634 N SER A 638 16.584 13.392 3.943 1.00 32.67 A NATOM 635 CA SER A 638 17.171 12.356 4.789 1.00 36.16 A C ATOM 636 CB SERA 638 16.370 11.049 4.680 1.00 36.46 A C ATOM 637 OG SER A 638 16.48510.468 3.390 1.00 37.37 A O ATOM 638 C SER A 638 18.633 12.098 4.4141.00 38.27 A C ATOM 639 O SER A 638 19.405 11.585 5.222 1.00 39.47 A OATOM 640 N HIS A 639 19.003 12.470 3.192 1.00 39.05 A N ATOM 641 CA HISA 639 20.361 12.275 2.687 1.00 40.58 A C ATOM 642 CB HIS A 639 20.31611.982 1.182 1.00 43.96 A C ATOM 643 CG HIS A 639 21.631 12.163 0.4871.00 48.30 A C ATOM 644 CD2 HIS A 639 21.997 12.983 −0.528 1.00 50.50 AC ATOM 645 ND1 HIS A 639 22.761 11.449 0.826 1.00 50.68 A N ATOM 646 CE1HIS A 639 23.765 11.821 0.051 1.00 51.18 A C ATOM 647 NE2 HIS A 63923.328 12.751 −0.779 1.00 51.79 A N ATOM 648 C HIS A 639 21.291 13.4602.937 1.00 39.66 A C ATOM 649 O HIS A 639 22.494 13.282 3.135 1.00 38.40A C ATOM 650 N LEU A 640 20.735 14.666 2.915 1.00 37.63 A N ATOM 651 CALEU A 640 21.525 15.874 3.114 1.00 37.30 A C ATOM 652 CB LEU A 64020.668 17.122 2.873 1.00 37.29 A C ATOM 653 CG LEU A 640 20.243 17.4671.445 1.00 39.00 A C ATOM 654 CD1 LEU A 640 19.407 18.743 1.465 1.0039.56 A C ATOM 655 CD2 LEU A 640 21.467 17.650 0.570 1.00 38.33 A C ATOM656 C LEU A 640 22.166 15.989 4.486 1.00 36.52 A C ATOM 657 O LEU A 64023.313 16.415 4.603 1.00 37.87 A O ATOM 658 N GLY A 641 21.424 15.6175.521 1.00 36.87 A N ATOM 659 CA GLY A 641 21.941 15.736 6.871 1.0036.66 A C ATOM 660 C GLY A 641 21.496 17.081 7.414 1.00 36.66 A C ATOM661 O GLY A 641 20.992 17.915 6.660 1.00 34.68 A O ATOM 662 N GLN A 64221.694 17.312 8.707 1.00 35.84 A N ATOM 663 CA GLN A 642 21.265 18.5649.321 1.00 36.94 A C ATOM 664 CB GLN A 642 20.971 18.341 10.811 1.0039.69 A C ATOM 665 CG GLN A 642 19.797 17.411 11.089 1.00 46.06 A C ATOM666 CD GLN A 642 19.281 17.517 12.524 1.00 50.41 A C ATOM 667 OE1 GLN A642 18.807 18.573 12.951 1.00 52.43 A O ATOM 668 NE2 GLN A 642 19.37116.421 13.271 1.00 52.58 A N ATOM 669 C GLN A 642 22.229 19.742 9.1721.00 34.61 A C ATOM 670 O GLN A 642 23.433 19.564 9.011 1.00 34.08 A OATOM 671 N HIS A 643 21.668 20.948 9.214 1.00 32.05 A N ATOM 672 CA HISA 643 22.442 22.178 9.138 1.00 30.15 A C ATOM 673 CB HIS A 643 22.75922.558 7.691 1.00 30.12 A C ATOM 674 CG HIS A 643 23.701 23.715 7.5711.00 28.97 A C ATOM 675 CD2 HIS A 643 25.023 23.763 7.279 1.00 28.03 A CATOM 676 ND1 HIS A 643 23.317 25.015 7.817 1.00 28.53 A N ATOM 677 CE1HIS A 643 24.362 25.814 7.683 1.00 28.66 A C ATOM 678 NE2 HIS A 64325.409 25.078 7.357 1.00 27.92 A N ATOM 679 C HIS A 643 21.617 23.2679.807 1.00 28.97 A C ATOM 680 O HIS A 643 20.396 23.329 9.639 1.00 27.72A O ATOM 681 N GLU A 644 22.285 24.124 10.570 1.00 28.26 A N ATOM 682 CAGLU A 644 21.606 25.177 11.303 1.00 28.55 A C ATOM 683 CB GLU A 64422.625 25.979 12.125 1.00 32.74 A C ATOM 684 CG GLU A 644 23.890 26.35411.375 1.00 38.99 A C ATOM 685 CD GLU A 644 25.014 25.341 11.558 1.0042.01 A C ATOM 686 OE1 GLU A 644 24.945 24.228 10.986 1.00 42.31 A OATOM 687 OE2 GLU A 644 25.976 25.666 12.289 1.00 45.83 A O ATOM 688 CGLU A 644 20.747 26.130 10.473 1.00 25.79 A C ATOM 689 O GLU A 64419.773 26.678 10.976 1.00 25.50 A O ATOM 690 N ASN A 645 21.085 26.3179.201 1.00 25.71 A N ATOM 691 CA ASN A 645 20.312 27.233 8.364 1.0024.49 A C ATOM 692 CB ASN A 645 21.253 28.223 7.685 1.00 23.04 A C ATOM693 CG ASN A 645 22.066 29.020 8.685 1.00 24.17 A C ATOM 694 OD1 ASN A645 23.286 28.877 8.761 1.00 25.55 A O ATOM 695 ND2 ASN A 645 21.39029.853 9.468 1.00 23.90 A N ATOM 696 C ASN A 645 19.425 26.545 7.3221.00 25.98 A C ATOM 697 O ASN A 645 19.097 27.126 6.286 1.00 23.32 A OATOM 698 N ILE A 646 19.053 25.305 7.609 1.00 26.04 A N ATOM 699 CA ILEA 646 18.162 24.544 6.754 1.00 26.70 A C ATOM 700 CB ILE A 646 18.84123.250 6.246 1.00 28.88 A C ATOM 701 CG2 ILE A 646 17.830 22.370 5.5311.00 31.04 A C ATOM 702 CG1 ILE A 646 20.021 23.594 5.327 1.00 31.04 A CATOM 703 CD1 ILE A 646 19.635 24.278 4.045 1.00 34.16 A C ATOM 704 C ILEA 646 16.949 24.178 7.603 1.00 26.93 A C ATOM 705 O ILE A 646 17.06224.025 8.827 1.00 27.80 A O ATOM 706 N VAL A 647 15.784 24.076 6.9731.00 25.95 A N ATOM 707 CA VAL A 647 14.580 23.663 7.687 1.00 27.82 A CATOM 708 CB VAL A 647 13.312 24.063 6.925 1.00 27.74 A C ATOM 709 CG1VAL A 647 12.077 23.579 7.672 1.00 29.09 A C ATOM 710 CG2 VAL A 64713.272 25.581 6.773 1.00 27.59 A C ATOM 711 C VAL A 647 14.739 22.1447.704 1.00 28.05 A C ATOM 712 O VAL A 647 14.341 21.449 6.769 1.00 29.26A O ATOM 713 N ASN A 648 15.347 21.645 8.775 1.00 28.15 A N ATOM 714 CAASN A 648 15.653 20.227 8.931 1.00 26.26 A C ATOM 715 CB ASN A 64816.573 20.033 10.145 1.00 26.67 A C ATOM 716 CG ASN A 648 17.902 20.7349.989 1.00 26.26 A C ATOM 717 OD1 ASN A 648 18.714 20.379 9.135 1.0026.67 A O ATOM 718 ND2 ASN A 648 18.130 21.747 10.813 1.00 28.60 A NATOM 719 C ASN A 648 14.518 19.227 9.041 1.00 25.68 A C ATOM 720 O ASN A648 13.458 19.505 9.598 1.00 26.37 A O ATOM 721 N LEU A 649 14.76918.042 8.503 1.00 26.85 A N ATOM 722 CA LEU A 649 13.807 16.950 8.5691.00 26.88 A C ATOM 723 CB LEU A 649 14.208 15.843 7.598 1.00 27.35 A CATOM 724 CG LEU A 649 13.355 14.576 7.642 1.00 27.47 A C ATOM 725 CD1LEU A 649 11.951 14.874 7.133 1.00 26.19 A C ATOM 726 CD2 LEU A 64914.018 13.497 6.810 1.00 26.76 A C ATOM 727 C LEU A 649 13.873 16.41410.002 1.00 28.37 A C ATOM 728 O LEU A 649 14.962 16.280 10.559 1.0026.93 A O ATOM 729 N LEU A 650 12.721 16.119 10.595 1.00 28.89 A N ATOM730 CA LEU A 650 12.680 15.603 11.961 1.00 33.13 A C ATOM 731 CB LEU A650 11.940 16.585 12.870 1.00 33.70 A C ATOM 732 CG LEU A 650 12.58017.970 12.987 1.00 34.96 A C ATOM 733 CD1 LEU A 650 11.746 18.843 13.9101.00 35.56 A C ATOM 734 CD2 LEU A 650 14.004 17.833 13.511 1.00 35.61 AC ATOM 735 C LEU A 650 12.003 14.234 12.032 1.00 33.70 A C ATOM 736 OLEU A 650 12.216 13.469 12.979 1.00 33.23 A O ATOM 737 N GLY A 65111.187 13.936 11.027 1.00 32.99 A N ATOM 738 CA GLY A 651 10.494 12.66210.995 1.00 31.78 A C ATOM 739 C GLY A 651 9.522 12.551 9.842 1.00 30.54A C ATOM 740 O GLY A 651 9.384 13.476 9.041 1.00 28.69 A O ATOM 741 NALA A 652 8.841 11.412 9.761 1.00 29.49 A N ATOM 742 CA ALA A 652 7.87311.172 8.705 1.00 29.18 A C ATOM 743 CB ALA A 652 8.589 10.764 7.4351.00 28.96 A C ATOM 744 C ALA A 652 6.884 10.083 9.101 1.00 30.64 A CATOM 745 O ALA A 652 7.180 9.231 9.940 1.00 30.25 A O ATOM 746 N CYS A653 5.706 10.123 8.494 1.00 30.79 A N ATOM 747 CA CYS A 653 4.682 9.1148.736 1.00 32.84 A C ATOM 748 CB CYS A 653 3.454 9.739 9.385 1.00 32.79A C ATOM 749 SG CYS A 653 3.856 10.592 10.905 1.00 34.89 A S ATOM 750 CCYS A 653 4.344 8.579 7.357 1.00 33.55 A C ATOM 751 O CYS A 653 3.6569.237 6.574 1.00 33.19 A O ATOM 752 N THR A 654 4.843 7.391 7.044. 1.0033.09 A N ATOM 753 CA THR A 654 4.606 6.830 5.722 1.00 33.59 A C ATOM754 CB THR A 654 5.938 6.526 5.023 1.00 33.05 A C ATOM 755 OG1 THR A 6546.655 5.533 5.767 1.00 32.61 A O ATOM 756 CG2 THR A 654 6.788 7.7934.945 1.00 33.62 A C ATOM 757 C THR A 654 3.743 5.579 5.726 1.00 35.09 AC ATOM 758 O THR A 654 3.459 5.021 4.669 1.00 34.98 A O ATOM 759 N HIS A655 3.322 5.152 6.915 1.00 35.32 A N ATOM 760 CA HIS A 655 2.473 3.9747.049 1.00 36.55 A C ATOM 761 CB HIS A 655 3.235 2.838 7.744 1.00 36.90A C ATOM 762 CG HIS A 655 4.554 2.519 7.113 1.00 38.59 A C ATOM 763 CD2HIS A 655 5.818 2.626 7.587 1.00 37.83 A C ATOM 764 ND1 HIS A 655 4.6692.045 5.823 1.00 39.61 A N ATOM 765 CE1 HIS A 655 5.946 1.875 5.531 1.0038.84 A C ATOM 766 NE2 HIS A 655 6.664 2.221 6.584 1.00 37.56 A N ATOM767 C HIS A 655 1.234 4.324 7.863 1.00 36.37 A C ATOM 768 O HIS A 6551.229 5.297 8.618 1.00 38.33 A O ATOM 769 N GLY A 656 0.182 3.530 7.6951.00 36.82 A N ATOM 770 CA GLY A 656 −1.047 3.746 8.434 1.00 36.86 A CATOM 771 C GLY A 656 −1.819 4.995 8.069 1.00 36.39 A C ATOM 772 O GLY A656 −2.604 5.492 8.876 1.00 38.07 A O ATOM 773 N GLY A 657 −1.604 5.5036.858 1.00 36.26 A N ATOM 774 CA GLY A 657 −2.303 6.702 6.429 1.00 36.55A C ATOM 775 C GLY A 657 −1.517 7.525 5.424 1.00 35.98 A C ATOM 776 OGLY A 657 −0.442 7.113 4.995 1.00 35.12 A O ATOM 777 N PRO A 658 −2.0358.696 5.018 1.00 36.54 A N ATOM 778 CD PRO A 658 −3.343 9.268 5.384 1.0038.10 A C ATOM 779 CA PRO A 658 −1.343 9.556 4.052 1.00 36.84 A C ATOM780 CB PRO A 658 −2.226 10.804 4.012 1.00 36.89 A C ATOM 781 CG PRO A658 −3.591 10.248 4.261 1.00 39.35 A C ATOM 782 C PRO A 658 0.084 9.8754.502 1.00 32.89 A C ATOM 783 O PRO A 658 0.358 9.970 5.696 1.00 31.66 AO ATOM 784 N VAL A 659 0.989 10.036 3.543 1.00 32.62 A N ATOM 785 CA VALA 659 2.379 10.354 3.858 1.00 31.70 A C ATOM 786 CB VAL A 659 3.26610.282 2.591 1.00 31.79 A C ATOM 787 CG1 VAL A 659 4.672 10.807 2.8911.00 31.41 A C ATOM 788 CG2 VAL A 659 3.339 8.845 2.100 1.00 32.68 A CATOM 789 C VAL A 659 2.496 11.750 4.467 1.00 31.56 A C ATOM 790 O VAL A659 1.960 12.724 3.926 1.00 32.04 A O ATOM 791 N LEU A 660 3.186 11.8335.598 1.00 28.87 A N ATOM 792 CA LEU A 660 3.393 13.100 6.291 1.00 29.74A C ATOM 793 CB LEU A 660 2.722 13.076 7.667 1.00 30.94 A C ATOM 794 CGLEU A 660 1.249 12.672 7.770 1.00 31.84 A C ATOM 795 CD1 LEU A 660 0.82112.721 9.230 1.00 33.18 A C ATOM 796 CD2 LEU A 660 0.388 13.601 6.9291.00 33.70 A C ATOM 797 C LEU A 660 4.885 13.344 6.486 1.00 28.75 A CATOM 798 O LEU A 660 5.609 12.457 6.942 1.00 28.50 A O ATOM 799 N VAL A661 5.349 14.543 6.148 1.00 28.59 A N ATOM 800 CA VAL A 661 6.760 14.8726.329 1.00 27.56 A C ATOM 801 CB VAL A 661 7.391 15.394 5.030 1.00 29.16A C ATOM 802 CG1 VAL A 661 8.879 15.670 5.253 1.00 30.68 A C ATOM 803CG2 VAL A 661 7.189 14.372 3.910 1.00 26.50 A C ATOM 804 C VAL A 6616.882 15.927 7.418 1.00 29.07 A C ATOM 805 O VAL A 661 6.383 17.0437.273 1.00 29.29 A O ATOM 806 N ILE A 662 7.555 15.565 8.506 1.00 27.78A N ATOM 807 CA ILE A 662 7.714. 16.451 9.651 1.00 29.50 A C ATOM 808 CBILE A 662 7.625 15.657 10.970 1.00 29.86 A C ATOM 809 CG2 ILE A 6627.496 16.620 12.143 1.00 30.78 A C ATOM 810 CG1 ILE A 662 6.411 14.72110.939 1.00 32.59 A C ATOM 811 CD1 ILE A 662 6.422 13.672 12.043 1.0032.41 A C ATOM 812 C ILE A 662 9.043 17.188 9.630 1.00 28.44 A C ATOM813 O ILE A 662 10.101 16.567 9.605 1.00 30.01 A O ATOM 814 N THR A 6638.983 18.515 9.639 1.00 28.71 A N ATOM 815 CA THR A 663 10.196 19.3299.619 1.00 28.93 A C ATOM 816 CB THR A 663 10.347 20.110 8.290 1.0027.31 A C ATOM 817 OG1 THR A 663 9.352 21.140 8.230 1.00 29.33 A O ATOM818 CG2 THR A 663 10.168 19.187 7.094 1.00 29.13 A C ATOM 819 C THR A663 10.126 20.355 10.736 1.00 29.48 A C ATOM 820 O THR A 663 9.09620.506 11.389 1.00 31.00 A O ATOM 821 N GLU A 664 11.225 21.064 10.9571.00 29.67 A N ATOM 822 CA GLU A 664 11.241 22.097 11.981 1.00 31.74 A CATOM 823 CB GLU A 664 12.630 22.729 12.075 1.00 31.41 A C ATOM 824 CGGLU A 664 13.736 21.729 12.333 1.00 34.94 A C ATOM 825 CD GLU A 66415.112 22.371 12.341 1.00 37.50 A C ATOM 826 OE1 GLU A 664 15.423 23.13211.398 1.00 36.63 A O ATOM 827 OE2 GLU A 664 15.885 22.107 13.284 1.0039.81 A O ATOM 828 C GLU A 664 10.216 23.149 11.564 1.00 31.00 A C ATOM829 O GLU A 664 9.918 23.300 10.374 1.00 28.32 A O ATOM 830 N TYR A 6659.667 23.851 12.550 1.00 32.33 A N ATOM 831 CA TYR A 665 8.680 24.90112.324 1.00 32.77 A C ATOM 832 CB TYR A 665 7.508 24.723 13.299 1.0034.33 A C ATOM 833 CG TYR A 665 6.602 25.930 13.444 1.00 34.33 A C ATOM834 CD1 TYR A 665 5.779 26.347 12.399 1.00 35.01 A C ATOM 835 CE1 TYR A665 4.932 27.453 12.545 1.00 36.08 A C ATOM 836 CD2 TYR A 665 6.56126.647 14.640 1.00 35.79 A C ATOM 837 CE2 TYR A 665 5.721 27.748 14.7951.00 35.87 A C ATOM 838 CZ TYR A 665 4.910 28.146 13.748 1.00 37.04 A CATOM 839 OH TYR A 665 4.078 29.230 13.911 1.00 38.04 A O ATOM 840 C TYRA 665 9.385 26.243 12.558 1.00 33.09 A C ATOM 841 O TYR A 665 10.18826.369 13.479 1.00 32.45 A O ATOM 842 N CYS A 666 9.098 27.231 11.7141.00 33.49 A N ATOM 843 CA CYS A 666 9.719 28.551 11.832 1.00 32.76 A CATOM 844 CB CYS A 666 10.359 28.935 10.487 1.00 32.71 A C ATOM 845 SGCYS A 666 11.647 27.746 9.963 1.00 31.28 A S ATOM 846 C CYS A 666 8.66429.572 12.256 1.00 33.47 A C ATOM 847 O CYS A 666 7.947 30.132 11.4251.00 31.41 A O ATOM 848 N CYS A 667 8.591 29.810 13.565 1.00 34.90 A NATOM 849 CA CYS A 667 7.598 30.705 14.155 1.00 36.88 A C ATOM 850 CB CYSA 667 7.831 30.809 15.671 1.00 38.94 A C ATOM 851 SG CYS A 667 9.40531.544 16.162 1.00 44.69 A S ATOM 852 C CYS A 667 7.406 32.111 13.5831.00 35.74 A C ATOM 853 O CYS A 667 6.293 32.628 13.615 1.00 36.27 A OATOM 854 N TYR A 668 8.460 32.733 13.059 1.00 35.00 A N ATOM 855 CA TYRA 668 8.319 34.087 12.519 1.00 33.58 A C ATOM 856 CB TYR A 668 9.63134.854 12.677 1.00 36.69 A C ATOM 857 CG TYR A 668 9.991 35.099 14.1231.00 39.90 A C ATOM 858 CD1 TYR A 668 11.188 34.623 14.657 1.00 40.56 AC ATOM 859 CE1 TYR A 668 11.511 34.828 15.998 1.00 43.29 A C ATOM 860CD2 TYR A 668 9.121 35.792 14.967 1.00 43.12 A C ATOM 861 CE2 TYR A 6689.433 36.003 16.309 1.00 43.78 A C ATOM 862 CZ TYR A 668 10.628 35.51716.816 1.00 44.47 A C ATOM 863 OH TYR A 668 10.930 35.707 18.142 1.0047.51 A O ATOM 864 C TYR A 668 7.848 34.153 11.070 1.00 32.26 A C ATOM865 O TYR A 668 7.569 35.232 10.546 1.00 31.85 A O ATOM 866 N GLY A 6697.751 33.002 10.422 1.00 28.38 A N ATOM 867 CA GLY A 669 7.292 32.9979.045 1.00 29.22 A C ATOM 868 C GLY A 669 8.368 33.395 8.054 1.00 26.58A C ATOM 869 O GLY A 669 9.561 33.302 8.348 1.00 27.94 A O ATOM 870 NASP A 670 7.945 33.860 6.885 1.00 27.59 A N ATOM 871 CA ASP A 670 8.88234.232 5.829 1.00 26.96 A C ATOM 872 CB ASP A 670 8.182 34.171 4.4691.00 27.09 A C ATOM 873 CG ASP A 670 7.106 35.223 4.316 1.00 29.74 A CATOM 874 OD1 ASP A 670 6.078 35.145 5.024 1.00 30.78 A O ATOM 875 OD2ASP A 670 7.290 36.137 3.487 1.00 29.75 A O ATOM 876 C ASP A 670 9.56035.589 5.983 1.00 25.53 A C ATOM 877 O ASP A 670 8.982 36.541 6.512 1.0024.94 A O ATOM 878 N LEU A 671 10.789 35.661 5.480 1.00 25.51 A N ATOM879 CA LEU A 671 11.609 36.864 5.537 1.00 24.25 A C ATOM 880 CB LEU A671 13.017 36.565 4.996 1.00 22.80 A C ATOM 881 CG LEU A 671 13.99237.744 4.925 1.00 22.98 A C ATOM 882 CD1 LEU A 671 14.258 38.265 6.3321.00 21.43 A C ATOM 883 CD2 LEU A 671 15.296 37.307 4.251 1.00 23.79 A CATOM 884 C LEU A 671 11.015 38.041 4.774 1.00 25.39 A C ATOM 885 O LEU A671 11.160 39.187 5.198 1.00 25.04 A O ATOM 886 N LEU A 672 10.36437.766 3.647 1.00 23.35 A N ATOM 887 CA LEU A 672 9.763 38.837 2.8561.00 25.62 A C ATOM 888 CB LEU A 672 9.126 38.277 1.583 1.00 22.70 A CATOM 889 CG LEU A 672 8.513 39.348 0.674 1.00 22.06 A C ATOM 890 CD1 LEUA 672 9.570 40.431 0.362 1.00 23.78 A C ATOM 891 CD2 LEU A 672 8.01638.707 −0.598 1.00 23.53 A C ATOM 892 C LEU A 672 8.713 39.608 3.6621.00 26.62 A C ATOM 893 O LEU A 672 8.737 40.841 3.707 1.00 27.62 A OATOM 894 N ASN A 673 7.784 38.888 4.284 1.00 27.85 A N ATOM 895 CA ASN A673 6.760 39.542 5.093 1.00 29.94 A C ATOM 896 CB ASN A 673 5.706 38.5395.567 1.00 30.08 A C ATOM 897 CG ASN A 673 4.636 38.286 4.518 1.00 33.58A C ATOM 898 OD1 ASN A 673 4.035 39.225 3.988 1.00 34.48 A O ATOM 899ND2 ASN A 673 4.388 37.020 4.218 1.00 36.08 A N ATOM 900 C ASN A 6737.383 40.247 6.291 1.00 28.90 A C ATOM 901 O ASN A 673 6.936 41.3236.678 1.00 28.73 A O ATOM 902 N PHE A 674 8.417 39.644 6.869 1.00 29.72A N ATOM 903 CA PHE A 674 9.115 40.223 8.019 1.00 30.74 A C ATOM 904 CEPHE A 674 10.205 39.263 8.507 1.00 31.80 A C ATOM 905 CG PHE A 67410.980 39.772 9.687 1.00 33.56 A C ATOM 906 CD1 PHE A 674 10.437 39.72410.968 1.00 36.14 A C ATOM 907 CD2 PHE A 674 12.254 40.312 9.519 1.0034.84 A C ATOM 908 CE1 PHE A 674 11.151 40.208 12.065 1.00 35.06 A CATOM 909 CE2 PHE A 674 12.976 40.797 10.608 1.00 34.87 A C ATOM 910 CZPHE A 674 12.422 40.745 11.886 1.00 34.77 A C ATOM 911 C PHE A 674 9.74541.571 7.668 1.00 32.95 A C ATOM 912 O PHE A 674 9.679 42.525 8.449 1.0032.49 A O ATOM 913 N LEU A 675 10.368 41.644 6.494 1.00 32.44 A N ATOM914 CA LEU A 675 11.003 42.874 6.038 1.00 34.31 A C ATOM 915 CE LEU A675 11.814 42.615 4.758 1.00 32.66 A C ATOM 916 CG LEU A 675 13.02241.692 4.909 1.00 32.78 A C ATOM 917 CD1 LEU A 675 13.614 41.373 3.5331.00 30.78 A C ATOM 918 CD2 LEU A 675 14.054 42.363 5.804 1.00 35.05 A CATOM 919 C LEU A 675 9.968 43.955 5.764 1.00 34.32 A C ATOM 920 O LEU A675 10.199 45.131 6.040 1.00 35.27 A O ATOM 921 N ARG A 676 8.825 43.5535.220 1.00 35.94 A N ATOM 922 CA ARG A 676 7.768 44.500 4.898 1.00 39.37A C ATOM 923 CB ARG A 676 6.744 43.832 3.976 1.00 37.16 A C ATOM 924 CGARG A 676 7.274 43.717 2.544 1.00 34.09 A C ATOM 925 CD ARG A 676 6.41342.878 1.617 1.00 34.64 A C ATOM 926 NE ARG A 676 6.988 42.888 0.2731.00 31.11 A N ATOM 927 CZ ARG A 676 6.408 42.380 −0.809 1.00 31.83 A CATOM 928 NH1 ARG A 676 5.219 41.802 −0.723 1.00 32.24 A N ATOM 929 NH2ARG A 676 7.012 42.479 −1.987 1.00 30.68 A N ATOM 930 C ARG A 676 7.09245.120 6.123 1.00 43.44 A C ATOM 931 O ARG A 676 6.626 46.257 6.067 1.0043.79 A O ATOM 932 N ARG A 677 7.058 44.392 7.233 1.00 46.91 A N ATOM933 CA ARG A 677 6.445 44.918 8.447 1.00 52.48 A C ATOM 934 CE ARG A 6775.751 43.791 9.214 1.00 54.41 A C ATOM 935 CG ARG A 677 6.675 42.6719.650 1.00 58.12 A C ATOM 936 CD ARG A 677 5.886 41.446 10.082 1.0061.40 A C ATOM 937 NE ARG A 677 6.764 40.350 10.484 1.00 64.57 A N ATOM938 CZ ARG A 677 6.368 39.091 10.625 1.00 65.16 A C ATOM 939 NH1 ARG A677 5.104 38.764 10.393 1.00 66.95 A N ATOM 940 NH2 ARG A 677 7.23438.159 11.000 1.00 66.24 A N ATOM 941 C ARG A 677 7.485 45.604 9.3351.00 54.60 A C ATOM 942 O ARG A 677 7.156 46.135 10.394 1.00 55.10 A OATOM 943 N LYS A 678 8.739 45.599 8.887 1.00 56.59 A N ATOM 944 CA LYS A678 9.832 46.217 9.631 1.00 58.57 A C ATOM 945 CE LYS A 678 10.98745.225 9.793 1.00 58.89 A C ATOM 946 CG LYS A 678 10.839 44.269 10.9641.00 59.02 A C ATOM 947 CD LYS A 678 10.957 45.010 12.282 1.00 59.46 A CATOM 948 CE LYS A 678 10.929 44.056 13.471 1.00 59.83 A C ATOM 949 NZLYS A 678 9.635 43.324 13.576 1.00 60.21 A N ATOM 950 C LYS A 678 10.35747.495 8.980 1.00 59.55 A C ATOM 951 O LYS A 678 11.309 48.099 9.4721.00 60.50 A O ATOM 952 N ARG A 679 9.741 47.904 7.877 1.00 60.41 A NATOM 953 CA ARG A 679 10.167 49.113 7.179 1.00 61.24 A C ATOM 954 CB ARGA 679 9.368 49.287 5.885 1.00 61.34 A C ATOM 955 CG ARG A 679 9.60348.191 4.858 1.00 61.16 A C ATOM 956 CD ARG A 679 8.858 48.477 3.5681.00 61.28 A C ATOM 957 NE ARG A 679 9.057 47.423 2.578 1.00 61.37 A NATOM 958 CZ ARG A 679 8.497 47.413 1.373 1.00 61.59 A C ATOM 959 NH1 ARGA 679 7.698 48.403 0.999 1.00 62.21 A N ATOM 960 NH2 ARG A 679 8.73646.411 0.540 1.00 61.00 A N ATOM 961 C ARG A 679 10.007 50.357 8.0521.00 61.79 A C ATOM 962 O ARG A 679 9.226 50.367 9.005 1.00 62.55 A OATOM 963 N GLN A 696 12.785 47.275 15.629 1.00 61.78 A N ATOM 964 CA GLNA 696 13.294 47.782 14.360 1.00 60.72 A C ATOM 965 CB GLN A 696 13.70149.250 14.502 1.00 62.22 A C ATOM 966 CG GLN A 696 12.622 50.245 14.0881.00 64.62 A C ATOM 967 CD GLN A 696 12.320 50.192 12.598 1.00 65.58 A CATOM 968 OE1 GLN A 696 11.817 49.189 12.089 1.00 66.39 A O ATOM 969 NE2GLN A 696 12.632 51.273 11.891 1.00 66.10 A N ATOM 970 C GLN A 69614.480 46.980 13.843 1.00 58.89 A C ATOM 971 O GLN A 696 15.215 46.36914.617 1.00 58.81 A O ATOM 972 N LEU A 697 14.656 46.987 12.525 1.0056.74 A N ATOM 973 CA LEU A 697 15.756 46.270 11.893 1.00 54.36 A C ATOM974 CB LEU A 697 15.348 45.766 10.505 1.00 55.20 A C ATOM 975 CG LEU A697 14.526 44.477 10.439 1.00 55.34 A C ATOM 976 CD1 LEU A 697 14.12544.196 9.000 1.00 54.88 A C ATOM 977 CD2 LEU A 697 15.346 43.326 11.0021.00 55.01 A C ATOM 978 C LEU A 697 16.985 47.150 11.758 1.00 52.28 A CATOM 979 O LEU A 697 16.882 48.337 11.451 1.00 53.04 A O ATOM 980 N SERA 698 18.150 46.559 11.985 1.00 48.72 A N ATOM 981 CA SER A 698 19.40247.286 11.873 1.00 45.53 A C ATOM 982 CB SER A 698 20.250 47.077 13.1241.00 45.79 A C ATOM 983 OG SER A 698 20.717 45.743 13.182 1.00 43.87 A OATOM 984 C SER A 698 20.151 46.749 10.667 1.00 44.43 A C ATOM 985 O SERA 698 19.780 45.716 10.108 1.00 42.52 A O ATOM 986 N SER A 699 21.20847.451 10.272 1.00 43.32 A N ATOM 987 CA SER A 699 22.020 47.025 9.1441.00 43.23 A C ATOM 988 CB SER A 699 23.090 48.081 8.831 1.00 45.00 A CATOM 989 OG SER A 699 23.855 48.400 9.982 1.00 49.17 A O ATOM 990 C SERA 699 22.664 45.685 9.492 1.00 42.93 A C ATOM 991 O SER A 699 22.81844.816 8.636 1.00 40.20 A O ATOM 992 N ARG A 753 23.022 45.521 10.7601.00 41.17 A N ATOM 993 CA ARG A 753 23.637 44.283 11.227 1.00 41.41 A CATOM 994 CB ARG A 753 24.010 44.409 12.710 1.00 44.31 A C ATOM 995 CGARG A 753 24.714 43.192 13.286 1.00 48.67 A C ATOM 996 CD ARG A 75325.323 43.494 14.649 1.00 53.14 A C ATOM 997 NE ARG A 753 26.362 44.51714.562 1.00 56.83 A N ATOM 998 CZ ARG A 753 27.115 44.912 15.585 1.0059.04 A C ATOM 999 NH1 ARG A 753 26.950 44.369 16.785 1.00 59.71 A NATOM 1000 NH2 ARG A 753 28.033 45.853 15.408 1.00 60.73 A N ATOM 1001 CARG A 753 22.690 43.095 11.017 1.00 38.44 A C ATOM 1002 O ARG A 75323.124 42.011 10.618 1.00 38.12 A O ATOM 1003 N ASP A 754 21.402 43.30211.288 1.00 35.66 A N ATOM 1004 CA ASP A 754 20.397 42.256 11.112 1.0033.99 A C ATOM 1005 CB ASP A 754 19.013 42.762 11.525 1.00 36.68 A CATOM 1006 CG ASP A 754 18.873 42.963 13.027 1.00 39.76 A C ATOM 1007 OD1ASP A 754 17.851 43.550 13.435 1.00 41.95 A O ATOM 1008 OD2 ASP A 75419.762 42.534 13.794 1.00 38.96 A O ATOM 1009 C ASP A 754 20.325 41.8119.646 1.00 33.47 A C ATOM 1010 O ASP A 754 20.234 40.617 9.350 1.0029.70 A O ATOM 1011 N LEU A 755 20.341 42.779 8.734 1.00 32.73 A N ATOM1012 CA LEU A 755 20.266 42.474 7.308 1.00 32.36 A C ATOM 1013 CB LEU A755 20.171 43.765 6.490 1.00 32.35 A C ATOM 1014 CG LEU A 755 18.97844.679 6.803 1.00 31.13 A C ATOM 1015 CD1 LEU A 755 18.974 45.851 5.8321.00 29.37 A C ATOM 1016 CD2 LEU A 755 17.664 43.897 6.695 1.00 30.37 AC ATOM 1017 C LEU A 755 21.480 41.655 6.875 1.00 32.73 A C ATOM 1018 OLEU A 755 21.358 40.704 6.101 1.00 30.20 A O ATOM 1019 N LEU A 75622.650 42.019 7.386 1.00 32.17 A N ATOM 1020 CA LEU A 756 23.870 41.2977.062 1.00 32.95 A C ATOM 1021 CB LEU A 756 25.091 42.038 7.617 1.0034.64 A C ATOM 1022 CG LEU A 756 25.654 43.190 6.777 1.00 38.54 A C ATOM1023 CD1 LEU A 756 26.153 42.646 5.445 1.00 37.97 A C ATOM 1024 CD2 LEUA 756 24.597 44.255 6.546 1.00 41.90 A C ATOM 1025 C LEU A 756 23.82239.873 7.612 1.00 32.82 A C ATOM 1026 O LEU A 756 24.357 38.950 6.9981.00 30.75 A O ATOM 1027 N HIS A 757 23.188 39.699 8.770 1.00 33.50 A NATOM 1028 CA HIS A 757 23.061 38.376 9.373 1.00 33.55 A C ATOM 1029 CBHIS A 757 22.512 38.474 10.801 1.00 38.05 A C ATOM 1030 CG HIS A 75723.524 38.921 11.811 1.00 43.27 A C ATOM 1031 CD2 HIS A 757 23.40639.716 12.901 1.00 45.11 A C ATOM 1032 ND1 HIS A 757 24.837 38.50311.781 1.00 45.58 A N ATOM 1033 CE1 HIS A 757 25.485 39.021 12.811 1.0046.89 A C ATOM 1034 NE2 HIS A 757 24.640 39.760 13.506 1.00 46.43 A NATOM 1035 C HIS A 757 22.136 37.494 8.533 1.00 30.73 A C ATOM 1036 O HISA 757 22.408 36.314 8.336 1.00 28.62 A O ATOM 1037 N PHE A 758 21.04338.071 8.047 1.00 28.90 A N ATOM 1038 CA PHE A 758 20.101 37.335 7.2131.00 28.09 A C ATOM 1039 CE PHE A 758 18.968 38.256 6.743 1.00 29.37 A CATOM 1040 CG PHE A 758 17.996 38.640 7.822 1.00 28.43 A C ATOM 1041 CD1PHE A 758 17.259 39.816 7.716 1.00 29.25 A C ATOM 1042 CD2 PHE A 75817.781 37.812 8.917 1.00 30.71 A C ATOM 1043 CE1 PHE A 758 16.315 40.1638.684 1.00 29.77 A C ATOM 1044 CE2 PHE A 758 16.837 38.149 9.893 1.0031.39 A C ATOM 1045 CZ PHE A 758 16.104 39.327 9.775 1.00 29.70 A C ATOM1046 C PHE A 758 20.865 36.839 5.995 1.00 26.37 A C ATOM 1047 O PHE A758 20.763 35.674 5.607 1.00 25.55 A O ATOM 1048 N SER A 759 21.63237.749 5.403 1.00 25.76 A N ATOM 1049 CA SER A 759 22.423 37.457 4.2141.00 24.80 A C ATOM 1050 CE SER A 759 23.144 38.729 3.760 1.00 26.49 A CATOM 1051 OG SER A 759 22.202 39.757 3.510 1.00 25.68 A O ATOM 1052 CSER A 759 23.422 36.322 4.435 1.00 24.92 A C ATOM 1053 O SER A 75923.515 35.402 3.616 1.00 24.17 A O ATOM 1054 N SER A 760 24.162 36.3865.537 1.00 24.42 A N ATOM 1055 CA SER A 760 25.152 35.355 5.867 1.0025.72 A C ATOM 1056 CE SER A 760 25.992 35.779 7.083 1.00 29.13 A C ATOM1057 OG SER A 760 26.884 36.825 6.744 1.00 37.41 A O ATOM 1058 C SER A760 24.533 33.995 6.161 1.00 24.67 A C ATOM 1059 O SER A 760 25.04932.967 5.728 1.00 25.74 A O ATOM 1060 N GLN A 761 23.439 33.980 6.9131.00 25.18 A N ATOM 1061 CA GLN A 761 22.792 32.720 7.245 1.00 25.42 A CATOM 1062 CE GLN A 761 21.656 32.970 8.242 1.00 26.19 A C ATOM 1063 CGGLN A 761 22.183 33.611 9.523 1.00 30.21 A C ATOM 1064 CD GLN A 76121.100 34.078 10.461 1.00 29.64 A C ATOM 1065 OE1 GLN A 761 20.00534.434 10.038 1.00 31.28 A O ATOM 1066 NE2 GLN A 761 21.413 34.10811.754 1.00 36.46 A N ATOM 1067 C GLN A 761 22.297 31.993 5.995 1.0024.08 A C ATOM 1068 O GLN A 761 22.461 30.782 5.881 1.00 23.84 A O ATOM1069 N VAL A 762 21.719 32.725 5.046 1.00 23.44 A N ATOM 1070 CA VAL A762 21.242 32.090 3.813 1.00 21.62 A C ATOM 1071 CB VAL A 762 20.37133.069 2.975 1.00 20.64 A C ATOM 1072 CG1 VAL A 762 19.981 32.423 1.6601.00 21.19 A C ATOM 1073 CG2 VAL A 762 19.136 33.459 3.760 1.00 20.60 AC ATOM 1074 C VAL A 762 22.417 31.600 2.959 1.00 21.49 A C ATOM 1075 OVAL A 762 22.353 30.536 2.335 1.00 21.71 A O ATOM 1076 N ALA A 76323.496 32.373 2.930 1.00 21.14 A N ATOM 1077 CA ALA A 763 24.664 31.9892.159 1.00 21.63 A C ATOM 1078 CB ALA A 763 25.691 33.130 2.144 1.0022.00 A C ATOM 1079 C ALA A 763 25.275 30.725 2.769 1.00 21.20 A C ATOM1080 O ALA A 763 25.807 29.878 2.058 1.00 22.45 A O ATOM 1081 N GLN A764 25.182 30.605 4.089 1.00 22.80 A N ATOM 1082 CA GLN A 764 25.71329.438 4.785 1.00 23.51 A C ATOM 1083 CB GLN A 764 25.666 29.662 6.2981.00 27.64 A C ATOM 1084 CG GLN A 764 26.717 30.648 6.797 1.00 29.90 A CATOM 1085 CD GLN A 764 26.526 31.029 8.253 1.00 35.51 A C ATOM 1086 OE1GLN A 764 26.070 30.225 9.064 1.00 38.54 A O ATOM 1087 NE2 GLN A 76426.891 32.257 8.595 1.00 37.48 A N ATOM 1088 C GLN A 764 24.880 28.2254.398 1.00 24.02 A C ATOM 1089 O GLN A 764 25.420 27.153 4.106 1.0023.48 A O ATOM 1090 N GLY A 765 23.563 28.401 4.380 1.00 23.88 A N ATOM1091 CA GLY A 765 22.691 27.303 4.004 1.00 24.09 A C ATOM 1092 C GLY A765 22.903 26.896 2.553 1.00 23.59 A C ATOM 1093 O GLY A 765 22.90425.702 2.214 1.00 20.85 A O ATOM 1094 N MET A 766 23.077 27.890 1.6871.00 23.50 A N ATOM 1095 CA MET A 766 23.301 27.623 0.268 1.00 23.20 A CATOM 1096 CB MET A 766 23.186 28.918 −0.547 1.00 23.05 A C ATOM 1097 CGMET A 766 21.766 29.486 −0.596 1.00 21.86 A C ATOM 1098 SD MET A 76620.548 28.295 −1.235 1.00 24.09 A S ATOM 1099 CE MET A 766 21.039 28.204−2.963 1.00 22.29 A C ATOM 1100 C MET A 766 24.671 26.975 0.036 1.0023.99 A C ATOM 1101 O MET A 766 24.821 26.125 −0.836 1.00 21.94 A O ATOM1102 N ALA A 767 25.669 27.379 0.812 1.00 24.25 A N ATOM 1103 CA ALA A767 26.993 26.788 0.670 1.00 25.63 A C ATOM 1104 CB ALA A 767 28.00127.508 1.565 1.00 29.76 A C ATOM 1105 C ALA A 767 26.876 25.315 1.0671.00 26.90 A C ATOM 1106 O ALA A 767 27.538 24.459 0.499 1.00 26.08 A OATOM 1107 N PHE A 768 26.012 25.029 2.038 1.00 27.54 A N ATOM 1108 CAPHE A 768 25.800 23.658 2.486 1.00 27.78 A C ATOM 1109 CB PHE A 76824.877 23.636 3.706 1.00 29.16 A C ATOM 1110 CG PHE A 768 24.494 22.2524.161 1.00 29.81 A C ATOM 1111 CD1 PHE A 768 25.430 21.411 4.757 1.0032.92 A C ATOM 1112 CD2 PHE A 768 23.187 21.799 4.008 1.00 32.00 A CATOM 1113 CE1 PHE A 768 25.067 20.137 5.197 1.00 33.70 A C ATOM 1114 CE2PHE A 768 22.813 20.529 4.442 1.00 31.44 A C ATOM 1115 CZ PHE A 76823.756 19.697 5.040 1.00 32.23 A C ATOM 1116 C PHE A 768 25.182 22.8381.353 1.00 27.16 A C ATOM 1117 O PHE A 768 25.652 21.744 1.044 1.0026.57 A O ATOM 1118 N LEU A 769 24.130 23.368 0.733 1.00 23.37 A N ATOM1119 CA LEU A 769 23.483 22.654 −0.362 1.00 25.00 A C ATOM 1120 CB LEU A769 22.274 23.442 −0.879 1.00 23.06 A C ATOM 1121 CG LEU A 769 21.06023.467 0.065 1.00 22.02 A C ATOM 1122 CD1 LEU A 769 19.968 24.363 −0.5241.00 25.71 A C ATOM 1123 CD2 LEU A 769 20.529 22.056 0.255 1.00 25.33 AC ATOM 1124 C LEU A 769 24.483 22.427 −1.492 1.00 23.96 A C ATOM 1125 OLEU A 769 24.595 21.322 −2.029 1.00 25.23 A O ATOM 1126 N ALA A 77025.212 23.478 −1.845 1.00 25.25 A N ATOM 1127 CA ALA A 770 26.216 23.389−2.900 1.00 25.98 A C ATOM 1128 CB ALA A 770 26.959 24.703 −3.017 1.0027.54 A C ATOM 1129 C ALA A 770 27.209 22.258 −2.620 1.00 27.89 A C ATOM1130 O ALA A 770 27.600 21.526 −3.536 1.00 28.96 A O ATOM 1131 N SER A771 27.608 22.111 −1.358 1.00 28.68 A N ATOM 1132 CA SER A 771 28.56821.076 −0.990 1.00 30.23 A C ATOM 1133 CB SER A 771 29.048 21.265 0.4591.00 31.85 A C ATOM 1134 OG SER A 771 28.061 20.885 1.406 1.00 30.80 A OATOM 1135 C SER A 771 28.007 19.670 −1.164 1.00 32.60 A C ATOM 1136 OSER A 771 28.768 18.703 −1.209 1.00 33.58 A O ATOM 1137 N LYS A 77226.681 19.561 −1.266 1.00 31.14 A N ATOM 1138 CA LYS A 772 26.012 18.272−1.435 1.00 31.62 A C ATOM 1139 CB LYS A 772 24.823 18.163 −0.480 1.0033.65 A C ATOM 1140 CG LYS A 772 25.125 18.456 0.970 1.00 35.63 A C ATOM1141 CD LYS A 772 25.958 17.364 1.606 1.00 39.90 A C ATOM 1142 CE LYS A772 26.145 17.627 3.094 1.00 40.74 A C ATOM 1143 NZ LYS A 772 26.88816.514 3.746 1.00 43.28 A N ATOM 1144 C LYS A 772 25.486 18.142 −2.8601.00 31.71 A C ATOM 1145 O LYS A 772 24.688 17.250 −3.158 1.00 32.73 A OATOM 1146 N ASN A 773 25.930 19.039 −3.734 1.00 31.26 A N ATOM 1147 CAASN A 773 25.483 19.053 −5.119 1.00 32.22 A C ATOM 1148 CB ASN A 77325.993 17.816 −5.860 1.00 35.15 A C ATOM 1149 CG ASN A 773 27.490 17.848−6.073 1.00 37.24 A C ATOM 1150 OD1 ASN A 773 28.046 18.874 −6.462 1.0040.31 A O ATOM 1151 ND2 ASN A 773 28.151 16.724 −5.826 1.00 38.15 A NATOM 1152 C ASN A 773 23.959 19.128 −5.198 1.00 31.31 A C ATOM 1153 OASN A 773 23.329 18.488 −6.047 1.00 31.24 A O ATOM 1154 N CYS A 77423.369 19.917 −4.303 1.00 28.26 A N ATOM 1155 CA CYS A 774 21.917 20.078−4.277 1.00 25.72 A C ATOM 1156 CB CYS A 774 21.388 19.899 −2.852 1.0023.53 A C ATOM 1157 SG CYS A 774 19.588 19.885 −2.687 1.00 27.47 A SATOM 1158 C CYS A 774 21.537 21.461 −4.789 1.00 26.86 A C ATOM 1159 OCYS A 774 22.038 22.471 −4.285 1.00 25.39 A O ATOM 1160 N ILE A 77520.672 21.504 −5.800 1.00 26.10 A N ATOM 1161 CA ILE A 775 20.218 22.777−6.354 1.00 26.93 A C ATOM 1162 CB ILE A 775 20.118 22.730 −7.896 1.0027.55 A C ATOM 1163 CG2 ILE A 775 21.502 22.522 −8.481 1.00 30.30 A CATOM 1164 CG1 ILE A 775 19.183 21.608 −8.343 1.00 30.30 A C ATOM 1165CD1 ILE A 775 18.867 21.645 −9.828 1.00 33.32 A C ATOM 1166 C ILE A 77518.869 23.125 −5.736 1.00 25.91 A C ATOM 1167 O ILE A 775 18.027 22.256−5.511 1.00 27.81 A O ATOM 1168 N HIS A 776 18.675 24.411 −5.468 1.0024.52 A N ATOM 1169 CA HIS A 776 17.477 24.909 −4.815 1.00 23.29 A CATOM 1170 CB HIS A 776 17.890 26.110 −3.943 1.00 24.21 A C ATOM 1171 CGHIS A 776 16.791 26.669 −3.097 1.00 24.03 A C ATOM 1172 CD2 HIS A 77616.677 26.789 −1.753 1.00 23.63 A C ATOM 1173 ND1 HIS A 776 15.65527.239 −3.631 1.00 23.23 A N ATOM 1174 CE1 HIS A 776 14.889 27.685−2.652 1.00 23.70 A C ATOM 1175 NE2 HIS A 776 15.485 27.426 −1.503 1.0022.77 A N ATOM 1176 C HIS A 776 16.362 25.288 −5.798 1.00 23.79 A C ATOM1177 O HIS A 776 15.219 24.855 −5.649 1.00 22.64 A O ATOM 1178 N ARG A777 16.716 26.102 −6.785 1.00 24.29 A N ATOM 1179 CA ARG A 777 15.81026.554 −7.840 1.00 25.62 A C ATOM 1180 CB ARG A 777 15.223 25.333 −8.5741.00 27.57 A C ATOM 1181 CG ARG A 777 16.303 24.507 −9.281 1.00 32.08 AC ATOM 1182 CD ARG A 777 15.733 23.457 −10.236 1.00 34.83 A C ATOM 1183NE ARG A 777 15.019 22.381 −9.551 1.00 38.69 A N ATOM 1184 CZ ARG A 77714.469 21.342 −10.177 1.00 41.11 A C ATOM 1185 NH1 ARG A 777 14.55521.244 −11.499 1.00 40.81 A N ATOM 1186 NH2 ARG A 777 13.834 20.402−9.486 1.00 39.14 A N ATOM 1187 C ARG A 777 14.699 27.559 −7.518 1.0025.50 A C ATOM 1188 O ARG A 777 13.957 27.949 −8.417 1.00 26.60 A O ATOM1189 N ASP A 778 14.561 27.989 −6.261 1.00 21.34 A N ATOM 1190 CA ASP A778 13.541 28.994 −5.946 1.00 20.57 A C ATOM 1191 CB ASP A 778 12.20928.335 −5.540 1.00 20.83 A C ATOM 1192 CG ASP A 778 11.001 29.288 −5.6771.00 22.46 A C ATOM 1193 OD1 ASP A 778 9.858 28.863 −5.387 1.00 23.53 AO ATOM 1194 OD2 ASP A 778 11.189 30.462 −6.065 1.00 23.50 A O ATOM 1195C ASP A 778 14.054 29.904 −4.811 1.00 19.92 A C ATOM 1196 O ASP A 77813.337 30.200 −3.868 1.00 20.94 A O ATOM 1197 N VAL A 779 15.309 30.322−4.907 1.00 19.46 A N ATOM 1198 CA VAL A 779 15.887 31.200 −3.882 1.0020.04 A C ATOM 1199 CB VAL A 779 17.407 31.351 −4.073 1.00 18.09 A CATOM 1200 CG1 VAL A 779 17.970 32.391 −3.084 1.00 17.98 A C ATOM 1201CG2 VAL A 779 18.078 29.991 −3.832 1.00 21.88 A C ATOM 1202 C VAL A 77915.196 32.556 −4.017 1.00 20.85 A C ATOM 1203 O VAL A 779 15.218 33.170−5.085 1.00 21.27 A O ATOM 1204 N ALA A 780 14.551 32.984 −2.933 1.0018.99 A N ATOM 1205 CA ALA A 780 13.814 34.242 −2.879 1.00 19.61 A CATOM 1206 CB ALA A 780 12.538 34.141 −3.710 1.00 17.53 A C ATOM 1207 CALA A 780 13.463 34.505 −1.413 1.00 19.77 A C ATOM 1208 O ALA A 780 13.39833.571 −0.612 1.00 19.86 A O ATOM 1209 N ALA A 781 13.237 35.766 −1.0651.00 20.41 A N ATOM 1210 CA ALA A 781 12.911 36.121 0.315 1.00 20.37 A CATOM 1211 CB ALA A 781 12.757 37.652 0.448 1.00 19.44 A C ATOM 1212 CALA A 781 11.647 35.408 0.811 1.00 20.67 A C ATOM 1213 O ALA A 78111.548 35.061 1.993 1.00 21.97 A O ATOM 1214 N ARG A 782 10.690 35.174−0.082 1.00 21.06 A N ATOM 1215 CA ARG A 782 9.462 34.485 0.313 1.0020.10 A C ATOM 1216 CB ARG A 782 8.451 34.471 −0.840 1.00 20.60 A C ATOM1217 CG ARG A 782 8.966 33.736 2.075 1.00 21.22 A C ATOM 1218 CD ARG A782 7.942 33.633 −3.195 1.00 20.84 A C ATOM 1219 NE ARG A 782 8.58933.082 −4.380 1.00 21.81 A N ATOM 1220 CZ ARG A 782 9.295 33.797 −5.2501.00 22.06 A C ATOM 1221 NH1 ARG A 782 9.437 35.106 −5.091 1.00 21.34 AN ATOM 1222 NH2 ARG A 782 9.897 33.196 −6.261 1.00 20.10 A N ATOM 1223 CARG A 782 9.799 33.044 0.715 1.00 21.70 A C ATOM 1224 O ARG A 782 9.00932.384 1.384 1.00 22.67 A O ATOM 1225 N ASN A 783 10.982 32.573 0.3221.00 21.65 A N ATOM 1226 CA ASN A 783 11.410 31.205 0.638 1.00 21.44 A CATOM 1227 CB ASN A 783 11.822 30.481 −0.647 1.00 22.37 A C ATOM 1228 CGASN A 783 10.619 30.092 −1.498 1.00 23.95 A C ATOM 1229 OD1 ASN A 7839.558 29.736 −0.961 1.00 21.09 A O ATOM 1230 ND2 ASN A 783 10.776 30.143−2.832 1.00 21.48 A N ATOM 1231 C ASN A 783 12.498 31.082 1.706 1.0021.95 A C ATOM 1232 O ASN A 783 13.195 30.065 1.812 1.00 23.59 A O ATOM1233 N VAL A 784 12.644 32.134 2.499 1.00 21.62 A N ATOM 1234 CA VAL A784 13.594 32.132 3.597 1.00 20.43 A C ATOM 1235 CB VAL A 784 14.58433.314 3.521 1.00 21.59 A C ATOM 1236 CG1 VAL A 784 15.494 33.301 4.7491.00 20.70 A C ATOM 1237 CG2 VAL A 784 15.440 33.210 2.241 1.00 20.73 AC ATOM 1238 C VAL A 784 12.698 32.288 4.827 1.00 22.32 A C ATOM 1239 OVAL A 784 11.898 33.224 4.907 1.00 21.28 A O ATOM 1240 N LEU A 78512.807 31.354 5.765 1.00 22.34 A N ATOM 1241 CA LEU A 785 11.980 31.4096.965 1.00 25.69 A C ATOM 1242 CB LEU A 785 11.335 30.042 7.234 1.0025.59 A C ATOM 1243 CG LEU A 785 9.974 29.741 6.589 1.00 31.99 A C ATOM1244 CD1 LEU A 785 9.820 30.454 5.265 1.00 27.32 A C ATOM 1245 CD2 LEU A785 9.803 28.232 6.438 1.00 26.69 A C ATOM 1246 C LEU A 785 12.81531.838 8.145 1.00 25.12 A C ATOM 1247 O LEU A 785 14.037 31.683 8.1451.00 25.05 A O ATOM 1248 N LEU A 786 12.148 32.385 9.151 1.00 25.64 A NATOM 1249 CA LEU A 786 12.839 32.858 1.0.334 1.00 26.80 A C ATOM 1250 CBLEU A 786 12.629 34.367 10.500 1.00 27.64 A C ATOM 1251 CG LEU A 78613.149 35.275 9.381 1.00 29.65 A C ATOM 1252 CD1 LEU A 786 12.801 36.7279.711 1.00 29.22 A C ATOM 1253 CD2 LEU A 786 14.651 35.106 9.228 1.0028.29 A C ATOM 1254 C LEU A 786 12.305 32.113 11.540 1.00 25.15 A C ATOM1255 O LEU A 786 11.094 32.045 11.757 1.00 27.13 A O ATOM 1256 N THR A787 13.212 31.535 12.311 1.00 28.10 A N ATOM 1257 CA THR A 787 12.81830.777 13.487 1.00 30.32 A C ATOM 1258 GB THR A 787 13.409 29.340 13.4241.00 30.73 A C ATOM 1259 OG1 THR A 787 12.862 28.546 14.480 1.00 32.26 AO ATOM 1260 CG2 THR A 787 14.926 29.372 13.548 1.00 29.22 A C ATOM 1261C THR A 787 13.305 31.507 14.740 1.00 32.88 A C ATOM 1262 O THR A 78713.603 32.704 14.689 1.00 31.75 A O ATOM 1263 N ASN A 788 13.376 30.79015.858 1.00 35.64 A N ATOM 1264 CA ASN A 788 13.836 31.360 17.123 1.0038.20 A C ATOM 1265 CB ASN A 788 14.132 30.236 18.118 1.00 39.74 A CATOM 1266 CG ASN A 788 13.104 29.128 18.061 1.00 42.58 A C ATOM 1267 OD1ASN A 788 11.937 29.327 18.405 1.00 45.37 A O ATOM 1268 ND2 ASN A 78813.530 27.951 17.616 1.00 44.02 A N ATOM 1269 C ASN A 788 15.102 32.18716.906 1.00 38.65 A C ATOM 1270 O ASN A 788 16.014 31.763 16.188 1.0039.21 A O ATOM 1271 N GLY A 789 15.156 33.362 17.527 1.00 39.11 A N ATOM1272 CA GLY A 789 16.316 34.225 17.385 1.00 38.28 A C ATOM 1273 C GLY A789 16.392 34.900 16.025 1.00 37.99 A C ATOM 1274 O GLY A 789 17.41435.498 15.670 1.00 37.34 A O ATOM 1275 N HIS A 790 15.308 34.807 15.2621.00 37.61 A N ATOM 1276 CA HIS A 790 15.256 35.404 13.933 1.00 38.10 AC ATOM 1277 GB HIS A 790 15.373 36.924 14.048 1.00 39.56 A C ATOM 1278CG HIS A 790 14.249 37.546 14.813 1.00 41.47 A C ATOM 1279 CD2 HIS A 79014.153 37.915 16.113 1.00 40.90 A C ATOM 1280 ND1 HIS A 790 13.00937.774 14.257 1.00 42.62 A N ATOM 1281 CE1 HIS A 790 12.195 38.25415.181 1.00 43.46 A C ATOM 1282 NE2 HIS A 790 12.865 38.348 16.316 1.0043.98 A N ATOM 1283 C HIS A 790 16.360 34.851 13.034 1.00 36.17 A C ATOM1284 O HIS A 790 16.878 35.548 12.162 1.00 37.76 A O ATOM 1285 N VAL A791 16.724 33.595 13.260 1.00 33.73 A N ATOM 1286 CA VAL A 791 17.74932.942 12.459 1.00 30.86 A C ATOM 1287 GB VAL A 791 18.351 31.729 13.2051.00 31.65 A C ATOM 1288 CG1 VAL A 791 19.373 31.026 12.330 1.00 31.86 AC ATOM 1289 CG2 VAL A 791 19.010 32.195 14.500 1.00 33.10 A C ATOM 1290C VAL A 791 17.084 32.474 11.165 1.00 27.95 A C ATOM 1291 O VAL A 79115.979 31.926 11.188 1.00 25.29 A O ATOM 1292 N ALA A 792 17.753 32.70210.040 1.00 26.39 A N ATOM 1293 CA ALA A 792 17.206 32.314 8.744 1.0026.00 A C ATOM 1294 GB ALA A 792 17.776 33.211 7.653 1.00 24.89 A C ATOM1295 C ALA A 792 17.456 30.856 8.389 1.00 23.83 A C ATOM 1296 O ALA A792 18.504 30.294 8.701 1.00 26.36 A O ATOM 1297 N LYS A 793 16.48030.246 7.730 1.00 26.04 A N ATOM 1298 CA LYS A 793 16.594 28.859 7.2941.00 25.20 A C ATOM 1299 GB LYS A 793 15.860 27.915 8.254 1.00 27.35 A CATOM 1300 CG LYS A 793 16.578 27.637 9.580 1.00 28.50 A C ATOM 1301 CDLYS A 793 15.648 26.895 10.527 1.00 27.71 A C ATOM 1302 GE LYS A 79316.360 26.431 11.789 1.00 29.22 A C ATOM 1303 NZ LYS A 793 17.314 25.32611.505 1.00 26.71 A N ATOM 1304 C LYS A 793 15.962 28.745 5.909 1.0025.45 A C ATOM 1305 O LYS A 793 15.032 29.481 5.584 1.00 24.20 A O ATOM1306 N ILE A 794 16.482 27.832 5.095 1.00 24.93 A N ATOM 1307 GA ILE A794 15.937 27.617 3.762 1.00 25.00 A C ATOM 1308 GB ILE A 794 17.00127.864 2.664 1.00 23.98 A C ATOM 1309 CG2 ILE A 794 17.407 29.337 2.6601.00 27.78 A C ATOM 1310 CG1 ILE A 794 18.227 26.976 2.901 1.00 26.09 AC ATOM 1311 CD1 ILE A 794 19.333 27.143 1.871 1.00 26.75 A C ATOM 1312 CILE A 794 15.431 26.175 3.692 1.00 23.46 A C ATOM 1313 O ILE A 79415.861 25.323 4.460 1.00 22.24 A O ATOM 1314 N GLY A 795 14.502 25.9142.786 1.00 23.49 A N ATOM 1315 CA GLY A 795 13.971 24.567 2.656 1.0023.61 A C ATOM 1316 C GLY A 795 13.200 24.430 1.364 1.00 24.05 A C ATOM1317 O GLY A 795 13.056 25.402 0.626 1.00 22.55 A O ATOM 1318 N ASP A796 12.727 23.226 1.064 1.00 24.93 A N ATOM 1319 CA ASP A 796 11.93623.031 −0.143 1.00 25.91 A C ATOM 1320 CB ASP A 796 12.102 21.633 0.7121.00 26.18 A C ATOM 1321 CG ASP A 796 11.526 21.523 −2.108 1.00 29.94 AC ATOM 1322 OD1 ASP A 796 10.592 22.300 −2.424 1.00 31.04 A O ATOM 1323OD2 ASP A 796 11.997 20.674 −2.882 1.00 30.49 A O ATOM 1324 C ASP A 79610.485 23.220 0.271 1.00 25.51 A C ATOM 1325 O ASP A 796 9.907 22.3560.925 1.00 27.31 A O ATOM 1326 N PHE A 797 9.901 24.347 −0.116 1.0025.97 A N ATOM 1327 CA PHE A 797 8.525 24.665 0.248 1.00 28.13 A C ATOM1328 CB PHE A 797 8.462 26.094 0.807 1.00 26.89 A C ATOM 1329 CG PHE A797 9.492 26.383 1.863 1.00 26.54 A C ATOM 1330 CD1 PHE A 797 10.11927.629 1.913 1.00 26.78 A C ATOM 1331 CD2 PHE A 797 9.846 25.418 2.8051.00 26.85 A C ATOM 1332 CE1 PHE A 797 11.080 27.905 2.882 1.00 27.17 AC ATOM 1333 CE2 PHE A 797 10.807 25.686 3.780 1.00 24.82 A C ATOM 1334CZ PHE A 797 11.427 26.933 3.818 1.00 26.11 A C ATOM 1335 C PHE A 7977.588 24.554 −0.943 1.00 29.04 A C ATOM 1336 O PHE A 797 6.413 24.898−0.847 1.00 30.66 A O ATOM 1337 N GLY A 798 8.112 24.068 −2.062 1.0030.54 A N ATOM 1338 CA GLY A 798 7.318 23.941 −3.271 1.00 32.47 A C ATOM1339 C GLY A 798 5.956 23.265 −3.183 1.00 33.84 A C ATOM 1340 O GLY A798 4.998 23.730 −3.794 1.00 32.72 A O ATOM 1341 N LEU A 799 5.85022.174 −2.434 1.00 34.76 A N ATOM 1342 CA LEU A 799 4.572 21.472 −2.3411.00 36.51 A C ATOM 1343 CB LEU A 799 4.781 20.083 −1.728 1.00 40.67 A CATOM 1344 CG LEU A 799 5.530 19.112 −2.654 1.00 43.92 A C ATOM 1345 CD1LEU A 799 5.895 17.839 −1.909 1.00 46.10 A C ATOM 1346 CD2 LEU A 7994.664 18.793 −3.865 1.00 47.14 A C ATOM 1347 C LEU A 799 3.482 22.232−1.585 1.00 36.55 A C ATOM 1348 O LEU A 799 2.297 21.916 −1.717 1.0036.02 A O ATOM 1349 N ALA A 800 3.877 23.241 −0.812 1.00 33.43 A N ATOM1350 CA ALA A 800 2.926 24.039 −0.053 1.00 33.51 A C ATOM 1351 CB ALA A800 3.294 24.022 1.420 1.00 33.66 A C ATOM 1352 C ALA A 800 2.864 25.480−0.551 1.00 31.46 A C ATOM 1353 O ALA A 800 2.196 26.320 0.047 1.0032.62 A O ATOM 1354 N ARG A 801 3.571 25.757 −1.642 1.00 31.79 A N ATOM1355 CA ARG A 801 3.618 27.091 −2.230 1.00 31.14 A C ATOM 1356 CB ARG A801 4.909 27.239 −3.047 1.00 31.63 A C ATOM 1357 CG ARG A 801 5.04228.528 −3.851 1.00 35.16 A C ATOM 1358 CD ARG A 801 5.013 29.762 −2.9661.00 33.53 A C ATOM 1359 NE ARG A 801 6.116 29.799 −2.007 1.00 34.21 A NATOM 1360 CZ ARG A 801 6.214 30.694 −1.028 1.00 32.78 A C ATOM 1361 NH1ARG A 801 5.280 31.621 −0.884 1.00 34.78 A N ATOM 1362 NH2 ARG A 8017.236 30.660 −0.186 1.00 31.78 A N ATOM 1363 C ARG A 801 2.395 27.316−3.119 1.00 31.19 A C ATOM 1364 O ARG A 801 2.117 26.520 −4.015 1.0029.81 A O ATOM 1365 N ASP A 802 1.665 28.398 −2.860 1.00 31.50 A N ATOM1366 CA ASP A 802 0.471 28.730 −3.631 1.00 32.83 A C ATOM 1367 CB ASP A802 −0.420 29.668 −2.806 1.00 34.72 A C ATOM 1368 CG ASP A 802 −1.67730.092 −3.539 1.00 35.12 A C ATOM 1369 OD1 ASP A 802 −2.226 29.260−4.312 1.00 34.82 A O ATOM 1370 OD2 ASP A 802 −2.132 31.240 −3.321 1.0034.71 A O ATOM 1371 C ASP A 802 0.912 29.392 −4.933 1.00 33.93 A C ATOM1372 O ASP A 802 0.741 30.593 −5.127 1.00 35.98 A O ATOM 1373 N ILE A803 1.468 28.578 −5.824 1.00 31.80 A N ATOM 1374 CA ILE A 803 1.99229.020 −7.114 1.00 32.36 A C ATOM 1375 CB ILE A 803 2.828 27.882 −7.7521.00 35.59 A C ATOM 1376 CG2 ILE A 803 3.310 28.286 −9.123 1.00 33.31 AC ATOM 1377 CG1 ILE A 803 4.021 27.552 −6.853 1.00 37.06 A C ATOM 1378CD1 ILE A 803 4.836 26.374 −7.324 1.00 41.55 A C ATOM 1379 C ILE A 8030.965 29.501 −8.145 1.00 30.44 A C ATOM 1380 O ILE A 803 1.249 30.394−8.942 1.00 31.65 A O ATOM 1381 N MET A 804 −0.215 28.899 −8.134 1.0027.98 A N ATOM 1382 CA MET A 804 −1.262 29.252 −9.083 1.00 28.49 A CATOM 1383 CB MET A 804 −2.415 28.246 −8.982 1.00 29.43 A C ATOM 1384 CGMET A 804 −2.031 26.813 −9.349 1.00 31.07 A C ATOM 1385 SD MET A 804−1.429 26.680 −11.051 1.00 35.46 A S ATOM 1386 CE MET A 804 −2.99426.637 −11.934 1.00 37.06 A C ATOM 1387 C MET A 804 −1.811 30.659 −8.8891.00 27.47 A C ATOM 1388 O MET A 804 −2.190 31.322 −9.856 1.00 28.22 A OATOM 1389 N ASN A 805 −1.844 31.109 −7.639 1.00 26.10 A N ATOM 1390 CAASN A 805 −2.389 32.412 −7.311 1.00 27.17 A C ATOM 1391 CB ASN A 805−3.426 32.245 −6.195 1.00 27.53 A C ATOM 1392 CG ASN A 805 −4.558 31.307−6.600 1.00 25.36 A C ATOM 1393 OD1 ASN A 805 −5.229 31.536 −7.604 1.0025.30 A O ATOM 1394 ND2 ASN A 805 −4.766 30.250 −5.831 1.00 25.09 A NATOM 1395 C ASN A 805 −1.357 33.476 −6.954 1.00 29.06 A C ATOM 1396 OASN A 805 −1.714 34.576 −6.534 1.00 29.22 A O ATOM 1397 N ASP A 806−0.079 33.149 −7.136 1.00 29.30 A N ATOM 1398 CA ASP A 806 0.998 34.096−6.866 1.00 28.84 A C ATOM 1399 CB ASP A 806 2.157 33.412 −6.133 1.0030.98 A C ATOM 1400 CG ASP A 806 3.219 34.403 −5.679 1.00 29.20 A C ATOM1401 OD1 ASP A 806 3.387 35.438 −6.355 1.00 29.11 A O ATOM 1402 OD2 ASPA 806 3.883 34.142 −4.658 1.00 30.93 A O ATOM 1403 C ASP A 806 1.48134.603 −8.222 1.00 29.89 A C ATOM 1404 O ASP A 806 2.066 33.848 −8.9921.00 28.06 A O ATOM 1405 N SER A 807 1.237 35.881 −8.507 1.00 29.68 A NATOM 1406 CA SER A 807 1.620 36.473 −9.787 1.00 31.34 A C ATOM 1407 CBSER A 807 1.022 37.880 −9.917 1.00 32.84 A C ATOM 1408 OG SER A 8071.554 38.752 −8.939 1.00 36.12 A O ATOM 1409 C SER A 807 3.1253 6.521−10.043 1.00 31.42 A C ATOM 1410 O SER A 807 3.556 36.816 −11.158 1.0031.90 A O ATOM 1411 N ASN A 808 3.921 36.232 −9.016 1.00 30.84 A N ATOM1412 CA ASN A 808 5.373 36.209 −9.163 1.00 30.18 A C ATOM 1413 CB ASN A808 6.054 36.257 −7.795 1.00 32.39 A C ATOM 1414 CG ASN A 808 6.00037.640 −7.172 1.00 30.81 A C ATOM 1415 OD1 ASN A 808 5.515 37.816 −6.0541.00 34.30 A O ATOM 1416 ND2 ASN A 808 6.503 38.628 −7.897 1.00 30.27 AN ATOM 1417 C ASN A 808 5.800 34.954 −9.919 1.00 31.26 A C ATOM 1418 OASN A 808 6.936 34.847 −10.384 1.00 30.54 A O ATOM 1419 N TYR A 8094.895 33.988 −10.023 1.00 30.03 A N ATOM 1420 CA TYR A 809 5.208 32.783−10.778 1.00 30.89 A C ATOM 1421 CB TYR A 809 4.741 31.525 −10.043 1.0028.06 A C ATOM 1422 CG TYR A 809 5.554 31.230 −8.792 1.00 26.14 A C ATOM1423 CD1 TYR A 809 5.292 31.899 −7.594 1.00 24.58 A C ATOM 1424 CE1 TYRA 809 6.060 31.665 −6.454 1.00 22.36 A C ATOM 1425 CD2 TYR A 809 6.61430.314 −8.819 1.00 23.89 A C ATOM 1426 CE2 TYR A 809 7.395 30.078 −7.6811.00 23.18 A C ATOM 1427 CZ TYR A 809 7.109 30.759 −6.500 1.00 22.75 A CATOM 1428 OH TYR A 809 7.862 30.545 −5.356 1.00 21.98 A O ATOM 1429 CTYR A 809 4.501 32.957 −12.121 1.00 31.30 A C ATOM 1430 O TYR A 8093.275 32.937 −12.207 1.00 32.33 A O ATOM 1431 N ILE A 810 5.308 33.154−13.156 1.00 34.61 A N ATOM 1432 CA ILE A 810 4.833 33.397 −14.507 1.0036.63 A C ATOM 1433 GB ILE A 810 5.886 34.213 −15.294 1.00 37.90 A CATOM 1434 CG2 ILE A 810 5.317 34.674 −16.630 1.00 39.20 A C ATOM 1435CG1 ILE A 810 6.325 35.425 −14.461 1.00 37.44 A C ATOM 1436 CD1 ILE A810 5.207 36.398 −14.139 1.00 38.11 A C ATOM 1437 C ILE A 810 4.51032.130 −15.278 1.00 38.89 A C ATOM 1438 O ILE A 810 5.275 31.164 −15.2711.00 36.85 A O ATOM 1439 N VAL A 811 3.361 32.145 −15.946 1.00 42.63 A NATOM 1440 CA VAL A 811 2.931 31.007 −16.738 1.00 46.63 A C ATOM 1441 GBVAL A 811 1.493 31.196 −17.260 1.00 47.03 A C ATOM 1442 CG1 VAL A 8111.116 30.042 −18.171 1.00 48.48 A C ATOM 1443 CG2 VAL A 811 0.524 31.278−16.093 1.00 48.85 A C ATOM 1444 C VAL A 811 3.873 30.857 −17.920 1.0048.78 A C ATOM 1445 O VAL A 811 4.120 31.810 −18.662 1.00 50.28 A O ATOM1446 N LYS A 812 4.409 29.657 −18.079 1.00 51.39 A N ATOM 1447 CA LYS A812 5.326 29.360 −19.166 1.00 53.36 A C ATOM 1448 GB LYS A 812 6.77029.452 −18.663 1.00 55.01 A C ATOM 1449 CG LYS A 812 7.839 29.521−19.749 1.00 57.32 A C ATOM 1450 CD LYS A 812 8.019 28.195 −20.473 1.0058.28 A C ATOM 1451 CE LYS A 812 9.203 28.254 −21.435 1.00 59.30 A CATOM 1452 NZ LYS A 812 9.394 26.975 −22.176 1.00 59.87 A N ATOM 1453 CLYS A 812 5.007 27.948 −19.655 1.00 53.67 A C ATOM 1454 O LYS A 8125.557 26.964 −19.161 1.00 53.46 A O ATOM 1455 N GLY A 813 4.097 27.859−20.620 1.00 54.01 A N ATOM 1456 CA GLY A 813 3.714 26.565 −21.155 1.0054.27 A C ATOM 1457 C GLY A 813 2.869 25.772 −20.178 1.00 54.01 A C ATOM1458 O GLY A 813 1.983 26.320 −19.521 1.00 53.87 A O ATOM 1459 N ALA A815 3.900 25.424 −17.091 1.00 45.88 A N ATOM 1460 CA ALA A 815 4.82525.681 −15.993 1.00 45.35 A C ATOM 1461 GB ALA A 815 6.262 25.480−16.465 1.00 44.67 A C ATOM 1462 C ALA A 815 4.651 27.093 −15.442 1.0043.98 A C ATOM 1463 O ALA A 815 4.312 28.021 −16.176 1.00 44.54 A O ATOM1464 N ARG A 816 4.881 27.243 −14.141 1.00 41.55 A N ATOM 1465 CA ARG A816 4.773 28.536 −13.467 1.00 38.90 A C ATOM 1466 GB ARG A 816 3.72028.471 −12.364 1.00 40.96 A C ATOM 1467 GG ARG A 816 2.365 27.986−12.832 1.00 44.60 A C ATOM 1468 CD ARG A 816 1.383 29.124 −12.971 1.0044.97 A C ATOM 1469 NE ARG A 816 0.455 28.681 −13.619 1.00 49.11 A NATOM 1470 CZ ARG A 816 −0.948 29.414 −13.707 1.00 49.56 A C ATOM 1471NH1 ARG A 816 0.979 30.632 −13.180 1.00 51.06 A N ATOM 1472 NH2 ARG A816 −2.015 28.935 −14.333 1.00 50.10 A N ATOM 1473 C ARG A 816 6.14728.774 −12.857 1.00 35.77 A C ATOM 1474 O ARG A 816 6.527 28.108 −11.8961.00 33.12 A O ATOM 1475 N LEU A 817 6.891 29.720 −13.416 1.00 32.40 A NATOM 1476 CA LEU A 817 8.238 29.986 −12.938 1.00 31.23 A C ATOM 1477 GBLEU A 817 9.240 29.758 −14.083 1.00 31.36 A C ATOM 1478 CG LEU A 8179.212 28.378 −14.763 1.00 33.58 A C ATOM 1479 CD1 LEU A 817 10.14628.371 −15.967 1.00 33.07 A C ATOM 1480 CD2 LEU A 817 9.615 27.303−13.763 1.00 34.77 A C ATOM 1481 C LEU A 817 8.436 31.384 −12.372 1.0028.71 A C ATOM 1482 O LEU A 817 7.863 32.358 −12.872 1.00 29.58 A O ATOM1483 N PRO A 818 9.245 31.497 −11.307 1.00 25.67 A N ATOM 1484 CD PRO A818 9.855 30.390 −10.545 1.00 27.34 A C ATOM 1485 CA PRO A 818 9.52432.795 −10.676 1.00 25.90 A C ATOM 1486 GB PRO A 818 10.051 32.392−9.297 1.00 26.91 A C ATOM 1487 CG PRO A 818 10.791 31.111 −9.595 1.0028.21 A C ATOM 1488 C PRO A 818 10.575 33.504 −11.534 1.00 24.30 A CATOM 1489 O PRO A 818 11.720 33.666 −11.135 1.00 24.57 A O ATOM 1490 NVAL A 819 10.165 33.924 −12.723 1.00 25.06 A N ATOM 1491 CA VAL A 81911.068 34.558 −13.678 1.00 25.38 A C ATOM 1492 CB VAL A 819 10.27535.022 −14.932 1.00 27.98 A C ATOM 1493 CG1 VAL A 819 11.174 35.784−15.877 1.00 29.83 A C ATOM 1494 CG2 VAL A 819 9.695 33.800 −15.648 1.0027.52 A C ATOM 1495 C VAL A 819 11.975 35.695 −13.192 1.00 22.75 A CATOM 1496 O VAL A 819 13.153 35.725 −13.544 1.00 21.93 A O ATOM 1497 NLYS A 820 11.457 36.614 −12.383 1.00 23.24 A N ATOM 1498 CA LYS A 82012.295 37.726 −11.917 1.00 23.65 A C ATOM 1499 CB LYS A 820 11.44638.787 −11.219 1.00 22.78 A C ATOM 1500 CG LYS A 820 10.681 39.690−12.170 1.00 23.46 A C ATOM 1501 CD LYS A 820 10.028 40.860 −11.436 1.0026.30 A C ATOM 1502 CE LYS A 820 9.266 41.757 −12.406 1.00 28.19 A CATOM 1503 NZ LYS A 820 8.786 43.009 −11.752 1.00 29.14 A N ATOM 1504 CLYS A 820 13.455 37.314 −11.007 1.00 20.98 A C ATOM 1505 O LYS A 82014.339 38.124 −10.703 1.00 21.94 A O ATOM 1506 N TRP A 821 13.447 36.061−10.576 1.00 21.43 A N ATOM 1507 CA TRP A 821 14.501 35.531 −9.708 1.0021.95 A C ATOM 1508 CB TRP A 821 13.877 34.771 −8.526 1.00 20.40 A CATOM 1509 CG TRP A 821 13.355 35.651 −7.425 1.00 21.20 A C ATOM 1510 CD2TRP A 821 12.089 36.327 −7.388 1.00 22.91 A C ATOM 1511 CE2 TRP A 82112.067 37.109 −6.203 1.00 20.76 A C ATOM 1512 CE3 TRP A 821 10.97636.354 −8.237 1.00 22.76 A C ATOM 1513 CD1 TRP A 821 14.025 36.029−6.292 1.00 21.77 A C ATOM 1514 NE1 TRP A 821 13.255 36.905 −5.555 1.0020.97 A N ATOM 1515 CZ2 TRP A 821 10.973 37.910 −5.851 1.00 22.45 A CATOM 1516 CZ3 TRP A 821 9.883 37.153 −7.887 1.00 23.18 A C ATOM 1517 CH2TRP A 821 9.893 37.922 −6.700 1.00 21.21 A C ATOM 1518 C TRP A 82115.426 34.576 −10.459 1.00 25.30 A C ATOM 1519 O TRP A 821 16.453 34.148−9.926 1.00 24.27 A O ATOM 1520 N MET A 822 15.083 34.258 −11.704 1.0025.46 A N ATOM 1521 CA MET A 822 15.868 33.284 −12.451 1.00 26.35 A CATOM 1522 CB MET A 822 14.923 32.440 −13.321 1.00 26.29 A C ATOM 1523 CGMET A 822 13.807 31.770 −12.531 1.00 29.03 A C ATOM 1524 SD MET A 82212.536 31.000 −13.580 1.00 33.03 A S ATOM 1525 CE MET A 822 13.50829.730 −14.402 1.00 34.78 A C ATOM 1526 C MET A 822 17.028 33.792−13.298 1.00 26.11 A C ATOM 1527 O MET A 822 16.946 34.838 −13.942 1.0027.94 A O ATOM 1528 N ALA A 823 18.108 33.020 −13.299 1.00 27.22 A NATOM 1529 CA ALA A 823 19.293 33.356 −14.075 1.00 29.26 A C ATOM 1530 CBALA A 823 20.443 32.430 −13.706 1.00 30.03 A C ATOM 1531 C ALA A 82318.943 33.197 −15.555 1.00 30.96 A C ATOM 1532 O ALA A 823 18.088 32.388−15.913 1.00 30.01 A O ATOM 1533 N PRO A 824 19.606 33.964 −16.429 1.0032.64 A N ATOM 1534 CD PRO A 824 20.732 34.872 −16.162 1.00 33.05 A CATOM 1535 CA PRO A 824 19.334 33.886 −17.868 1.00 36.11 A C ATOM 1536 CBPRO A 824 20.350 34.861 −18.464 1.00 36.00 A C ATOM 1537 CG PRO A 82421.480 34.831 −17.473 1.00 37.14 A C ATOM 1538 C PRO A 824 19.430 32.480−18.469 1.00 36.52 A C ATOM 1539 O PRO A 824 18.550 32.074 −19.219 1.0037.88 A O ATOM 1540 N GLU A 825 20.482 31.738 −18.138 1.00 37.16 A CATOM 1541 CA GLU A 825 20.635 30.387 −18.679 1.0.0 37.90 A C ATOM 1542CB GLU A 825 21.939 29.742 −18.191 1.00 37.37 A C ATOM 1543 CG GLU A 82521.981 29.490 −16.696 1.00 38.94 A C ATOM 1544 CD GLU A 825 22.73430.564 −15.943 1.00 39.03 A C ATOM 1545 OE1 GLU A 825 22.632 31.753−16.321 1.00 35.79 A O ATOM 1546 OE2 GLU A 825 23.425 30.212 −14.9661.00 40.40 A O ATOM 1547 C GLU A 825 19.450 29.509 −18.286 1.00 37.51 AC ATOM 1548 O GLU A 825 19.036 28.637 −19.051 1.00 36.46 A O ATOM 1549 NSER A 826 18.905 29.737 −17.090 1.00 36.70 A N ATOM 1550 CA SER A 82617.756 28.968 −16.618 1.00 36.53 A C ATOM 1551 CB SER A 826 17.51029.212 −15.122 1.00 35.67 A C ATOM 1552 OG SER A 826 18.527 28.619−14.339 1.00 32.85 A O ATOM 1553 C SER A 826 16.516 29.376 −17.401 1.0038.69 A C ATOM 1554 O SER A 826 15.623 28.563 −17.644 1.00 39.70 A OATOM 1555 N ILE A 827 16.475 30.646 −17.787 1.00 39.66 A N ATOM 1556 CAILE A 827 15.359 31.200 −18.543 1.00 41.87 A C ATOM 1557 CB ILE A 82715.288 32.735 −18.374 1.00 41.39 A C ATOM 1558 CG2 ILE A 827 14.23533.319 −19.307 1.00 41.88 A C ATOM 1559 CG1 ILE A 827 14.988 33.088−16.914 1.00 40.54 A C ATOM 1560 CD1 ILE A 827 14.921 34.573 −16.6541.00 40.32 A C ATOM 1561 C ILE A 827 15.449 30.904 −20.039 1.00 43.01 AC ATOM 1562 O ILE A 827 14.459 30.539 −20.662 1.00 45.05 A O ATOM 1563 NPHE A 828 16.638 31.060 −20.611 1.00 44.96 A N ATOM 1564 CA PHE A 82816.816 30.855 −22.045 1.00 46.18 A C ATOM 1565 CB PHE A 828 17.75631.932 −22.592 1.00 46.21 A C ATOM 1566 CG PHE A 828 17.361 33.323−22.203 1.00 45.87 A C ATOM 1567 CD1 PHE A 828 16.098 33.807 −22.5061.00 47.66 A C ATOM 1568 CD2 PHE A 828 18.242 34.144 −21.516 1.00 46.78A C ATOM 1569 CE1 PHE A 828 15.716 35.090 −22.130 1.00 47.02 A C ATOM1570 CE2 PHE A 828 17.869 35.427 −21.137 1.00 45.88 A C ATOM 1571 CZ PHEA 828 16.603 35.899 −21.446 1.00 46.14 A C ATOM 1572 C PHE A 828 17.30429.475 −22.481 1.00 47.41 A C ATOM 1573 O PHE A 828 16.941 29.001−23.559 1.00 46.29 A O ATOM 1574 N ASP A 829 18.121 28.831 −21.653 1.0048.48 A N ATOM 1575 CA ASP A 829 18.643 27.511 −21.992 1.00 49.25 A CATOM 1576 CB ASP A 829 20.170 27.502 −21.879 1.00 50.73 A C ATOM 1577 CGASP A 829 20.813 28.679 −22.588 1.00 51.29 A C ATOM 1578 OD1 ASP A 82920.362 29.018 −23.703 1.00 51.01 A O ATOM 1579 OD2 ASP A 829 21.77229.262 −22.036 1.00 52.69 A O ATOM 1580 C ASP A 829 18.058 26.424−21.103 1.00 49.72 A C ATOM 1581 O ASP A 829 18.333 25.242 −21.293 1.0050.40 A O ATOM 1582 N CYS A 830 17.250 26.830 −20.130 1.00 49.53 A NATOM 1583 CA CYS A 830 16.631 25.889 −19.212 1.00 48.08 A C ATOM 1584 CBCYS A 830 15.655 24.996 −19.974 1.00 50.60 A C ATOM 1585 SG CYS A 83014.455 25.950 −20.936 1.00 56.39 A S ATOM 1586 C CYS A 830 17.695 25.051−18.499 1.00 45.33 A C ATOM 1587 O CYS A 830 17.523 23.855 −18.258 1.0045.13 A O ATOM 1588 N VAL A 831 18.806 25.703 −18.181 1.00 42.08 A NATOM 1589 CA VAL A 831 19.907 25.069 −17.477 1.00 40.31 A C ATOM 1590 CBVAL A 831 21.270 25.533 −18.031 1.00 40.86 A C ATOM 1591 CG1 VAL A 83122.391 25.055 −17.123 1.00 41.87 A C ATOM 1592 CG2 VAL A 831 21.47024.990 −19.439 1.00 41.81 A C ATOM 1593 C VAL A 831 19.811 25.486−16.012 1.00 39.46 A C ATOM 1594 O VAL A 831 19.648 26.668 −15.707 1.0036.83 A O ATOM 1595 N TYR A 832 19.904 24.514 −15.115 1.00 38.97 A NATOM 1596 CA TYR A 832 19.834 24.784 −13.683 1.00 38.57 A C ATOM 1597 CBTYR A 832 18.562 24.185 −13.078 1.00 40.68 A C ATOM 1598 CG TYR A 83217.279 24.884 −13.470 1.00 44.99 A C ATOM 1599 CD1 TYR A 832 16.63824.592 −14.671 1.00 47.10 A C ATOM 1600 CE1 TYR A 832 15.433 25.209−15.013 1.00 48.30 A C ATOM 1601 CD2 TYR A 832 16.689 25.819 −12.6171.00 47.41 A C ATOM 1602 CE2 TYR A 832 15.490 26.441 −12.946 1.00 48.07A C ATOM 1603 CZ TYR A 832 14.865 26.130 −14.142 1.00 48.95 A C ATOM1604 OH TYR A 832 13.660 26.721 −14.447 1.00 51.19 A O ATOM 1605 C TYR A832 21.041 24.194 −12.978 1.00 36.09 A C ATOM 1606 O TYR A 832 21.22322.982 −12.965 1.00 36.46 A O ATOM 1607 N THR A 833 21.859 25.058−12.390 1.00 34.91 A N ATOM 1608 CA THR A 833 23.055 24.623 −11.676 1.0034.70 A C ATOM 1609 CB THR A 833 24.316 24.832 −12.518 1.00 33.56 A CATOM 1610 OG1 THR A 833 24.607 26.241 −12.578 1.00 34.75 A O ATOM 1611CG2 THR A 833 24.108 24.307 −13.937 1.00 36.16 A C ATOM 1612 C THR A 83323.211 25.455 −10.411 1.00 34.07 A C ATOM 1613 O THR A 833 22.394 26.334−10.135 1.00 33.13 A O ATOM 1614 N VAL A 834 24.272 25.188 −9.655 1.0032.64 A N ATOM 1615 CA VAL A 834 24.533 25.939 −8.431 1.00 32.94 A CATOM 1616 CB VAL A 834 25.758 25.365 −7.687 1.00 34.05 A C ATOM 1617 CG1VAL A 834 26.125 26.249 −6.491 1.00 34.80 A C ATOM 1618 CG2 VAL A 83425.441 23.956 −7.211 1.00 33.84 A C ATOM 1619 C VAL A 834 24.764 27.415−8.756 1.00 32.61 A C ATOM 1620 O VAL A 834 24.373 28.294 −7.986 1.0030.61 A O ATOM 1621 N GLN A 835 25.394 27.683 −9.901 1.00 31.06 A N ATOM1622 CA GLN A 835 25.662 29.050 −10.327 1.00 30.91 A C ATOM 1623 CB GLNA 835 26.550 29.071 −11.580 1.00 33.73 A C ATOM 1624 CG GLN A 835 27.89728.390 −11.411 1.00 38.14 A C ATOM 1625 CD GLN A 835 27.789 26.880−11.390 1.00 41.64 A C ATOM 1626 OE1 GLN A 835 27.435 26.252 −12.3921.00 44.54 A O ATOM 1627 NE2 GLN A 835 28.086 26.288 −10.245 1.00 43.71A N ATOM 1628 C GLN A 835 24.354 29.782 −10.619 1.00 29.24 A C ATOM 1629O GLN A 835 24.274 31.005 −10.475 1.00 28.16 A O ATOM 1630 N SER A 83623.343 29.033 −11.046 1.00 26.36 A N ATOM 1631 CA SER A 836 22.02729.600 −11.322 1.00 26.94 A C ATOM 1632 CB SER A 836 21.100 28.552−11.946 1.00 28.83 A C ATOM 1633 OG SER A 836 21.619 28.072 −13.177 1.0039.97 A O ATOM 1634 C SER A 836 21.423 30.085 −9.997 1.00 25.54 A C ATOM1635 O SER A 836 20.822 31.160 −9.944 1.00 23.88 A O ATOM 1636 N ASP A837 21.590 29.294 −8.937 1.00 23.44 A N ATOM 1637 CA ASP A 837 21.06929.666 −7.612 1.00 22.87 A C ATOM 1638 CB ASP A 837 21.223 28.522 −6.5871.00 21.76 A C ATOM 1639 CG ASP A 837 20.251 27.353 −6.824 1.00 26.24 AC ATOM 1640 OD1 ASP A 837 19.127 27.572 −7.326 1.00 22.61 A O ATOM 1641OD2 ASP A 837 20.614 26.205 −6.475 1.00 26.73 A O ATOM 1642 C ASP A 83721.806 30.887 −7.072 1.00 20.33 A C ATOM 1643 O ASP A 837 21.258 31.649−6.281 1.00 21.19 A O ATOM 1644 N VAL A 838 23.062 31.059 −7.479 1.0020.59 A N ATOM 1645 CA VAL A 838 23.857 32.206 −7.039 1.00 19.23 A CATOM 1646 CB VAL A 838 25.322 32.102 −7.537 1.00 19.55 A C ATOM 1647 CG1VAL A 838 26.057 33.428 −7.305 1.00 20.98 A C ATOM 1648 CG2 VAL A 83826.036 30.964 −6.804 1.00 21.35 A C ATOM 1649 C VAL A 838 23.238 33.500−7.581 1.00 20.52 A C ATOM 1650 O VAL A 838 23.179 34.517 −6.887 1.0019.90 A O ATOM 1651 N TRP A 839 22.810 33.460 −8.836 1.00 18.46 A N ATOM1652 CA TRP A 839 22.159 34.609 −9.453 1.00 21.09 A C ATOM 1653 CB TRP A839 21.728 34.268 −10.889 1.00 20.07 A C ATOM 1654 CG TRP A 839 20.88435.332 −11.573 1.00 21.41 A C ATOM 1655 CD2 TRP A 839 21.289 36.193−12.646 1.00 24.44 A C ATOM 1656 CE2 TRP A 839 20.178 37.005 −12.9721.00 25.22 A C ATOM 1657 CE3 TRP A 839 22.482 36.357 −13.363 1.00 25.77A C ATOM 1658 CD1 TRP A 839 19.585 35.649 −11.302 1.00 23.59 A C ATOM1659 NE1 TRP A 839 19.152 36.651 −12.136 1.00 25.28 A N ATOM 1660 CZ2TRP A 839 20.225 37.971 −13.987 1.00 28.13 A C ATOM 1661 CZ3 TRP A 83922.528 37.322 −14.377 1.00 27.43 A C ATOM 1662 CH2 TRP A 839 21.40438.113 −14.675 1.00 25.19 A C ATOM 1663 C TRP A 839 20.928 34.953 −8.6111.00 21.19 A C ATOM 1664 O TRP A 839 20.727 36.109 −8.224 1.00 20.89 A OATOM 1665 N SER A 840 20.121 33.938 −8.319 1.00 21.96 A N ATOM 1666 CASER A 840 18.907 34.122 −7.528 1.00 21.65 A C ATOM 1667 CS SER A 84018.155 32.800 −7.383 1.00 22.22 A C ATOM 1668 OG SER A 840 17.702 32.334−8.642 1.00 25.05 A C ATOM 1669 C SER A 840 19.235 34.678 −6.147 1.0021.66 A C ATOM 1670 O SER A 840 18.483 35.483 −5.603 1.00 20.11 A O ATOM1671 N TYR A 841 20.350 34.231 −5.583 1.00 21.97 A N ATOM 1672 CA TYR A841 20.773 34.708 −4.276 1.00 20.78 A C ATOM 1673 CB TYR A 841 22.02333.967 −3.817 1.00 20.77 A C ATOM 1674 CG TYR A 841 22.572 34.515 −2.5191.00 21.90 A C ATOM 1675 CD1 TYR A 841 22.030 34.129 −1.296 1.00 19.00 AC ATOM 1676 CE1 TYR A 841 22.514 34.676 −0.089 2.00 19.51 A C ATOM 1677CD2 TYR A 841 23.603 35.457 −2.522 1.00 19.80 A C ATOM 1678 CE2 TYR A841 24.085 36.009 −1.337 1.00 20.67 A C ATOM 1679 CZT YR A 841 23.54135.610 −0.128 1.00 19.20 A C ATOM 1680 OH TYR A 841 24.055 36.136 1.0441.00 23.37 A O ATOM 1681 C TYR A 841 21.058 36.209 −4.343 1.00 21.29 A CATOM 1682 O TYR A 841 20.896 36.916 −3.354 1.00 21.31 A O ATOM 1683 NGLY A 842 21.495 36.681 −5.509 1.00 21.07 A N ATOM 1684 CA GLY A 84221.780 38.097 −5.699 1.00 21.51 A C ATOM 1685 C GLY A 842 20.483 38.892−5.686 1.00 21.46 A C ATOM 1686 O GLY A 842 20.433 40.003 −5.155 1.0021.16 A O ATOM 1687 N ILE A 843 19.437 38.318 −6.275 1.00 19.90 A N ATOM1688 CA ILE A 843 18.111 38.949 −6.300 1.00 19.14 A C ATOM 1689 CB ILE A843 17.124 38.152 −7.202 1.00 19.48 A C ATOM 1690 CG2 ILE A 843 15.71738.768 −7.136 1.00 19.99 A C ATOM 1691 CG1 ILE A 843 17.643 38.126−8.654 1.00 19.93 A C ATOM 1692 CD1 ILE A 843 17.690 39.496 −9.345 1.0021.14 A C ATOM 1693 C ILE A 843 17.577 38.973 −4.852 1.00 20.59 A C ATOM1694 O ILE A 843 16.952 39.942 −4.432 1.00 18.68 A O ATOM 1695 N LEU A844 17.822 37.900 −4.103 1.00 18.05 A N ATOM 1696 CA LEU A 844 17.38437.832 −2.702 1.00 18.39 A C ATOM 1697 CB LEU A 844 17.763 36.476 −2.1001.00 18.49 A C ATOM 1698 CG LEU A 844 17.341 35.958 −0.707 1.00 24.74 AC ATOM 1699 CD1 LEU A 844 18.566 35.777 0.136 1.00 26.26 A C ATOM 1700CD2 LEU A 844 16.314 36.842 −0.034 1.00 20.82 A C ATOM 1701 C LEU A 84418.064 38.956 −1.920 1.00 18.40 A C ATOM 1702 O LEU A 844 17.435 39.597−1.081 1.00 18.40 A O ATOM 1703 N LEU A 845 19.349 39.188 −2.189 1.0017.22 A N ATOM 1704 CA LEU A 845 20.094 40.252 −1.503 1.00 19.83 A CATOM 1705 CB LEU A 845 21.564 40.286 −1.945 1.00 21.47 A C ATOM 1706 CGLEU A 845 22.550 39.286 −1.341 1.00 24.97 A C ATOM 1707 CD1 LEU A 84523.943 39.522 −1.921 1.00 25.32 A C ATOM 1708 CD2 LEU A 845 22.58539.442 0.162 1.00 27.48 A C ATOM 1709 C LEU A 845 19.472 41.611 −1.7811.00 21.02 A C ATOM 1710 O LEU A 845 19.414 42.471 −0.905 1.00 21.54 A OATOM 1711 N TRP A 846 19.023 41.808 −3.015 1.00 18.78 A N ATOM 1712 CATRP A 846 18.386 43.065 −3.387 1.00 19.24 A C ATOM 1713 CB TRP A 84618.135 43.099 −4.904 1.00 18.36 A C ATOM 1714 CG TRP A 846 17.666 44.427−5.397 1.00 19.12 A C ATOM 1715 CD2 TRP A 846 16.311 44.880 −5.474 1.0018.67 A C ATOM 1716 CE2 TRP A 846 16.339 46.211 −5.943 1.00 20.25 A CATOM 1717 CE3 TRP A 846 15.068 44.287 −5.191 1.00 21.90 A C ATOM 1718CD1 TRP A 846 18.445 45.470 −5.813 1.00 18.34 A C ATOM 1719 NE1 TRP A846 17.654 46.545 −6.143 1.00 19.55 A N ATOM 1720 CZ2 TRP A 846 15.17146.965 −6.137 1.00 18.90 A C ATOM 1721 CZ3 TRP A 846 13.912 45.032−5.383 1.00 18.91 A C ATOM 1722 CH2 TRP A 846 13.972 46.360 −5.852 1.0019.95 A C ATOM 1723 C TRP A 846 17.063 43.196 −2.617 1.00 20.29 A C ATOM1724 O TRP A 846 16.687 44.295 −2.197 1.00 20.60 A O ATOM 1725 N GLU A847 16.354 42.084 −2.430 1.00 18.32 A N ATOM 1726 CA GLU A 847 15.09642.121 −1.677 1.00 20.83 A C ATOM 1727 CB GLU A 847 14.388 40.767 −1.6901.00 21.03 A C ATOM 1728 CG GLU A 847 13.843 40.301 −3.026 1.00 22.05 AC ATOM 1729 CD GLU A 847 13.127 38.968 −2.882 1.00 21.19 A C ATOM 1730OE1 GLU A 847 11.887 38.961 −2.708 1.00 23.94 A O ATOM 1731 OE2 GLU A847 13.812 37.929 −2.917 1.00 20.13 A O ATOM 1732 C GLU A 847 15.36242.482 −0.215 1.00 20.02 A C ATOM 1733 O GLT A 847 14.621 43.252 0.3921.00 21.93 A O ATOM 1734 N ILE A 848 16.407 41.891 0.351 1.00 20.95 A NATOM 1735 CA ILE A 848 16.762 42.153 1.736 1.00 22.78 A C ATOM 1736 GBILE A 848 17.938 41.261 2.178 1.00 23.55 A C ATOM 1737 CG2 ILE A 84818.418 41.671 3.584 1.00 24.98 A C ATOM 1738 CG1 ILE A 848 17.515 39.7942.154 1.00 19.41 A C ATOM 1739 CD1 ILE A 848 18.635 38.813 2.568 1.0020.86 A C ATOM 1740 C ILE A 848 17.168 43.617 1.947 1.00 23.73 A C ATOM1741 O ILE A 848 16.682 44.277 2.862 1.00 23.90 A O ATOM 1742 N PHE A849 18.048 44.129 1.091 1.00 22.34 A N ATOM 1743 CA PHE A 849 18.51345.495 1.269 1.00 21.50 A C ATOM 1744 GB PHE A 849 19.950 45.594 0.7661.00 20.67 A C ATOM 1745 CG PHE A 849 20.923 44.848 1.638 1.00 24.48 A CATOM 1746 CD1 PHE A 849 21.439 45.441 2.788 1.00 24.74 A C ATOM 1747 CD2PHE A 849 21.251 43.522 1.361 1.00 24.69 A C ATOM 1748 CE1 PHE A 84922.266 44.723 3.656 1.00 26.97 A C ATOM 1749 CE2 PHE A 849 22.074 42.7902.219 1.00 26.68 A C ATOM 1750 CZ PHE A 849 22.583 43.393 3.374 1.0028.40 A C ATOM 1751 C PHE A 849 17.627 46.614 0.735 1.00 23.57 A C ATOM1752 O PHE A 849 17.996 47.789 0.807 1.00 25.95 A O ATOM 1753 N SER A850 16.461 46.242 0.207 1.00 21.47 A N ATOM 1754 CA SER A 850 15.47447.209 −0.259 1.00 23.11 A C ATOM 1755 CB SER A 850 14.951 46.856 −1.6571.00 23.52 A C ATOM 1756 OG SER A 850 14.191 45.650 −1.647 1.00 22.60 AO ATOM 1757 C SER A 850 14.322 47.099 0.743 1.00 23.85 A C ATOM 1758 OSER A 850 13.297 47.764 0.612 1.00 23.78 A O ATOM 1759 N LEU A 85114.518 46.246 1.744 1.00 23.92 A N ATOM 1760 CA LEU A 851 13.508 45.9792.767 1.00 26.63 A C ATOM 1761 CB LEU A 851 13.196 47.239 3.578 1.0030.38 A C ATOM 1762 GG LEU A 851 14.365 47.768 4.417 1.00 31.54 A C ATOM1763 CD1 LEU A 851 13.879 48.927 5.284 1.00 34.28 A C ATOM 1764 CD2 LEUA 851 14.934 46.661 5.292 1.00 31.71 A C ATOM 1765 C LEU A 851 12.23145.397 2.168 1.00 26.55 A C ATOM 1766 O LEU A 851 11.109 45.778 2.5361.00 26.87 A O ATOM 1767 N GLY A 852 12.403 44.475 1.225 1.00 26.49 A NATOM 1768 CA GLY A 852 11.257 43.809 0.629 1.00 26.06 A C ATOM 1769 CGLY A 852 10.551 44.320 −0.617 1.00 26.04 A C ATOM 1770 O GLY A 8529.405 43.936 −0.856 1.00 26.29 A O ATOM 1771 N LEU A 853 11.192 45.166−1.418 1.00 25.62 A N ATOM 1772 CA LEU A 853 10.549 45.638 −2.645 1.0025.25 A C ATOM 1773 GB LEU A 853 11.360 46.775 −3.283 1.00 25.04 A CATOM 1774 GG LEU A 853 11.482 48.112 −2.542 1.00 26.96 A C ATOM 1775 CD1LEU A 853 12.402 49.031 −3.333 1.00 27.36 A C ATOM 1776 CD2 LEU A 85310.102 48.751 −2.370 1.00 28.88 A C ATOM 1777 C LEU A 853 10.472 44.475−3.645 1.00 24.36 A C ATOM 1778 O LEU A 853 11.282 43.558 −3.579 1.0023.84 A O ATOM 1779 N ASN A 854 9.501 44.510 −4.562 1.00 25.24 A N ATOM1780 GA ASN A 854 9.394 43.471 −5.595 1.00 24.26 A C ATOM 1781 CB ASN A854 8.027 43.536 −6.300 1.00 27.10 A C ATOM 1782 CG ASN A 854 7.84542.436 −7.359 1.00 30.71 A C ATOM 1783 OD1 ASN A 854 7.704 42.724 −8.5501.00 33.31 A O ATOM 1784 ND2 ASN A 854 7.848 41.176 −6.923 1.00 31.20 AN ATOM 1785 C ASN A 854 10.521 43.815 −6.582 1.00 23.02 A C ATOM 1786 OASN A 854 10.688 44.977 −6.960 1.00 22.75 A O ATOM 1787 N PRO A 85511.317 42.821 −6.995 1.00 23.48 A N ATOM 1788 CD PRO A 855 11.317 41.413−6.547 1.00 22.75 A C ATOM 1789 CA PRO A 855 12.421 43.075 −7.935 1.0023.55 A C ATOM 1790 GB PRO A 855 13.032 41.686 −8.132 1.00 22.61 A CATOM 1791 CG PRO A 855 12.752 41.001 −6.809 1.00 25.22 A C ATOM 1792 CPRO A 855 11.949 43.703 −9.255 1.00 23.12 A C ATOM 1793 O PRO A 85510.808 43.506 −9.671 1.00 24.77 A O ATOM 1794 N TYR A 856 12.828 44.462−9.904 1.00 22.83 A N ATOM 1795 CA TYR A 856 12.487 45.116 −11.164 1.0024.91 A C ATOM 1796 GB TYR A 856 12.343 44.051 −12.261 1.00 23.41 A CATOM 1797 CG TYR A 856 13.591 43.221 −12.451 1.00 24.72 A C ATOM 1798CD1 TYR A 856 14.687 43.730 −13.151 1.00 22.35 A C ATOM 1799 CE1 TYR A856 15.854 42.997 −13.294 1.00 22.63 A C ATOM 1800 CD2 TYR A 856 13.69641.941 −11.896 1.00 23.64 A C ATOM 1801 GE2 TYR A 856 14.862 41.196−12.035 1.00 23.41 A C ATOM 1802 GZ TYR A 856 15.938 41.735 −12.735 1.0023.19 A C ATOM 1803 OH TYR A 856 17.103 41.023 −12.863 1.00 26.10 A OATOM 1804 C TYR A 856 11.165 45.864 −10.961 1.00 26.21 A C ATOM 1805 OTYR A 856 10.189 45.634 −11.678 1.00 27.12 A O ATOM 1806 N PRO A 85711.126 46.787 −9.981 1.00 27.10 A N ATOM 1807 CD PRO A 857 12.281 47.278−9.207 1.00 27.99 A C ATOM 1808 CA PRO A 857 9.920 47.564 −9.670 1.0030.26 A C ATOM 1809 CB PRO A 857 10.409 48.566 −8.612 1.00 30.65 A CATOM 1810 CG PRO A 857 11.873 48.693 −8.895 1.00 30.35 A C ATOM 1811 CPRO A 857 9.215 48.232 −10.850 1.00 31.72 A C ATOM 1812 O PRO A 8579.826 48.961 −11.624 1.00 31.38 A O ATOM 1813 N GLY A 858 7.921 47.953−10.976 1.00 34.17 A N ATOM 1814 CA GLY A 858 7.129 48.530 −12.046 1.0037.08 A C ATOM 1815 C GLY A 858 7.333 47.891 −13.409 1.00 39.30 A C ATOM1816 O GLY A 858 6.619 48.222 −14.356 1.00 40.60 A O ATOM 1817 N ILE A859 8.298 46.982 −13.520 1.00 38.93 A N ATOM 1818 CA ILE A 859 8.56746.323 −14.795 1.00 39.91 A C ATOM 1819 GB ILE A 859 10.077 46.062−14.993 1.00 40.10 A C ATOM 1820 CG2 ILE A 859 10.320 45.365 −16.3371.00 39.94 A C ATOM 1821 GG1 ILE A 859 10.842 47.384 −14.936 1.00 38.90A C ATOM 1822 CD1 ILE A 859 12.340 47.236 −15.138 1.00 38.67 A C ATOM1823 C ILE A 859 7.828 44.998 −14.887 1.00 40.26 A C ATOM 1824 O ILE A859 8.036 44.098 −14.070 1.00 40.34 A O ATOM 1825 N LEU A 860 6.95844.890 −15.884 1.00 40.88 A N ATOM 1826 CA LEU A 860 6.181 43.678−16.094 1.00 41.13 A C ATOM 1827 GB LEU A 860 4.956 43.973 −16.963 1.0044.17 A C ATOM 1828 CG LEU A 860 3.917 44.964 −16.432 1.00 45.61 A CATOM 1829 CD1 LEU A 860 2.847 45.185 −17.492 1.00 45.40 A C ATOM 1830CD2 LEU A 860 3.303 44.431 −15.143 1.00 46.55 A C ATOM 1831 C LEU A 8607.035 42.624 −16.779 1.00 40.77 A C ATOM 1832 O LEU A 860 8.004 42.947−17.473 1.00 40.42 A O ATOM 1833 N VAL A 861 6.678 41.361 −16.575 1.0040.50 A N ATOM 1834 CA VAL A 861 7.408 40.271 −17.197 1.00 39.36 A CATOM 1835 CE VAL A 861 7.278 38.969 −16.383 1.00 39.30 A C ATOM 1836 CC1VAL A 861 7.940 37.817 −17.127 1.00 39.10 A C ATOM 1837 CG2 VAL A 8617.924 39.149 −15.015 1.00 37.93 A C ATOM 1838 C VAL A 861 6.856 40.042−18.599 1.00 39.52 A C ATOM 1839 O VAL A 861 5.700 39.667 −18.769 1.0039.07 A O ATOM 1840 N ASN A 862 7.694 40.295 −19.598 1.00 40.50 A N ATOM1841 CA ASN A 862 7.328 40.108 −20.996 1.00 40.72 A C ATOM 1842 GB ASN A862 6.300 41.157 −21.444 1.00 40.69 A C ATOM 1843 CG ASN A 862 6.72742.573 −21.127 1.00 42.48 A C ATOM 1844 OD1 ASN A 862 7.854 42.982−21.413 1.00 42.17 A O ATOM 1845 ND2 ASN A 862 5.815 43.340 −20.541 1.0043.91 A N ATOM 1846 C ASN A 862 8.584 40.198 −21.849 1.00 41.01 A C ATOM1847 O ASN A 862 9.694 40.223 −21.320 1.00 39.88 A O ATOM 1848 N SER A863 6.411 40.249 −23.166 1.00 41.77 A N ATOM 1849 CA SER A 863 9.54040.321 −24.084 1.00 42.40 A C ATOM 1850 CB SER A 863 9.045 40.542−25.518 1.00 44.68 A C ATOM 1851 OG SER A 863 8.265 39.442 −25.954 1.0047.68 A O ATOM 1852 C SER A 863 10.550 41.402 −23.728 1.00 41.88 A CATOM 1853 O SER A 863 11.759 41.169 −23.793 1.00 41.70 A O ATOM 1854 NLYS A 864 10.066 42.586 −23.366 1.00 41.97 A N ATOM 1855 CA LYS A 86410.969 43.675 −23.009 1.00 41.85 A C ATOM 1856 CB LYS A 864 10.18844.941 −22.645 1.00 44.41 A C ATOM 1857 CG LYS A 864 9.420 45.586−23.794 1.00 48.47 A C ATOM 1858 CD LYS A 864 8.173 44.798 −24.169 1.0050.60 A C ATOM 1859 CE LYS A 864 7.299 45.595 −25.126 1.00 52.30 A CATOM 1860 NZ LYS A 864 6.022 44.895 −25.424 1.00 53.82 A N ATOM 1861 CLYS A 864 11.844 43.264 −21.828 1.00 39.55 A C ATOM 1862 O LYS A 86413.054 43.496 −21.832 1.00 39.40 A O ATOM 1863 N PHE A 865 11.229 42.653−20.820 1.00 39.12 A N ATOM 1864 CA PHE A 865 11.966 42.213 −19.638 1.0038.06 A C ATOM 1865 CB PHE A 865 11.023 41.562 −18.623 1.00 36.64 A CATOM 1866 CG PHE A 865 11.742 40.908 −17.475 1.00 35.09 A C ATOM 1867CD1 PHE A 865 12.356 41.679 −16.487 1.00 35.06 A C ATOM 1868 CD2 PHE A865 11.854 39.523 −17.408 1.00 33.09 A C ATOM 1869 CE1 PHE A 865 13.07641.075 −15.448 1.00 33.16 A C ATOM 1870 CE2 PHE A 865 12.573 38.909−16.374 1.00 33.59 A C ATOM 1871 CZ PHE A 865 13.186 39.687 −15.394 1.0033.11 A C ATOM 1872 C PHE A 865 13.062 41.214 −20.003 1.00 37.01 A CATOM 1873 O PHE A 865 14.221 41.384 −19.630 1.00 36.03 A O ATOM 1874 NTYR A 866 12.679 40.164 −20.721 1.00 37.56 A N ATOM 1875 CA TYR A 86613.622 39.136 −21.138 1.00 38.07 A C ATOM 1876 CB TYR A 866 12.90538.068 −21.963 1.00 37.23 A C ATOM 1877 CG TYR A 866 11.923 37.233−21.177 1.00 37.11 A C ATOM 1878 CD1 TYR A 866 10.591 37.133 −21.5741.00 37.20 A C ATOM 1879 CE1 TYR A 866 9.692 36.332 −20.880 1.00 37.90 AC ATOM 1880 CD2 TYR A 866 12.333 36.508 −20.057 1.00 36.89 A C ATOM 1881CE2 TYR A 866 11.444 35.703 −19.359 1.00 37.09 A C ATOM 1882 CZ TYR A866 10.127 35.619 −19.772 1.00 37.53 A C ATOM 1883 OH TYR A 866 9.24234.833 −19.074 1.00 37.38 A O ATOM 1884 C TYR A 866 14.780 39.717−21.940 1.00 38.15 A C ATOM 1885 O TYR A 866 15.923 39.287 −21.786 1.0038.37 A O ATOM 1886 N LYS A 867 14.489 40.697 −22.792 1.00 39.37 A NATOM 1887 CA LYS A 867 15.528 41.327 −23.603 1.00 39.25 A C ATOM 1888 CBLYS A 867 14.915 42.281 −24.635 1.00 41.07 A C ATOM 1889 CC LYS A 86714.130 41.598 −25.737 1.00 44.49 A C ATOM 1890 CD LYS A 867 13.58842.618 −26.729 1.00 47.60 A C ATOM 1891 CE LYS A 867 12.748 41.952−27.805 1.00 49.22 A C ATOM 1892 NZ LYS A 867 11.581 41.245 −27.210 1.0052.03 A N ATOM 1893 C LYS A 867 16.481 42.101 −22.716 1.00 37.95 A CATOM 1894 O LYS A 867 17.688 42.111 −22.943 1.00 37.68 A O ATOM 1895 NLEU A 868 15.931 42.759 −21.702 1.00 37.61 A N ATOM 1896 CA LEU A 86816.745 43.532 −20.777 1.00 37.63 A C ATOM 1897 CB LEU A 868 15.84844.268 −19.776 1.00 38.23 A C ATOM 1898 CC LEU A 868 15.087 45.472−20.334 1.00 39.69 A C ATOM 1899 CD1 LEU A 868 14.050 45.946 −19.3371.00 41.66 A C ATOM 1900 CD2 LEU A 868 16.079 46.582 −20.652 1.00 42.42A C ATOM 1901 C LEU A 868 17.729 42.634 −20.034 1.00 35.67 A C ATOM 1902O LEU A 868 18.936 42.846 −20.090 1.00 35.83 A O ATOM 1903 N VAL A 86917.213 41.623 −19.347 1.00 36.69 A N ATOM 1904 CA VAL A 869 18.08040.721 −18.597 1.00 38.09 A C ATOM 1905 CB VAL A 869 17.261 39.621−17.873 1.00 39.24 A C ATOM 1906 CG1 VAL A 869 16.401 40.248 −16.7901.00 38.16 A C ATOM 1907 CG2 VAL A 869 16.389 38.873 −18.863 1.00 41.19A C ATOM 1908 C VAL A 869 19.127 40.066 −19.498 1.00 38.28 A C ATOM 1909O VAL A 869 20.300 39.982 −19.138 1.00 36.50 A O ATOM 1910 N LYS A 87018.710 39.617 −20.676 1.00 38.66 A N ATOM 1911 CA LYS A 870 19.65138.982 −21.589 1.00 40.80 A C ATOM 1912 CB LYS A 870 18.917 38.412−22.807 1.00 42.63 A C ATOM 1913 CO LYS A 870 19.704 37.334 −23.547 1.0045.89 A C ATOM 1914 CD LYS A 870 18.858 36.665 −24.620 1.00 48.70 A CATOM 1915 CE LYS A 870 19.481 35.349 −25.084 1.00 50.99 A C ATOM 1916 NZLYS A 870 20.848 35.522 −25.648 1.00 51.81 A N ATOM 1917 C LYS A 87020.703 39.992 −22.032 1.00 39.69 A C ATOM 1918 O LYS A 870 21.872 39.648−22.193 1.00 41.55 A O ATOM 1919 N ASP A 871 20.291 41.245 −22.206 1.0039.79 A N ATOM 1920 CA ASP A 871 21.210 42.294 −22.633 1.00 39.72 A CATOM 1921 CB ASP A 871 20.435 43.473 −23.244 1.00 42.15 A C ATOM 1922 COASP A 871 19.689 43.090 −24.521 1.00 45.25 A C ATOM 1923 OD1 ASP A 87120.140 42.162 −25.226 1.00 44.93 A O ATOM 1924 OD2 ASP A 871 18.65443.724 −24.829 1.00 47.25 A O ATOM 1925 C ASP A 871 22.149 42.804−21.537 1.00 39.23 A C ATOM 1926 O ASP A 871 23.003 43.646 −21.796 1.0039.23 A O ATOM 1927 N GLY A 872 21.993 42.302 −20.314 1.00 37.91 A NATOM 1928 CA GLY A 872 22.876 42.719 −19.236 1.00 35.32 A C ATOM 1929 CGLY A 872 22.337 43.752 −18.262 1.00 34.33 A C ATOM 1930 O GLY A 87223.098 44.322 −17.482 1.00 34.53 A O ATOM 1931 N TYR A 873 21.034 44.008−18.302 1.00 33.63 A N ATOM 1932 CA TYR A 873 20.441 44.985 −17.391 1.0033.06 A C ATOM 1933 CB TYR A 873 18.984 45.254 −17.773 1.00 33.91 A CATOM 1934 CO TYR A 873 18.255 46.135 −16.786 1.00 35.24 A C ATOM 1935CD1 TYR A 873 18.496 47.509 −16.736 1.00 36.54 A C ATOM 1936 CE1 TYR A873 17.849 48.323 −15.802 1.00 37.89 A C ATOM 1937 CD2 TYR A 873 17.34645.589 −15.874 1.00 36.66 A C ATOM 1938 CE2 TYR A 873 16.696 46.391−14.932 1.00 35.88 A C ATOM 1939 CZ TYR A 873 16.951 47.755 −14.902 1.0038.27 A C ATOM 1940 OH TYR A 873 16.316 48.546 −13.978 1.00 36.23 A OATOM 1941 C TYR A 873 20.487 44.455 −15.956 1.00 29.67 A C ATOM 1942 OTYR A 873 20.287 43.269 −15.731 1.00 27.02 A O ATOM 1943 N GLN A 87420.756 45.342 −15.000 1.00 29.08 A N ATOM 1944 CA GLN A 874 20.80644.983 −13.580 1.00 29.02 A C ATOM 1945 CB GLN A 874 22.258 44.872−13.087 1.00 31.26 A C ATOM 1946 CO GLN A 874 23.008 43.681 −13.678 1.0032.68 A C ATOM 1947 CD GLN A 874 24.476 43.620 −13.287 1.00 31.96 A CATOM 1948 OE1 GLN A 874 25.202 42.723 −13.725 1.00 37.30 A O ATOM 1949NE2 GLN A 874 24.920 44.560 −12.468 1.00 29.71 A N ATOM 1950 C GLN A 87420.074 46.050 −12.776 1.00 27.53 A C ATOM 1951 O GLN A 874 20.074 47.224−13.142 1.00 28.08 A O ATOM 1952 N MET A 875 19.436 45.634 −11.689 1.0027.33 A N ATOM 1953 CA MET A 875 18.706 46.564 −10.833 1.00 24.49 A CATOM 1954 CB MET A 875 17.947 45.811 −9.741 1.00 22.12 A C ATOM 1955 CGMET A 875 16.757 45.009 −10.200 1.00 20.05 A C ATOM 1956 SD MET A 87515.847 44.386 −8.775 1.00 22.51 A S ATOM 1957 CE MET A 875 16.689 42.827−8.532 1.00 19.64 A C ATOM 1958 C MET A 875 19.684 47.515 −10.168 1.0024.42 A C ATOM 1959 O MET A 875 20.836 47.158 −9.924 1.00 24.14 A O ATOM1960 N ALA A 876 19.215 48.723 −9.869 1.00 23.99 A N ATOM 1961 CA ALA A876 20.035 49.726 −9.210 1.00 25.95 A C ATOM 1962 CB ALA A 876 19.33951.093 −9.269 1.00 26.52 A C ATOM 1963 C ALA A 876 20.282 49.334 −7.7571.00 26.67 A C ATOM 1964 O ALA A 876 19.537 48.544 −7.182 1.00 26.17 A OATOM 1965 N GLN A 877 21.332 49.893 −7.168 1.00 26.33 A N ATOM 1966 CAGLN A 877 21.667 49.624 −5.768 1.00 26.11 A C ATOM 1967 CB GLN A 87722.874 50.478 −5.359 1.00 28.43 A C ATOM 1968 CO GLN A 877 23.213 50.463−3.875 1.00 28.07 A C ATOM 1969 CD GLN A 877 24.475 51.257 −3.570 1.0033.40 A C ATOM 1970 QE1 GLN A 877 24.890 52.104 −4.357 1.00 34.37 A OATOM 1971 NE2 GLN A 877 25.081 50.994 −2.420 1.00 32.88 A N ATOM 1972 CGLN A 877 20.462 49.943 −4.875 1.00 26.20 A C ATOM 1973 O GLN A 87719.825 50.987 −5.029 1.00 28.53 A O ATOM 1974 N PRO A 878 20.126 49.032−3.945 1.00 25.80 A N ATOM 1975 CD PRO A 878 20.732 47.698 −3.822 1.0026.50 A C ATOM 1976 CA PRO A 878 19.010 49.166 −3.002 1.00 27.36 A CATOM 1977 CB PRO A 878 18.974 47.804 −2.311 1.00 26.99 A C ATOM 1978 CGPRO A 878 19.585 46.896 −3.281 1.00 28.13 A c ATOM 1979 C PRO A 87819.320 50.282 −2.010 1.00 25.74 A C ATOM 1980 O PRO A 878 20.478 50.509−1.673 1.00 25.44 A O ATOM 1981 N ALA A 879 18.279 50.945 −1.524 1.0026.30 A N ATOM 1982 CA ALA A 879 18.445 52.056 −0.592 1.00 27.29 A CATOM 1983 CB ALA A 879 17.075 52.565 −0.142 1.00 25.88 A C ATOM 1984 CALA A 879 19.307 51.742 0.624 1.00 26.75 A C ATOM 1985 O ALA A 87920.092 52.583 1.051 1.00 29.14 A O ATOM 1986 N PHE A 880 19.202 50.5321.165 1.00 25.72 A N ATOM 1987 CA PHE A 880 19.972 50.213 2.362 1.0026.31 A C ATOM 1988 CB PHE A 880 19.047 49.627 3.428 1.00 28.37 A C ATOM1989 CG PHE A 880 17.899 50.519 3.771 1.00 29.95 A C ATOM 1990 CD1 PHE A880 16.678 50.384 3.123 1.00 32.51 A C ATOM 1991 CD2 PHE A 880 18.05051.532 4.715 1.00 31.03 A C ATOM 1992 CE1 PHE A 880 15.621 51.243 3.4061.00 33.31 A C ATOM 1993 CE2 PHE A 880 16.998 52.399 5.006 1.00 32.39 AC ATOM 1994 CZ PHE A 880 15.784 52.257 4.353 1.00 33.31 A C ATOM 1995 CPHE A 880 21.187 49.325 2.202 1.00 26.89 A C ATOM 1996 O PHE A 88021.775 48.882 3.191 1.00 26.72 A O ATOM 1997 N ALA A 881 21.582 49.0780.962 1.00 27.32 A N ATOM 1998 CA ALA A 881 22.736 48.246 0.703 1.0027.94 A C ATOM 1999 CB ALA A 881 22.546 47.485 −0.616 1.00 29.37 A CATOM 2000 C ALA A 881 24.028 49.048 0.642 1.00 30.57 A C ATOM 2001 O ALAA 881 24.118 50.052 −0.066 1.00 29.11 A O ATOM 2002 N PRO A 882 25.03748.638 1.423 1.00 32.05 A N ATOM 2003 CD PRO A 882 24.988 47.755 2.6011.00 33.91 A C ATOM 2004 CA PRO A 882 26.304 49.367 1.372 1.00 34.17 A CATOM 2005 CB PRO A 882 27.101 48.748 2.517 1.00 34.87 A C ATOM 2006 CGPRO A 882 26.037 48.372 3.497 1.00 34.72 A C ATOM 2007 C PRO A 88226.880 49.005 0.005 1.00 34.84 A C ATOM 2008 O PRO A 882 26.557 47.946−0.537 1.00 32.74 A O ATOM 2009 N LYS A 883 27.712 49.873 −0.560 1.0035.18 A N ATOM 2010 CA LYS A 883 28.305 49.615 −1.870 1.00 36.75 A CATOM 2011 CB LYS A 883 29.385 50.654 −2.167 1.00 39.56 A C ATOM 2012 CGLYS A 883 30.149 50.408 −3.463 1.00 41.70 A C ATOM 2013 CD LYS A 88331.300 51.386 −3.605 1.00 46.30 A C ATOM 2014 CE LYS A 883 32.198 51.030−4.785 1.00 47.44 A C ATOM 2015 NZ LYS A 883 33.382 51.939 −4.867 1.0048.85 A N ATOM 2016 C LYS A 883 28.908 48.212 −2.00 41.00 36.73 A C ATOM2017 O LYS A 883 28.779 47.571 −3.047 1.00 37.14 A O ATOM 2018 N ASN A884 29.565 47.736 −0.951 1.00 35.03 A N ATOM 2019 CA ASN A 884 30.19246.418 −0.987 1.00 34.74 A C ATOM 2020 CB ASN A 884 31.053 46.224 0.2591.00 37.97 A C ATOM 2021 CG ASN A 884 32.318 47.048 0.216 1.00 41.02 A CATOM 2022 OD1 ASN A 884 32.383 48.070 −0.472 1.00 42.58 A O ATOM 2023ND2 ASN A 884 33.332 46.617 0.958 1.00 42.68 A N ATOM 2024 C ASN A 88429.188 45.284 −1.109 1.00 32.58 A C ATOM 2025 O ASN A 884 29.474 44.258−1.722 1.00 32.18 A O ATOM 2026 N ILE A 885 28.018 45.469 −0.512 1.0031.95 A N ATOM 2027 CA ILE A 885 26.972 44.461 −0.578 1.00 30.39 A CATOM 2028 CB ILE A 885 25.859 44.745 0.459 1.00 30.06 A C ATOM 2029 CC2ILE A 885 24.731 43.747 0.312 1.00 30.92 A C ATOM 2030 CG1 ILE A 88526.445 44.705 1.871 1.00 32.44 A C ATOM 2031 CD1 ILE A 885 27.153 43.4142.215 1.00 34.23 A C ATOM 2032 C ILE A 885 26.396 44.493 −1.996 1.0028.80 A C ATOM 2033 O ILE A 885 26.090 43.451 −2.572 1.00 27.47 A O ATOM2034 N TYR A 886 26.256 45.689 −2.561 1.00 27.42 A N ATOM 2035 CA TYR A886 25.734 45.805 −3.918 1.00 27.23 A C ATOM 2036 CB TYR A 886 25.51447.276 −4.292 1.00 27.39 A C ATOM 2037 CG TYR A 886 24.935 47.473 −5.6751.00 27.39 A C ATOM 2038. CD1 TYR A 886 23.774 46.808 −6.066 1.00 27.64A C ATOM 2039 CE1 TYR A 886 23.239 46.977 −7.342 1.00 28.02 A C ATOM2040 CD2 TYR A 886 25.552 48.321 −6.601 1.00 28.67 A C ATOM 2041 CE2 TYRA 886 25.025 48.497 −7.885 1.00 28.90 A C ATOM 2042 CZ TYR A 886 23.87047.822 −8.247 1.00 28.99 A C ATOM 2043 OH TYR A 886 23.345 47.974 −9.5101.00 28.49 A O ATOM 2044 C TYR A 886 26.737 45.153 −4.873 1.00 27.22 A CATOM 2045 O TYR A 886 26.356 44.594 −5.899 1.00 27.84 A O ATOM 2046 NSER A 887 28.021 45.218 −4.524 1.00 27.56 A N ATOM 2047 CA SER A 88729.051 44.600 −5.353 1.00 28.78 A C ATOM 2048 CB SER A 887 30.446 44.897−4.799 1.00 31.23 A C ATOM 2049 OG SER A 887 30.700 46.291 −4.802 1.0035.41 A O ATOM 2050 C SER A 887 28.843 43.088 −5.417 1.00 27.15 A C ATOM2051 O SER A 887 29.180 42.461 −6.411 1.00 26.08 A O ATOM 2052 N ILE A888 28.288 42.505 −4.355 1.00 26.96 A N ATOM 2053 CA ILE A 888 28.03541.068 −4.340 1.00 26.66 A C ATOM 2054 CB ILE A 888 27.623 40.551 −2.9401.00 26.97 A C ATOM 2055 CG2 ILE A 888 27.329 39.049 −3.014 1.00 25.87 AC ATOM 2056 CG1 ILE A 888 28.744 40.812 −1.932 1.00 29.82 A C ATOM 2057CD1 ILEA 888 28.368 40.465 −0.507 1.00 29.33 A C ATOM 2058 C ILE A 88826.913 40.763 −5.314 1.00 24.54 A C ATOM 2059 O ILE A 888 26.991 39.801−6.067 1.00 24.10 A O ATOM 2060 N MET A 889 25.872 41.596 −5.295 1.0024.37 A N ATOM 2061 CA MET A 889 24.733 41.426 −6.187. 1.00.24.31 A.CATOM 2062 CB MET A 889 23.721 42.558 5.981 1.00 24.18 A C ATOM 2063 CGMET A 889 23.021 42.541 −4.614 1.00 24.24 A C ATOM 2064 SD MET A 88921.876 43.943 −4.442 1.00 24.46 A S ATOM 2065 CE MET A 889 22.192 44.419−2.726 1.00 24.20 A C ATOM 2066 C MET A 889 25.193 41.421 −7.640 1.0025.77 A C ATOM 2067 O MET A 889 24.802 40.550 −8.429 1.00 23.93 A O ATOM2068 N GLN A 890 26.035 42.394 −7.978 1.00 26.71 A N ATOM 2069 CA GLN A890 26.561 42.525 −9.332 1.00 28.97 A C ATOM 2070 CB GLN A 890 27.44243.776 −9.429 1.00 29.48 A C ATOM 2071 CG GLN A 890 26.668 45.076 −9.2191.00 30.61 A C ATOM 2072 CD GLN A 890 27.546 46.309 −9.285 1.00 32.25 AC ATOM 2073 OE1 GLN A 890 28.447 46.488 −8.468 1.00 33.10 A O ATOM 2074NE2 GLN A 890 27.279 47.173 −10.259 1.00 32.57 A N ATOM 2075 C GLN A 89027.350 41.287 −9.739 1.00 27.86 A C ATOM 2076 O GLN A 890 27.247 40.826−10.878 1.00 30.13 A O ATOM 2077 N ALA A 891 28.133 40.755 −8.806 1.0027.34 A N ATOM 2078 CA ALA A 891 28.934 39.560 −9.058 1.00 27.20 A CATOM 2079 CB ALA A 891 29.835 39.270 −7.858 1.00 27.77 A C ATOM 2080 CALA A 891 28.011 38.378 −9.331 1.00 26.78 A C ATOM 2081 O ALA A 89128.248 37.598 −10.252 1.00 25.81 A O ATOM 2082 N CYS A 892 26.954 38.255−8.528 1.00 25.33 A N ATOM 2083 CA CYS A 892 25.977 37.183 −8.694 1.0023.44 A C ATOM 2084 CB CYS A 892 24.912 37.234 −7.586 1.00 21.37 A CATOM 2085 SG CYS A 892 25.501 36.833 −5.923 1.00 25.09 A S ATOM 2086 CCYS A 892 25.259 37.287 −10.032 1.00 22.41 A C ATOM 2087 O CYS A 89224.802 36.279 −10.576 1.00 21.96 A O ATOM 2088 N TRP A 893 25.138 38.513−10.540 1.00 22.92 A N ATOM 2089 CA TRP A 893 24.445 38.748 −11.802 1.0024.15 A C ATOM 2090 CB TRP A 893 23.640 40.049 −11.731 1.00 23.99 A CATOM 2091 CG TRP A 893 22.602 40.070 −10.621 1.00 25.25 A C ATOM 2092CD2 TRP A 893 22.139 41.219 −9.905 1.00 24.67 A C ATOM 2093 CE2 TRP A893 21.168 40.770 −8.971 1.00 25.85 A C ATOM 2094 CE3 TRP A 893 22.44942.588 −9.957 1.00 24.95 A C ATOM 2095 CD1 TRP A 893 21.911 38.997−10.113 1.00 26.64 A C ATOM 2096 NE1 TRP A 893 21.050 39.412 −9.118 1.0024.18 A N ATOM 2097 CZ2 TRP A 893 20.505 41.644 −8.097 1.00 23.40 A CATOM 2098 CZ3 TRP A 893 21.793 43.457 −9.085 1.00 22.62 A C ATOM 2099CH2 TRP A 893 20.827 42.977 −8.166 1.00 21.93 A C ATOM 2100 C TRP A 89325.344 38.773 −13.043 1.00 27.09 A C ATOM 2101 O TRP A 893 24.948 39.287−14.092 1.00 27.52 A O ATOM 2102 N ALA A 894 26.553 38.238 −12.926 1.0030.21 A N ATOM 2103 CA ALA A 894 27.443 38.182 −14.085 1.00 31.38 A CATOM 2104 CB ALA A 894 28.788 37.593 −13.686 1.00 32.39 A C ATOM 2105 CALA A 894 26.736 37.267 −15.084 1.00 31.53 A C ATOM 2106 O ALA A 89426.229 36.215 −14.705 1.00 30.02 A O ATOM 2107 N LEU A 895 26.680 37.670−16.351 1.00 32.91 A N ATOM 2108 CA LEU A 895 26.011 36.866 −17.367 1.0033.93 A C ATOM 2109 CB LEU A 895 25.980 37.612 −18.707 1.00 34.40 A CATOM 2110 CG LEU A 895 25.046 38.827 −18.789 1.00 37.38 A C ATOM 2111CD1 LEU A 895 25.127 39.442 −20.180 1.00 38.41 A C ATOM 2112 CD2 LEU A895 23.619 38.405 −18.487 1.00 36.13 A C ATOM 2113 C LEU A 895 26.67135.503 −17.544 1.00 34.31 A C ATOM 2114 O LEU A 895 25.994 34.497−17.740 1.00 34.78 A O ATOM 2115 N GLU A 896 27.995 35.478 −17.472 1.0037.15 A N ATOM 2116 CA GLU A 896 28.745 34.238 −17.607 1.00 39.52 A CATOM 2117 CB GLU A 896 30.185 34.564 −18.025 1.00 42.43 A C ATOM 2118 CGGLU A 896 31.080 33.366 −18.278 1.00 48.49 A C ATOM 2119 CD GLU A 89632.398 33.763 −18.927 1.00 52.37 A C ATOM 2120 OE1 GLU A 896 33.13434.588 −18.336 1.00 53.43 A O ATOM 2121 OE2 GLU A 896 32.695 33.254−20.033 1.00 54.83 A O ATOM 2122 C GLU A 896 28.720 33.520 −16.251 1.0037.75 A C ATOM 2123 O GLU A 896 29.301 33.998 −15.280 1.00 37.75 A OATOM 2124 N PRO A 897 28.031 32.370 −16.170 1.00 37.87 A N ATOM 2125 CDPRO A 897 27.209 31.770 −17.237 1.00 37.58 A C ATOM 2126 CA PRO A 89727.922 31.581 −14.937 1.00 37.70 A C ATOM 2127 CB PRO A 897 27.25030.301 −15.419 1.00 37.56 A C ATOM 2128 CG PRO A 897 26.322 30.816−16.465 1.00 37.35 A C ATOM 2129 C PRO A 897 29.226 31.312 −14.189 1.0038.10 A C ATOM 2130 O PRO A 897 29.242 31.281 −12.955 1.00 36.69 A OATOM 2131 N THR A 898 30.320 31.124 −14.923 1.00 38.36 A N ATOM 2132 CATHR A 898 31.608 30.849 −14.288 1.00 37.76 A C ATOM 2133 CB THR A 89832.593 30.172 −15.268 1.00 38.94 A C ATOM 2134 OG1 THR A 898 32.95131.093 −16.304 1.00 40.73 A O ATOM 2135 CG2 THR A 898 31.957 28.941−15.889 1.00 39.66 A C ATOM 2136 C THR A 898 32.265 32.108 −13.746 1.0037.96 A C ATOM 2137 O THR A 898 33.294 32.038 −13.072 1.00 38.29 A OATOM 2138 N HIS A 899 31.681 33.264 −14.043 1.00 37.07 A N ATOM 2139 CAHIS A 899 32.233 34.519 −13.562 1.00 37.73 A C ATOM 2140 CB HIS A 89932.081 35.605 −14.623 1.00 42.21 A C ATOM 2141 CG HIS A 899 33.27836.494 −14.742 1.00 48.88 A C ATOM 2142 CD2 HIS A 899 34.151 36.682−15.761 1.00 50.32 A C ATOM 2143 ND1 HIS A 899 33.710 37.306 −13.7131.00 90.96 A N ATOM 2144 CE1 HIS A 899 34.796 37.955 −14.094 1.00 51.86A C ATOM 2145 NE2 HIS A 899 35.085 37.593 −15.333 1.00 53.20 A N ATOM2146 C HIS A 899 31.543 34.946 −12.268 1.00 35.74 A C ATOM 2147 O HIS A899 31.897 35.964 −11.665 1.00 35.35 A C ATOM 2148 N ARG A 900 30.55434.160 −11.854 1.00 33.68 A N ATOM 2149 CA ARG A 900 29.819 34.422−10.618 1.00 32.79 A C ATOM 2150 CB ARG A 900 28.419 33.797 −10.673 1.0031.57 A C ATOM 2151 CG ARG A 900 27.532 34.351 −11.759 1.00 31.01 A CATOM 2152 CD ARG A 900 26.215 33.604 −11.853 1.00 28.64 A C ATOM 2153 NEARG A 900 25.516 33.987 −13.071 1.00 29.23 A N ATOM 2154 CZ ARG A 90024.644 33.223 −13.714 1.00 27.03 A C ATOM 2155 NH1 ARG A 900 24.33532.012 −13.252 1.00 28.97 A N ATOM 2156 NH2 ARG A 900 24.120 33.652−14.853 1.00 29.12 A N ATOM 2157 C ARG A 900 30.589 33.778 −9.482 1.0032.53 A C ATOM 2158 O ARG A 900 31.235 32.747 −9.665 1.00 32.70 A O ATOM2159 N PRO A 901 30.530 34.371 −8.287 1.00 31.70 A N ATOM 2160 CD PRO A901 29.816 35.591 −7.868 1.00 31.21 A C ATOM 2161 CA PRO A 901 31.25733.773 −7.169 1.00 31.11 A C ATOM 2162 CB PRO A 901 31.205 34.866 −6.1121.00 31.76 A C ATOM 2163 CG PRO A 901 29.852 35.482 −6.358 1.00 32.84 AC ATOM 2164 C PRO A 901 30.556 32.499 −6.708 1.00 32.06 A C ATOM 2165 OPRO A 901 29.437 32.203 −7.138 1.00 29.97 A O ATOM 2166 N THR A 90231.221 31.740 −5.844 1.00 31.96 A N ATOM 2167 CA THR A 902 30.616 30.530−5.302 1.00 29.99 A C ATOM 2168 CB THR A 902 31.675 29.455 −5.000 1.0028.30 A C ATOM 2169 OG1 THR A 902 32.517 29.905 −3.938 1.00 28.94 A OATOM 2170 CG2 THR A 902 32.524 29.184 −6.236 1.00 29.96 A C ATOM 2171 CTHR A 902 29.976 30.973 −3.991 1.00 28.78 A C ATOM 2172 O THR A 90230.268 32.065 −3.502 1.00 28.62 A O ATOM 2173 N PHE A 903 29.100 30.1543.421 1.00 28.57 A N ATOM 2174 CA PHE A 903 28.478 30.536 −2.157 1.0029.13 A C ATOM 2175 CB PHE A 903 27.343 29.570 −1.787 1.00 28.81 A CATOM 2176 CG PHE A 903 26.064 29.835 −2.532 1.00 27.49 A C ATOM 2177 CD1PHE A 903 25.381 31.034 −2.348 1.00 25.90 A C ATOM 2178 CD2 PHE A 90325.558 28.906 −3.435 1.00 26.86 A C ATOM 2179 CE1 PHE A 903 24.21531.308 −3.051 1.00 22.70 A C ATOM 2180 CE2 PHE A 903 24.385 29.169−4.149 1.00 25.78 A C ATOM 2181 CZ PHE A 903 23.713 30.372 −3.957 1.0023.53 A C ATOM 2182 C PHE A 903 29.516 30.586 −1.045 1.00 30.49 A C ATOM2183 O PHE A 903 29.411 31.403 −0.128 1.00 29.48 A O ATOM 2184 N GLN A904 30.534 29.732 −1.134 1.00 32.67 A N ATOM 2185 CA GLN A 904 31.58229.731 −0.119 1.00 34.69 A C ATOM 2186 CB GLN A 904 32.546 28.563 −0.3421.00 38.18 A C ATOM 2187 CG GLN A 904 33.580 28.423 0.761 1.00 43.01 A CATOM 2188 CD GLN A 904 32.967 28.567 2.142 1.00 45.54 A C ATOM 2189 OE1GLN A 904 32.147 27.750 2.562 1.00 47.82 A O ATOM 2190 NE2 GLN A 90433.354 29.622 2.852 1.00 47.75 A N ATOM 2191 C GLN A 904 32.345 31.061−0.140 1.00 34.49 A C ATOM 2192 O GLN A 904 32.704 31.606 0.904 1.0032.29 A O ATOM 2193 N GLN A 905 32.585 31.585 −1.337 1.00 35.55 A N ATOM2194 CA GLN A 905 33.277 32.855 −1.471 1.00 35.22 A C ATOM 2195 CB GLN A905 33.669 33.086 −2.930 1.00 35.06.A C ATOM 2196 CG GLN A 905 34.89432.287 −3.331 1.00 38.42 A C ATOM 2197 CD GLN A 905 35.079 32.173 −4.8271.00 38.16 A C ATOM 2198 OE1 GLN A 905 36.085 31.636 −5.297 1.00 43.96 AO ATOM 2199 NE2 GLN A 905 34.113 32.663 −5.586 1.00 36.11 A N ATOM 2200C GLN A 905 32.397 33.991 −0.962 1.00 35.01 A C ATOM 2201 O GLN A 90532.887 34.948 −0.363 1.00 34.50 A O ATOM 2202 N ILE A 906 31.091 33.877−1.186 1.00 34.36 A N ATOM 2203 CA ILE A 906 30.168 34.901 −0.721 1.0033.30 A C ATOM 2204 CB ILE A 906 28.744 34.634 −1.257 1.00 30.88 A CATOM 2205 CG2 ILE A 906 27.713 35.434 −0.466 1.00 30.71 A C ATOM 2206CG1 ILE A 906 28.697 34.989 −2.748 1.00 31.17 A C ATOM 2207 CD1 ILE A906 27.396 34.636 −3.434 1.00 28.64 A C ATOM 2208 C ILE A 906 30.18134.941 0.808 1.00 34.77 A C ATOM 2209 O ILE A 906 30.255 36.018 1.4061.00 31.91 A O ATOM 2210 N CYS A 907 30.129 33.768 1.433 1.00 36.66 A NATOM 2211 CA CYS A 907 30.158 33.674 2.894 1.00 40.20 A C ATOM 2212 GBCYS A 907 30.198 32.213 3.338 1.00 39.93 A C ATOM 2213 SG CYS A 90728.611 31.428 3.449 1.00 44.12 A S ATOM 2214 C CYS A 907 31.368 34.3743.490 1.00 41.65 A C ATOM 2215 O CYS A 907 31.245 35.172 4.420 1.0042.40 A O ATOM 2216 N SER A 908 32.538 34.053 2.949 1.00 43.49 A N ATOM2217 CA SER A 908 33.794 34.619 3.417 1.00 45.17 A C ATOM 2218 GB SER A908 34.953 34.051 2.599 1.00 46.62 A C ATOM 2219 OG SER A 908 36.19934.452 3.139 1.00 50.76 A O ATOM 2220 C SER A 908 33.801 36.137 3.3241.00 45.72 A C ATOM 2221 O SER A 908 34.236 36.826 4.251 1.00 45.92 A OATOM 2222 N PHE A 909 33.319 36.655 2.199 1.00 45.06 A N ATOM 2223 CAPHE A 909 33.274 38.093 1.977 1.00 44.08 A C ATOM 2224 GB PHE A 90932.807 38.384 0.553 1.00 42.79 A C ATOM 2225 CG PHE A 909 32.905 39.8280.166 1.00 43.94 A C ATOM 2226 CD1 PHE A 909 34.140 40.470 0.130 1.0042.21 A C ATOM 2227 CD2 PHE A 909 31.768 40.543 −0.193 1.00 41.49 A CATOM 2228 CE1 PHE A 909 34.239 41.799 −0.259 1.00 42.41 A C ATOM 2229CE2 PHE A 909 31.859 41.874 −0.585 1.00 42.63 A C ATOM 2230 CZ PHE A 90933.097 42.503 −0.620 1.00 42.40 A C ATOM 2231 C PHE A 909 32.333 38.7452.983 1.00 44.82 A C ATOM 2232 O PHE A 909 32.633 39.808 3.528 1.0045.91 A O ATOM 2233 NLEU A 910 31.191 38.109 3.223 1.00 44.06 A N ATOM2234 CA LEU A 910 30.227 38.625 4.181 1.00 45.22 A C ATOM 2235 CB LEU A910 28.911 37.852 4.089 1.00 41.44 A C ATOM 2236 CG LEU A 910 28.07738.064 2.827 1.00 39.78 A C ATOM 2237 CD1 LEU A 910 26.881 37.122 2.8531.00 39.13 A C ATOM 2238 CD2 LEU A 910 27.619 39.519. 2.748 1.00 38.00 AC ATOM 2239 C LEU A 910 30.808 38.482 5.582 1.00 47.78 A C ATOM 2240 OLEU A 910 30.569 39.318 6.457 1.00 47.63 A O ATOM 2241 N GLN A 91131.574 37.416 5.788 1.00 51.82 A N ATOM 2242 CA GLN A 911 32.193 37.1617.084 1.00 56.05 A C ATOM 2243 CB GLN A 911 32.944 35.826. 7.051 1.0057.62 A C ATOM 2244 CG GLN A 911 33.337 35.290 8.417 1.00 60.18 A C ATOM2245 CD GLN A 911 33.861 33.862 8.345 1.00 61.94 A C ATOM 2246 OE1 GLN A911 34.842 33.587 7.655 1.00 62.84 A O ATOM 2247 NE2 GLN A 911 33.21132.948 9.059 1.00 62.59 A N ATOM 2248 C GLN A 911 33.153 38.314 7.3811.00 58.14 A C ATOM 2249 O GLN A 911 33.185 38.838 8.493 1.00 58.49 A OATOM 2250 N GLU A 912 33.919 38.712 6.369 1.00 60.16 A N ATOM 2251 CAGLU A 912 34.858 39.813 6.509 1.00 62.99 A C ATOM 2252 CB GLU A 91235.750 39.916 5.273 1.00 63.37 A C ATOM 2253 CG GLU A 912 36.509 38.6424.945 1.00 64.99 A C ATOM 2254 CD GLU A 912 37.419 38.809 3.741 1.0066.51 A C ATOM 2255 OE1 GLU A 912 36.923 39.203 2.662 1.00 66.38 A OATOM 2256 OE2 GLU A 912 38.632 38.545 3.867 1.00 67.43 A O ATOM 2257 CGLU A 912 34.060 41.101 6.657 1.00 64.48 A C ATOM 2258 O GLU A 91234.620 42.186 6.837 1.00 64.98 A O ATOM 2259 N GLN A 913 32.742 40.9546.577 1.00 66.11 A N ATOM 2260 GA GLN A 913 31.798 42.054 6.678 1.0067.44 A C ATOM 2261 CB GLN A 913 32.214 43.024 7.781 1.00 68.94 A C ATOM2262 CG GLN A 913 32.210 42.381 9.160 1.00 70.90 A C ATOM 2263 CD GLN A913 32.575 43.351 10.268 1.00 72.14 A C ATOM 2264 OE1 GLN A 913 33.66543.920 10.271 1.00 73.21 A O ATOM 2265 NE2 GLN A 913 31.662 43.54811.214 1.00 72.27 A N ATOM 2266 C GLN A 913 31.681 42.774 5.344 1.0067.51 A C ATOM 2267 O GLN A 913 30.582 42.920 4.806 1.00 68.02 A O ATOM2268 N ALA A 914 32.815 43.202 4.800 1.00 67.46 A N ATOM 2269 GA ALA A914 32.840 43.906 3.520 1.00 66.59 A C ATOM 2270 CB ALA A 914 32.12043.085 2.464 1.00 66.19 A C ATOM 2271 C ALA A 914 32.194 45.284 3.6561.00 66.26 A C ATOM 2272 O ALA A 914 32.708 46.273 3.134 1.00 66.94 A OATOM 2273 N GLN A 915 31.072 45.337 4.370 1.00 66.11 A N ATOM 2274 CAGLN A 915 30.343 46.580 4.604 1.00 65.66 A C ATOM 2275 CB GLN A 91529.936 47.211 3.273 1.00 65.97 A C ATOM 2276 CG GLN A 915 30.859 48.3282.828 1.00 66.33 A C ATOM 2277 CD GLN A 915 30.128 49.641 2.672 1.0067.07 A C ATOM 2278 OE1 GLN A 915 29.554 50.164 3.632 1.00 67.25 A OATOM 2279 NE2 GLN A 915 30.135 50.181 1.458 1.00 66.90 A N ATOM 2280 CGLN A 915 29.109 46.378 5.483 1.00 64.80 A C ATOM 2281 O GLN A 91528.468 45.328 5.440 1.00 65.35 A O ATOM 2282 N ALA A 916 28.782 47.3936.280 1.00 63.80 A N ATOM 2283 CA ALA A 916 27.628 47.328 7.171 1.0062.26 A C ATOM 2284 CB ALA A 916 28.094 47.384 8.638 1.00 60.15 A C ATOM2285 C ALA A 916 26.671 48.473 6.889 1.00 61.91 A C ATOM 2286 O ALA A916 25.554 48.197 6.387 1.00 61.71 A O ATOM 2287 OXT ALA A 916 27.0304.9.6487.168 1.00 61.76 A O ATOM 2288 C1 INH I 1000 4.821 29.492 6.6941.00 31.11 I C ATOM 2289 C2 INH I 1000 4.066 30.667 7.019 1.00 33.00 I CATOM 2290 C3 INH I 1000 4.010 31.171 8.345 1.00 32.48 I C ATOM 2291 C4INH I 1000 4.712 30.516 9.396 1.00 31.97 I C ATOM 2292 C5 INH I 10005.468 29.342 9.098 1.00 31.58 I C ATOM 2293 C6 INH I 1000 5.530 28.8167.763 1.00 29.91 I C ATOM 2294 C7 INH I 1000 6.308 28.520 3.306 1.0029.12 I C ATOM 2295 C8 INH I 1000 6.200 29.300 4.626 1.00 30.39 I C ATOM2296 N1 INH I 1000 4.890 29.102 5.331 1.00 32.22 I N ATOM 2297 C9 INH I1000 3.620 28.770 4.602 1.00 31.09 I C ATOM 2298 C10 INH I 1000 3.85728.041 3.260 1.00 30.49 I C ATOM 2299 C11 INH I 1000 5.038 28.628 2.4681.00 30.53 I C ATOM 2300 C12 INH I 1000 5.224 27.874 1.154 1.00 27.13 IC ATOM 2301 C13 INH I 1000 4.658 31.047 10.801 1.00 34.41 I C ATOM 2302O1 INH I 1000 3.393 30.696 11.364 1.00 38.64 I O ATOM 2303 C14 INH I1000 7.069 26.794 8.131 1.00 28.71 I C ATOM 2304 N2 INH I 1000 6.19727.613 7.430 1.00 28.05 I N ATOM 2305 02 INH I 1000 7.478 26.985 9.2801.00 30.81 I O ATOM 2306 C16 INH I 1000 7.448 25.614 7.357 1.00 26.57 IC ATOM 2307 C16 INH I 1000 8.285 24.552 7.649 1.00 26.78 I C ATOM 2308C17 INH I 1000 8.266 23.688 6.517 1.00 28.27 I C ATOM 2309 C18 INH I1000 7.418 24.279 5.603 1.00 26.96 I C ATOM 2310 O3 INH I 1000 6.91825.440 6.094 1.00 27.67 I O ATOM 2311 C19 INH I 1000 7.010 23.900 4.3001.00 27.52 I C ATOM 2312 N3 INH I 1000 6.683 23.601 3.228 1.00 28.92 I NATOM 2313 O HOH W 1 10.164 40.940 −3.146 1.00 21.08 W O ATOM 2314 O HOHW 2 7.936 37.125 −3.614 1.00 22.66 W O ATOM 2315 O HOH W 3 13.953 27.8230.701 1.00 25.69 W O ATOM 2316 O HOH W 4 16.609 38.256 −12.304 1.0024.24 W O ATOM 2317 O HOH W 5 15.463 37.003 −14.494 1.00 28.69 W O ATOM2318 O HOH W 6 12.958 32.094 −7.055 1.00 23.76 W O ATOM 2319 O HOH W 78.733 36.704 −11.363 1.00 25.45 W O ATOM 2320 O HOH W 8 10.417 36.756−2.552 1.00 23.52 W O ATOM 2321 O HOH W 9 17.184 29.603 −7.251 1.0025.10 W O ATOM 2322 O HOH W 10 21.459 40.971 −16.856 1.00 34.51 W O ATOM2323 O HOH W 11 11.509 26.503 −1.609 1.00 24.67 W O ATOM 2324 O HOH W 124.068 30.522 −11.763 1.00 30.45 W O ATOM 2325 O HOH W 13 7.206 36.7548.481 1.00 28.49 W O ATOM 2326 O HOH W 14 24.856 47.149 −11.673 1.0036.87 W O ATOM 2327 O HOH W 15 30.041 25.070 −0.613 1.00 28.85 W O ATOM2328 O HOH W 16 7.804 39.907 −4.499 1.00 29.84 W O ATOM 2329 O HOH W 1719.195 42.824 11.432 1.00 23.73 W O ATOM 2330 O HOH W 18 6.029 35.9041.295 1.00 32.21 W O ATOM 2331 O HOH W 19 32.052 13.285 −12.059 1.0043.10 W O ATOM 2332 O HOH W 20 30.535 27.128 −2.441 1.00 36.26 W o ATOM2333 O HOH W 21 23.962 41.086 −15.791 1.00 33.42 W O ATOM 2334 O HOH W22 14.853 47.840 −11.833 1.00 27.61 W O ATOM 2335 O HOH W 23 6.11631.381 −10.205 1.00 31.05 W O ATOM 2336 O HOH W 24 17.746 14.311 −6.6441.00 33.07 W O ATOM 2337 O HOH W 25 8.417 27.795 −2.249 1.00 35.12 W OATOM 2338 O HOH W 26 0.869 31.7.36 −11.288 1.00 34.67 W O ATOM 2339 OHOH W 27 13.031 25.416 −3.919 1.00 31.11 W O ATOM 2340 O HOH W 28 10.55228.209 15.464 1.00 44.08 W O ATOM 2341 O HOH W 29 6.047 32.847 1.7621.00 32.15 W O ATOM 2342 O HOH W 30 28.653 27.676 −4.452 1.00 33.50 W OATOM 2343 O HOH W 31 12.680 18.023 −3.373 1.00 35.86 W O ATOM 2344 O HOHW 32 12.248 49.285 −12.196 1.00 34.47 W O ATOM 2345 O HOH W 33 22.84425.229 −4.874 1.00 34.91 W O ATOM 2346 O HOH W 34 18.041 30.547 −11.5681.00 35.72 W O ATOM 2347 O HOH W 35 0.359 30.834 3.181 1.00 37.12 W OATOM 2348 O HOH W 36 12.464 21.249 4.826 1.00 32.13 W O ATOM 2349 O HOHW 37 31.088 42.980 −8.204 1.00 33.32 W O ATOM 2350 O HOH W 38 5.26435.914 −3.440 1.00 33.62 W O ATOM 2351 O HOH W 39 17.371 17.662 7.0301.00 40.85 W O ATOM 2352 O HOH W 40 29.961 37.594 −17.391 1.00 43.48 W OATOM 2353 O HOH W 41 18.158 23.617 13.470 1.00 42.33 W O ATOM 2354 O HOHW 42 22.984 51.388 −8.847 1.00 36.61 W O ATOM 2355 O HOH W 43 24.40527.822 14.803 1.00 31.01 W O ATOM 2356 O HOH W 44 −4.934 31.704 −2.4021.00 32.46 W O ATOM 2357 O HOH W 45 25.084 14.109 3.129 1.00 48.04 W OATOM 2358 O HOH W 46 20.063 53.568 −6.478 1.00 32.40 W O ATOM 2359 O NOHW 47 22.061 48.313 5.634 1.00 36.00 W O ATOM 2360 O HOH W 48 10.18722.802 14.864 1.00 37.95 W O ATOM 2361 O HOH W 49 0.008 13.070 2.1141.00 45.21 W O ATOM 2362 O HOH W 50 25.041 14.480 −2.610 1.00 45.49 W OATOM 2363 O HOH W 51 6.656 46.258 −0.949 1.00 39.79 W O ATOM 2364 O HOHW 52 13.822 50.139 −0.359 1.00 40.63 W O ATOM 2365 O HOH W 53 22.38753.214 2.600 1.00 38.29 W O ATOM 2366 O HOH W 54 9.153 26.472 −4.2181.00 36.65 W O ATOM 2367 O HOH W 55 14.610 31.184 −9.251 1.00 31.27 W OATOM 2368 O HOH W 56 24.935 17.603 8.567 1.00 44.53 W O ATOM 2369 O HOHW 57 7.252 46.276 −4.053 1.00 39.45 W O ATOM 2370 O HOH W 58 25.81841.981 −17.191 1.00 40.37 W O ATOM 2371 O HOH W 59 28.022 40.016 −17.2281.00 48.52 W O ATOM 2372 O HOH W 60 29.274 48.054 −6.225 1.00 44.84 W OATOM 2373 O HOH W 61 −5.269 19.566 7.820 1.00 56.98 W O ATOM 2374 O HOHW 62 2.640 24.211 −5.163 1.00 50.27 W O ATOM 2375 O HOH W 63 7.92320.900 −1.169 1.00 37.33 W O ATOM 2376 O HOH W 64 27.634 45.162 −13.2071.00 46.05 W O ATOM 2377 O HOH W 65 7.070 38.833 −10.815 1.00 35.97 W OATOM 2378 O HOH W 66 −1.437 33.817 −10.585 1.00 42.27 W.0 ATOM 2379 OHOH W 67 2.293 29.053 −0.105 1.00 43.18 W O ATOM 2380 O HOH W 68 −0.33729.845 0.902 1.00 44.30 W O ATOM 2381 O HOH W 69 13.627 17.597 −11.5811.00 52.67 WO ATOM 2382 O HOH W 70 10.652 22.799 4.564 1.00 49.65 W OATOM 2383 O HOH W 71 32.699 40.511 −10.516 1.00 53.08 W O ATOM 2384 OHOH W 72 30.236 43.692 −12.518 1.00 48.54 W O ATOM 2385 O HOH W 7319.844 27.263 13.669 1.00 44.13 W O ATOM 2386 O HOH W 74 17.734 29.53516.425 1.00 42.59 W O ATOM 2387 O HOH W 75 7.234 19.806 7.154 1.00 46.54W O ATOM 2388 O HOH W 76 26.364 11.064 −2.697 1.00 41.27 W O ATOM 2389 OHOH W 77 9.100 50.578 −6.099 1.00 36.36 W O ATOM 2390 O HOH W 78 11.85452.633 −2.732 1.00 53.20 W O ATOM 2391 O HOH W 79 11.974 56.050 1.3751.00 76.32 W O ATOM 2392 O HOH W 80 22.479 50.601 −11.573 1.00 47.12 W OATOM 2393 O HOH W 81 −0.004 0.007 6.072 1.00 38.70 W O ATOM 2394 O HOH W82 4.477 41.554 −4.606 1.00 34.09 W O ATOM 2395 O HOH W 83 27.838 53.3440.486 1.00 48.36 W O ATOM 2396 O HOH W 84 22.017 53.906 −8.187 1.0038.28 W O ATOM 2397 O HOH W 85 12.617 34.402 19.138 1.00 41.13 W O ATOM2398 O HOH W 86 2.912 32.727 4.894 1.00 51.51 W O ATOM 2399 O HOH W 8727.534 26.168 5.351 1.00 31.51 W O ATOM 2400 O HOH W 88 11.125 12.829−7.881 1.00 52.64 W O ATOM 2401 O HOH W 89 21.024 21.470 12.494 1.0041.27 W O ATOM 2402 O HOH W 90 14.012 14.000 14.848 1.00 47.62 W O ATOM2403 O HOH W 91 11.506 10.890 14.020 1.00 42.83 W O ATOM 2404 O HOH W 921.120 31.537 10.417 1.00 42.16 W O ATOM 2405 O HOH W 93 4.751 32.9383.780 1.00 42.70 W O ATOM 2406 O HOH W 94 19.088 36.501 11.901 1.0040.49 W O ATOM 2407 O HOH W 95 23.080 30.887 11.698 1.00 32.51 W O ATOM2408 O HOH W 96 −3.355 27.300 −3.494 1.00 40.37 W O ATOM 2409 O HOH W 976.415 47.469 −17.497 1.00 45.34 W O ATOM 2410 O HOH W 98 27.847 44.555−15.690 1.00 43.12 W O ATOM 2411 O HOH W 99 21.740 53.159 −2.940 1.0045.77 W O ATOM 2412 O HOH W 100 34.748 28.537 −3.258 1.00 33.58 W O ATOM2413 O HOH W 101 32.169 31.691 5.630 1.00 49.99 W O

TABLE 2 Coordinates of c-FMS (FGF-chimera) in complex with 793693(Quinolone) ATOM 1 CB VAL A 548 9.777 25.835 −8.002 1.00 47.46 A C ATOM2 CG1 VAL A 548 8.868 25.978 −6.788 1.00 47.60 A C ATOM 3 CG2 VAL A 5489.490 26.966 −8.985 1.00 47.02 A C ATOM 4 C VAL A 548 11.681 24.617−6.732 1.00 48.10 A C ATOM 5 O VAL A 548 11.759 24.714 −5.500 1.00 48.85A O ATOM 6 N VAL A 548 12.137 26.116 −8.795 1.00 48.54 A N ATOM 7 CA VALA 548 11.286 25.876 −7.583 1.00 48.22 A C ATOM 8 N ARG A 549 11.95023.462 −7.364 1.00 46.82 A N ATOM 9 CA ARG A 549 12.337 22.234 −6.6291.00 43.63 A C ATOM 10 CB ARG A 549 11.770 20.963 −7.295 1.00 43.39 A CATOM 11 CG ARG A 549 10.347 21.048 −7.864 1.00 44.56 A C ATOM 12 CD ARGA 549 9.277 21.106 −6.786 1.00 46.33 A C ATOM 13 NE ARG A 549 7.90721.191 −7.312 1.00 47.70 A N ATOM 14 CZ ARG A 549 7.390 20.356 −8.2171.00 50.05 A C ATOM 15 NH1 ARG A 549 8.134 19.371 −8.719 1.00 50.64 A NATOM 16 NH2 ARG A 549 6.113 20.471 −8.592 1.00 48.71 A N ATOM 17 C ARG A549 13.862 22.062 −6.549 1.00 42.80 A C ATOM 18 O ARG A 549 14.57422.221 −7.548 1.00 42.02 A O ATOM 19 N TRP A 550 14.351 21.721 −5.3551.00 42.29 A N ATOM 20 CA TRP A 550 15.781 21.487 −5.106 1.00 40.36 A CATOM 21 CB TRP A 550 16.006 21.156 −3.615 1.00 38.80 A C ATOM 22 CG TRPA 550 16.042 22.368 −2.722 1.00 36.46 A C ATOM 23 CD2 TRP A 550 16.47722.430 −1.347 1.00 34.47 A C ATOM 24 CE2 TRP A 550 16.435 23.793 −0.9561.00 33.72 A C ATOM 25 CE3 TRP A 550 16.905 21.474 −0.416 1.00 33.16 A CATOM 26 CD1 TRP A 550 15.751 23.657 −3.087 1.00 36.01 A C ATOM 27 NE1TRP A 550 15.988 24.513 −2.034 1.00 35.68 A N ATOM 28 CZ2 TRP A 55016.806 24.226 0.328 1.00 31.12 A C ATOM 29 CZ3 TRP A 550 17.278 21.9070.866 1.00 33.47 A C ATOM 30 CH2 TRP A 550 17.226 23.279 1.221 1.0031.47 A C ATOM 31 C TRP A 550 16.208 20.319 −5.980 1.00 40.36 A C ATOM32 O TRP A 550 15.378 19.524 −6.371 1.00 40.45 A O ATOM 33 N LYS A 55117.493 20.192 −6.282 1.00 42.69 A N ATOM 34 CA LYS A 551 17.931 19.099−7.152 1.00 44.73 A C ATOM 35 CB LYS A 551 17.579 19.456 −8.604 1.0046.90 A C ATOM 36 CG LYS A 551 18.037 18.468 −9.677 1.00 49.06 A C ATOM37 CD LYS A 551 17.445 18.874 −11.027 1.00 50.07 A C ATOM 38 CE LYS A551 17.674 17.820 −12.114 1.00 51.26 A C ATOM 39 NZ LYS A 551 16.90718.163 −13.364 1.00 51.81 A N ATOM 40 C LYS A 551 19.418 18.795 −7.0581.00 44.73 A C ATOM 41 O LYS A 551 20.244 19.714 −7.096 1.00 45.59 A OATOM 42 N ILE A 552 19.767 17.516 −6.928 1.00 45.19 A N ATOM 43 CA ILE A552 21.182 17.141 −6.877 1.00 45.37 A C ATOM 44 CB ILE A 552 21.42615.803 −6.160 1.00 44.06 A C ATOM 45 CG2 ILE A 552 22.931 15.518 −6.1201.00 44.22 A C ATOM 46 CG1 ILE A 552 20.839 15.842 −4.747 1.00 42.66 A CATOM 47 CD1 ILE A 552 21.480 16.846 −3.850 1.00 41.98 A C ATOM 48 C ILEA 552 21.617 16.969 −8.329 1.00 46.39 A C ATOM 49 O ILE A 552 20.85916.433 −9.149 1.00 47.88 A O ATOM 50 N ILE A 553 22.820 17.429 −8.6541.00 46.14 A N ATOM 51 CA ILE A 553 23.311 17.311 −10.015 1.00 47.07 A CATOM 52 CB ILE A 553 23.498 18.692 −10.671 1.00 45.77 A C ATOM 53 CG2ILE A 553 22.166 19.422 −10.744 1.00 44.44 A C ATOM 54 CG1 ILE A 55324.515 19.511 −9.884 1.00 44.08 A C ATOM 55 CD1 ILE A 553 24.861 20.821−10.552 1.00 43.43 A C ATOM 56 C ILE A 533 24.634 16.577 −10.011 1.0049.28 A C ATOM 57 O ILE A 553 25.279 16.455 −8.972 1.00 49.94 A O ATOM58 N GLU A 554 25.042 16.084 −11.174 1.00 53.01 A N ATOM 59 CA GLU A 55426.298 15.347 −11.266 1.00 56.51 A C ATOM 60 CB GLU A 554 26.274 14.398−12.473 1.00 56.86 A C ATOM 61 CG GLU A 554 24.962 13.622 −12.621 1.0057.21 A C ATOM 62 CD GLU A 554 25.072 12.456 −13.585 1.00 58.05 A C ATOM63 OE1 GLU A 554 25.672 12.623 −14.677 1.00 58.33 A O ATOM 64 OE2 GLU A554 24.547 11.370 −13.248 1.00 57.79 A O ATOM 65 C GLU A 554 27.49316.288 −11.362 1.00 58.04 A C ATOM 66 O GLU A 554 27.438 17.311 −12.0551.00 57.43 A O ATOM 67 N SER A 555 28.571 15.932 −10.662 1.00 60.36 A NATOM 68 CA SER A 555 29.785 16.742 −10.657 1.00 62.16 A C ATOM 69 CB SERA 555 29.444 18.152 −10.159 1.00 61.27 A C ATOM 70 OG SER A 555 30.60318.952 −10.040 1.00 62.36 A O ATOM 71 C SER A 555 30.941 16.168 −9.8161.00 63.44 A C ATOM 72 O SER A 555 30.801 15.160 −9.111 1.00 63.42 A OATOM 73 N TYR A 556 32.085 16.836 −9.919 1.00 64.74 A N ATOM 74 CA TYR A556 33.304 16.502 −9.186 1.00 65.12 A C ATOM 75 CB TYR A 556 34.19815.582 −10.024 1.00 67.00 A C ATOM 76 CG TYR A 556 34.653 16.207 −11.3191.00 69.41 A C ATOM 77 CD1 TYR A 556 35.629 17.212 −11.329 1.00 70.07 AC ATOM 78 CE1 TYR A 556 36.015 17.839 −12.513 1.00 71.36 A C ATOM 79 CD2TYR A 556 34.074 15.835 −12.535 1.00 70.87 A C ATOM 80 CE2 TYR A 55634.455 16.453 −13.730 1.00 72.35 A C ATOM 81 CZ TYR A 556 35.425 17.457−13.710 1.00 72.66 A C ATOM 82 OH TYR A 556 35.796 18.083 −14.884 1.0074.24 A O ATOM 83 C TYR A 556 33.988 17.857 −8.969 1.00 64.79 A C ATOM84 O TYR A 556 33.788 18.787 −9.754 1.00 65.23 A O ATOM 85 N GLU A 55734.782 17.987 −7.915 1.00 63.66 A N ATOM 86 CA GLU A 557 34.455 19.255−7.661 1.00 61.63 A C ATOM 87 CB GLU A 557 35.870 19.333 −6.197 1.0060.62 A C ATOM 88 CG GLU A 557 34.701 19.154 −5.258 1.00 60.14 A C ATOM89 CD GLU A 557 35.123 18.907 −3.825 1.00 60.19 A C ATOM 90 OE1 GLU A557 35.710 19.824 −3.199 1.00 59.18 A O ATOM 91 OE2 GLU A 557 34.86417.786 −3.330 1.00 59.67 A O ATOM 92 C GLU A 557 36.670 19.402 −8.5651.00 61.26 A C ATOM 93 O GLU A 557 36.530 19.611 −9.769 1.00 60.42 A OATOM 94 N SER A 560 31.488 18.870 −4.386 1.00 44.83 A N ATOM 95 CA SER A560 32.184 17.628 −4.054 1.00 44.18 A C ATOM 96 CB SER A 560 31.65017.052 −2.734 1.00 45.04 A C ATOM 97 OG SER A 560 32.563 16.115 −2.1761.00 44.63 A O ATOM 98 C SER A 560 31.980 16.618 −5.186 1.00 42.67 A CATOM 99 O SER A 560 31.951 16.994 −6.363 1.00 41.27 A O ATOM 100 N TYR A561 31.861 15.340 −4.830 1.00 40.78 A N ATOM 101 CA TYR A 561 31.63514.307 −5.830 1.00 39.98 A C ATOM 102 CB TYR A 561 32.786 13.295 −5.8571.00 38.19 A C ATOM 103 CG TYR A 561 32.658 12.257 −6.962 1.00 36.14 A CATOM 104 CD1 TYR A 561 33.644 12.119 −7.948 1.00 33.88 A C ATOM 105 CE1TYR A 561 33.532 11.145 −8.958 1.00 31.64 A C ATOM 106 CD2 TYR A 56131.554 11.396 −7.014 1.00 37.03 A C ATOM 107 CE2 TYR A 561 31.437 10.421−8.021 1.00 34.86 A C ATOM 108 CZ TYR A 561 32.425 10.306 −8.984 1.0032.03 A C ATOM 109 OH TYR A 561 32.263 9.373 −9.975 1.00 30.08 A O ATOM110 C TYR A 561 30.327 13.593 −5.534 1.00 40.35 A C ATOM 111 O TYR A 56130.097 13.103 −4.422 1.00 40.31 A O ATOM 112 N THR A 562 29.469 13.537−6.542 1.00 40.36 A N ATOM 113 CA THR A 562 28.178 12.889 −6.407 1.0040.36 A C ATOM 114 CB THR A 562 27.117 13.651 −7.265 1.00 40.33 A C ATOM115 OG1 THR A 562 26.669 14.811 −6.539 1.00 40.09 A O ATOM 116 CG2 THR A562 25.929 12.752 −7.619 1.00 40.05 A C ATOM 117 C THR A 562 28.28311.407 −6.806 1.00 40.23 A C ATOM 118 O THR A 562 28.352 11.082 −7.9901.00 39.80 A O ATOM 119 N PHE A 563 28.318 10.527 −5.800 1.00 40.51 A NATOM 120 CA PHE A 563 28.408 9.075 −6.001 1.00 40.62 A C ATOM 121 CB PHEA 563 29.058 8.371 −4.798 1.00 38.90 A C ATOM 122 CG PHE A 563 30.4798.769 −4.553 1.00 39.05 A C ATOM 123 CD1 PHE A 563 30.785 9.778 −3.6431.00 39.01 A C ATOM 124 CD2 PHE A 563 31.514 8.167 −5.268 1.00 38.88 A CATOM 125 CE1 PHE A 563 32.093 10.186 −3.450 1.00 38.37 A C ATOM 126 CE2PHE A 563 32.825 8.567 −5.084 1.00 38.04 A C ATOM 127 CZ PHE A 56333.114 9.583 −4.171 1.00 39.34 A C ATOM 128 C PHE A 563 27.027 8.465−6.193 1.00 42.16 A C ATOM 129 O PHE A 563 26.900 7.333 −6.679 1.0042.38 A O ATOM 130 N ILE A 564 25.998 9.200 −5.776 1.00 43.21 A N ATOM131 CA ILE A 564 24.629 8.721 −5.908 1.00 44.39 A C ATOM 132 CB ILE A564 24.142 7.935 −4.643 1.00 42.82 A C ATOM 133 CG2 ILE A 564 25.0896.799 −4.317 1.00 43.12 A C ATOM 134 CG1 ILE A 564 24.004 8.886 −3.4561.00 40.80 A C ATOM 135 CD1 ILE A 564 23.426 8.240 −2.231 1.00 39.56 A CATOM 136 C ILE A 564 23.637 9.858 −6.112 1.00 46.88 A C ATOM 137 O ILE A564 23.855 11.002 −5.688 1.00 47.99 A O ATOM 138 N ASP A 565 22.5359.520 −6.764 1.00 48.46 A N ATOM 139 CA ASP A 565 21.461 10.463 −6.9881.00 49.02 A C ATOM 140 CB ASP A 565 21.251 10.685 −8.473 1.00 49.70 A CATOM 141 CG ASP A 565 20.153 11.680 −8.739 1.00 52.38 A C ATOM 142 OD1ASP A 565 18.971 11.340 −8.483 1.00 50.74 A O ATOM 143 OD2 ASP A 56520.480 12.813 −9.179 1.00 53.81 A O ATOM 144 C ASP A 565 20.222 9.806−6.380 1.00 49.28 A C ATOM 145 O ASP A 565 19.585 8.981 −7.035 1.0049.57 A O ATOM 146 N PRO A 566 19.864 10.171 −5.123 1.00 49.29 A N ATOM147 CD PRO A 566 20.420 11.388 −4.487 1.00 48.41 A C ATOM 148 CA PRO A566 18.720 9.667 −4.339 1.00 48.67 A C ATOM 149 CB PRO A 566 18.31410.886 −3.519 1.00 47.63 A C ATOM 150 CG PRO A 566 19.671 11.458 −3.1601.00 47.76. A C ATOM 151 C PRO A 566 17.537 9.042 −5.100 1.00 49.01 A CATOM 152 O PRO A 566 16.392 9.477 −4.952 1.00 48.50 A O ATOM 153 N THR A567 17.828 8.011 −5.895 1.00 49.02 A N ATOM 154 CA THR A 567 16.8227.296 −6.680 1.00 48.69 A C ATOM 155 CB THR A 567 17.453 6.646 −7.9551.00 48.16 A C ATOM 156 OG1 THR A 567 17.888 7.670 −8.862 1.00 47.36 A OATOM 157 CG2 THR A 567 16.441 5.745 −8.661 1.00 47.85 A C ATOM 158 C THRA 567 16.228 6.194 −5.805 1.00 48.90 A C ATOM 159 O THR A 567 16.8485.774 −4.820 1.00 48.98 A O ATOM 160 N ASN A 572 16.451 6.958 4.066 1.0058.95 A N ATOM 161 CA ASN A 572 16.475 6.107 5.249 1.00 57.82 A C ATOM162 CB ASN A 572 17.113 6.842 6.433 1.00 58.19 A C ATOM 163 CG ASN A 57218.624 6.753 6.435 1.00 58.70 A C ATOM 164 OD1 ASN A 572 19.189 5.6596.499 1.00 58.34 A O ATOM 165 ND2 ASN A 572 19.291 7.908 6.372 1.0058.40 A N ATOM 166 C ASN A 572 15.095 5.649 5.677 1.00 57.49 A C ATOM167 O ASN A 572 14.157 5.547 4.873 1.00 58.14 A O ATOM 168 N GLU A 57315.023 5.372 6.975 1.00 56.22 A N ATOM 169 CA GLU A 573 13.840 4.9337.693 1.00 55.42 A C ATOM 170 CB GLU A 573 13.577 3.436 7.475 1.00 55.42A C ATOM 171 CG GLU A 573 12.363 2.870 8.251 1.00 57.51 A C ATOM 172 CDGLU A 573 11.243 2.305 7.350 1.00 58.82 A C ATOM 173 QE1 GLU A 57311.519 1.419 6.497 1.00 58.32 A O ATOM 174 OE2 GLU A 573 10.074 2.7427.508 1.00 58.48 A O ATOM 175 C GLU A 573 14.269 5.212 9.132 1.00 55.07A C ATOM 176 O GLU A 573 13.623 4.805 10.101 1.00 55.41 A O ATOM 177 NLYS A 574 15.392 5.915 9.249 1.00 54.11 A N ATOM 178 CA LYS A 574 15.9366.297 10.541 1.00 53.36 A C ATOM 179 CB LYS A 574 17.467 6.325 10.4991.00 53.22 A C ATOM 180 CG LYS A 574 18.053 7.361 9.549 1.00 53.68 A CATOM 181 CD LYS A 574 19.329 7.986 10.125 1.00 54.66 A C ATOM 182 CE LYSA 574 19.886 9.112 9.243 1.00 54.48 A C ATOM 183 NZ LYS A 574 20.74910.058 10.020 1.00 52.12 A N ATOM 184 C LYS A 574 15.413 7.693 10.8651.00 53.43 A C ATOM 185 O LYS A 574 15.749 8.276 11.905 1.00 53.22 A OATOM 186 N TRP A 575 14.595 8.225 9.957 1.00 52.72 A N ATOM 187 CA TRP A575 14.011 9.557 10.124 1.00 52.04 A C ATOM 188 CB TRP A 575 13.96910.293 8.774 1.00 50.58 A C ATOM 189 CG TRP A 575 15.311 10.802 8.3331.00 48.44 A C ATOM 190 CD2 TRP A 575 16.035 11.912 8.890 1.00 48.04 A CATOM 191 CE2 TRP A 575 17.270 11.990 8.208 1.00 47.26 A C ATOM 192 CE3TRP A 575 15.759 12.847 9.902 1.00 47.70 A C ATOM 193 CD1 TRP A 57516.111 10.273 7.364 1.00 48.56 A C ATOM 194 NE1 TRP A 575 17.289 10.9797.283 1.00 48.02 A N ATOM 195 CZ2 TRP A 575 18.233 12.965 8.504 1.0046.38 A C ATOM 196 CZ3 TRP A 575 16.720 13.819 10.196 1.00 47.71 A CATOM 197 CH2 TRP A 575 17.943 13.866 9.497 1.00 46.13 A C ATOM 198 C TRPA 575 12.603 9.452 10.697 1.00 51.94 A C ATOM 199 O TRP A 575 12.03510.430 11.207 1.00 50.44 A O ATOM 200 N GLU A 576 12.067 8.237 10.6141.00 52.48 A N ATOM 201 CA GLU A 576 10.728 7.927 11.082 1.00 52.63 A CATOM 202 CB GLU A 576 10.487 6.432 11.026 1.00 50.30 A C ATOM 203 CG GLUA 576 9.047 6.087 10.804 1.00 47.68 A C ATOM 204 CD GLU A 576 8.5596.501 9.438 1.00 46.73 A C ATOM 205 OE1 GLU A 576 9.402 6.664 8.513 1.0045.59 A O ATOM 206 OE2 GLU A 576 7.323 6.643 9.293 1.00 46.12 A O ATOM207 C GLU A 576 10.457 8.410 12.492 1.00 54.23 A C ATOM 208 O GLU A 57611.362 8.499 13.330 1.00 53.34 A O ATOM 209 N PHE A 577 9.188 8.70412.740 1.00 55.65 A N ATOM 210 CA PHE A 577 8.745 9.199 14.030 1.0057.24 A C ATOM 211 CB PHE A 577 8.933 10.720 14.075 1.00 57.19 A C ATOM212 CG PHE A 577 8.445 11.364 15.338 1.00 57.52 A C ATOM 213 CD1 PHE A577 9.063 11.103 16.552 1.00 58.05 A C ATOM 214 CD2 PHE A 577 7.36312.240 15.310 1.00 57.93 A C ATOM 215 CE1 PHE A 577 8.607 11.709 17.7251.00 59.37 A C ATOM 216 CE2 PHE A 577 6.899 12.852 16.474 1.00 57.78 A CATOM 217 CZ PHE A 577 7.521 12.586 17.683 1.00 58.40 A C ATOM 218 C PHEA 577 7.270 8.821 14.183 1.00 58.45 A C ATOM 219 O PHE A 577 6.499 8.89713.216 1.00 58.06 A O ATOM 220 N PRO A 578 6.870 8.378 15.393 1.00 59.30A N ATOM 221 CD PRO A 578 7.732 8.207 16.579 1.00 59.32 A C ATOM 222 CAPRO A 578 5.485 7.981 15.691 1.00 59.55 A C ATOM 223 CB PRO A 578 5.5457.629 17.176 1.00 60.03 A C ATOM 224 CG PRO A 578 6.985 7.172 17.3671.00 59.74 A C ATOM 225 C PRO A 578 4.585 9.180 15.420 1.00 60.11 A CATOM 226 O PRO A 578 4.831 10.259 15.945 1.00 60.70 A O ATOM 227 N ARG A579 3.543 9.009 14.620 1.00 60.91 A N ATOM 228 CA ARG A 579 2.697 10.14814.296 1.00 62.33 A C ATOM 229 CB ARG A 579 1.984 9.909 12.973 1.0061.81 A C ATOM 230 CG ARG A 579 0.759 9.052 13.055 1.00 62.38 A C ATOM231 CD ARG A 579 0.142 8.998 11.686 1.00 62.86 A C ATOM 232 NE ARG A 5791.062 8.365 10.749 1.00 64.66 A N ATOM 233 CZ ARG A 579 1.077 8.5919.440 1.00 65.17 A C ATOM 234 NH1 ARG A 579 0.226 9.450 8.897 1.00 64.30A N ATOM 235 NH2 ARG A 579 1.925 7.930 8.665 1.00 65.79 A N ATOM 236 CARG A 579 1.683 10.550 15.355 1.00 63.97 A C ATOM 237 O ARG A 579 0.85911.438 15.126 1.00 64.19 A O ATOM 238 N ASN A 580 1.742 9.906 16.5151.00 65.85 A N ATOM 239 CA ASN A 580 0.823 10.233 17.596 1.00 67.58 A CATOM 240 CB ASN A 580 0.098 8.979 18.079 1.00 66.76 A C ATOM 241 CG ASNA 580 1.053 7.880 18.463 1.00 67.04 A C ATOM 242 OD1 ASN A 580 1.9648.093 19.266 1.00 66.33 A O ATOM 243 ND2 ASN A 580 0.857 6.691 17.8901.00 67.17 A N ATOM 244 C ASN A 580 1.564 10.897 18.759 1.00 69.12 A CATOM 245 O ASN A 580 1.013 11.033 19.856 1.00 70.57 A O ATOM 246 N ASN A581 2.819 11.287 18.517 1.00 69.76 A N ATOM 247 CA ASN A 581 3.64511.993 19.512 1.00 70.25 A C ATOM 248 CB ASN A 581 4.951 11.252 19.8011.00 71.22 A C ATOM 249 CG ASN A 581 4.721 9.853 20.290 1.00 73.11 A CATOM 250 OD1 ASN A 581 4.214 9.004 19.550 1.00 73.82 A O ATOM 251 ND2ASN A 581 5.083 9.595 21.546 1.00 73.82 A N ATOM 252 C ASN A 581 3.98413.328 18.868 1.00 69.49 A C ATOM 253 O ASN A 581 5.005 13.952 19.1761.00 69.49 A O ATOM 254 N LEU A 582 3.098 13.742 17.969 1.00 67.91 A NATOM 255 CA LEU A 582 3.243 14.962 17.204 1.00 66.65 A C ATOM 256 CB LEUA 582 3.602 14.564 15.770 1.00 66.90 A C ATOM 257 CG LEU A 582 4.36315.480 14.821 1.00 66.79 A C ATOM 258 CD1 LEU A 582 5.697 15.862 15.4411.00 67.13 A C ATOM 259 CD2 LEU A 582 4.573 14.743 13.496 1.00 66.19 A CATOM 260 C LEU A 582 1.896 15.687 17.240 1.00 65.55 A C ATOM 261 O LEU A582 0.967 15.301 16.527 1.00 65.82 A O ATOM 262 N GLN A 583 1.773 16.72518.062 1.00 64.23 A N ATOM 263 CA GLN A 583 0.500 17.435 18.134 1.0063.98 A C ATOM 264 CB GLN A 583 0.148 17.793 19.584 1.00 65.93 A C ATOM265 CG GLN A 583 −1.172 18.574 19.695 1.00 68.34 A C ATOM 266 CD GLN A583 −1.557 18.936 21.127 1.00 70.63 A C ATOM 267 OE1 GLN A 583 −2.47719.735 21.352 1.00 71.24 A O ATOM 268 NE2 GLN A 583 −0.861 18.345 22.1021.00 72.41 A N ATOM 269 C GLN A 583 0.445 18.693 17.274 1.00 62.44 A CATOM 270 O GLN A 583 1.289 19.582 17.401 1.00 61.40 A O ATOM 271 N PHE A584 −0.573 18.753 16.414 1.00 60.79 A N ATOM 272 CA PHE A 584 −0.78419.877 15.508 1.00 59.46 A C ATOM 273 CB PHE A 584 −2.076 19.696 14.7021.00 59.96 A C ATOM 274 CG PHE A 584 −1.999 18.639 13.620 1.00 61.31 A CATOM 275 CD1 PHE A 584 −1.425 17.389 13.872 1.00 61.49 A C ATOM 276 CD2PHE A 584 −2.594 18.864 12.373 1.00 60.40 A C ATOM 277 CE1 PHE A 584−1.451 16.377 12.898 1.00 61.69 A C ATOM 278 CE2 PHE A 584 −2.628 17.86311.397 1.00 60.75 A C ATOM 279 CZ PHE A 584 −2.057 16.615 11.657 1.0060.92 A C ATOM 280 C PHE A 584 −0.869 21.223 16.214 1.00 58.55 A C ATOM281 O PHE A 584 −1.059 21.310 17.428 1.00 58.42 A O ATOM 282 N GLY A 585−0.724 22.270 15.410 1.00 57.90 A N ATOM 283 CA GLY A 585 −0.806 23.64515.868 1.00 55.24 A C ATOM 284 C GLY A 585 −1.573 24.289 14.732 1.0054.21 A C ATOM 285 O GLY A 585 −2.255 23.575 13.984 1.00 53.50 A O ATOM286 N LYS A 586 −1.477 25.602 14.564 1.00 52.61 A N ATOM 287 CA LYS A586 −2.206 26.217 13.462 1.00 52.03 A C ATOM 288 CB LYS A 586 −2.34427.731 13.675 1.00 52.50 A C ATOM 289 CG LYS A 586 −1.043 28.494 13.6991.00 53.47 A C ATOM 290 CD LYS A 586 −1.283 29.919 14.146 1.00 54.15 A CATOM 291 CE LYS A 586 0.020 30.699 14.236 1.00 56.06 A C ATOM 292 NZ LYSA 586 1.019 30.064 15.148 1.00 56.51 A N ATOM 293 C LYS A 586 −1.52325.928 12.123 1.00 50.75 A C ATOM 294 O LYS A 586 −0.380 25.454 12.0881.00 51.32 A O ATOM 295 N THR A 587 −2.245 26.192 11.032 1.00 49.11 A NATOM 296 CA THR A 587 −1.743 26.004 9.664 1.00 46.40 A C ATOM 297 CB THRA 587 −2.912 25.829 8.668 1.00 44.62 A C ATOM 298 OG1 THR A 587 −3.25124.438 8.559 1.00 43.84 A O ATOM 299 CG2 THR A 587 −2.543 26.379 7.2951.00 44.21 A C ATOM 300 C THR A 587 −0.937 27.249 9.267 1.00 45.63 A CATOM 301 O THR A 587 −1.513 28.311 9.027 1.00 46.78 A O ATOM 302 N LEU A588 0.385 27.117 9.199 1.00 43.21 A N ATOM 303 CA LEU A 588 1.254 28.2448.862 1.00 40.58 A C ATOM 304 CB LEU A 588 2.717 27.839 9.047 1.00 39.80A C ATOM 305 CG LEU A 588 3.055 27.211 10.397 1.00 38.97 A C ATOM 306CD1 LEU A 588 4.500 26.733 10.408 1.00 38.34 A C ATOM 307 CD2 LEU A 5882.821 28.239 11.486 1.00 39.66 A C ATOM 308 C LEU A 588 1.047 28.7447.434 1.00 38.98 A C ATOM 309 O LEU A 588 1.135 29.944 7.157 1.00 39.08A O ATOM 310 N GLY A 589 0.776 27.824 6.522 1.00 36.15 A N ATOM 311 CAGLY A 589 0.582 28.224 5.148 1.00 32.79 A C ATOM 312 C GLY A 589 0.14827.029 4.337 1.00 31.77 A C ATOM 313 O GLY A 589 0.288 25.876 4.781 1.0031.23 A O ATOM 314 N ALA A 590 −0.385 27.298 3.149 1.00 29.67 A N ATOM315 CA ALA A 590 0.842 26.236 2.284 1.00 29.14 A C ATOM 316 CB ALA A 590−2.239 25.825 2.664 1.00 28.16 A C ATOM 317 C ALA A 590 −0.815 26.7050.850 1.00 30.86 A C ATOM 318 O ALA A 590 −0.976 27.899 0.569 1.00 30.01A O ATOM 319 N GLY A 591 −0.599 25.752 −0.055 1.00 32.99 A N ATOM 320 CAGLY A 591 −0.563 26.045 −1.474 1.00 33.79 A C ATOM 321 C GLY A 591−1.517 25.121 −2.205 1.00 34.76 A C ATOM 322 O GLY A 591 −2.200 24.295−1.589 1.00 35.27 A O ATOM 323 N ALA A 592 1.549 25.247 −3.525 1.0035.51 A N ATOM 324 CA ALA A 592 −2.423 24.442 −4.349 1.00 36.91 A C ATOM325 CB ALA A 592 −2.563 25.108 −5.701 1.00 39.07 A C ATOM 326 C ALA A592 −1.946 22.993 −4.517 1.00 38.33 A C ATOM 327 O ALA A 592 −2.13822.385 −5.581 1.00 38.44 A O ATOM 328 N PHE A 593 −1.339 22.435 −3.4731.00 39.11 A N ATOM 329 CA PHE A 593 −0.829 21.066 −3.529 1.00 40.25 A CATOM 330 CB PHE A 593 0.586 21.056 −4.110 1.00 42.24 A C ATOM 331 CG PHEA 593 0.638 20.813 −5.590 1.00 45.96 A C ATOM 332 CD1 PHE A 593 1.79521.106 −6.311 1.00 46.96 A C ATOM 333 CD2 PHE A 593 −0.459 20.270 −6.2661.00 47.22 A C ATOM 334 CE1 PHE A 593 1.870 20.862 −7.690 1.00 48.43 A CATOM 335 CE2 PHE A 593 −0.400 20.021 −7.644 1.00 48.72 A C ATOM 336 CZPHE A 593 0.771 20.319 −8.360 1.00 49.10 A C ATOM 337 C PHE A 593 −0.79220.426 −2.155 1.00 40.13 A C ATOM 338 O PHE A 593 −0.903 19.200 −2.0211.00 39.70 A O ATOM 339 N GLY A 594 −0.621 21.269 −1.142 1.00 39.49 A NATOM 340 CA GLY A 594 −0.548 20.789 0.222 1.00 39.74 A C ATOM 341 C GLYA 594 −0.464 21.955 1.192 1.00 40.32 A C ATOM 342 O GLY A 594 −0.50823.125 0.791 1.00 40.45 A O ATOM 343 N LYS A 595 −0.347 21.642 2.4761.00 39.54 A N ATOM 344 CA LYS A 595 −0.278 22.675 3.490 1.00 40.16 A CATOM 345 CB LYS A 595 −1.602 22.776 4.242 1.00 41.91 A C ATOM 346 CG LYSA 595 −1.976 21.529 5.037 1.00 43.05 A C ATOM 347 CD LYS A 595 −3.27621.800 5.821 1.00 45.55 A C ATOM 348 CE LYS A 595 −3.783 20.584 6.6001.00 43.58 A C ATOM 349 NZ LYS A 595 −4.944 20.960 7.462 1.00 42.35 A NATOM 350 C LYS A 595 0.807 22.309 4.461 1.00 40.18 A C ATOM 351 O LYS A595 1.177 21.145 4.586 1.00 40.62 A O ATOM 352 N VAL A 596 1.321 23.3055.158 1.00 39.05 A N ATOM 353 CA VAL A 596 2.367 23.054 6.117 1.00 39.09A C ATOM 354 CB VAL A 596 3.705 23.672 5.612 1.00 38.09 A C ATOM 355 CG1VAL A 596 3.446 25.032 5.008 1.00 39.37 A C ATOM 356 CG2 VAL A 596 4.71523.770 6.740 1.00 37.48 A C ATOM 357 C VAL A 596 1.886 23.662 7.433 1.0039.87 A C ATOM 358 O VAL A 596 1.573 24.858 7.501 1.00 39.54 A O ATOM359 N VAL A 597 1.791 22.837 8.474 1.00 39.98 A N ATOM 360 CA VAL A 5971.314 23.344 9.757 1.00 41.26 A C ATOM 361 CB VAL A 597 −0.004 22.68110.162 1.00 40.40 A C ATOM 362 CG1 VAL A 597 −1.027 22.886 9.074 1.0041.23 A C ATOM 363 CG2 VAL A 597 0.217 21.196 10.430 1.00 40.26 A C ATOM364 C VAL A 597 2.266 23.207 10.933 1.00 41.81 A C ATOM 365 O VAL A 5973.124 22.315 10.984 1.00 41.25 A O ATOM 366 N GLU A 598 2.100 24.10811.889 1.00 42.35 A N ATOM 367 CA GLU A 598 2.927 24.077 13.076 1.0043.71 A C ATOM 368 CB GLU A 598 2.648 25.305 13.948 1.00 45.75 A C ATOM369 CG GLU A 598 3.489 25.375 15.204 1.00 49.66 A C ATOM 370 CD GLU A598 3.257 26.654 15.986 1.00 52.68 A C ATOM 371 OE1 GLU A 598 2.10226.908 16.403 1.00 54.25 A O ATOM 372 OE2 GLU A 598 4.235 27.408 16.1791.00 54.95 A O ATOM 373 C GLU A 598 2.512 22.811 13.790 1.00 42.85 A CATOM 374 O GLU A 598 1.522 22.184 13.407 1.00 42.66 A O ATOM 375 N ALA A599 3.267 22.429 14.812 1.00 42.36 A N ATOM 376 CA ALA A 599 2.95421.235 15.577 1.00 42.59 A C ATOM 377 CB ALA A 599 2.879 20.029 14.6551.00 42.42 A C ATOM 378 C ALA A 599 4.013 21.028 16.638 1.00 43.17 A CATOM 379 O ALA A 599 5.175 21.363 16.429 1.00 42.92 A O ATOM 380 N THR A600 3.604 20.484 17.783 1.00 45.74 A N ATOM 381 CA THR A 600 4.52720.239 18.896 1.00 46.98 A C ATOM 382 CB THR A 600 3.827 20.428 20.2551.00 46.38 A C ATOM 383 OG1 THR A 600 2.967 21.569 20.187 1.00 46.88 A OATOM 384 CG2 THR A 600 4.852 20.650 21.359 1.00 45.90 A C ATOM 385 C THRA 600 5.044 18.814 18.816 1.00 47.64 A C ATOM 386 O THR A 600 4.26917.878 18.625 1.00 48.05 A O ATOM 387 N ALA A 601 6.355 18.657 18.9561.00 48.89 A N ATOM 388 CA ALA A 601 6.972 17.340 18.886 1.00 50.15 A CATOM 389 CB ALA A 601 8.255 17.402 18.096 1.00 51.30 A C ATOM 390 C ALAA 601 7.267 16.865 20.275 1.00 51.62 A C ATOM 391 O ALA A 601 7.70917.643 21.118 1.00 52.75 A O ATOM 392 N PHE A 602 7.032 15.581 20.5121.00 53.24 A N ATOM 393 CA PHE A 602 7.273 15.008 21.828 1.00 53.71 A CATOM 394 CB PHE A 602 6.000 14.316 22.358 1.00 53.99 A C ATOM 395 CG PHEA 602 4.799 15.235 22.453 1.00 54.08 A C ATOM 396 CD1 PHE A 602 3.64714.981 21.698 1.00 54.14 A C ATOM 397 CD2 PHE A 602 4.832 16.370 23.2631.00 53.77 A C ATOM 398 CE1 PHE A 602 2.538 15.847 21.738 1.00 54.26 A CATOM 399 CE2 PHE A 602 3.736 17.241 23.313 1.00 55.38 A C ATOM 400 CZPHE A 602 2.579 16.976 22.542 1.00 54.52 A C ATOM 401 C PHE A 602 8.44014.030 21.773 1.00 53.26 A C ATOM 402 O PHE A 602 8.308 12.894 21.3141.00 52.77 A O ATOM 403 N GLY A 603 9.592 14.494 22.236 1.00 53.76 A NATOM 404 CA GLY A 603 10.761 13.645 22.242 1.00 55.58 A C ATOM 405 C GLYA 603 11.318 13.418 20.855 1.00 57.09 A C ATOM 406 O GLY A 603 11.13712.347 20.263 1.00 57.32 A C ATOM 407 N LEU A 604 11.988 14.436 20.3291.00 57.92 A N ATOM 408 CA LEU A 604 12.584 14.334 19.012 1.00 59.02 A CATOM 409 CB LEU A 604 12.107 15.474 18.105 1.00 58.01 A C ATOM 410 CGLEU A 604 11.282 15.020 16.888 1.00 57.50 A C ATOM 411 CD1 LEU A 60410.666 16.223 16.194 1.00 56.71 A C ATOM 412 CD2 LEU A 604 12.164 14.24215.918 1.00 56.60 A C ATOM 413 C LEU A 604 14.092 14.367 19.171 1.0060.28 A C ATOM 414 O LEU A 604 14.651 15.298 19.764 1.00 59.64 A O ATOM415 N GLY A 605 14.739 13.321 18.659 1.00 61.92 A N ATOM 416 CA GLY A605 16.184 13.217 18.742 1.00 63.58 A C ATOM 417 C GLY A 605 16.66712.315 19.863 1.00 64.29 A C ATOM 418 O GLY A 605 15.884 11.746 20.6281.00 63.59 A O ATOM 419 N LYS A 606 17.983 12.190 19.956 1.00 65.90 A NATOM 420 CA LYS A 606 18.606 11.363 20.976 1.00 67.72 A C ATOM 421 CBLYS A 606 20.119 11.279 20.694 1.00 67.82 A C ATOM 422 CG LYS A 60620.848 10.088 21.315 1.00 66.78 A C ATOM 423 CD LYS A 606 21.378 10.39422.708 1.00 66.18 A C ATOM 424 CE LYS A 606 22.560 11.349 22.663 1.0065.29 A C ATOM 425 NZ LYS A 606 23.132 11.567 24.023 1.00 63.98 A N ATOM426 C LYS A 606 18.342 11.996 22.345 1.00 68.60 A C ATOM 427 O LYS A 60618.651 11.412 23.383 1.00 68.46 A O ATOM 428 N GLU A 607 17.738 13.18122.341 1.00 69.61 A N ATOM 429 CA GLU A 607 17.482 13.892 23.585 1.0071.49 A C ATOM 430 CB GLU A 607 18.165 15.265 23.539 1.00 73.40 A C ATOM431 CG GLU A 607 19.685 15.208 23.440 1.00 75.48 A C ATOM 432 CD GLU A607 20.297 14.230 24.432 1.00 77.59 A C ATOM 433 OE1 GLU A 607 19.82314.169 25.593 1.00 78.50 A O ATOM 434 OE2 GLU A 607 21.260 13.527 24.0501.00 78.23 A O ATOM 435 C GLU A 607 16.026 14.075 24.028 1.00 71.67 A CATOM 436 O GLU A 607 15.752 14.862 24.940 1.00 71.66 A O ATOM 437 N ASPA 608 15.096 13.367 23.398 1.00 71.22 A N ATOM 438 CA ASP A 608 13.68313.468 23.778 1.00 70.84 A C ATOM 439 CB ASP A 608 13.469 12.893 25.1801.00 71.01 A C ATOM 440 CG ASP A 608 14.065 11.509 25.341 1.00 72.07 A CATOM 441 OD1 ASP A 608 13.887 10.920 26.429 1.00 72.52 A O ATOM 442 OD2ASP A 608 14.715 11.017 24.387 1.00 72.73 A O ATOM 443 C ASP A 60813.118 14.888 23.755 1.00 70.11 A C ATOM 444 O ASP A 608 12.034 15.13224.294 1.00 69.90 A O ATOM 445 N ALA A 609 13.847 15.815 23.138 1.0069.11 A N ATOM 446 CA ALA A 609 13.411 17.206 23.054 1.00 67.51 A C ATOM447 CB ALA A 609 14.217 17.943 21.991 1.00 66.81 A C ATOM 448 C ALA A609 11.922 17.291 22.733 1.00 66.71 A C ATOM 449 O ALA A 609 11.38416.464 21.998 1.00 66.61 A O ATOM 450 N VAL A 610 11.259 18.290 23.3011.00 65.54 A N ATOM 451 CA VAL A 610 9.839 18.490 23.063 1.00 64.41 A CATOM 452 CB VAL A 610 9.028 18.321 24.369 1.00 64.82 A C ATOM 453 CG1VAL A 610 7.540 18.440 24.083 1.00 65.29 A C ATOM 454 CG2 VAL A 6109.336 16.971 24.995 1.00 65.20 A C ATOM 455 C VAL A 610 9.646 19.90322.522 1.00 63.24 A C ATOM 456 O VAL A 610 9.097 20.776 23.205 1.0063.99 A O ATOM 457 N LEU A 611 10.104 20.127 21.292 1.00 60.87 A N ATOM458 CA LEU A 611 9.992 21.447 20.680 1.00 58.34 A C ATOM 459 CB LEU A611 11.371 21.925 20.194 1.00 58.56 A C ATOM 460 CG LEU A 611 12.33720.912 19.567 1.00 58.25 A C ATOM 461 CD1 LEU A 611 11.676 20.162 18.4031.00 57.90 A C ATOM 462 CD2 LEU A 611 13.578 21.661 19.106 1.00 57.40 AC ATOM 463 C LEU A 611 8.973 21.587 19.552 1.00 55.71 A C ATOM 464 O LEUA 611 8.323 20.619 19.139 1.00 54.40 A O ATOM 465 N LYS A 612 8.84122.824 19.078 1.00 53.29 A N ATOM 466 CA LYS A 612 7.918 23.172 18.0041.00 51.02 A C ATOM 467 CB LYS A 612 7.635 24.681 18.005 1.00 51.20 A CATOM 468 CG LYS A 612 6.199 25.086 18.351 1.00 51.42 A C ATOM 469 CD LYSA 612 6.067 26.608 18.289 1.00 52.85 A C ATOM 470 CE LYS A 612 4.75127.130 18.878 1.00 52.48 A C ATOM 471 NZ LYS A 612 4.673 28.625 18.7651.00 49.96 A N ATOM 472 C LYS A 612 8.530 22.788 16.676 1.00 48.82 A CATOM 473 O LYS A 612 9.726 22.982 16.448 1.00 48.95 A O ATOM 474 N VAL A613 7.706 22.239 15.799 1.00 46.61 A N ATOM 475 CA VAL A 613 8.17921.838 14.493 1.00 45.17 A C ATOM 476 CB VAL A 613 8.383 20.305 14.3951.00 44.41 A C ATOM 477 CG1 VAL A 613 9.247 19.838 15.546 1.00 43.71 A CATOM 478 CG2 VAL A 613 7.040 19.577 14.379 1.00 42.13 A C ATOM 479 C VALA 613 7.156 22.253 13.471 1.00 44.74 A C ATOM 480 O VAL A 613 6.03922.644 13.818 1.00 44.06 A O ATOM 481 N ALA A 614 7.552 22.169 12.2051.00 44.55 A N ATOM 482 CA ALA A 614 6.673 22.515 11.092 1.00 42.54 A CATOM 483 CB ALA A 614 7.304 23.596 10.224 1.00 42.26 A C ATOM 484 C ALAA 614 6.499 21.238 10.301 1.00 40.83 A C ATOM 485 O ALA A 614 7.47020.627 9.852 1.00 40.31 A O ATOM 486 N VAL A 615 5.254 20.826 10.1441.00 39.66 A N ATOM 487 CA VAL A 615 4.978 19.609 9.430 1.00 38.18 A CATOM 488 CB VAL A 615 3.877 18.811 10.146 1.00 37.39 A C ATOM 489 CG1VAL A 615 3.451 17.617 9.311 1.00 36.78 A C ATOM 490 CG2 VAL A 615 4.39418.345 11.506 1.00 37.52 A C ATOM 491 C VAL A 615 4.562 19.887 8.0081.00 39.09 A C ATOM 492 O VAL A 615 3.507 20.485 7.770 1.00 40.21 A OATOM 493 N LYS A 616 5.416 19.487 7.067 1.00 39.16 A N ATOM 494 CA LYS A616 5.126 19.633 5.649 1.00 38.90 A C ATOM 495 CB LYS A 616 6.370 19.3594.792 1.00 38.33 A C ATOM 496 CG LYS A 616 7.209 20.560 4.349 1.00 37.04A C ATOM 497 CD LYS A 616 8.050 20.163 3.120 1.00 37.18 A C ATOM 498 CELYS A 616 8.839 21.329 2.484 1.00 37.18 A C ATOM 499 NZ LYS A 616 10.17921.640 3.122 1.00 35.27 A N ATOM 500 C LYS A 616 4.168 18.475 5.460 1.0040.85 A C ATOM 501 O LYS A 616 4.290 17.473 6.175 1.00 40.89 A O ATOM502 N MET A 617 3.226 18.605 4.525 1.00 43.10 A N ATOM 503 CA MET A 6172.257 17.540 4.217 1.00 45.85 A C ATOM 504 CB MET A 617 1.320 17.2575.400 1.00 46.75 A C ATOM 505 CG MET A 617 0.179 18.263 5.530 1.00 47.63A C ATOM 506 SD MET A 617 −1.019 17.872 6.812 1.00 47.39 A S ATOM 507 CEMET A 617 −0.012 18.106 8.348 1.00 43.61 A C ATOM 508 C MET A 617 1.39417.908 3.010 1.00 47.58 A C ATOM 509 O MET A 617 1.268 19.082 2.643 1.0046.47 A O ATOM 510 N LEU A 618 0.785 16.896 2.403 1.00 50.18 A N ATOM511 CA LEU A 618 −0.064 17.123 1.245 1.00 53.27 A C ATOM 512 CB LEU A618 0.184 16.051 0.187 1.00 51.71 A C ATOM 513 CG LEU A 618 1.578 16.100−0.420 1.00 51.87 A C ATOM 514 CD1 LEU A 618 1.844 14.812 −1.170 1.0052.80 A C ATOM 515 CD2 LEU A 618 1.694 17.320 −1.333 1.00 52.23 A C ATOM516 C LEU A 618 −1.513 17.074 1.662 1.00 55.48 A C ATOM 517 O LEU A 618−1.828 16.962 2.849 1.00 55.89 A O ATOM 518 N LYS A 619 −2.390 17.1650.670 1.00 58.32 A N ATOM 519 CA LYS A 619 −3.821 17.094 0.901 1.0060.54 A C ATOM 520 CB LYS A 619 −4.541 18.172 0.082 1.00 61.02 A C ATOM521 CG LYS A 619 −4.258 19.599 0.552 1.00 61.12 A C ATOM 522 CD LYS A619 −5.156 20.624 −0.146 1.00 61.54 A C ATOM 523 CE LYS A 619 −4.93522.033 0.423 1.00 61.49 A C ATOM 524 NZ LYS A 619 −5.770 23.074 −0.2371.00 59.44 A N ATOM 525 C LYS A 619 −4.283 15.698 0.482 1.00 62.04 A CATOM 526 O LYS A 619 3.468 14.850 0.096 1.00 63.25 A O ATOM 527 N SER A620 −5.584 15.453 0.570 1.00 63.14 A N ATOM 528 CA SER A 620 −6.14514.163 0.187 1.00 63.83 A C ATOM 529 CB SER A 620 −7.474 13.977 0.9021.00 64.74 A C ATOM 530 OG SER A 620 −8.218 15.185 0.852 1.00 66.31 A OATOM 531 C SER A 620 −6.342 14.140 −1.327 1.00 64.02 A C ATOM 532 O SERA 620 −6.326 13.087 −1.962 1.00 62.56 A O ATOM 533 N THR A 621 −6.51715.329 −1.890 1.00 65.98 A N ATOM 534 CA THR A 621 −6.709 15.512 −3.3231.00 68.26 A C ATOM 535 CB THR A 621 −6.813 17.019 −3.674 1.00 69.69 A CATOM 536 OG1 THR A 621 −7.756 17.653 −2.797 1.00 70.32 A O ATOM 537 CG2THR A 621 −7.263 17.209 −5.129 1.00 70.36 A C ATOM 538 C THR A 621−5.532 14.930 −4.102 1.00 68.61 A C ATOM 539 O THR A 621 −5.666 14.567−5.271 1.00 68.73 A O ATOM 540 N ALA A 622 −4.381 14.854 −3.442 1.0069.45 A N ATOM 541 CA ALA A 622 −3.151 14.339 −4.046 1.00 70.40 A C ATOM542 CB ALA A 622 −2.124 14.066 −2.951 1.00 69.26 A C ATOM 543 C ALA A622 −3.324 13.085 −4.907 1.00 71.40 A C ATOM 544 O ALA A 622 −4.40012.475 −4.953 1.00 71.17 A O ATOM 545 N HIS A 623 −2.249 12.718 −5.6011.00 72.42 A N ATOM 546 CA HIS A 623 −2.236 11.523 −6.437 1.00 74.07 A CATOM 547 CB HIS A 623 −3.010 11.731 −7.745 1.00 75.62 A C ATOM 548 CGHIS A 623 −3.356 10.447 −8.439 1.00 76.73 A C ATOM 549 CD2 HIS A 623−4.522 9.998 −8.959 1.00 77.03 A C ATOM 550 ND1 HIS A 623 −2.438 9.435−8.637 1.00 76.39 A N ATOM 551 CE1 HIS A 623 −3.023 8.421 −9.247 1.0076.34 A C ATOM 552 NE2 HIS A 623 −4.290 8.737 −9.454 1.00 76.89 A N ATOM553 C HIS A 623 −0.814 11.084 −6.773 1.00 73.74 A C ATOM 554 O HIS A 6230.077 11.916 −6.931 1.00 73.75 A O ATOM 555 N ALA A 624 −0.630 9.767−6.877 1.00 73.46 A N ATOM 556 CA ALA A 624 0.651 9.135 −7.193 1.0072.27 A C ATOM 557 CB ALA A 624 0.507 8.314 −8.466 1.00 73.40 A C ATOM558 C ALA A 624 1.827 10.101 −7.328 1.00 71.40 A C ATOM 559 O ALA A 6242.760 10.080 −6.522 1.00 70.85 A O ATOM 560 N ASP A 625 1.776 10.942−8.355 1.00 70.30 A N ATOM 561 CA ASP A 625 2.828 11.917 −8.602 1.0069.00 A C ATOM 562 CB ASP A 625 2.448 12.787 −9.793 1.00 68.86 A C ATOM563 CG ASP A 625 2.087 11.965 −11.013 1.00 69.75 A C ATOM 564 OD1 ASP A625 1.948 12.556 −12.106 1.00 70.10 A 0 ATOM 565 OD2 ASP A 625 1.93710.725 −10.878 1.00 69.40 A O ATOM 566 C ASP A 625 3.089 12.784 −7.3741.00 68.17 A C ATOM 567 O ASP A 625 4.127 12.635 −6.726 1.00 68.35 A OATOM 568 N GLU A 626 2.150 13.677 −7.050 1.00 67.26 A N ATOM 569 CA GLUA 626 2.295 14.563 −5.888 1.00 65.82 A C ATOM 570 CB GLU A 626 0.93915.134 −5.420 1.00 66.32 A C ATOM 571 CG GLU A 626 −0.287 14.763 −6.2481.00 67.25 A C ATOM 572 CD GLU A 626 −0.413 15.574 −7.521 1.00 67.65 A CATOM 573 OE1 GLU A 626 0.512 16.818 −7.416 1.00 66.55 A O ATOM 574 OE2GLU A 626 −0.420 14.966 −8.620 1.00 68.59 A O ATOM 575 C GLU A 626 2.92413.810 −4.718 1.00 64.43 A C ATOM 576 O GLU A 626 3.774 14.347 −4.0061.00 64.33 A O ATOM 577 N LYS A 627 2.498 12.566 −4.524 1.00 62.26 A NATOM 578 CA LYS A 627 3.024 11.752 −3.444 1.00 60.61 A C ATOM 579 CB LYSA 627 2.289 10.413 −3.390 1.00 60.13 A C ATOM 580 CG LYS A 627 0.95310.444 −2.675 1.00 59.46 A C ATOM 581 CD LYS A 627 0.360 9.041 −2.5851.00 59.44 A C ATOM 582 CE LYS A 627 −0.703 8.943 −1.497 1.00 59.95 A CATOM 583 NZ LYS A 627 −1.834 9.910 −1.687 1.00 60.51 A N ATOM 584 C LYSA 627 4.527 11.500 −3.565 1.00 59.80 A C ATOM 585 O LYS A 627 5.28911.827 −2.654 1.00 60.28 A O ATOM 586 N GLU A 628 4.954 10.929 −4.6901.00 58.99 A N ATOM 587 CA GLU A 628 6.366 10.606 −4.894 1.00 58.12 A CATOM 588 CB GLU A 628 6.583 9.944 −6.251 1.00 60.18 A C ATOM 589 CG GLUA 628 7.448 8.689 −6.174 1.00 62.35 A C ATOM 590 CD GLU A 628 8.3208.515 −7.403 1.00 64.37 A C ATOM 591 OE1 GLU A 628 9.312 9.274 −7.5391.00 64.18 A O ATOM 592 OE2 GLU A 628 8.006 7.628 −8.233 1.00 65.02 A OATOM 593 C GLU A 628 7.305 11.795 −4.775 1.00 56.52 A C ATOM 594 O GLU A628 8.358 11.700 −4.133 1.00 56.18 A O ATOM 595 N ALA A 629 6.933 12.905−5.408 1.00 54.19 A N ATOM 596 CA ALA A 629 7.746 14.116 −5.354 1.0051.42 A C ATOM 597 CB ALA A 629 6.956 15.297 −5.889 1.00 50.46 A C ATOM598 C ALA A 629 8.169 14.370 −3.909 1.00 50.27 A C ATOM 599 O ALA A 6299.361 14.432 −3.607 1.00 50.38 A O ATOM 600 N LEU A 630 7.189 14.492−3.016 1.00 48.76 A N ATOM 601 CA LEU A 630 7.461 14.722 −1.596 1.0047.63 A C ATOM 602 CB LEU A 630 6.162 14.567 −0.795 1.00 47.73 A C ATOM603 CG LEU A 630 6.152 14.933 0.695 1.00 47.87 A C ATOM 604 CD1 LEU A630 6.488 16.413 0.908 1.00 47.17 A C ATOM 605 CD2 LEU A 630 4.77214.622 1.247 1.00 48.26 A C ATOM 606 C LEU A 630 8.542 13.758 −1.0601.00 46.70 A C ATOM 607 O LEU A 630 9.429 14.152 −0.294 1.00 46.04 A OATOM 608 N MET A 631 8.466 12.492 −1.454 1.00 44.91 A N ATOM 609 CA META 631 9.461 11.537 −1.009 1.00 43.83 A C ATOM 610 CB MET A 631 9.06210.130 −1.426 1.00 44.32 A C ATOM 611 CG MET A 631 7.891 9.569 −0.6561.00 44.22 A C ATOM 612 SD MET A 631 8.316 9.152 1.065 1.00 47.72 A SATOM 613 CE MET A 631 10.126 9.049 0.987 1.00 45.34 A C ATOM 614 C MET A631 10.773 11.925 −1.672 1.00 43.77 A C ATOM 615 O MET A 631 11.83911.886 −1.047 1.00 44.18 A O ATOM 616 N SER A 632 10.687 12.308 −2.9441.00 43.05 A N ATOM 617 CA SER A 632 11.866 12.711 −3.697 1.00 43.11 A CATOM 618 CB SER A 632 11.484 13.175 −5.094 1.00 42.94 A C ATOM 619 OGSER A 632 10.586 12.270 −5.701 1.00 47.91 A O ATOM 620 C SER A 63212.536 13.860 −2.980 1.00 42.96 A C ATOM 621 O SER A 632 13.723 14.100−3.150 1.00 44.22 A O ATOM 622 N GLU A 633 11.766 14.582 −2.183 1.0043.52 A N ATOM 623 CA GLU A 633 12.305 15.712 −1.446 1.00 44.57 A C ATOM624 CB GLU A 633 11.236 16.778 −1.298 1.00 46.61 A C ATOM 625 CG GLU A633 11.672 18.020 −0.570 1.00 48.46 A C ATOM 626 CD GLU A 633 10.57419.052 −0.602 1.00 49.51 A C ATOM 627 OE1 GLU A 633 10.189 19.436 −1.7321.00 47.74 A O ATOM 628 OE2 GLU A 633 10.090 19.454 0.487 1.00 49.71 A OATOM 629 C GLU A 633 12.813 15.297 −0.076 1.00 44.80 A C ATOM 630 O GLUA 633 13.878 15.746 0.352 1.00 45.44 A O ATOM 631 N LEU A 634 12.05214.451 0.620 1.00 44.75 A N ATOM 632 CA LEU A 634 12.486 13.990 1.9361.00 43.68 A C ATOM 633 CB LEU A 634 11.575 12.885 2.483 1.00 42.62 A CATOM 634 CG LEU A 634 11.726 12.476 3.961 1.00 39.90 A C ATOM 635 CD1LEU A 634 11.626 10.969 4.063 1.00 40.11 A C ATOM 636 CD2 LEU A 63413.041 12.933 4.533 1.00 37.97 A C ATOM 637 C LEU A 634 13.866 13.4111.698 1.00 43.56 A C ATOM 638 O LEU A 634 14.825 13.724 2.409 1.00 44.11A O ATOM 639 N LYS A 635 13.963 12.572 0.675 1.00 42.93 A N ATOM 640 CALYS A 635 15.237 11.954 0.364 1.00 43.61 A C ATOM 641 CB LYS A 63515.093 11.102 −0.903 1.00 43.67 A C ATOM 642 CG LYS A 635 14.249 9.851−0.646 1.00 42.81 A C ATOM 643 CD LYS A 635 13.719 9.215 −1.917 1.0044.05 A C ATOM 644 CE LYS A 635 12.787 8.051 −1.574 1.00 43.53 A C ATOM645 NZ LYS A 635 11.937 7.648 −2.727 1.00 42.36 A N ATOM 646 C LYS A 63516.331 13.021 0.243 1.00 42.97 A C ATOM 647 O LYS A 635 17.283 13.0441.043 1.00 43.13 A O ATOM 648 N ILE A 636 16.181 13.920 −0.724 1.0041.60 A N ATOM 649 CA ILE A 636 17.151 14.986 −0.916 1.00 40.52 A C ATOM650 CB ILE A 636 16.579 16.066 −1.875 1.00 40.14 A C ATOM 651 CG2 ILE A636 17.075 17.435 −1.486 1.00 39.55 A C ATOM 652 CG1 ILE A 636 16.96015.735 −3.325 1.00 40.03 A C ATOM 653 CD1 ILE A 636 16.315 14.463 −3.8991.00 39.72 A C ATOM 654 C ILE A 636 17.495 15.589 0.451 1.00 40.21 A CATOM 655 O ILE A 636 18.650 15.895 0.739 1.00 38.66 A O ATOM 656 N MET A637 16.485 15.737 1.297 1.00 41.91 A N ATOM 657 CA MET A 637 16.69116.279 2.637 1.00 43.31 A C ATOM 658 CB MET A 637 15.353 16.479 3.3531.00 45.76 A C ATOM 659 CG MET A 637 14.552 17.650 2.848 1.00 47.72 A CATOM 660 SD MET A 637 15.671 19.051 2.818 1.00 54.05 A S ATOM 661 CE META 637 15.347 19.836 4.443 1.00 52.49 A C ATOM 662 C MET A 637 17.57215.382 3.496 1.00 43.08 A C ATOM 663 O MET A 637 18.513 15.856 4.1301.00 42.20 A O ATOM 664 N SER A 638 17.271 14.087 3.518 1.00 44.00 A NATOM 665 CA SER A 638 18.047 13.148 4.332 1.00 45.46 A C ATOM 666 CB SERA 638 17.266 11.844 4.547 1.00 45.91 A C ATOM 667 OG SER A 638 16.90911.235 3.320 1.00 46.46 A O ATOM 668 C SER A 638 19.422 12.828 3.7651.00 45.50 A C ATOM 669 O SER A 638 20.197 12.109 4.396 1.00 45.66 A OATOM 670 N HIS A 639 19.712 13.364 2.579 1.00 46.12 A N ATOM 671 CA HISA 639 21.002 13.166 1.900 1.00 46.30 A C ATOM 672 CB HIS A 639 20.79913.120 0.363 1.00 48.85 A C ATOM 673 CG HIS A 639 22.077 13.077 −0.4321.00 50.22 A C ATOM 674 CD2 HIS A 639 22.797 14.067 −1.014 1.00 50.07 AC ATOM 675 ND1 HIS A 639 22.769 11.907 −0.681 1.00 51.40 A N ATOM 676CE1 HIS A 639 23.858 12.180 −1.380 1.00 50.36 A C ATOM 677 NE2 HIS A 63923.899 13.483 −1.594 1.00 49.64 A N ATOM 678 C HIS A 639 21.926 14.3332.255 1.00 45.06 A C ATOM 679 O HIS A 639 23.071 14.145 2.674 1.00 45.09A O ATOM 680 N LEU A 640 21.418 15.548 2.082 1.00 43.04 A N ATOM 681 CALEU A 640 22.217 16.723 2.371 1.00 41.53 A C ATOM 682 CB LEU A 64021.428 18.003 2.055 1.00 39.83 A C ATOM 683 CG LEU A 640 20.997 18.1640.595 1.00 37.72 A C ATOM 684 CD1 LEU A 640 20.139 19.389 0.473 1.0038.42 A C ATOM 685 CD2 LEU A 640 22.207 18.271 −0.315 1.00 37.15 A CATOM 686 C LEU A 640 22.669 16.734 3.821 1.00 40.05 A C ATOM 687 O LEU A640 23.778 17.157 4.123 1.00 40.86 A O ATOM 688 N GLY A 641 21.82416.240 4.713 1.00 39.29 A N ATOM 689 CA GLY A 641 22.171 16.260 6.1191.00 38.12 A C ATOM 690 C GLY A 641 21.620 17.537 6.723 1.00 37.74 A CATOM 691 O GLY A 641 20.684 18.130 6.183 1.00 38.36 A O ATOM 692 N GLN A642 22.201 17.987 7.824 1.00 37.63 A N ATOM 693 CA GLN A 642 21.70319.187 8.475 1.00 38.41 A C ATOM 694 CB GLN A 642 21.112 18.803 9.8411.00 40.74 A C ATOM 695 CG GLN A 642 19.899 17.862 9.727 1.00 46.32 A CATOM 696 CD GLN A 642 19.310 17.427 11.086 1.00 50.87 A C ATOM 697 OE1GLN A 642 18.988 18.258 11.951 1.00 53.07 A O ATOM 698 NE2 GLN A 64219.158 16.116 11.267 1.00 52.04 A N ATOM 699 C GLN A 642 22.719 20.3248.622 1.00 36.73 A C ATOM 700 O GLN A 642 23.887 20.100 8.921 1.00 36.06A O ATOM 701 N HIS A 643 22.258 21.549 8.393 1.00 36.40 A N ATOM 702 CAHIS A 643 23.100 22.737 8.513 1.00 37.09 A C ATOM 703 CB HIS A 64323.569 23.175 7.133 1.00 36.25 A C ATOM 704 CG HIS A 643 24.506 24.3407.154 1.00 36.15 A C ATOM 705 CD2 HIS A 643 25.776 24.468 6.700 1.0034.47 A C ATOM 706 ND1 HIS A 643 24.139 25.585 7.624 1.00 36.77 A N ATOM707 CE1 HIS A 643 25.141 26.431 7.453 1.00 34.95 A C ATOM 708 NE2 HIS A643 26.145 25.779 6.894 1.00 34.03 A N ATOM 709 C HIS A 643 22.33523.880 9.211 1.00 38.26 A C ATOM 710 O HIS A 643 21.125 24.067 8.9961.00 38.71 A O ATOM 711 N GLU A 644 23.039 24.631 10.055 1.00 37.93 A NATOM 712 CA GLU A 644 22.427 25.726 10.796 1.00 38.96 A C ATOM 713 CBGLU A 644 23.499 26.504 11.573 1.00 41.54 A C ATOM 714 CG GLU A 64424.665 26.995 10.729 1.00 48.20 A C ATOM 715 CD GLU A 644 25.737 25.92610.486 1.00 52.47 A C ATOM 716 OE1 GLU A 644 25.382 24.786 10.095 1.0054.85 A O ATOM 717 OE2 GLU A 644 26.944 26.232 10.669 1.00 54.22 A OATOM 718 C GLU A 644 21.623 26.682 9.906 1.00 38.04 A C ATOM 719 O GLU A644 20.520 27.123 10.283 1.00 36.83 A O ATOM 720 N ASN A 645 22.16526.963 8.718 1.00 36.67 A N ATOM 721 CA ASN A 645 21.552 27.879 7.7581.00 34.88 A C ATOM 722 CB ASN A 645 22.671 28.652 7.072 1.00 34.55 A CATOM 723 CG ASN A 645 23.458 29.487 8.061 1.00 36.13 A C ATOM 724 OD1ASN A 645 24.636 29.820 7.848 1.00 35.85 A O ATOM 725 ND2 ASN A 64522.799 29.842 9.165 1.00 36.31 A N ATOM 726 C ASN A 645 20.603 27.2616.729 1.00 35.00 A C ATOM 727 O ASN A 645 20.280 27.878 5.706 1.00 35.18A O ATOM 728 N ILE A 646 20.139 26.047 7.010 1.00 34.34 A N ATOM 729 CAILE A 646 19.215 25.338 6.126 1.00 33.01 A C ATOM 730 CB ILE A 64619.885 24.064 5.565 1.00 34.95 A C ATOM 731 CG2 ILE A 646 18.873 23.1314.965 1.00 36.91 A C ATOM 732 CG1 ILE A 646 20.905 24.458 4.510 1.0038.74 A C ATOM 733 CD1 ILE A 646 20.311 25.268 3.379 1.00 41.12 A C ATOM734 C ILE A 646 18.020 24.950 6.980 1.00 32.12 A C ATOM 735 O ILE A 64618.155 24.819 8.200 1.00 32.51 A O ATOM 736 N VAL A 647 16.846 24.8006.376 1.00 30.96 A N ATOM 737 CA VAL A 647 15.706 24.385 7.171 1.0029.78 A C ATOM 738 CB VAL A 647 14.352 24.885 6.601 1.00 29.12 A C ATOM739 CG1 VAL A 647 13.202 24.336 7.436 1.00 28.08 A C ATOM 740 CG2 VAL A647 14.294 26.413 6.648 1.00 28.12 A C ATOM 741 C VAL A 647 15.77122.869 7.154 1.00 30.17 A C ATOM 742 O VAL A 647 15.101 22.196 6.3761.00 30.94 A O ATOM 743 N ASN A 648 16.616 22.350 8.032 1.00 29.94 A NATOM 744 CA ASN A 648 16.844 20.927 8.190 1.00 30.90 A C ATOM 745 CB ASNA 648 17.723 20.714 9.416 1.00 30.96 A C ATOM 746 CG ASN A 648 19.01021.503 9.348 1.00 29.79 A C ATOM 747 OD1 ASN A 648 19.876 21.236 8.5101.00 29.29 A O ATOM 748 ND2 ASN A 648 19.142 22.488 10.226 1.00 28.64 AN ATOM 749 C ASN A 648 15.612 20.026 8.335 1.00 31.70 A C ATOM 750 O ASNA 648 14.514 20.474 8.662 1.00 30.96 A O ATOM 751 N LEU A 649 15.82618.738 8.084 1.00 32.54 A N ATOM 752 CA LEU A 649 14.786 17.730 8.2421.00 33.14 A C ATOM 753 CB LEU A 649 15.089 16.528 7.344 1.00 28.99 A CATOM 754 CG LEU A 649 14.287 15.233 7.485 1.00 26.96 A C ATOM 755 CD1LEU A 649 12.848 15.392 7.009 1.00 23.89 A C ATOM 756 CD2 LEU A 64914.970 14.190 6.649 1.00 26.32 A C ATOM 757 C LEU A 649 14.924 17.3279.721 1.00 36.01 A C ATOM 758 O LEU A 649 15.926 17.680 10.373 1.0038.12 A O ATOM 759 N LEU A 650 13.937 16.614 10.258 1.00 36.80 A N ATOM760 CA LEU A 650 13.995 16.173 11.647 1.00 37.86 A C ATOM 761 CB LEU A650 13.354 17.211 12.579 1.00 36.61 A C ATOM 762 CG LEU A 650 14.11318.538 12.793 1.00 36.51 A C ATOM 763 CD1 LEU A 650 13.215 19.583 13.4611.00 35.25 A C ATOM 764 CD2 LEU A 650 15.363 18.295 13.627 1.00 36.71 AC ATOM 765 C LEU A 650 13.274 14.836 11.766 1.00 40.29 A C ATOM 766 OLEU A 650 13.545 14.048 12.689 1.00 41.90 A O ATOM 767 N GLY A 65112.367 14.581 10.820 1.00 41.26 A N ATOM 768 CA GLY A 651 11.611 13.33710.822 1.00 42.25 A C ATOM 769 C GLY A 651 10.513 13.251 9.769 1.0042.59 A C ATOM 770 O GLY A 651 10.261 14.207 9.023 1.00 42.13 A O ATOM771 N ALA A 652 9.861 12.093 9.711 1.00 42.68 A N ATOM 772 CA ALA A 6528.788 11.861 8.760 1.00 43.88 A C ATOM 773 CB ALA A 652 9.368 11.4657.418 1.00 42.81 A C ATOM 774 C ALA A 652 7.830 10.781 9.260 1.00 45.91A C ATOM 775 O ALA A 652 8.134 10.048 10.201 1.00 46.00 A O ATOM 776 NCYS A 653 6.673 10.678 8.616 1.00 49.02 A N ATOM 777 CA CYS A 653 5.6699.691 9.002 1.00 52.05 A C ATOM 778 CB CYS A 653 4.424 10.397 9.554 1.0050.34 A C ATOM 779 SG CYS A 653 4.711 11.301 11.087 1.00 48.96 A S ATOM780 C CYS A 653 5.251 8.797 7.838 1.00 55.38 A C ATOM 781 O CYS A 6534.067 8.494 7.690 1.00 57.20 A O ATOM 782 N THR A 654 6.209 8.364 7.0201.00 58.03 A N ATOM 783 CA THR A 654 5.896 7.519 5.864 1.00 59.93 A CATOM 784 CB THR A 654 7.178 7.075 5.129 1.00 60.45 A C ATOM 785 OG1 THRA 654 8.180 6.683 6.084 1.00 59.85 A O ATOM 786 CG2 THR A 654 7.6908.209 4.239 1.00 61.12 A C ATOM 787 C THR A 654 5.061 6.266 6.127 1.0061.61 A C ATOM 788 O THR A 654 4.550 5.661 5.180 1.00 62.11 A O ATOM 789N HIS A 655 4.920 5.873 7.394 1.00 63.46 A N ATOM 790 CA HIS A 655 4.1464.675 7.739 1.00 64.35 A C ATOM 791 CB HIS A 655 5.075 3.566 8.260 1.0064.71 A C ATOM 792 CG HIS A 655 6.018 3.042 7.222 1.00 66.29 A C ATOM793 CD2 HIS A 655 7.371 3.047 7.164 1.00 66.69 A C ATOM 794 ND1 HIS A655 5.584 2.505 6.027 1.00 65.94 A N ATOM 795 CE1 HIS A 655 6.629 2.2115.274 1.00 66.66 A C ATOM 796 NE2 HIS A 655 7.726 2.531 5.940 1.00 67.30A N ATOM 797 C HIS A 655 3.040 4.920 8.750 1.00 64.14 A C ATOM 798 O HISA 655 3.229 5.629 9.740 1.00 64.66 A O ATOM 799 N GLY A 656 1.885 4.3168.500 1.00 63.68 A N ATOM 800 CA GLY A 656 0.770 4.480 9.408 1.00 63.01A C ATOM 801 C GLY A 656 0.210 5.504 8.878 1.00 62.94 A C ATOM 802 O GLYA 656 −1.090 5.973 9.611 1.00 63.90 A O ATOM 803 N GLY A 657 −0.0595.857 7.604 1.00 61.27 A N ATOM 804 CA GLY A 657 −0.962 6.822 7.008 1.0060.06 A C ATOM 805 C GLY A 657 0.314 7.704 5.961 1.00 59.32 A C ATOM 806O GLY A 657 0.507 7.242 5.168 1.00 60.41 A O ATOM 807 N PRO A 658 0.6688.993 5.932 1.00 58.00 A N ATOM 808 CD PRO A 658 −1.741 9.633 6.711 1.0058.15 A C ATOM 809 CA PRO A 658 −0.100 9.927 4.956 1.00 56.17 A C ATOM810 CB PRO A 658 1.029 11.142 5.046 1.00 57.98 A C ATOM 811 CG PRO A 658−2.297 10.604 5.710 1.00 58.85 A C ATOM 812 C PRO A 658 1.332 10.3015.316 1.00 54.33 A C ATOM 813 O PRO A 658 1.698 10.304 6.493 1.00 53.99A O ATOM 814 N VAL A 659 2.136 10.613 4.303 1.00 51.99 A N ATOM 815 CAVAL A 659 3.516 11.018 4.529 1.00 48.73 A C ATOM 816 CB VAL A 659 4.33411.016 3.219 1.00 49.60 A C ATOM 817 CG1 VAL A 659 5.619 11.831 3.3981.00 49.75 A C ATOM 818 CG2 VAL A 659 4.677 9.587 2.823 1.00 50.37 A CATOM 819 C VAL A 659 3.504 12.434 5.086 1.00 46.09 A C ATOM 820 O VAL A659 2.824 13.306 4.556 1.00 45.70 A O ATOM 821 N LEU A 660 4.260 12.6486.157 1.00 43.65 A N ATOM 822 CA LEU A 660 4.359 13.951 6.804 1.00 40.46A C ATOM 823 CB LEU A 660 3.611 13.946 8.133 1.00 38.99 A C ATOM 824 CGLEU A 660 2.199 13.363 8.182 1.00 37.65 A C ATOM 825 CD1 LEU A 660 1.76013.331 9.640 1.00 36.70 A C ATOM 826 CD2 LEU A 660 1.229 14.185 7.3251.00 35.95 A C ATOM 827 C LEU A 660 5.834 14.196 7.074 1.00 39.69 A CATOM 828 O LEU A 660 6.457 13.485 7.864 1.00 38.69 A O ATOM 829 N VAL A661 6.384 15.203 6.410 1.00 39.08 A N ATOM 830 CA VAL A 661 7.786 15.5656.547 1.00 37.28 A C ATOM 831 CB VAL A 661 8.269 16.165 5.203 1.00 36.94A C ATOM 832 CG1 VAL A 661 9.759 16.430 5.236 1.00 37.84 A C ATOM 833CG2 VAL A 661 7.919 15.207 4.072 1.00 34.93 A C ATOM 834 C VAL A 6617.920 16.569 7.715 1.00 37.43 A C ATOM 835 O VAL A 661 7.359 17.6757.681 1.00 38.10 A O ATOM 836 N ILE A 662 8.649 16.168 8.755 1.00 36.23A N ATOM 837 CA ILE A 662 8.831 16.997 9.953 1.00 33.62 A C ATOM 838 GBILE A 662 9.000 16.121 11.200 1.00 32.67 A C ATOM 839 CG2 ILE A 6628.828 16.971 12.458 1.00 32.70 A C ATOM 840 CG1 ILE A 662 7.986 14.97311.159 1.00 33.80 A C ATOM 841 CD1 ILE A 662 8.087 13.984 12.307 1.0032.32 A C ATOM 842 C ILE A 662 10.064 17.871 9.861 1.00 33.11 A C ATOM843 O ILE A 662 11.183 17.375 10.008 1.00 34.70 A O ATOM 844 N THR A 6639.883 19.166 9.639 1.00 31.83 A N ATOM 845 CA THR A 663 11.044 20.0439.543 1.00 30.37 A C ATOM 846 CG THR A 663 11.148 20.705 8.134 1.0028.46 A C ATOM 847 OG1 THR A 663 10.074 21.623 7.929 1.00 23.93 A O ATOM848 CG2 THR A 663 11.084 19.634 7.054 1.00 28.18 A C ATOM 849 C THR A663 11.084 21.109 10.626 1.00 31.37 A C ATOM 850 O THR A 663 10.11821.291 11.387 1.00 31.98 A O ATOM 851 N GLU A 664 12.214 21.804 10.6971.00 31.85 A N ATOM 852 CA GLU A 664 12.420 22.847 11.695 1.00 32.96 A CATOM 853 CB GLU A 664 13.766 23.552 11.470 1.00 31.62 A C ATOM 854 CGGLU A 664 14.974 22.696 11.797 1.00 30.91 A C ATOM 855 CD GLU A 66416.276 23.325 11.334 1.00 30.03 A C ATOM 856 OE1 GLU A 664 16.344 23.77510.164 1.00 27.70 A O ATOM 857 OE2 GLU A 664 17.231 23.356 12.143 1.0029.73 A O ATOM 858 C GLU A 664 11.319 23.885 11.683 1.00 33.49 A C ATOM859 O GLU A 664 10.645 24.077 10.673 1.00 33.09 A O ATOM 860 N TYR A 66511.141 24.548 12.820 1.00 35.24 A N ATOM 861 CA TYR A 665 10.146 25.60012.921 1.00 37.77 A C ATOM 862 CB TYR A 665 9.031 25.214 13.897 1.0036.57 A C ATOM 863 CG TYR A 665 8.170 26.401 14.253 1.00 35.04 A C ATOM864 CD1 TYR A 665 7.151 26.837 13.403 1.00 34.36 A C ATOM 865 CE1 TYR A665 6.422 27.996 13.692 1.00 34.05 A C ATOM 866 CD2 TYR A 665 8.43627.147 15.402 1.00 34.11 A C ATOM 867 CE2 TYR A 665 7.723 28.296 15.6971.00 34.50 A C ATOM 868 CZ TYR A 665 6.719 28.718 14.845 1.00 34.33 A CATOM 869 OH TYR A 665 6.021 29.859 15.176 1.00 35.67 A O ATOM 870 C TYRA 665 10.789 26.913 13.387 1.00 39.64 A C ATOM 871 O TYR A 665 11.05727.088 14.579 1.00 39.44 A O ATOM 872 N CYS A 666 11.033 27.827 12.4441.00 40.96 A N ATOM 873 CA CYS A 666 11.616 29.135 12.758 1.00 41.83 A CATOM 874 CB CYS A 666 12.280 29.726 11.510 1.00 43.59 A C ATOM 875 SGCYS A 666 13.353 28.545 10.653 1.00 48.95 A S ATOM 876 C CYS A 66610.477 30.045 13.243 1.00 40.90 A C ATOM 877 O CYS A 666 9.463 30.21512.551 1.00 40.75 A O ATOM 878 N CYS A 667 10.659 30.637 14.424 1.0039.87 A N ATOM 879 CA CYS A 667 9.638 31.475 15.047 1.00 38.75 A C ATOM880 CB CYS A 667 9.884 31.535 16.544 1.00 37.04 A C ATOM 881 SG CYS A667 11.303 32.554 16.930 1.00 37.20 A S ATOM 882 C CYS A 667 9.43832.905 14.547 1.00 38.99 A C ATOM 883 O CYS A 667 8.480 33.560 14.9661.00 39.50 A O ATOM 884 N TYR A 668 10.301 33.406 13.666 1.00 38.76 A NATOM 885 CA TYR A 668 10.118 34.778 13.192 1.00 37.86 A C ATOM 886 CBTYR A 668 11.423 35.567 13.289 1.00 39.08 A C ATOM 887 CG TYR A 66811.950 35.704 14.700 1.00 40.51 A C ATOM 888 CD1 TYR A 668 13.154 35.10815.067 1.00 40.65 A C ATOM 889 CE1 TYR A 668 13.631 35.194 16.367 1.0041.44 A C ATOM 890 CD2 TYR A 668 11.229 36.401 15.677 1.00 40.42 A CATOM 891 CE2 TYR A 668 11.698 36.490 16.987 1.00 40.93 A C ATOM 892 CZTYR A 668 12.901 35.882 17.322 1.00 41.28 A C ATOM 893 OH TYR A 66813.387 35.942 18.608 1.00 42.08 A O ATOM 894 C TYR A 668 9.567 34.92111.787 1.00 37.66 A C ATOM 895 O TYR A 668 9.465 36.038 11.275 1.0038.42 A O ATOM 896 N GLY A 669 9.215 33.811 11.146 1.00 36.39 A N ATOM897 CA GLY A 669 8.664 33.917 9.800 1.00 35.01 A C ATOM 898 C GLY A 6699.665 34.229 8.698 1.00 33.23 A C ATOM 899 O GLY A 669 10.865 34.4108.962 1.00 31.61 A 0 ATOM 900 N ASP A 670 9.185 34.301 7.458 1.00 32.96A N ATOM 901 CA ASP A 670 10.097 34.567 6.351 1.00 34.51 A C ATOM 902 CBASP A 670 9.425 34.356 5.004 1.00 36.89 A C ATOM 903 CG ASP A 670 8.27735.291 4.786 1.00 39.07 A C ATOM 904 OD1 ASP A 670 7.331 35.226 5.5971.00 42.09 A 0 ATOM 905 OD2 ASP A 670 8.317 36.078 3.814 1.00 38.90 A OATOM 906 C ASP A 670 10.721 35.948 6.376 1.00 33.50 A C ATOM 907 O ASP A670 10.141 36.917 6.871 1.00 34.11 A O ATOM 908 N LEU A 671 11.92636.007 5.828 1.00 32.00 A N ATOM 909 CA LEU A 671 12.717 37.220 5.7661.00 30.56 A C ATOM 910 CB LEU A 671 14.049 36.921 5.086 1.00 29.38 A CATOM 911 CG LEU A 671 15.024 38.079 5.060 1.00 27.72 A C ATOM 912 CD1LEU A 671 15.297 38.580 6.476 1.00 28.85 A C ATOM 913 CD2 LEU A 67116.343 37.634 4.468 1.00 25.25 A C ATOM 914 C LEU A 671 12.047 38.3805.055 1.00 30.73 A C ATOM 915 O LEU A 671 12.006 39.484 5.597 1.00 31.35A O ATOM 916 N LEU A 672 11.524 38.134 3.847 1.00 31.36 A N ATOM 917 CALEU A 672 10.876 39.191 3.054 1.00 29.11 A C ATOM 918 CB LEU A 67210.079 38.609 1.875 1.00 27.63 A C ATOM 919 CG LEU A 672 9.647 39.7760.976 1.00 29.12 A C ATOM 920 CD1 LEU A 672 10.920 40.310 0.321 1.0027.18 A C ATOM 921 CD2 LEU A 672 8.611 39.391 −0.088 1.00 25.81 A C ATOM922 C LEU A 672 9.947 39.997 3.949 1.00 28.12 A C ATOM 923 O LEU A 67210.204 41.162 4.234 1.00 27.96 A O ATOM 924 N ASN A 673 8.872 39.3744.410 1.00 28.50 A N ATOM 925 CA ASN A 673 7.958 40.081 5.284 1.00 30.72A C ATOM 926 CB ASN A 673 6.897 39.126 5.806 1.00 31.32 A C ATOM 927 CGASN A 673 5.968 38.656 4.690 1.00 37.25 A C ATOM 928 OD1 ASN A 673 5.35639.484 3.976 1.00 38.63 A O ATOM 929 ND2 ASN A 673 5.866 37.329 4.5101.00 37.97 A N ATOM 930 C ASN A 673 8.703 40.779 6.419 1.00 31.06 A CATOM 931 O ASN A 673 8.523 41.978 6.641 1.00 32.69 A O ATOM 932 N PHE A674 9.569 40.060 7.116 1.00 30.27 A N ATOM 933 CA PHE A 674 10.31640.675 8.200 1.00 30.42 A C ATOM 934 CB PHE A 674 11.417 39.734 8.6531.00 28.99 A C ATOM 935 CG PHE A 674 12.209 40.252 9.805 1.00 27.40 A CATOM 936 CD1 PHE A 674 11.751 40.083 11.107 1.00 26.16 A C ATOM 937 CD2PHE A 674 13.432 40.884 9.592 1.00 27.49 A C ATOM 938 CE1 PHE A 67412.510 40.530 12.194 1.00 26.70 A C ATOM 939 CE2 PHE A 674 14.201 41.33610.672 1.00 27.78 A C ATOM 940 CZ PHE A 674 13.735 41.153 11.979 1.0026.07 A C ATOM 941 C PHE A 674 10.933 42.016 7.761 1.00 32.01 A C ATOM942 O PHE A 674 10.614 43.079 8.312 1.00 31.59 A O ATOM 943 N LEU A 67511.828 41.957 6.777 1.00 33.12 A N ATOM 944 CA LEU A 675 12.463 43.1546.254 1.00 33.67 A C ATOM 945 CB LEU A 675 13.081 42.901 4.883 1.0032.87 A C ATOM 946 CG LEU A 675 14.475 42.270 4.839 1.00 32.88 A C ATOM947 CD1 LEU A 675 14.937 42.245 3.382 1.00 31.65 A C ATOM 948 CD2 LEU A675 15.462 43.075 5.709 1.00 3.0.77 A C ATOM 949 C LEU A 675 11.41844.225 6.107 1.00 35.58 A C ATOM 950 O LEU A 675 11.634 45.366 6.5001.00 37.69 A O ATOM 951 N ARG A 676 10.272 43.868 5.546 1.00 37.06 A NATOM 952 CA ARG A 676 9.223 44.856 5.365 1.00 39.79 A C ATOM 953 CB ARGA 676 8.083 44.235 4.575 1.00 37.41 A C ATOM 954 CG ARG A 676 8.49544.028 3.167 1.00 36.66 A C ATOM 955 CD ARG A 676 7.495 43.242 2.3821.00 37.47 A C ATOM 956 NE ARG A 676 7.818 43.340 0.966 1.00 37.69 A NATOM 957 CZ ARG A 676 7.211 42.657 0.007 1.00 38.35 A C ATOM 958 NH1 ARGA 676 6.236 41.801 0.307 1.00 36.82 A N ATOM 959 NH2 ARG A 676 7.56942.861 −4.257 1.00 38.52 A N ATOM 960 C ARG A 676 8.705 45.515 6.6561.00 43.19 A C ATOM 961 O ARG A 676 8.761 46.746 6.787 1.00 44.01 A OATOM 962 N ARG A 677 8.225 44.719 7.612 1.00 44.82 A N ATOM 963 CA ARG A677 7.716 45.293 8.849 1.00 47.84 A C ATOM 964 CB ARG A 677 7.126 44.2009.750 1.00 47.26 A C ATOM 965 CG ARG A 677 8.142 43.508 10.632 1.0046.40 A C ATOM 966 CD ARG A 677 7.461 42.657 11.687 1.00 47.38 A C ATOM967 NE ARG A 677 8.419 42.187 12.685 1.00 47.37 A N ATOM 968 CZ ARG A677 8.083 41.617 13.839 1.00 47.14 A C ATOM 969 NH1 ARG A 677 6.80041.440 14.153 1.00 45.13 A N ATOM 970 NH2 ARG A 677 9.036 41.266 14.6821.00 48.51 A N ATOM 971 C ARG A 677 8.766 46.105 9.641 1.00 50.32 A CATOM 972 O ARG A 677 8.413 47.073 10.324 1.00 52.40 A O ATOM 973 N LYS A678 10.043 45.727 9.549 1.00 51.64 A N ATOM 974 CA LYS A 678 11.11346.427 10.282 1.00 52.12 A C ATOM 975 CB LYS A 678 12.089 45.407 10.9121.00 52.78 A C ATOM 976 CG LYS A 678 11.594 44.627 12.153 1.00 54.58 A CATOM 977 CD LYS A 678 11.663 45.467 13.448 1.00 56.99 A C ATOM 978 CELYS A 678 11.827 44.610 14.726 1.00 57.75 A C ATOM 979 NZ LYS A 67810.731 43.595 14.961 1.00 57.92 A N ATOM 980 C LYS A 678 11.934 47.4379.457 1.00 51.89 A C ATOM 981 O LYS A 678 13.160 47.479 9.578 1.00 51.79A O ATOM 982 N ARG A 679 11.283 48.253 8.630 1.00 52.05 A N ATOM 983 CAARG A 679 12.024 49.243 7.827 1.00 52.67 A C ATOM 984 CB ARG A 67911.195 49.742 6.633 1.00 53.33 A C ATOM 985 CG ARG A 679 10.676 48.6725.682 1.00 53.84 A C ATOM 986 CD ARG A 679 10.209 49.335 4.403 1.0053.77 A C ATOM 987 NE ARG A 679 9.629 48.408 3.439 1.00 53.62 A N ATOM988 CZ ARG A 679 9.509 48.675 2.141 1.00 54.38 A C ATOM 989 NH1 ARG A679 9.937 49.835 1.650 1.00 53.74 A N ATOM 990 NH2 ARG A 679 8.94547.789 1.330 1.00 56.06 A N ATOM 991 C ARG A 679 12.438 50.459 8.6561.00 52.18 A C ATOM 992 O ARG A 679 11.860 51.543 8.517 1.00 51.05 A OATOM 993 N GLN A 696 14.557 48.720 14.957 1.00 59.40 A N ATOM 994 CA GLNA 696 15.173 49.426 13.830 1.00 60.13 A C ATOM 995 CB GLN A 696 15.57950.857 14.234 1.00 60.61 A C ATOM 996 CG GLN A 696 14.413 51.836 14.4051.00 63.46 A C ATOM 997 CD GLN A 696 13.732 52.212 13.083 1.00 65.31 A CATOM 998 OE1 GLN A 696 13.650 51.400 12.150 1.00 66.02 A O ATOM 999 NE2GLN A 696 13.222 53.445 13.008 1.00 65.34 A N ATOM 1000 C GLN A 69616.405 48.681 13.326 1.00 59.31 A C ATOM 1001 O GLN A 696 17.481 48.78613.911 1.00 59.60 A O ATOM 1002 N LEU A 697 16.244 47.932 12.241 1.0057.87 A N ATOM 1003 CA LEU A 697 17.349 47.175 11.669 1.00 57.22 A CATOM 1004 CB LEU A 697 17.009 46.771 10.231 1.00 55.72 A C ATOM 1005 CGLEU A 697 16.161 45.517 10.012 1.00 53.36 A C ATOM 1006 CD1 LEU A 69715.385 45.627 8.723 1.00 52.05 A C ATOM 1007 CD2 LEU A 697 17.065 44.3069.986 1.00 53.76 A C ATOM 1008 C LEU A 697 18.632 47.998 11.676 1.0057.63 A C ATOM 1009 O LEU A 697 18.575 49.228 11.652 1.00 58.68 A O ATOM1010 N SER A 698 19.779 47.320 11.720 1.00 57.12 A N ATOM 1011 CA SER A698 21.080 47.993 11.699 1.00 57.41 A C ATOM 1012 CB SER A 698 21.94947.548 12.868 1.00 57.84 A C ATOM 1013 OG SER A 698 22.599 46.327 12.5641.00 58.41 A O ATOM 1014 C SER A 698 21.755 47.571 10.408 1.00 57.42 A CATOM 1015 O SER A 698 21.358 46.578 9.811 1.00 57.31 A O ATOM 1016 N SERA 699 22.782 48.296 9.979 1.00 58.06 A N ATOM 1017 CA SER A 699 23.47747.924 8.735 1.00 58.95 A C ATOM 1018 CB SER A 699 24.580 48.895 8.3861.00 60.27 A C ATOM 1019 OG SER A 699 25.783 48.562 9.064 1.00 63.30 A OATOM 1020 C SER A 699 24.016 46.524 8.875 1.00 58.44 A C ATOM 1021 O SERA 699 24.173 45.812 7.883 1.00 59.32 A O ATOM 1022 N ARG A 753 24.31946.131 10.111 1.00 57.50 A N ATOM 1023 CA ARG A 753 24.885 44.813 10.3651.00 56.27 A C ATOM 1024 CB ARG A 753 25.806 44.850 11.590 1.00 57.71 AC ATOM 1025 CG ARG A 753 27.252 44.471 11.277 1.00 60.17 A C ATOM 1026CD ARG A 753 27.927 43.718 12.440 1.00 62.10 A C ATOM 1027 NE ARG A 75327.949 44.488 13.683 1.00 62.96 A N ATOM 1028 CZ ARG A 753 28.454 44.04714.832 1.00 62.84 A C ATOM 1029 NH1 ARG A 753 28.984 42.829 14.906 1.0061.45 A N ATOM 1030 NH2 ARG A 753 28.431 44.829 15.909 1.00 62.76 A NATOM 1031 C ARG A 753 23.835 43.713 10.537 1.00 54.44 A C ATOM 1032 OARG A 753 24.134 42.539 10.332 1.00 54.78 A O ATOM 1033 N ASP A 75422.614 44.076 10.918 1.00 52.29 A N ATOM 1034 CA ASP A 754 21.555 43.07811.076 1.00 50.78 A C ATOM 1035 CB ASP A 754 20.266 43.742 11.566 1.0052.23 A C ATOM 1036 CG ASP A 754 20.385 44.293 12.987 1.00 54.72 A CATOM 1037 OD1 ASP A 754 19.756 45.344 13.272 1.00 55.78 A O ATOM 1038OD2 ASP A 754 21.094 43.673 13.820 1.00 54.42 A O ATOM 1039 C ASP A 75421.312 42.458 9.703 1.00 49.58 A C ATOM 1040 O ASP A 754 20.951 41.2849.575 1.00 49.18 A O ATOM 1041 N LEU A 755 21.521 43.286 8.681 1.0048.13 A N ATOM 1042 CA LEU A 755 21.351 42.918 7.284 1.00 45.35 A C ATOM1043 CB LEU A 755 21.212 44.180 6.429 1.00 44.16 A C ATOM 1044 CG LEU A755 20.084 45.180 6.711 1.00 42.77 A C ATOM 1045 CD1 LEU A 755 20.37046.495 5.994 1.00 42.55 A C ATOM 1046 CD2 LEU A 755 18.756 44.607 6.2541.00 42.98 A C ATOM 1047 C LEU A 755 22.582 42.149 6.838 1.00 45.56 A CATOM 1048 O LEU A 755 22.473 41.130 6.161 1.00 47.10 A O ATOM 1049 N LEUA 756 23.756 42.660 7.204 1.00 44.57 A N ATOM 1050 CA LEU A 756 25.02842.027 6.860 1.00 42.03 A C ATOM 1051 CB LEU A 756 26.174 42.747 7.5781.00 42.56 A C ATOM 1052 CG LEU A 756 27.247 43.411 6.698 1.00 44.02 A CATOM 1053 CD1 LEU A 756 26.659 43.876 5.358 1.00 44.45 A C ATOM 1054 CD2LEU A 756 27.852 44.595 7.454 1.00 44.30 A C ATOM 1055 C LEU A 75624.955 40.563 7.273 1.00 40.49 A C ATOM 1056 O LEU A 756 25.443 39.6896.530 1.00 39.91 A O ATOM 1057 N HIS A 757 24.438 40.312 8.455 1.0039.05 A N ATOM 1058 CA HIS A 757 24.313 38.969 9.008 1.00 38.67 A C ATOM1059 CB HIS A 757 23.850 39.972 10.461 1.00 39.96 A C ATOM 1060 CG HIS A757 24.903 39.609 11.382 1.00 42.42 A C ATOM 1061 CD2 HIS A 757 25.13239.395 12.701 1.00 43.15 A C ATOM 1062 ND1 HIS A 757 25.882 40.48910.961 1.00 44.30 A N ATOM 1063 CE1 HIS A 757 26.669 40.792 11.980 1.0044.09 A C ATOM 1064 NE2 HIS A 757 26.236 40.141 13.048 1.00 44.91 A NATOM 1065 C HIS A 757 23.368 38.083 8.186 1.00 37.46 A C ATOM 1066 O HISA 757 23.668 36.913 7.914 1.00 38.54 A O ATOM 1067 N PHE A 758 22.22838.631 7.788 1.00 35.07 A N ATOM 1068 CA PHE A 758 21.298 37.876 6.6931.00 33.92 A C ATOM 1069 CB PHE A 758 20.111 38.760 6.553 1.00 34.57 A CATOM 1070 CG PHE A 758 19.288 39.292 7.710 1.00 34.94 A C ATOM 1071 CD1PHE A 758 18.420 40.364 7.513 1.00 34.35 A C ATOM 1072 CD2 PHE A 75819.356 38.713 8.975 1.00 35.86 A C ATOM 1073 CE1 PHE A 758 17.634 40.8498.551 1.00 35.83 A C ATOM 1074 CE2 PHE A 758 18.570 39.191 10.027 1.0036.98 A C ATOM 1075 CZ PHE A 758 17.707 40.261 9.815 1.00 37.14 A C ATOM1076 C PHE A 758 22.071 37.450 5.698 1.00 33.32 A C ATOM 1077 O PHE A758 22.102 36.260 5.324 1.00 30.94 A O ATOM 1078 N SER A 759 22.70038.440 5.058 1.00 33.23 A N ATOM 1079 CA SER A 759 23.479 38.233 3.8351.00 33.64 A C ATOM 1080 CB SER A 759 24.210 39.513 3.438 1.00 32.58 A CATOM 1081 OG SER A 759 23.307 40.418 2.839 1.00 33.68 A O ATOM 1082 CSER A 759 24.491 37.098 3.896 1.00 34.39 A C ATOM 1083 O SER A 75924.571 36.294 2.965 1.00 34.14 A O ATOM 1084 N SER A 760 25.274 37.0214.965 1.00 34.05 A N ATOM 1085 CA SER A 760 26.244 35.950 5.028 1.0034.77 A C ATOM 1086 CB SER A 760 27.384 36.324 5.954 1.00 35.70 A C ATOM1087 OG SER A 760 28.156 37.322 5.312 1.00 37.17 A O ATOM 1088 C SER A760 25.632 34.621 5.426 1.00 35.09 A C ATOM 1089 O SER A 760 25.94833.580 4.826 1.00 34.56 A O ATOM 1090 N GLN A 761 24.757 34.639 6.4231.00 35.27 A N ATOM 1091 CA GLN A 761 24.114 33.398 6.827 1.00 36.23 A CATOM 1092 CB GLN A 761 22.999 33.689 7.801 1.00 36.55 A C ATOM 1093 CGGLN A 761 23.495 34.221 9.101 1.00 38.95 A C ATOM 1094 CD GLN A 76122.377 34.847 9.865 1.00 42.10 A C ATOM 1095 OE1 GLN A 761 21.910 35.9359.517 1.00 44.25 A O ATOM 1096 NE2 GLN A 761 21.903 34.156 10.896 1.0043.26 A N ATOM 1097 C GLN A 761 23.552 32.689 5.589 1.00 35.95 A C ATOM1098 O GLN A 761 23.942 31.556 5.283 1.00 37.99 A O ATOM 1099 N VAL A762 22.653 33.351 4.867 1.00 33.11 A N ATOM 1100 CA VAL A 762 22.09432.740 3.669 1.00 31.49 A C ATOM 1101 CB VAL A 762 21.143 33.722 2.9341.00 30.83 A C ATOM 1102 CG1 VAL A 762 20.662 33.117 1.657 1.00 30.39 AC ATOM 1103 CG2 VAL A 762 19.933 34.048 3.808 1.00 31.70 A C ATOM 1104 CVAL A 762 23.219 32.308 2.706 1.00 30.40 A C ATOM 1105 O VAL A 76223.146 31.255 2.056 1.00 29.86 A O ATOM 1106 N ALA A 763 24.270 33.1172.614 1.00 30.05 A N ATOM 1107 CA ALA A 763 25.363 32.801 1.704 1.0028.49 A C ATOM 1108 CB ALA A 763 26.334 33.958 1.636 1.00 24.87 A C ATOM1109 C ALA A 763 26.041 31.548 2.232 1.00 29.71 A C ATOM 1110 O ALA A763 26.613 30.754 1.471 1.00 30.02 A O ATOM 1111 N GLN A 764 25.97231.366 3.546 1.00 29.59 A N ATOM 1112 CA GLN A 764 26.564 30.189 4.1511.00 29.26 A C ATOM 1113 CB GLN A 764 26.532 30.289 5.668 1.00 29.11 A CATOM 1114 CG GLN A 764 27.689 31.079 6.195 1.00 33.57 A C ATOM 1115 CDGLN A 764 27.646 31.200 7.685 1.00 36.30 A C ATOM 1116 OE1 GLN A 76427.433 30.206 8.389 1.00 38.99 A O ATOM 1117 NE2 GLN A 764 27.851 32.4218.192 1.00 38.37 A N ATOM 1118 C GLN A 764 25.793 28.970 3.688 1.0028.58 A C ATOM 1119 O GLN A 764 26.368 38.080 3.043 1.00 30.46 A O ATOM1120 N GLY A 765 24.498 28.928 4.014 1.00 25.79 A N ATOM 1121 CA GLY A765 23.666 27.812 3.593 1.00 22.81 A C ATOM 1122 C GLY A 765 23.98527.465 2.152 1.00 20.77 A C ATOM 1123 O GLY A 765 24.415 26.355 1.8611.00 22.11 A O ATOM 1124 N MET A 766 23.804 28.424 1.249 1.00 20.46 A NATOM 1125 CA MET A 766 24.100 28.214 −0.166 1.00 20.55 A C ATOM 1126 CBMET A 766 24.013 29.544 −0.906 1.00 19.86 A C ATOM 1127 CG MET A 76622.597 30.100 −0.927 1.00 19.64 A C ATOM 1128 SD MET A 766 21.455 28.787−1.464 1.00 16.58 A S ATOM 1129 CE MET A 766 21.868 28.634 −3.237 1.0017.84 A C ATOM 1130 C MET A 766 25.476 27.567 −0.365 1.00 21.32 A C ATOM1131 O MET A 766 25.616 26.623 −1.147 1.00 22.29 A O ATOM 1132 N ALA A767 26.487 28.062 0.346 1.00 22.01 A N ATOM 1133 CA ALA A 767 27.82627.480 0.268 1.00 21.37 A C ATOM 1134 CB ALA A 767 28.737 28.115 1.3131.00 21.12 A C ATOM 1135 C ALA A 767 27.686 25.982 0.544 1.00 22.44 A CATOM 1136 O ALA A 767 28.309 25.150 −0.136 1.00 23.19 A O ATOM 1137 NPHE A 768 26.850 26.561 1.533 1.00 22.41 A N ATOM 1138 CA PHE A 76826.583 24.464 1.934 1.00 22.61 A C ATOM 1139 CB PHE A 768 25.682 24.2433.154 1.00 20.10 A C ATOM 1140 CG PHE A 768 25.559 22.906 3.783 1.0020.92 A C ATOM 1141 CD1 PHE A 768 26.654 22.320 4.419 1.00 19.31 A CATOM 1142 CD2 PHE A 768 24.336 22.232 3.781 1.00 21.35 A C ATOM 1143 CE1PHE A 768 26.537 21.088 5.048 1.00 15.93 A C ATOM 1144 CE2 PHE A 76824.204 20.989 4.411 1.00 17.40 A C ATOM 1145 CZ PHE A 768 25.314 20.4265.043 1.00 17.68 A C ATOM 1146 C PHE A 768 25.909 23.454 0.828 1.0024.17 A C ATOM 1147 O PHE A 768 26.451 22.439 0.361 1.00 26.26 A O ATOM1148 N LEU A 769 24.724 23.895 0.406 1.00 24.65 A N ATOM 1149 CA LEU A769 24.011 23.182 −0.652 1.00 25.15 A C ATOM 1150 CB LEU A 769 22.76923.964 −1.108 1.00 24.29 A C ATOM 1151 CG LEU A 769 21.635 24.103 −0.0711.00 23.39 A C ATOM 1152 CD1 LEU A 769 20.390 24.620 −0.780 1.00 22.16 AC ATOM 1153 CD2 LEU A 769 21.319 22.749 0.596 1.00 21.69 A C ATOM 1154 CLEU A 769 24.992 23.012 −1.797 1.00 25.54 A C ATOM 1155 O LEU A 76925.057 21.954 −2.423 1.00 27.42 A O ATOM 1156 N ALA A 770 25.782 24.051−2.050 1.00 24.75 A N ATOM 1157 CA ALA A 770 26.785 23.987 −3.098 1.0022.83 A C ATOM 1158 CB ALA A 770 27.625 25.230 −3.075 1.00 22.71 A CATOM 1159 C ALA A 770 27.680 22.761 −2.907 1.00 23.22 A C ATOM 1160 OALA A 770 27.842 21.969 −3.836 1.00 21.83 A O ATOM 1161 N SER A 77128.247 22.597 −1.701 1.00 23.57 A N ATOM 1162 CA SER A 771 29.154 21.469−1.412 1.00 23.96 A C ATOM 1163 CB SER A 771 30.031 21.773 −0.186 1.0021.46 A C ATOM 1164 OG SER A 771 29.280 21.787 1.011 1.00 16.59 A O ATOM1165 C SER A 771 28.433 20.144 −1.190 1.00 25.73 A C ATOM 1166 O SER A771 28.661 19.455 −0.186 1.00 27.35 A O ATOM 1167 N LYS A 772 27.55819.808 −2.132 1.00 26.55 A N ATOM 1168 CA LYS A 772 26.759 18.583 −2.1141.00 26.30 A C ATOM 1169 CB LYS A 772 25.597 18.654 −1.108 1.00 24.46 AC ATOM 1170 CG LYS A 772 25.960 18.945 0.327 1.00 23.55 A C ATOM 1171 CDLYS A 772 26.709 17.801 0.979 1.00 25.55 A C ATOM 1172 CE LYS A 77226.882 18.047 2.470 1.00 27.02 A C ATOM 1173 NZ LYS A 772 27.695 16.9903.143 1.00 26.21 A N ATOM 1174 C LYS A 772 26.154 18.517 −3.501 1.0027.13 A C ATOM 1175 O LYS A 772 25.215 17.765 −3.725 1.00 28.56 A O ATOM1176 N ASN A 773 26.685 19.322 −4.421 1.00 28.70 A N ATOM 1177 CA ASN A773 26.176 19.367 −5.797 1.00 30.22 A C ATOM 1178 CB ASN A 773 26.57118.105 −6.569 1.00 29.39 A C ATOM 1179 CG ASN A 773 28.067 17.945 −6.7011.00 30.63 A C ATOM 1180 OD1 ASN A 773 28.839 18.770 −6.195 1.00 30.99 AO ATOM 1181 ND2 ASN A 773 28.495 16.875 −7.386 1.00 31.19 A N ATOM 1182C ASN A 773 24.661 19.439 −5.713 1.00 30.44 A C ATOM 1183 O ASN A 77323.957 18.589 −6.267 1.00 33.19 A O ATOM 1184 N CYS A 774 24.155 20.426−4.989 1.00 29.26 A N ATOM 1185 CA CYS A 774 22.712 20.568 −4.838 1.0029.03 A C ATOM 1186 CB CYS A 774 22.296 20.297 −3.390 1.00 28.88 A CATOM 1187 SG CYS A 774 20.560 20.659 −3.012 1.00 22.93 A S ATOM 1188 CCYS A 774 22.264 21.951 −5.218 1.00 29.34 A C ATOM 1189 O CYS A 77422.557 22.907 −4.509 1.00 29.01 A O ATOM 1190 N ILE A 775 21.558 22.058−6.338 1.00 30.96 A N ATOM 1191 CA ILE A 775 21.054 23.355 −6.798 1.0032.07 A C ATOM 1192 CB ILE A 775 20.987 23.417 −8.344 1.00 33.69 A CATOM 1193 CG2 ILE A 775 22.339 22.990 −8.945 1.00 32.43 A C ATOM 1194CG1 ILE A 775 19.867 22.508 −8.859 1.00 33.62 A C ATOM 1195 CD1 ILE A775 19.718 22.565 −10.369 1.00 34.80 A C ATOM 1196 C ILE A 775 19.65123.633 −6.218 1.00 31.07 A C ATOM 1197 O ILE A 775 18.818 22.723 −6.1131.00 31.57 A O ATOM 1198 N HIS A 776 19.421 24.893 −5.851 1.00 28.28 A NATOM 1199 CA HIS A 776 18.175 25.372 −5.251 1.00 26.67 A C ATOM 1200 CBHIS A 776 18.509 26.621 −4.411 1.00 26.79 A C ATOM 1201 CG HIS A 77617.495 26.968 −3.361 1.00 25.14 A C ATOM 1202 CD2 HIS A 776 17.45126.679 −2.035 1.00 23.62 A C ATOM 1203 ND1 HIS A 776 16.392 27.758−3.615 1.00 24.32 A N ATOM 1204 CE1 HIS A 776 15.714 27.938 −2.492 1.0022.67 A C ATOM 1205 NE2 HIS A 776 16.334 27.292 −1.519 1.00 20.45 A NATOM 1206 C HIS A 776 17.161 25.709 −6.355 1.00 26.75 A C ATOM 1207 OHIS A 776 16.036 25.204 −6.368 1.00 28.37 A O ATOM 1208 N ARG A 77716.702 26.566 −7.284 1.00 25.81 A N ATOM 1209 CA ARG A 777 16.702 26.970−8.387 1.00 25.45 A C ATOM 1210 CB ARG A 777 16.063 25.743 −9.068 1.0025.56 A C ATOM 1211 CG ARG A 777 17.055 24.642 −9.438 1.00 25.44 A CATOM 1212 CD ARG A 777 16.587 23.737 −10.608 1.00 26.98 A C ATOM 1213 NEARG A 777 15.403 22.899 −10.367 1.00 27.69 A N ATOM 1214 CZ ARG A 77715.009 21.911 −11.182 1.00 28.74 A C ATOM 1215 NH1 ARG A 777 15.70321.623 −12.283 1.00 28.01 A N ATOM 1216 NH2 ARG A 777 13.904 21.218−10.920 1.00 28.98 A N ATOM 1217 C ARG A 777 15.607 27.964 −7.959 1.0026.63 A C ATOM 1218 O ARG A 777 14.820 28.441 −8.809 1.00 27.57 A O ATOM1219 N ASP A 778 15.532 28.290 −6.667 1.00 25.07 A N ATOM 1220 CA ASP A778 14.517 29.262 −6.252 1.00 25.74 A C ATOM 1221 CB ASP A 778 13.21928.591 −5.814 1.00 25.07 A C ATOM 1222 CG ASP A 778 12.067 29.578 −5.7441.00 24.70 A C ATOM 1223 OD1 ASP A 778 10.948 29.167 −5.382 1.00 26.02 AO ATOM 1224 OD2 ASP A 778 12.284 30.774 −6.063 1.00 24.59 A O ATOM 1225C ASP A 778 14.944 30.189 −5.142 1.00 26.73 A C ATOM 1226 O ASP A 77814.191 30.390 −4.182 1.00 26.97 A O ATOM 1227 N VAL A 779 16.141 30.756−5.259 1.00 27.60 A N ATOM 1228 CA VAL A 779 16.599 31.666 −4.226 1.0029.25 A C ATOM 1229 CB VAL A 779 18.104 31.908 −4.312 1.00 29.28 A CATOM 1230 CG1 VAL A 779 18.478 33.082 −3.429 1.00 29.41 A C ATOM 1231CG2 VAL A 779 18.850 30.644 −3.857 1.00 26.69 A C ATOM 1232 C VAL A 77915.850 32.983 −4.356 1.00 30.11 A C ATOM 1233 O VAL A 779 15.727 33.530−5.457 1.00 31.42 A O ATOM 1234 N ALA A 780 15.322 33.464 −3.224 1.0030.18 A N ATOM 1235 CA ALA A 780 14.556 34.705 −3.149 1.00 30.18 A CATOM 1236 CB ALA A 780 13.268 34.574 −3.962 1.00 28.98 A C ATOM 1237 CALA A 780 14.236 34.958 −1.667 1.00 32.26 A C ATOM 1238 O ALA A 78014.119 34.014 −0.861 1.00 33.04 A O ATOM 1239 N ALA A 781 14.082 36.225−1.295 1.00 32.78 A N ATOM 1240 CA ALA A 781 13.848 36.524 0.111 1.0031.09 A C ATOM 1241 CB ALA A 781 13.607 38.046 0.275 1.00 31.62 A C ATOM1242 C ALA A 781 12.706 35.732 0.728 1.00 29.29 A C ATOM 1243 O ALA A781 12.749 35.375 1.905 1.00 27.82 A O ATOM 1244 N ARG A 782 11.96435.421 −0.072 1.00 28.36 A N ATOM 1245 CA ARG A 782 10.560 34.667 0.4391.00 26.36 A C ATOM 1246 CB ARG A 782 9.450 34.609 −0.620 1.00 23.06 A CATOM 1247 CG ARG A 782 9.914 34.118 −1.987 1.00 21.59 A C ATOM 1248 CDARG A 782 8.752 33.891 −2.925 1.00 19.55 A C ATOM 1249 NE ARG A 7829.169 33.292 −4.186 1.00 19.28 A N ATOM 1250 CZ ARG A 782 9.942 33.893−5.087 1.00 22.50 A C ATOM 1251 NH1 ARG A 782 10.394 35.125 −4.875 1.0023.14 A N ATOM 1252 NH2 ARG A 782 10.267 33.261 −6.213 1.00 24.84 A NATOM 1253 C ARG A 782 10.927 33.253 0.921 1.00 26.61 A C ATOM 1254 O ARGA 782 10.224 32.686 1.760 1.00 28.52 A O ATOM 1255 N ASN A 783 12.01732.684 0.413 1.00 25.41 A N ATOM 1256 CA ASN A 783 12.422 31.337 0.8191.00 24.69 A C ATOM 1257 CB ASN A 783 12.974 30.542 −0.366 1.00 26.52 AC ATOM 1258 CG ASN A 783 11.889 30.043 −1.286 1.00 28.60 A C ATOM 1259OD1 ASN A 783 10.828 29.584 −0.831 1.00 29.47 A O ATOM 1260 ND2 ASN A783 12.147 30.109 −2.594 1.00 29.33 A N ATOM 1261 C ASN A 783 13.46431.316 1.920 1.00 24.79 A C ATOM 1262 O ASN A 783 14.231 30.343 2.0471.00 26.13 A O ATOM 1263 N VAL A 784 13.530 32.401 2.683 1.00 24.11 A NATOM 1264 CA VAL A 784 14.454 32.492 3.801 1.00 21.92 A C ATOM 1265 CBVAL A 784 15.379 33.683 3.727 1.00 18.04 A C ATOM 1266 CG1 VAL A 78416.267 33.698 4.958 1.00 17.80 A C ATOM 1267 CG2 VAL A 784 16.214 33.6172.488 1.00 17.69 A C ATOM 1268 C VAL A 784 13.599 32.686 5.035 1.0024.87 A C ATOM 1269 O VAL A 784 12.660 33.503 5.050 1.00 26.53 A O ATOM1270 N LEU A 785 13.917 31.921 6.068 1.00 25.17 A N ATOM 1271 CA LEU A785 13.194 32.000 7.309 1.00 23.73 A C ATOM 1272 CB LEU A 785 12.72930.612 7.722 1.00 24.02 A C ATOM 1273 CG LEU A 785 11.217 30.440 7.7981.00 24.49 A C ATOM 1274 CD1 LEU A 785 10.551 31.107 6.596 1.00 24.92 AC ATOM 1275 CD2 LEU A 785 10.902 28.959 7.839 1.00 25.29 A C ATOM 1276 CLEU A 785 14.167 32.514 8.328 1.00 24.62 A C ATOM 1277 O LEU A 78515.395 32.380 8.152 1.00 23.48 A O ATOM 1278 N LEU A 786 13.622 33.1139.383 1.00 25.43 A N ATOM 1279 CA LEU A 786 14.432 33.601 10.489 1.0026.09 A C ATOM 1280 CB LEU A 786 14.160 35.070 10.758 1.00 25.39 A CATOM 1281 CG LEU A 786 14.380 36.036 9.613 1.00 25.91 A C ATOM 1282 CD1LEU A 786 14.584 37.440 10.203 1.00 27.81 A C ATOM 1283 CD2 LEU A 78615.600 35.632 8.831 1.00 25.86 A C ATOM 1284 C LEU A 786 14.066 32.77511.738 1.00 27.31 A C ATOM 1285 O LEU A 786 12.882 32.626 12.092 1.0026.32 A O ATOM 1286 N THR A 787 15.081 32.223 12.392 1.00 28.25 A N ATOM1287 CA THR A 787 14.843 31.438 13.584 1.00 30.47 A C ATOM 1288 CB THR A787 15.540 30.112 13.485 1.00 29.89 A C ATOM 1289 CG1 THR A 787 15.31229.375 14.693 1.00 30.51 A O ATOM 1290 CG2 THR A 787 17.032 30.33213.276 1.00 29.64 A C ATOM 1291 C THR A 787 15.354 32.183 14.825 1.0032.31 A C ATOM 1292 O THR A 787 15.623 33.387 14.771 1.00 33.50 A O ATOM1293 N ASN A 788 15.497 31.479 15.942 1.00 33.65 A N ATOM 1294 CA ASN A788 15.969 32.122 17.164 1.00 34.49 A C ATOM 1295 CB ASN A 788 16.15331.087 18.270 1.00 34.64 A C ATOM 1296 CG ASN A 788 15.025 30.088 18.3131.00 35.28 A C ATOM 1297 OD1 ASN A 788 13.860 30.443 18.125 1.00 36.48 AO ATOM 1298 ND2 ASN A 788 15.360 28.826 18.564 1.00 37.16 A N ATOM 1299C ASN A 788 17.270 32.900 16.957 1.00 35.10 A C ATOM 1300 O ASN A 78818.237 32.394 16.368 1.00 35.22 A O ATOM 1301 N GLY A 789 17.280 34.13517.459 1.00 36.15 A N ATOM 1302 CA GLY A 789 18.443 34.993 17.333 1.0035.99 A C ATOM 1303 C GLY A 789 18.422 35.595 15.948 1.00 37.63 A C ATOM1304 O GLY A 789 19.415 36.182 15.501 1.00 38.64 A O ATOM 1305 N HIS A790 17.280 35.449 15.266 1.00 37.25 A N ATOM 1306 CA HIS A 790 17.12035.966 13.909 1.00 36.21 A C ATOM 1307 CB HIS A 790 17.227 37.488 13.9311.00 37.45 A C ATOM 1308 CG HIS A 790 16.076 38.161 14.605 1.00 39.57 AC ATOM 1309 CD2 HIS A 790 15.984 38.781 15.804 1.00 40.04 A C ATOM 1310ND1 HIS A 790 14.820 38.240 14.033 1.00 41.90 A N ATOM 1311 CE1 HIS A790 14.005 38.882 14.851 1.00 40.87 A C ATOM 1312 NE2 HIS A 790 14.68739.222 14.932 1.00 41.48 A N ATOM 1313 C HIS A 790 18.203 35.366 12.9901.00 35.04 A C ATOM 1314 O HIS A 790 18.915 36.089 12.277 1.00 34.98 A OATOM 1315 N VAL A 791 18.337 34.045 13.021 1.00 32.48 A N ATOM 1316 CAVAL A 791 19.336 33.384 12.198 1.00 31.11 A C ATOM 1317 CB VAL A 79120.033 32.229 12.970 1.00 28.98 A C ATOM 1318 CG1 VAL A 791 21.02331.526 12.062 1.00 26.43 A C ATOM 1319 CG2 VAL A 791 20.747 32.78314.198 1.00 26.95 A C ATOM 1320 C VAL A 791 18.669 32.848 10.938 1.0031.18 A C ATOM 1321 O VAL A 791 17.774 31.996 11.005 1.00 32.21 A O ATOM1322 N ALA A 792 19.096 33.345 9.784 1.00 29.28 A N ATOM 1323 CA ALA A792 18.483 32.887 8.550 1.00 29.24 A C ATOM 1324 CB ALA A 792 18.99533.702 7.390 1.00 28.84 A C ATOM 1325 C ALA A 792 18.742 31.407 8.3001.00 28.92 A C ATOM 1326 O ALA A 792 19.724 30.850 8.790 1.00 29.89 A OATOM 1327 N LYS A 793 17.845 30.788 7.536 1.00 28.40 A N ATOM 1328 CALYS A 793 17.935 29.376 7.141 1.00 26.56 A C ATOM 1329 CB LYS A 79317.190 28.482 8.137 1.00 26.44 A C ATOM 1330 CG LYS A 793 17.927 28.2329.437 1.00 26.60 A C ATOM 1331 CD LYS A 793 16.970 27.847 10.542 1.0024.41 A C ATOM 1332 CE LYS A 793 17.671 26.936 11.501 1.00 23.61 A CATOM 1333 NZ LYS A 793 17.798 25.611 10.839 1.00 22.29 A N ATOM 1334 CLYS A 793 17.241 29.237 5.796 1.00 25.29 A C ATOM 1335 O LYS A 79316.020 29.191 5.778 1.00 26.49 A O ATOM 1336 N ILE A 794 17.970 29.1904.680 1.00 24.36 A N ATOM 1337 CA ILE A 794 17.293 29.026 3.382 1.0023.29 A C ATOM 1338 CB ILE A 794 18.249 29.072 2.178 1.00 24.59 A C ATOM1339 CG2 ILE A 794 18.220 30.467 1.503 1.00 21.76 A C ATOM 1340 CG1 ILEA 794 19.629 25.589 2.619 1.00 25.81 A C ATOM 1341 CD1 ILE A 794 20.55728.266 1.447 1.00 27.91 A C ATOM 1342 C ILE A 794 16.598 27.669 3.2921.00 21.79 A C ATOM 1343 O ILE A 794 16.986 26.704 3.948 1.00 18.28 A OATOM 1344 N GLY A 795 15.558 27.617 2.472 1.00 22.23 A N ATOM 1345 CAGLY A 795 14.817 26.383 2.278 1.00 23.50 A C ATOM 1346 C GLY A 79513.954 26.536 1.045 1.00 23.16 A C ATOM 1347 O GLY A 795 14.258 27.3690.183 1.00 24.05 A O ATOM 1348 N ASP A 796 12.900 25.736 0.935 1.0023.18 A N ATOM 1349 CA ASP A 796 11.988 25.842 −0.207 1.00 24.74 A CATOM 1350 CB ASP A 796 12.292 24.770 −1.260 1.00 21.99 A C ATOM 1351 CGASP A 796 11.274 24.750 −2.402 1.00 20.56 A C ATOM 1352 OD1 ASP A 79610.490 25.711 −2.554 1.00 20.63 A O ATOM 1353 OD2 ASP A 796 11.26023.762 −3.168 1.00 20.59 A O ATOM 1354 C ASP A 796 10.589 25.665 0.3591.00 27.66 A C ATOM 1355 O ASP A 796 10.238 24.606 0.883 1.00 28.74 A OATOM 1356 N PHE A 797 9.784 24.706 0.267 1.00 30.29 A N ATOM 1357 CA PHEA 797 8.446 26.630 0.826 1.00 33.58 A C ATOM 1358 CB PHE A 797 8.25727.818 1.767 1.00 32.46 A C ATOM 1359 CG PHE A 797 9.443 28.061 2.6571.00 28.84 A C ATOM 1360 CD1 PHE A 797 9.963 29.339 2.813 1.00 27.57 A CATOM 1361 CD2 PHE A 797 10.055 27.005 3.314 1.00 27.78 A C ATOM 1362 CE1PHE A 797 11.080 29.565 3.606 1.00 26.86 A C ATOM 1363 CE2 PHE A 79711.179 27.225 4.118 1.00 27.11 A C ATOM 1364 CZ PHE A 797 11.689 28.5084.260 1.00 25.82 A C ATOM 1365 C PHE A 797 7.331 26.577 −0.228 1.0036.07 A C ATOM 1366 O PHE A 797 6.195 26.984 0.032 1.00 36.94 A O ATOM1367 N GLY A 798 7.664 26.077 −1.415 1.00 37.75 A N ATOM 1368 CA GLY A798 6.669 29.598 −2.463 1.00 40.17 A C ATOM 1369 C GLY A 798 5.34525.454 −1.908 1.00 41.72 A C ATOM 1370 O GLY A 798 4.293 25.985 −2.2821.00 42.22 A O ATOM 1371 N LEU A 799 5.383 24.453 −1.017 1.00 41.92 A NATOM 1372 CA LEU A 799 4.149 23.909 −0.430 1.00 42.62 A C ATOM 1373 CBLEU A 799 4.432 22.869 0.650 1.00 40.37 A C ATOM 1374 CG LEU A 799 4.57221.393 0.310 1.00 38.80 A C ATOM 1375 OD1 LEU A 799 4.529 20.641 1.6181.00 36.55 A C ATOM 1376 CD2 LEU A 799 3.471 20.919 −0.626 1.00 37.18 AC ATOM 1377 C LEU A 799 3.303 24.990 0.218 1.00 44.55 A C ATOM 1378 OLEU A 799 2.094 25.071 −0.021 1.00 46.72 A O ATOM 1379 N ALA A 800 3.94425.812 1.045 1.00 45.01 A N ATOM 1380 CA ALA A 800 3.255 26.880 1.7531.00 45.56 A C ATOM 1381 CB ALA A 800 4.186 27.490 2.756 1.00 45.21 A CATOM 1382 C ALA A 800 2.662 27.967 0.844 1.00 46.08 A C ATOM 1383 O ALAA 800 1.445 28.142 0.803 1.00 47.63 A O ATOM 1384 N ARG A 801 3.50728.697 0.122 1.00 45.88 A N ATOM 1385 CA ARG A 801 3.025 29.757 −0.7661.00 44.83 A C ATOM 1386 CB ARG A 801 4.184 30.379 −1.554 1.00 45.47 A CATOM 1387 CG ARG A 801 5.452 30.641 −0.764 1.00 49.11 A C ATOM 1388 CDARG A 801 5.326 31.841 0.156 1.00 52.38 A C ATOM 1389 NE ARG A 801 6.57232.087 0.883 1.00 54.60 A N ATOM 1390 CZ ARG A 801 6.756 33.090 1.7341.00 55.08 A C ATOM 1391 NH1 ARG A 801 5.772 33.963 1.967 1.00 55.63 A NATOM 1392 NH2 ARG A 801 7.918 33.219 2.366 1.00 53.49 A N ATOM 1393 CARG A 801 2.031 29.189 −1.775 1.00 44.25 A C ATOM 1394 O ARG A 801 2.03827.987 −2.060 1.00 42.45 A O ATOM 1395 N ASP A 802 1.173 30.059 −2.3081.00 44.21 A N ATOM 1396 CA ASP A 802 0.219 29.652 −3.330 1.00 44.56 A CATOM 1397 CB ASP A 802 −1.169 30.201 −3.065 1.00 43.94 A C ATOM 1398 CGASP A 802 −2.104 29.937 −4.224 1.00 44.76 A C ATOM 1399 OD1 ASP A 802−1.951 28.863 −4.856 1.00 45.50 A O ATOM 1400 OD2 ASP A 802 −2.98030.780 −4.508 1.00 44.99 A O ATOM 1401 C ASP A 802 0.698 30.213 −4.6531.00 46.09 A C ATOM 1402 O ASP A 802 0.381 31.353 −4.996 1.00 46.29 A OATOM 1403 N ILE A 803 1.457 29.411 −5.396 1.00 48.06 A N ATOM 1404 CAILE A 803 2.009 29.838 −6.686 1.00 49.16 A C ATOM 1405 CB ILE A 8032.970 28.774 −7.266 1.00 49.80 A C ATOM 1406 CG2 ILE A 803 3.561 29.271−8.563 1.00 49.54 A C ATOM 1407 CG1 ILE A 803 4.105 28.502 −6.276 1.0049.74 A C ATOM 1408 CD1 ILE A 803 5.047 27.411 −6.735 1.00 51.31 A CATOM 1409 C ILE A 803 0.950 30.154 −7.734 1.00 48.78 A C ATOM 1410 O ILEA 803 1.180 30.958 −8.643 1.00 49.97 A O ATOM 1411 N MET A 804 −0.20629.521 −7.623 1.00 48.18 A N ATOM 1412 CA MET A 804 −1.264 29.789 −8.5791.00 48.57 A C ATOM 1413 CB MET A 804 −2.493 28.934 −8.266 1.00 48.91 AC ATOM 1414 CG MET A 804 −2.329 27.453 −8.566 1.00 49.47 A C ATOM 1415SD MET A 804 −1.731 27.144 −10.242 1.00 50.31 A S ATOM 1416 CE MET A 804−2.882 28.193 −11.264 1.00 48.86 A C ATOM 1417 C MET A 804 −1.675 31.268−8.593 1.00 48.66 A C ATOM 1418 O MET A 804 −2.235 31.751 −9.587 1.0049.24 A O ATOM 1419 N ASN A 805 −1.392 31.992 −7.510 1.00 47.80 A N ATOM1420 CA ASN A 805 −1.795 33.397 −7.437 1.00 47.66 A C ATOM 1421 CB ASN A805 −2.982 33.517 −6.459 1.00 46.12 A C ATOM 1422 CG ASN A 805 −4.21732.707 −6.935 1.00 47.45 A C ATOM 1423 OD1 ASN A 805 −4.862 33.062−7.935 1.00 44.80 A O ATOM 1424 ND2 ASN A 805 −4.532 31.608 −6.227 1.0045.99 A N ATOM 1425 C ASN A 805 −0.681 34.401 −7.095 1.00 47.57 A C ATOM1426 O ASN A 805 −0.946 35.576 −6.820 1.00 47.42 A O ATOM 1427 N ASP A806 0.569 33.946 −7.136 1.00 47.31 A N ATOM 1428 CA ASP A 806 1.69934.822 −6.832 1.00 46.51 A C ATOM 1429 CB ASP A 806 2.795 34.045 −6.1061.00 44.80 A C ATOM 1430 CG ASP A 806 3.923 34.938 −5.638 1.00 44.35 A CATOM 1431 OD1 ASP A 806 4.218 35.920 −6.349 1.00 45.00 A O ATOM 1432 OD2ASP A 806 4.524 34.662 −4.573 1.00 42.69 A O ATOM 1433 C ASP A 806 2.25635.412 −8.128 1.00 47.25 A C ATOM 1434 O ASP A 806 2.858 34.698 −8.9431.00 48.15 A O ATOM 1435 N SER A 807 2.058 36.716 −8.309 1.00 46.99 A NATOM 1436 CA SER A 807 2.512 37.434 −9.503 1.00 45.34 A C ATOM 1437 CBSER A 807 2.095 38.902 −9.403 1.00 46.69 A C ATOM 1438 OG SER A 8072.426 39.438 −8.124 1.00 47.87 A O ATOM 1439 C SER A 807 4.011 37.354−9.762 1.00 44.82 A C ATOM 1440 O SER A 807 4.512 37.956 −10.715 1.0044.40 A C ATOM 1441 N ASN A 808 4.739 36.631 −8.917 1.00 44.38 A N ATOM1442 CA ASN A 808 6.176 36.495 −9.123 1.00 44.20 A O ATOM 1443 CB ASN A808 6.901 36.382 −7.794 1.00 42.14 A C ATOM 1444 CG ASN A 808 6.76437.625 −6.976 1.00 41.22 A C ATOM 1445 OD1 ASN A 808 5.926 37.699 −6.0771.00 40.16 A O ATOM 1446 ND2 ASN A 808 7.572 38.634 −7.295 1.00 40.32 AN ATOM 1447 C ASN A 808 6.515 35.297 −9.995 1.00 45.11 A C ATOM 1448 OASN A 808 7.596 35.241 −10.596 1.00 45.69 A O ATOM 1449 N TYR A 8095.596 34.337 −10.062 1.00 45.48 A N ATOM 1450 CA TYR A 809 5.801 33.151−10.884 1.00 45.96 A C ATOM 1451 CB TYR A 809 5.306 31.894 −10.141 1.0044.87 A C ATOM 1452 CG TYR A 809 6.103 31.567 −8.878 1.00 42.44 A C ATOM1453 CD1 TYR A 809 5.931 32.302 −7.705 1.00 41.24 A C ATOM 1454 CE1 TYRA 809 6.735 32.082 −6.590 1.00 40.55 A C ATOM 1455 CD2 TYR A 809 7.09830.587 −8.895 1.00 41.55 A C ATOM 1456 CE2 TYR A 809 7.905 30.356 −7.7881.00 40.97 A C ATOM 1457 CZ TYR A 809 7.724 31.113 −6.641 1.00 41.56 A CATOM 1458 OH TYR A 809 8.573 30.935 −5.569 1.00 41.77 A O ATOM 1459 CTYR A 809 5.052 33.353 −12.205 1.00 47.93 A C ATOM 1460 O TYR A 8093.816 33.310 −12.254 1.00 47.87 A O ATOM 1461 N ILE A 810 5.811 33.630−13.265 1.00 49.68 A N ATOM 1462 CA ILE A 810 5.239 33.837 −14.591 1.0051.31 A C ATOM 1463 CB ILE A 810 6.240 34.542 −15.556 1.00 50.90 A CATOM 1464 CG2 ILE A 810 5.575 34.796 −16.911 1.00 50.67 A C ATOM 1465CG1 ILE A 810 6.733 35.863 −14.948 1.00 49.67 A C ATOM 1466 CD1 ILE A810 5.648 36.910 −14.727 1.00 50.14 A C ATOM 1467 C ILE A 810 4.96532.428 −15.090 1.00 53.20 A C ATOM 1468 O ILE A 810 5.675 31.496 −14.7121.00 53.01 A O ATOM 1469 N VAL A 811 3.943 32.267 −15.925 1.00 55.80 A NATOM 1470 CA VAL A 811 3.589 30.941 −16.421 1.00 58.00 A C ATOM 1471 CBVAL A 811 2.107 30.854 −16.838 1.00 57.90 A C ATOM 1472 CG1 VAL A 8111.757 29.406 −17.135 1.00 57.27 A C ATOM 1473 CG2 VAL A 811 1.206 31.416−15.742 1.00 57.65 A C ATOM 1474 C VAL A 811 4.424 30.509 −17.608 1.0059.84 A C ATOM 1475 O VAL A 811 4.745 31.318 −18.488 1.00 59.79 A O ATOM1476 N LYS A 812 4.750 29.219 −17.626 1.00 61.92 A N ATOM 1477 CA LYS A812 5.556 26.618 −18.684 1.00 64.39 A C ATOM 1478 CB LYS A 812 6.68027.774 −18.068 1.00 64.37 A C ATOM 1479 CG LYS A 812 8.053 27.933−18.717 1.00 65.27 A C ATOM 1480 CD LYS A 812 8.109 27.421 −20.153 1.0065.52 A C ATOM 1481 CE LYS A 812 9.523 27.567 −20.731 1.00 65.92 A CATOM 1482 NZ LYS A 812 9.622 27.067 −22.138 1.00 66.18 A N ATOM 1483 CLYS A 812 4.681 27.722 −19.560 1.00 65.99 A C ATOM 1484 O LYS A 8125.193 26.963 −20.383 1.00 66.62 A O ATOM 1485 N GLY A 813 3.364 27.802−19.372 1.00 67.59 A N ATOM 1486 CA GLY A 813 2.451 26.984 −20.162 1.0068.75 A C ATOM 1487 C GLY A 813 1.173 26.586 −19.436 1.00 69.34 A C ATOM1488 O GLY A 813 0.350 25.824 −19.961 1.00 69.57 A O ATOM 1489 N ALA A815 4.920 25.771 −16.664 1.00 47.05 A N ATOM 1490 CA ALA A 815 4.85925.737 −15.208 1.00 46.22 A C ATOM 1491 CB ALA A 815 6.033 24.927−14.649 1.00 44.49 A C ATOM 1492 C ALA A 815 4.867 27.150 −14.619 1.0046.57 A C ATOM 1493 O ALA A 815 4.404 28.114 −15.255 1.00 46.62 A O ATOM1494 N ARG A 816 5.402 27.259 −13.403 1.00 46.06 A N ATOM 1495 CA ARG A816 5.481 28.524 −12.686 1.00 44.06 A C ATOM 1496 CB ARG A 816 4.56428.460 −11.471 1.00 44.35 A C ATOM 1497 CG ARG A 816 3.120 28.148−11.803 1.00 44.43 A C ATOM 1498 CD ARG A 816 2.407 29.380 −12.326 1.0046.99 A C ATOM 1499 NE ARG A 816 1.056 29.067 −12.776 1.00 48.19 A NATOM 1500 CZ ARG A 816 0.108 29.976 −12.978 1.00 49.22 A C ATOM 1501 NH1ARG A 816 0.364 31.266 −12.768 1.00 48.00 A N ATOM 1502 NH2 ARG A 816−1.100 29.591 −13.384 1.00 49.75 A N ATOM 1503 C ARG A 816 6.920 28.772−12.242 1.00 43.22 A C ATOM 1504 O ARG A 816 7.482 27.981 −11.483 1.0042.87 A O ATOM 1505 N LEU A 817 7.507 29.872 −12.711 1.00 42.48 A N ATOM1506 CA LEU A 817 8.887 30.213 −12.373 1.00 41.35 A C ATOM 1507 CB LEU A817 9.788 29.978 −13.586 1.00 40.61 A C ATOM 1508 CG LEU A 817 9.79628.614 −14.284 1.00 40.08 A C ATOM 1509 CD1 LEU A 817 10.894 28.607−15.357 1.00 39.23 A C ATOM 1510 CD2 LEU A 817 10.050 27.504 −13.2731.00 40.83 A C ATOM 1511 C LEU A 817 9.062 31.669 −11.905 1.00 42.22 A CATOM 1512 O LEU A 817 8.431 32.588 −12.443 1.00 43.26 A O ATOM 1513 NPRO A 818 9.927 31.898 −10.896 1.00 41.77 A N ATOM 1514 CD PRO A 81810.786 30.919 −10.198 1.00 41.58 A C ATOM 1515 CA PRO A 818 10.16733.249 −10.385 1.00 40.86 A C ATOM 1516 CB PRO A 818 10.845 32.983−9.050 1.00 40.11 A C ATOM 1517 CG PRO A 818 11.711 31.803 −9.377 1.0040.45 A C ATOM 1518 C PRO A 818 11.103 33.906 −11.381 1.00 40.85 A CATOM 1519 O PRO A 818 12.308 33.994 −11.145 1.00 42.26 A O ATOM 1520 NVAL A 819 10.551 34.363 −12.498 1.00 40.30 A N ATOM 1521 CA VAL A 81911.369 34.958 −13.548 1.00 39.24 A C ATOM 1522 CB VAL A 819 10.50635.417 −14.736 1.00 39.81 A C ATOM 1523 CG1 VAL A 819 11.415 35.814−15.915 1.00 38.99 A C ATOM 1524 CG2 VAL A 819 9.554 34.303 −15.138 1.0038.68 A C ATOM 1525 C VAL A 819 12.293 36.106 −13.169 1.00 38.75 A CATOM 1526 O VAL A 819 13.3963 36.193 −13.698 1.00 40.19 A O ATOM 1527 NLYS A 820 11.865 36.994 −12.275 1.00 38.33 A N ATOM 1528 CA LYS A 82012.718 38.123 −11.893 1.00 36.81 A C ATOM 1529 CB LYS A 820 11.89839.173 −11.148 1.00 35.36 A C ATOM 1530 CG LYS A 820 10.915 39.904−12.036 1.00 34.95 A C ATOM 1531 CD LYS A 820 10.074 40.898 −11.257 1.0036.22 A C ATOM 1532 CE LYS A 820 9.275 41.793 −12.203 1.00 37.60 A CATOM 1533 NZ LYS A 820 8.466 42.851 −11.519 1.00 38.11 A N ATOM 1534 CLYS A 820 13.942 37.728 −11.060 1.00 37.42 A C ATOM 1535 O LYS A 82014.803 38.568 −10.777 1.00 38.46 A O ATOM 1536 N TRP A 821 14.027 36.453−10.680 1.00 37.35 A N ATOM 1537 CA TRP A 821 15.151 35.942 −9.887 1.0037.18 A C ATOM 1538 CB TRP A 821 14.636 35.116 −8.690 1.00 34.50 A CATOM 1539 CG TRP A 821 14.216 35.951 −7.510 1.00 30.89 A C ATOM 1540 CD2TRP A 821 12.960 36.626 −7.330 1.00 29.37 A C ATOM 1541 CE2 TRP A 82113.055 37.373 −6.132 1.00 28.80 A C ATOM 1542 CE3 TRP A 821 11.76636.677 −8.067 1.00 28.13 A C ATOM 1543 CD1 TRP A 821 14.991 36.297−6.444 1.00 29.50 A C ATOM 1544 NE1 TRP A 821 14.304 37.154 −5.614 1.0028.41 A N ATOM 1545 CZ2 TRP A 821 12.002 38.165 −5.651 1.00 27.44 A CATOM 1546 CZ3 TRP A 821 10.712 37.471 −7.588 1.00 27.54 A C ATOM 1547CH2 TRP A 821 10.844 38.203 −6.391 1.00 28.55 A C ATOM 1548 C TRP A 82116.063 35.062 −10.740 1.00 38.39 A C ATOM 1549 O TRP A 821 17.273 34.963−10.501 1.00 38.45 A O ATOM 1550 N MET A 822 15.473 34.428 −11.744 1.0039.53 A N ATOM 1551 CA MET A 822 16.214 33.523 −12.614 1.00 40.92 A CATOM 1552 CB MET A 822 15.250 32.805 −13.555 1.00 40.44 A C ATOM 1553 CGMET A 822 14.080 32.169 −12.846 1.00 40.13 A C ATOM 1554 SD MET A 82213.276 31.016 −13.946 1.00 40.12 A S ATOM 1555 CE MET A 822 14.68929.953 −14.292 1.00 40.12 A C ATOM 1556 C MET A 822 17.303 34.196−13.435 1.00 41.09 A C ATOM 1557 O MET A 822 17.122 35.316 −13.929 1.0039.55 A O ATOM 1558 N ALA A 823 18.426 33.488 −13.576 1.00 41.48 A NATOM 1559 CA ALA A 823 19.560 33.976 −14.346 1.00 42.84 A C ATOM 1560 CBALA A 823 20.728 33.040 −14.196 1.00 42.51 A C ATOM 1561 C ALA A 82319.114 34.022 −15.800 1.00 44.58 A C ATOM 1562 O ALA A 823 18.021 33.553−16.128 1.00 46.00 A O ATOM 1563 N PRO A 824 19.944 34.595 −16.694 1.0045.37 A N ATOM 1564 CD PRO A 824 21.291 35.174 −16.516 1.00 44.61 A CATOM 1565 CA PRO A 824 19.533 34.650 −18.099 1.00 45.02 A C ATOM 1566 CBPRO A 824 20.524 35.638 −18.701 1.00 44.82 A C ATOM 1567 CG PRO A 82421.780 35.342 −17.944 1.00 43.90 A C ATOM 1568 C PRO A 824 19.672 33.251−18.671 1.00 45.28 A C ATOM 1569 O PRO A 824 18.824 32.785 −19.419 1.0046.71 A O ATOM 1570 N GLU A 825 20.745 32.580 −18.278 1.00 45.14 A NATOM 1571 CA GLU A 825 21.017 31.232 −18.726 1.00 45.11 A C ATOM 1572 CBGLU A 825 22.281 30.702 −18.036 1.00 45.92 A C ATOM 1573 CG GLU A 82522.074 30.353 −16.559 1.00 47.24 A C ATOM 1574 CD GLU A 825 23.30730.602 −15.702 1.00 48.26 A C ATOM 1575 OE1 GLU A 825 23.659 31.789−15.495 1.00 47.23 A O ATOM 1576 OE2 GLU A 825 23.923 29.609 −15.2341.00 49.60 A O ATOM 1577 C GLU A 825 19.830 30.330 −18.393 1.00 45.16 AC ATOM 1578 O GLU A 825 19.592 29.345 −19.090 1.00 46.79 A O ATOM 1579 NSER A 826 19.086 30.657 −17.338 1.00 44.06 A N ATOM 1580 CA SER A 82617.934 29.837 −16.943 1.00 44.12 A C ATOM 1581 CB SER A 826 17.69829.925 −15.434 1.00 42.91 A C ATOM 1582 OG SER A 826 18.753 29.326−14.717 1.00 44.46 A O ATOM 1583 C SER A 826 16.638 30.214 −17.658 1.0044.60 A C ATOM 1584 O SER A 826 15.805 29.351 −17.955 1.00 44.60 A OATOM 1585 N ILE A 827 16.455 31.502 −17.915 1.00 44.67 A N ATOM 1586 CAILE A 827 15.247 31.954 −18.588 1.00 46.62 A C ATOM 1587 CB ILE A 82715.121 33.491 −18.531 1.00 47.35 A C ATOM 1588 CG2 ILE A 827 13.72833.917 −19.007 1.00 45.99 A C ATOM 1589 CG1 ILE A 827 15.400 33.989−17.107 1.00 47.61 A C ATOM 1590 CD1 ILE A 827 15.586 35.509 −17.0081.00 47.72 A C ATOM 1591 C ILE A 827 15.282 31.543 −20.061 1.00 46.90 AC ATOM 1592 O ILE A 827 14.308 31.020 −20.607 1.00 47.05 A O ATOM 1593 NPHE A 828 16.435 31.764 −20.679 1.00 47.41 A N ATOM 1594 CA PHE A 82816.653 31.487 −22.093 1.00 47.91 A C ATOM 1595 CB PHE A 828 17.75732.406 −22.597 1.00 48.29 A C ATOM 1596 CG PHE A 828 17.500 33.848−22.325 1.00 47.93 A C ATOM 1597 CD1 PHE A 828 16.511 34.531 −23.0211.00 49.26 A C ATOM 1598 CD2 PHE A 828 18.226 34.520 −21.358 1.00 47.72A C ATOM 1599 CE1 PHE A 828 16.251 35.872 −22.753 1.00 50.35 A C ATOM1600 CE2 PHE A 828 17.977 35.850 −21.081 1.00 49.48 A C ATOM 1601 CZ PHEA 828 16.985 36.534 −21.781 1.00 49.28 A C ATOM 1602 C PHE A 828 16.98830.060 −22.506 1.00 48.04 A C ATOM 1603 O PHE A 828 16.429 29.558−23.482 1.00 47.41 A O ATOM 1604 N ASP A 829 17.903 29.425 −21.773 1.0049.17 A N ATOM 1605 CA ASP A 829 18.361 28.065 −22.081 1.00 50.44 A CATOM 1606 CB ASP A 829 19.899 28.040 −22.127 1.00 51.80 A C ATOM 1607 CGASP A 829 20.488 29.171 −22.976 1.00 53.82 A C ATOM 1608 OD1 ASP A 82919.964 29.430 −24.089 1.00 53.65 A O ATOM 1609 OD2 ASP A 829 21.48929.790 −22.538 1.00 53.72 A O ATOM 1610 C ASP A 829 17.888 26.950−21.135 1.00 50.70 A C ATOM 1611 O ASP A 829 18.333 25.805 −21.254 1.0051.27 A O ATOM 1612 N CYS A 830 16.991 27.264 −20.206 1.00 51.18 A NATOM 1613 CA CYS A 830 16.521 26.257 −19.253 1.00 51.26 A C ATOM 1614 CBCYS A 830 15.559 25.286 −19.939 1.00 50.99 A C ATOM 1615 SG CYS A 83014.034 26.085 −20.528 1.00 53.22 A S ATOM 1616 C CYS A 830 17.737 25.509−18.704 1.00 51.01 A C ATOM 1617 O CYS A 830 17.956 24.335 −19.002 1.0051.56 A O ATOM 1618 N VAL A 831 18.534 26.215 −17.911 1.00 50.46 A NATOM 1619 CA VAL A 831 19.739 25.652 −17.324 1.00 50.82 A C ATOM 1620 CBVAL A 831 20.975 26.047 −18.155 1.00 52.43 A C ATOM 1621 CG1 VAL A 83122.256 25.632 −17.438 1.00 53.04 A C ATOM 1622 CG2 VAL A 831 20.88825.390 −19.531 1.00 53.33 A C ATOM 1623 C VAL A 831 19.902 26.144−15.889 1.00 50.25 A C ATOM 1624 O VAL A 831 19.969 27.348 −15.630 1.0049.69 A O ATOM 1625 N TYR A 832 19.971 25.194 −14.963 1.00 49.59 A NATOM 1626 CA TYR A 832 20.088 25.498 −13.549 1.00 48.73 A C ATOM 1627 CBTYR A 832 18.849 25.012 −12.822 1.00 50.01 A C ATOM 1628 CG TYR A 83217.577 25.649 −13.303 1.00 50.90 A C ATOM 1629 CD1 TYR A 832 17.14925.488 −14.614 1.00 51.52 A C ATOM 1630 CE1 TYR A 832 15.948 26.042−15.048 1.00 53.03 A C ATOM 1631 CD2 TYR A 832 16.777 26.386 −12.4301.00 52.51 A C ATOM 1632 CE2 TYR A 832 15.572 26.942 −12.848 1.00 53.68A C ATOM 1633 CZ TYR A 832 15.162 26.764 −14.158 1.00 53.12 A C ATOM1634 OH TYR A 832 13.952 27.280 −14.559 1.00 54.35 A O ATOM 1635 C TYR A832 21.306 24.864 −12.914 1.00 48.22 A C ATOM 1636 O TYR A 832 21.31723.669 −12.597 1.00 48.01 A O ATOM 1637 N THR A 833 22.318 25.693 12.7121.00 46.77 A N ATOM 1638 CA THR A 833 23.579 25.284 −12.113 1.00 45.84 AC ATOM 1639 CB THR A 833 24.729 25.609 −13.074 1.00 46.27 A C ATOM 1640OG1 THR A 833 25.479 26.732 −12.583 1.00 47.62 A O ATOM 1641 CG2 THR A833 24.156 25.968 −14.447 1.00 46.01 A C ATOM 1642 C THR A 833 23.75626.073 −10.817 1.00 44.74 A C ATOM 1643 O THR A 833 22.898 26.875−10.457 1.00 44.34 A O ATOM 1644 N VAL A 834 24.859 25.848 −10.113 1.0044.12 A N ATOM 1645 CA VAL A 834 25.108 26.585 −8.878 1.00 43.23 A CATOM 1646 CB VAL A 834 26.343 26.007 −8.109 1.00 41.84 A C ATOM 1647 CG1VAL A 834 26.759 26.928 −6.980 1.00 41.68 A C ATOM 1648 CG2 VAL A 83425.998 24.670 −7.532 1.00 40.77 A C ATOM 1649 C VAL A 834 25.348 28.066−9.214 1.00 43.25 A C ATOM 1650 O VAL A 834 25.020 28.963 −8.423 1.0042.09 A O ATOM 1651 N GLN A 835 25.909 28.314 −10.399 1.00 43.44 A NATOM 1652 CA GLN A 835 26.204 29.676 −10.833 1.00 43.30 A C ATOM 1653 CBGLN A 835 27.234 29.662 −11.959 1.00 44.84 A C ATOM 1654 CG GLN A 83528.563 29.049 −11.548 1.00 47.79 A C ATOM 1655 CD GLN A 835 28.72827.617 −12.048 1.00 51.70 A C ATOM 1656 OE1 GLN A 835 28.957 27.374−13.251 1.00 50.76 A O ATOM 1657 NE2 GLN A 835 28.603 26.653 −11.1251.00 54.44 A N ATOM 1658 C GLN A 835 24.939 30.393 −11.274 1.00 42.24 AC ATOM 1659 O GLN A 835 24.959 31.592 −11.588 1.00 41.50 A O ATOM 1660 NSER A 836 23.840 29.643 −11.296 1.00 40.57 A N ATOM 1661 CA SER A 83622.543 30.192 −11.646 1.00 39.60 A C ATOM 1662 CB SER A 836 21.68329.128 −12.287 1.00 41.57 A C ATOM 1663 OG SER A 836 22.483 27.997−12.546 1.00 46.23 A O ATOM 1664 C SER A 836 21.933 30.588 −10.319 1.0038.43 A C ATOM 1665 O SER A 836 21.189 31.575 −10.228 1.00 37.93 A OATOM 1666 N ASP A 837 22.254 29.812 −9.283 1.00 37.17 A N ATOM 1667 CAASP A 837 21.743 30.097 −7.946 1.00 35.99 A C ATOM 1668 CB ASP A 83721.866 28.875 −7.050 1.00 32.58 A C ATOM 1669 CG ASP A 837 20.810 27.852−7.381 1.00 32.59 A C ATOM 1670 OD1 ASP A 837 19.943 28.180 −8.230 1.0031.27 A O ATOM 1671 OD2 ASP A 837 20.842 26.739 −6.810 1.00 34.25 A OATOM 1672 C ASP A 837 22.454 31.280 −7.329 1.00 36.00 A C ATOM 1673 OASP A 837 21.859 32.040 −6.551 1.00 37.62 A O ATOM 1674 N VAL A 83823.725 31.444 −7.681 1.00 34.50 A N ATOM 1675 CA VAL A 838 24.476 32.569−7.177 1.00 32.49 A C ATOM 1676 CB VAL A 838 25.900 32.533 −7.655 1.0031.06 A C ATOM 1677 CG1 VAL A 838 26.601 33.788 −7.213 1.00 32.20 A CATOM 1678 CG2 VAL A 838 26.587 31.316 −7.095 1.00 31.15 A C ATOM 1679 CVAL A 838 23.811 33.823 −7.722 1.00 32.52 A C ATOM 1680 O VAL A 83823.615 34.797 −6.995 1.00 33.25 A O ATOM 1681 N TRP A 839 23.459 33.794−9.004 1.00 32.42 A N ATOM 1682 CA TRP A 839 22.804 34.939 −9.628 1.0032.61 A C ATOM 1683 CB TRP A 839 22.337 34.616 −11.048 1.00 34.46 A CATOM 1684 CG TRP A 839 21.456 35.713 −11.639 1.00 37.76 A C ATOM 1685CD2 TRP A 839 21.823 36.644 −12.673 1.00 38.29 A C ATOM 1686 CE2 TRP A839 20.711 37.485 −12.893 1.00 38.36 A C ATOM 1687 CE3 TRP A 839 22.98636.846 −13.431 1.00 38.11 A C ATOM 1688 CD1 TRP A 839 20.162 36.029−11.283 1.00 36.56 A C ATOM 1689 NE1 TRP A 839 19.714 37.091 −12.0341.00 36.61 A N ATOM 1690 CZ2 TRP A 839 20.731 38.515 −13.851 1.00 40.38A C ATOM 1691 CZ3 TRP A 839 23.003 37.869 −14.377 1.00 38.58 A C ATOM1692 CH2 TRP A 839 21.884 38.687 −14.579 1.00 39.46 A C ATOM 1693 C TRPA 839 21.586 35.356 −8.831 1.00 31.93 A C ATOM 1694 O TRP A 839 21.42136.526 −8.485 1.00 31.69 A O ATOM 1695 N SER A 840 20.701 34.402 −8.5731.00 31.14 A N ATOM 1696 CA SER A 840 19.504 34.739 −7.828 1.00 29.25 AC ATOM 1697 CB SER A 840 18.643 33.499 −7.639 1.00 28.58 A C ATOM 1698OG SER A 840 17.997 33.182 −8.861 1.00 25.79 A O ATOM 1699 C SER A 84019.943 35.314 −6.494 1.00 27.95 A C ATOM 1700 O SER A 840 19.485 36.381−6.071 1.00 27.37 A O ATOM 1701 N TYR A 841 20.874 34.618 −5.858 1.0026.46 A N ATOM 1702 CA TYR A 841 21.366 35.063 −4.569 1.00 25.43 A CATOM 1703 CB TYR A 841 22.659 34.333 −4.196 1.00 23.03 A C ATOM 1704 CGTYR A 841 23.205 34.835 −2.899 1.00 21.12 A C ATOM 1705 CD1 TYR A 84122.571 34.533 −1.699 1.00 18.77 A C ATOM 1706 CE1 TYR A 841 23.02435.055 −0.505 1.00 17.12 A C ATOM 1707 CD2 TYR A 841 24.314 35.682−2.870 1.00 21.23 A C ATOM 1708 CE2 TYR A 841 24.778 36.216 −1.669 1.0019.31 A C ATOM 1709 CZ TYR A 841 24.126 35.884 −0.499 1.00 18.51 A CATOM 1710 OH TYR A 841 24.633 36.314 0.692 1.00 20.49 A O ATOM 1711 CTYR A 841 21.610 36.565 −4.644 1.00 25.70 A C ATOM 1712 O TYR A 84121.177 37.316 −3.788 1.00 27.50 A O ATOM 1713 N GLY A 842 22.306 37.012−5.672 1.00 25.89 A N ATOM 1714 CA GLY A 842 22.530 38.432 −5.779 1.0027.08 A C ATOM 1715 C GLY A 842 21.186 39.143 −5.714 1.00 28.76 A C ATOM1716 O GLY A 842 20.990 40.059 −4.909 1.00 29.63 A O ATOM 1717 N ILE A843 20.248 38.723 −6.559 1.00 29.17 A N ATOM 1718 CA ILE A 843 18.92339.341 −6.571 1.00 29.04 A C ATOM 1719 CB ILE A 843 17.922 38.519 −7.4241.00 29.83 A C ATOM 1720 CG2 ILE A 843 16.558 39.213 −7.435 1.00 29.22 AC ATOM 1721 CG1 ILE A 843 18.473 38.346 −8.844 1.00 30.14 A C ATOM 1722CD1 ILE A 843 18.849 39.681 −9.546 1.00 30.86 A C ATOM 1723 C ILE A 84318.384 39.413 −5.147 1.00 27.54 A C ATOM 1724 O ILE A 843 17.593 40.303−4.814 1.00 27.05 A O ATOM 1725 N LEU A 844 18.823 38.464 −4.319 1.0025.77 A N ATOM 1726 CA LEU A 844 18.404 38.379 −2.925 1.00 23.95 A CATOM 1727 CB LEU A 844 18.823 37.038 −2.339 1.00 22.60 A C ATOM 1728 CGLEU A 844 18.007 36.527 −1.161 1.00 23.96 A C ATOM 1729 CD1 LEU A 84418.588 35.181 −0.679 1.00 22.98 A C ATOM 1730 CD2 LEU A 844 18.00038.562 −0.055 1.00 22.24 A C ATOM 1731 C LEU A 844 19.042 39.520 −2.1381.00 23.82 A C ATOM 1732 O LEU A 844 18.346 40.260 −1.438 1.00 24.35 A OATOM 1733 N LEU A 845 20.362 39.667 −2.253 1.00 23.97 A N ATOM 1734 CALEU A 845 21.068 40.747 −1.563 1.00 24.96 A C ATOM 1735 CB LEU A 84522.493 40.912 −2.092 1.00 24.83 A C ATOM 1736 CG LEU A 845 23.617 40.104−1.455 1.00 26.19 A C ATOM 1737 CD1 LEU A 845 24.951 40.580 −2.047 1.0025.66 A C ATOM 1738 CD2 LEU A 845 23.587 40.280 0.064 1.00 25.43 A CATOM 1739 C LEU A 845 20.331 42.044 −1.825 1.00 25.10 A C ATOM 1740 OLEU A 845 20.213 42.886 −0.943 1.00 26.26 A O ATOM 1741 N TRP A 84619.836 42.189 −3.047 1.00 25.92 A N ATOM 1742 CA TRP A 846 19.111 43.391−3.429 1.00 27.20 A C ATOM 1743 CB TRP A 846 18.690 43.303 −4.889 1.0028.10 A C ATOM 1744 CG TRP A 846 18.405 44.618 −5.427 1.00 29.35 A CATOM 1745 CD2 TRP A 846 17.128 45.246 −5.488 1.00 30.68 A C ATOM 1746CE2 TRP A 846 17.328 46.557 −5.968 1.00 31.20 A C ATOM 1747 CE3 TRP A846 15.830 44.827 −5.182 1.00 31.98 A C ATOM 1748 CD1 TRP A 846 19.31045.532 −5.864 1.00 30.65 A C ATOM 1749 NE1 TRP A 846 18.672 46.712−6.190 1.00 31.91 A N ATOM 1750 CZ2 TRP A 846 16.278 47.455 −6.151 1.0031.91 A C ATOM 1751 CZ3 TRP A 846 14.781 45.722 −5.365 1.00 34.23 A CATOM 1752 CH2 TRP A 846 15.015 47.023 −5.845 1.00 32.94 A C ATOM 1753 CTRP A 846 17.878 43.598 −2.540 1.00 28.07 A C ATOM 1754 O TRP A 84617.723 44.662 −1.923 1.00 27.24 A O ATOM 1755 N GLU A 847 17.015 42.580−2.472 1.00 27.74 A N ATOM 1756 CA GLU A 847 15.815 42.634 −1.642 1.0028.78 A C ATOM 1757 CB GLU A 847 15.130 41.273 −1.579 1.00 28.44 A CATOM 1758 CG GLU A 847 14.909 40.591 −2.895 1.00 28.83 A C ATOM 1759 CDGLU A 847 14.358 39.191 −2.709 1.00 30.52 A C ATOM 1760 OE1 GLU A 84713.155 39.058 −2.390 1.00 29.79 A O ATOM 1761 OE2 GLU A 847 15.14138.219 −2.871 1.00 32.84 A O ATOM 1762 C GLU A 847 16.215 43.000 −0.2171.00 30.16 A C ATOM 1763 O GLU A 847 15.569 43.817 0.438 1.00 32.31 A OATOM 1764 N ILE A 848 17.273 42.365 0.269 1.00 30.31 A N ATOM 1765 CAILE A 848 17.754 42.630 1.616 1.00 31.54 A C ATOM 1766 CB ILE A 84819.079 41.854 1.933 1.00 30.65 A C ATOM 1767 CG2 ILE A 848 19.774 42.4693.137 1.00 29.78 A C ATOM 1768 CG1 ILE A 848 18.776 40.384 2.219 1.0029.15 A C ATOM 1769 CD1 ILE A 848 19.992 39.575 2.625 1.00 29.49 A CATOM 1770 C ILE A 848 18.011 44.109 1.868 1.00 32.93 A C ATOM 1771 O ILEA 848 17.360 44.719 2.718 1.00 33.92 A O ATOM 1772 N PHE A 849 18.95144.691 1.128 1.00 33.60 A N ATOM 1773 CA PHE A 849 19.299 46.087 1.3601.00 34.71 A C ATOM 1774 CB PHE A 849 20.688 46.353 0.800 1.00 34.23 A CATOM 1775 CG PHE A 849 21.771 45.709 1.605 1.00 35.50 A C ATOM 1776 CD1PHE A 849 22.219 46.304 2.787 1.00 35.86 A C ATOM 1777 CD2 PHE A 84922.301 44.478 1.226 1.00 36.01 A C ATOM 1778 CE1 PHE A 849 23.176 45.6833.582 1.00 35.75 A C ATOM 1779 CE2 PHE A 849 23.264 43.843 2.013 1.0036.59 A C ATOM 1780 CZ PHE A 849 23.702 44.446 3.196 1.00 37.14 A C ATOM1781 C PHE A 849 18.311 47.137 0.895 1.00 34.75 A C ATOM 1782 O PHE A849 18.411 48.310 1.277 1.00 35.16 A O ATOM 1783 N SER A 850 17.35746.719 0.075 1.00 35.12 A N ATOM 1784 CA SER A 850 16.342 47.633 −0.4161.00 35.03 A C ATOM 1785 CB SER A 850 15.828 47.155 −1.769 1.00 32.96 AC ATOM 1786 OG SER A 850 15.498 45.783 −1.698 1.00 33.19 A O ATOM 1787 CSER A 850 15.231 47.605 0.630 1.00 36.05 A C ATOM 1788 O SER A 85014.315 48.437 0.623 1.00 36.81 A O ATOM 1789 N LEU A 851 15.349 46.6431.542 1.00 36.02 A N ATOM 1790 CA LEU A 851 14.385 46.441 2.625 1.0035.60 A C ATOM 1791 CB LEU A 851 14.101 47.555 3.373 1.00 37.67 A C ATOM1792 CG LEU A 851 15.230 48.389. 4.197 1.00 36.08 A C ATOM 1793 CD1 LEUA 851 14.838 49.817 4.580 1.00 36.21 A C ATOM 1794 CD2 LEU A 851 15.51947.537 5.437 1.00 33.58 A C ATOM 1795 C LEU A 851 13.077 45.860 2.1191.00 34.18 A C ATOM 1796 O LEU A 851 11.966 46.137 2.502 1.00 33.48 A OATOM 1797 N GLY A 852 13.181 44.863 1.247 1.00 33.26 A N ATOM 1798 CAGLY A 852 11.991 44.215 0.739 1.00 34.41 A C ATOM 1799 C GLY A 85211.260 44.843 −0.436. 1.00 35.72 A C ATOM 1800 O GLY A 852 10.046 44.661−0.585 1.00 37.01 A O ATOM 1801 N LEU A 853 11.947 45.610 −1.269 1.0035.84 A N ATOM 1802 CA LEU A 853 11.251 46.145 −2.421 1.00 35.42 A CATOM 1803 CB LEU A 853 12.046 48.639 −3.083 1.00 35.09 A C ATOM 1804 CGLEU A 853 12.016 48.639 −2.346 1.00 36.22 A C ATOM 1805 CD1 LEU A 85312.578 49.727 −3.262 1.00 35.56 A C ATOM 1806 CD2 LEU A 853 10.58549.000 −1.933 1.00 33.65 A C ATOM 1807 C LEU A 853 11.150 44.927 −3.3331.00 36.14 A C ATOM 1808 O LEU A 853 11.779 43.902 −3.078 1.00 34.32 A OATOM 1809 N ASN A 854 10.332 45.006 −4.367 1.00 37.36 A N ATOM 1810 CAASN A 854 10.207 43.882 −5.270 1.00 39.40 A C ATOM 1811 CB ASN A 8548.778 43.822 −5.818 1.00 40.56 A C ATOM 1812 CG ASN A 854 8.611 42.810−6.944 1.00 41.40 A C ATOM 1813 OD1 ASN A 854 8.783 43.143 −8.123 1.0040.39 A O ATOM 1814 ND2 ASN A 854 8.277 41.565 −6.584 1.00 41.80 A NATOM 1815 C ASN A 854 11.228 44.153 −6.357 1.00 41.36 A C ATOM 1816 OASN A 854 11.360 45.290 −6.823 1.00 44.25 A O ATOM 1817 N PRO A 85511.973 43.123 −6.780 1.00 41.56 A N ATOM 1818 CD PRO A 855 11.706 41.682−6.636 1.00 41.17 A C ATOM 1819 CA PRO A 855 12.974 43.368 −7.827 1.0041.57 A C ATOM 1820 CB PRO A 855 13.464 41.960 −8.184 1.00 41.41 A CATOM 1821 CG PRO A 855 13.024 41.097 −7.009 1.00 40.77 A C ATOM 1822 CPRO A 855 12.354 44.068 −9.042 1.00 41.80 A C ATOM 1823 O PRO A 85511.156 43.921 −9.292 1.00 41.16 A O ATOM 1824 N TYR A 856 13.168 44.826−9.778 1.00 42.44 A N ATOM 1825 CA TYR A 856 12.702 45.509 −10.983 1.0042.53 A C ATOM 1826 CB TYR A 856 12.589 44.485 −12.122 1.00 41.46 A CATOM 1827 CG TYR A 856 13.868 43.708 −12.378 1.00 40.50 A C ATOM 1828CD1 TYR A 856 15.010 44.347 −12.860 1.00 41.18 A C ATOM 1829 CE1 TYR A856 16.213 43.653 −13.055 1.00 39.36 A C ATOM 1830 CD2 TYR A 856 13.95442.344 −12.100 1.00 40.90 A C ATOM 1831 CE2 TYR A 856 15.159 41.634−12.295 1.00 39.00 A C ATOM 1832 CZ TYR A 856 16.279 42.303 −12.769 1.0038.35 A C ATOM 1833 OH TYR A 856 17.474 41.654 −12.931 1.00 37.51 A OATOM 1834 C TYR A 856 11.340 46.179 −10.740 1.00 44.72 A C ATOM 1835 OTYR A 856 10.385 45.994 −11.525 1.00 44.34 A O ATOM 1836 N PRO A 85711.234 46.978 −9.656 1.00 45.22 A N ATOM 1837 CD PRO A 857 12.359 47.599−8.934 1.00 45.05 A C ATOM 1838 CA PRO A 857 9.979 47.662 −9.342 1.0045.77 A C ATOM 1839 CB PRO A 857 10.389 48.615 −8.207 1.00 44.86 A CATOM 1840 CG PRO A 857 11.793 48.966 −8.591 1.00 45.19 A C ATOM 1841 CPRO A 857 9.425 48.398 −10.530 1.00 47.01 A C ATOM 1842 O PRO A 85710.175 49.009 −11.284 1.00 48.01 A O ATOM 1843 N GLY A 858 8.112 48.235−10.718 1.00 48.60 A N ATOM 1844 CA GLY A 858 7.493 49.000 −11.843 1.0049.33 A C ATOM 1845 C GLY A 858 7.651 48.211 −13.121 1.00 49.93 A C ATOM1846 O GLY A 858 6.703 48.041 −13.884 1.00 49.36 A O ATOM 1847 N ILE A859 8.861 47.725 −13.362 1.00 51.82 A N ATOM 1848 CA ILE A 859 9.11649.946 −14.564 1.00 52.74 A C ATOM 1849 CB ILE A 859 10.600 46.510−14.648 1.00 51.90 A C ATOM 1850 CG2 ILE A 859 10.820 45.612 −15.8751.00 49.64 A C ATOM 1851 CG1 ILE A 859 11.490 47.757 −14.682 1.00 51.23A C ATOM 1852 CD1 ILE A 859 12.971 47.468 −14.810 1.00 52.25 A C ATOM1853 C ILE A 859 8.227 45.710 −14.573 1.00 53.47 A C ATOM 1854 O ILE A859 8.190 44.952 −13.062 1.00 54.33 A O ATOM 1855 N LEU A 860 7.49045.530 −15.661 1.00 53.92 A N ATOM 1856 CA LEU A 860 6.624 44.372−15.802 1.00 54.95 A C ATOM 1857 CB LEU A 860 5.405 44.721 −16.647 1.0054.62 A C ATOM 1858 CG LEU A 860 4.266 45.377 −15.883 1.00 54.69 A CATOM 1859 CD1 LEU A 860 3.174 45.804 −16.863 1.00 54.11 A C ATOM 1860CD2 LEU A 860 3.738 44.385 −14.842 1.00 53.39 A C ATOM 1861 C LEU A 8607.414 43.269 −16.485 1.00 55.92 A C ATOM 1862 O LEU A 860 8.288 43.551−17.315 1.00 56.56 A O ATOM 1863 N VAL A 861 7.116 42.018 −16.137 1.0056.40 A N ATOM 1864 CA VAL A 861 7.810 40.886 −16.741 1.00 56.75 A CATOM 1865 CB VAL A 861 7.794 39.648 −15.837 1.00 57.11 A C ATOM 1866 CG1VAL A 861 8.291 38.433 −16.614 1.00 57.72 A C ATOM 1867 CG2 VAL A 8618.672 39.878 −14.636 1.00 57.58 A C ATOM 1868 C VAL A 861 7.173 40.488−18.056 1.00 56.83 A C ATOM 1869 O VAL A 861 5.994 40.146 −18.096 1.0056.20 A O ATOM 1870 N ASN A 862 7.972 40.530 −19.122 1.00 58.09 A N ATOM1871 CA ASN A 862 7.532 40.157 −20.470 1.00 58.33 A C ATOM 1872 CB ASN A862 6.396 41.049 −20.926 1.00 58.00 A C ATOM 1873 CG ASN A 862 6.77542.490 −20.899 1.00 57.98 A C ATOM 1874 OD1 ASN A 862 7.904 42.851−21.243 1.00 57.83 A O ATOM 1875 ND2 ASN A 862 5.837 43.338 −20.495 1.0059.11 A N ATOM 1876 C ASN A 862 8.675 40.272 −21.477 1.00 58.22 A C ATOM1877 O ASN A 862 9.834 40.018 −21.144 1.00 59.35 A O ATOM 1878 N SER A863 8.339 40.678 −22.699 1.00 57.67 A N ATOM 1879 CA SER A 863 9.31440.820 −23.786 1.00 57.58 A C ATOM 1880 CB SER A 863 8.586 41.277−25.051 1.00 57.51 A C ATOM 1881 OG SER A 863 7.434 40.475 −25.272 1.0057.98 A O ATOM 1882 C SER A 863 10.474 41.778 −23.484 1.00 56.90 A CATOM 1883 O SER A 863 11.650 41.384 −23.503 1.00 56.18 A O ATOM 1884 NLYS A 864 10.133 43.036 −23.215 1.00 56.54 A N ATOM 1885 CA LYS A 86411.124 44.067 −22.911 1.00 55.90 A C ATOM 1886 CB LYS A 864 10.42645.406 −22.593 1.00 56.34 A C ATOM 1887 CG LYS A 864 10.335 46.411−23.754 1.00 56.79 A C ATOM 1888 CD LYS A 864 9.256 46.061 −24.784 1.0056.51 A C ATOM 1889 CE LYS A 864 9.310 47.001 −25.998 1.00 54.59 A CATOM 1890 NZ LYS A 864 8.320 46.616 −27.037 1.00 52.64 A N ATOM 1891 CLYS A 864 12.023 43.678 −21.733 1.00 54.93 A C ATOM 1892 O LYS A 86413.225 43.953 −21.737 1.00 54.82 A O ATOM 1893 N PHE A 865 11.441 43.039−20.724 1.00 53.70 A N ATOM 1894 CA PHE A 865 12.209 42.655 −19.554 1.0051.68 A C ATOM 1895 CB PHE A 865 11.328 41.959 −18.521 1.00 51.93 A CATOM 1896 CG PHE A 865 12.082 41.539 −17.290 1.00 50.94 A C ATOM 1897CD1 PHE A 865 12.417 42.471 −16.314 1.00 50.22 A C ATOM 1898 CD2 PHE A865 12.538 40.232 −17.154 1.00 49.70 A C ATOM 1899 CE1 PHE A 865 13.19742.114 −15.235 1.00 48.71 A C ATOM 1900 CE2 PHE A 865 13.319 39.867−16.082 1.00 49.27 A C ATOM 1901 CZ PHE A 865 13.650 40.812 −15.120 1.0049.95 A C ATOM 1902 C PHE A 865 13.337 41.726 −19.929 1.00 51.27 A CATOM 1903 O PHE A 865 14.509 42.032 −19.684 1.00 50.46 A O ATOM 1904 NTYR A 866 12.969 40.587 −20.518 1.00 51.20 A N ATOM 1905 CA TYR A 86613.932 39.568 −20.934 1.00 51.22 A C ATOM 1906 CB TYR A 866 13.23138.488 −21.775 1.00 50.16 A C ATOM 1907 CG TYR A 866 12.136 37.701−21.051 1.00 49.71 A C ATOM 1908 CD1 TYR A 866 10.907 37.459 −21.6691.00 49.36 A C ATOM 1909 CE1 TYR A 866 9.893 36.746. −21.035 1.00 48.45A C ATOM 1910 CD2 TYR A 866 12.328 37.195 −19.764 1.00 49.33 A C ATOM1911 CE2 TYR A 866 11.313 36.468 −19.115 1.00 49.67 A C ATOM 1912 CZ TYRA 866 10.095 36.251 −19.763 1.00 49.61 A C ATOM 1913 OH TYR A 866 9.07835.539 −19.152 1.00 48.47 A O ATOM 1914 C TYR A 866 15.081 40.216−21.722 1.00 52.28 A C ATOM 1915 O TYR A 866 16.265 39.999 −21.410 1.0051.80 A O ATOM 1916 N LYS A 867 14.738 41.021 −22.729 1.00 52.53 A NATOM 1917 CA LYS A 867 15.766 41.700 −23.506 1.00 53.19 A C ATOM 1918 CBLYS A 867 15.135 42.627 −24.549 1.00 53.72 A C ATOM 1919 CG LYS A 86714.486 41.860 −25.704 1.00 54.98 A C ATOM 1920 CD LYS A 867 13.64642.763 −26.616 1.00 55.16 A C ATOM 1921 CE LYS A 867 13.076 41.973−27.800 1.00 54.75 A C ATOM 1922 NZ LYS A 867 11.947 42.678 −28.500 1.0053.29 A N ATOM 1923 C LYS A 867 16.663 42.288 −22.550 1.00 53.62 A CATOM 1924 O LYS A 867 17.885 42.388 −22.622 1.00 54.34 A O ATOM 1925 NLEU A 868 16.066 43.240 −21.628 1.00 53.78 A N ATOM 1926 CA LEU A 86816.861 44.016 −20.679 1.00 53.49 A C ATOM 1927 CB LEU A 868 15.96844.702 −19.635 1.00 51.96 A C ATOM 1928 CG LEU A 868 15.067 45.845−20.116 1.00 51.67 A C ATOM 1929 CD1 LEU A 868 14.303 46.435 −18.9391.00 50.79 A C ATOM 1930 CD2 LEU A 868 15.909 46.921 −20.778 1.00 51.53A C ATOM 1931 C LEU A 868 17.911 43.166 −19.962 1.00 54.47 A C ATOM 1932O LEU A 868 19.113 43.457 −20.048 1.00 54.79 A O ATOM 1933 N VAL A 86917.476 42.108 −19.276 1.00 54.34 A N ATOM 1934 CA VAL A 869 18.42841.283 −18.533 1.00 54.52 A C ATOM 1935 CB VAL A 869 17.718 40.172−17.727 1.00 54.55 A C ATOM 1936 CG1 VAL A 869 16.729 40.798 −16.7461.00 53.88 A C ATOM 1937 CG2 VAL A 869 17.016 39.209 −18.663 1.00 55.04A C ATOM 1938 C VAL A 869 19.515 40.658 −19.406 1.00 54.82 A C ATOM 1939O VAL A 869 20.700 40.730 −19.058 1.00 54.33 A O ATOM 1940 N LYS A 87019.125 40.051 −20.530 1.00 54.49 A N ATOM 1941 CA LYS A 870 20.10939.444 −21.419 1.00 53.67 A C ATOM 1942 CB LYS A 870 19.446 38.771−22.625 1.00 55.07 A C ATOM 1943 CG LYS A 870 20.468 38.110 −23.576 1.0057.96 A C ATOM 1944 CD LYS A 870 19.926 37.882 −25.004 1.00 59.71 A CATOM 1945 CE LYS A 870 20.992 37.290 −25.969 1.00 59.99 A C ATOM 1946 NZLYS A 870 22.201 38.158 −26.197 1.00 57.97 A N ATOM 1947 C LYS A 87021.030 40.542 −21.925 1.00 53.11 A C ATOM 1948 O LYS A 870 22.244 40.358−22.010 1.00 53.00 A O ATOM 1949 N ASP A 871 20.447 41.691 −22.256 1.0052.58 A N ATOM 1950 CA ASP A 871 21.229 42.810 −22.762 1.00 51.95 A CATOM 1951 CB ASP A 871 20.322 43.822 −23.484 1.00 52.71 A C ATOM 1952 CGASP A 871 19.579 43.205 −24.693 1.00 54.58 A C ATOM 1953 OD1 ASP A 87120.230 42.578 −25.564 1.00 54.79 A O ATOM 1954 OD2 ASP A 871 18.33443.350 −24.783 1.00 56.24 A O ATOM 1955 C ASP A 871 22.046 43.499−21.668 1.00 51.49 A C ATOM 1956 O ASP A 871 22.471 44.633 −21.836 1.0052.44 A O ATOM 1957 N GLY A 872 22.252 42.815 −20.541 1.00 51.03 A NATOM 1958 CA GLY A 872 23.068 43.359 −19.458 1.00 48.81 A C ATOM 1959 CGLY A 872 22.494 44.211 −18.328 1.00 47.69 A C ATOM 1960 O GLY A 87223.170 44.423 −17.322 1.00 47.38 A O ATOM 1961 N TYR A 873 21.267 44.703−18.463 1.00 46.46 A N ATOM 1962 CA TYR A 873 20.677 45.545 −17.421 1.0044.77 A C ATOM 1963 CB TYR A 873 19.188 45.768 −17.703 1.00 45.43 A CATOM 1964 CG TYR A 873 18.497 46.688 −16.715 1.00 46.58 A C ATOM 1965CD1 TYR A 873 19.046 47.931 −16.390 1.00 47.68 A C ATOM 1966 CE1 TYR A873 18.399 48.813 −15.514 1.00 48.10 A C ATOM 1967 CD2 TYR A 873 17.27746.338 −16.138 1.00 46.56 A C ATOM 1968 CE2 TYR A 873 16.616 47.210−15.261 1.00 48.36 A C ATOM 1969 CZ TYR A 873 17.184 48.451 −14.953 1.0048.99 A C ATOM 1970 OH TYR A 873 16.537 49.330 −14.096 1.00 49.14 A OATOM 1971 C TYR A 873 20.833 44.997 −16.000 1.00 43.89 A C ATOM 1972 OTYR A 873 20.675 43.797 −15.764 1.00 42.83 A O ATOM 1973 N GLN A 87421.153 45.892 −15.065 1.00 42.47 A N ATOM 1974 CA GLN A 874 21.29645.554 −13.646 1.00 39.50 A C ATOM 1975 CB GLN A 874 22.759 45.571−13.227 1.00 36.77 A C ATOM 1976 CG GLN A 874 23.575 44.483 −13.858 1.0036.62 A C ATOM 1977 CD GLN A 874 24.956 44.362 −13.241 1.00 38.12 A CATOM 1978 OE1 GLN A 874 25.765 43.514 −13.652 1.00 38.18 A O ATOM 1979NE2 GLN A 874 25.240 45.210 −12.246 1.00 38.83 A N ATOM 1980 C GLN A 87420.531 46.601 −12.842 1.00 39.65 A C ATOM 1981 O GLN A 874 20.520 47.781−13.197 1.00 40.80 A O ATOM 1982 N MET A 875 19.863 46.187 −11.774 1.0039.91 A N ATOM 1983 CA MET A 875 19.128 47.160 −10.977 1.00 38.05 A CATOM 1984 CB MET A 875 18.291 46.488 −9.903 1.00 36.59 A C ATOM 1985 CGMET A 875 17.058 45.821 −10.426 1.00 35.06 A C ATOM 1986 SD MET A 87516.320 44.921 −9.071 1.00 36.61 A S ATOM 1987 CE MET A 875 17.741 43.782−8.662 1.00 34.79 A C ATOM 1988 C MET A 875 20.114 48.078 −10.309 1.0038.08 A C ATOM 1989 O MET A 875 21.250 47.685 −10.004 1.00 35.99 A OATOM 1990 N ALA A 876 19.663 49.307 −10.085 1.00 39.06 A N ATOM 1991 CAALA A 876 20.484 50.319 −9.443 1.00 40.02 A C ATOM 1992 CB ALA A 87619.737 51.645 −9.416 1.00 39.61 A C ATOM 1993 C ALA A 876 20.795 49.867−8.024 1.00 40.10 A C ATOM 1994 O ALA A 876 20.201 48.910 −7.518 1.0041.02 A O ATOM 1995 N GLN A 877 21.732 50.545 −7.383 1.00 40.19 A N ATOM1996 CA GLN A 877 22.064 50.202 −6.012 1.00 40.94 A C ATOM 1997 CB GLN A877 23.221 51.070 −5.514 1.00 40.44 A C ATOM 1998 CG GLN A 877 23.80550.612 −4.201 1.00 38.88 A C ATOM 1999 CD GLN A 877 25.003 51.443 −3.8271.00 40.07 A C ATOM 2000 OE1 GLN A 877 25.837 51.785 −4.681 1.00 36.60 AO ATOM 2001 NE2 GLN A 877 25.108 51.775 −2.543 1.00 41.58 A N ATOM 2002C GLN A 877 20.837 50.431 −5.131 1.00 40.26 A C ATOM 2003 O GLN A 87720.039 51.339 −5.391 1.00 41.16 A O ATOM 2004 N PRO A 878 20.634 49.575−4.117 1.00 39.06 A N ATOM 2005 CD PRO A 878 21.078 48.178 −3.997 1.0038.28 A C ATOM 2006 CA PRO A 878 19.462 49.817 −3.275 1.00 38.73 A CATOM 2007 CB PRO A 878 19.254 48.485 −2.566 1.00 37.56 A C ATOM 2008 CGPRO A 878 19.812 47.501 −3.537 1.00 38.22 A C ATOM 2009 C PRO A 87819.859 50.919 −2.311 1.00 40.02 A C ATOM 2010 O PRO A 878 21.049 51.224−2.162 1.00 43.09 A O ATOM 2011 N ALA A 879 18.874 51.506 −1.647 1.0040.03 A N ATOM 2012 CA ALA A 879 19.112 52.595 −0.698 1.00 38.55 A CATOM 2013 CB ALA A 879 17.759 53.093 −0.132 1.00 39.34 A C ATOM 2014 CALA A 879 20.075 52.345 0.461 1.00 36.50 A C ATOM 2015 O ALA A 87920.874 53.220 0.780 1.00 34.67 A O ATOM 2016 N PHE A 880 20.007 51.1751.093 1.00 35.90 A N ATOM 2017 CA PHE A 880 20.855 50.916 2.263 1.0036.69 A C ATOM 2018 CB PHE A 880 19.998 50.340 3.391 1.00 36.08 A C ATOM2019 CG PHE A 880 18.783 51.141 3.675 1.00 35.80 A C ATOM 2020 CD1 PHE A880 17.750 51.196 2.752 1.00 37.62 A C ATOM 2021 CD2 PHE A 880 18.69551.897 4.833 1.00 36.45 A C ATOM 2022 CE1 PHE A 880 16.635 52.006 2.9801.00 38.57 A C ATOM 2023 CE2 PHE A 880 17.603 52.703 5.074 1.00 35.87 AC ATOM 2024 CZ PHE A 880 16.566 52.760 4.144 1.00 37.72 A C ATOM 2025 CPHE A 880 22.081 50.031 2.083 1.00 36.95 A C ATOM 2026 O PHE A 88022.791 49.720 3.058 1.00 35.55 A O ATOM 2027 N ALA A 881 22.344 49.6290.848 1.00 37.70 A N ATOM 2028 CA ALA A 881 23.483 48.762 0.589 1.0038.50 A C ATOM 2029 CB ALA A 881 23.254 47.971 −0.689 1.00 39.04 A CATOM 2030 C ALA A 881 24.774 49.540 0.477 1.00 38.99 A C ATOM 2031 O ALAA 881 24.869 50.480 −0.322 1.00 39.31 A O ATOM 2032 N PRO A 882 25.78249.179 1.294 1.00 39.35 A N ATOM 2033 CD PRO A 882 25.758 48.198 2.3941.00 39.77 A C ATOM 2034 CA PRO A 882 27.075 49.877 1.232 1.00 39.44 A CATOM 2035 CB PRO A 882 27.925 49.139 2.267 1.00 38.67 A C ATOM 2036 CGPRO A 882 26.918 48.666 3.265 1.00 39.70 A C ATOM 2037 C PRO A 88227.549 49.594 −0.189 1.00 39.75 A C ATOM 2038 O PRO A 882 27.027 48.676−0.830 1.00 40.47 A O ATOM 2039 N LYS A 883 28.515 50.345 −0.701 1.0040.07 A N ATOM 2040 CA LYS A 883 28.953 50.074 −2.063 1.00 40.05 A CATOM 2041 CB LYS A 883 30.071 51.022 −2.491 1.00 40.32 A C ATOM 2042 CGLYS A 883 30.340 50.956 −3.981 1.00 40.37 A C ATOM 2043 CD LYS A 88331.172 52.132 −4.428 1.00 42.89 A C ATOM 2044 CE LYS A 883 31.240 52.228−5.940 1.00 44.13 A C ATOM 2045 NZ LYS A 883 32.135 53.346 −6.359 1.0044.31 A N ATOM 2046 C LYS A 883 29.432 48.632 −2.168 1.00 40.14 A C ATOM2047 O LYS A 883 28.884 47.845 −2.945 1.00 41.79 A O ATOM 2048 N ASN A884 30.444 48.285 −1.376 1.00 38.84 A N ATOM 2049 CA ASN A 884 30.99946.932 −1.385 1.00 36.94 A C ATOM 2050 CB ASN A 884 31.754 46.674 −0.0821.00 37.30 A C ATOM 2051 CG ASN A 884 33.180 47.201 −0.121 1.00 34.33 AC ATOM 2052 OD1 ASN A 884 33.532 48.043 −0.956 1.00 30.64 A O ATOM 2053NE2 ASN A 884 34.007 46.703 0.792 1.00 34.01 A N ATOM 2054 C ASN A 88429.937 45.863 −1.591 1.00 35.29 A C ATOM 2055 O ASN A 884 30.084 45.007−2.455 1.00 36.84 A O ATOM 2056 N ILE A 885 28.870 45.906 −0.806 1.0033.33 A N ATOM 2057 CA ILE A 885 27.807 44.925 −0.970 1.00 31.56 A CATOM 2058 CB ILE A 885 26.680 45.118 0.081 1.00 30.08 A C ATOM 2059 CG2ILE A 885 25.360 44.577 −0.448 1.00 26.71 A C ATOM 2060 CG1 ILE A 88527.067 44.400 1.376 1.00 30.16 A C ATOM 2061 CD1 ILE A 885 28.559 44.5621.750 1.00 31.47 A C ATOM 2062 C ILE A 885 27.228 45.036 −2.375 1.0031.11 A C ATOM 2063 O ILE A 885 26.948 44.025 −3.020 1.00 31.24 A O ATOM2064 N TYR A 886 27.046 46.258 −2.858 1.00 30.72 A N ATOM 2065 CA TYR A886 26.503 46.415 −4.199 1.00 30.22 A C ATOM 2066 CB TYR A 886 26.26447.876 −4.539 1.00 29.01 A C ATOM 2067 CG TYR A 886 25.609 48.047 −5.8901.00 29.11 A C ATOM 2068 CD1 TYR A 886 24.246 47.828 −6.060 1.00 28.56 AC ATOM 2069 CE1 TYR A 886 23.641 47.964 −7.318 1.00 27.53 A C ATOM 2070CD2 TYR A 886 26.539 48.406 −7.009 1.00 28.85 A C ATOM 2071 CE2 TYR A886 25.767 45.837 −8.264 1.00 28.26 A C ATOM 2072 CZ TYR A 886 24.40648.311 −8.411 1.00 27.60 A C ATOM 2073 OH TYR A 886 23.834 48.385 −9.6681.00 27.32 A O ATOM 2074 C TYR A 886 27.474 45.819 −5.212 1.00 29.96 A CATOM 2075 O TYR A 886 27.066 45.355 −6.281 1.00 30.42 A O ATOM 2076 NSER A 887 28.762 45.838 −4.886 1.00 28.70 A N ATOM 2077 CA SER A 88729.738 45.271 −5.791 1.00 28.83 A C ATOM 2078 CB SER A 887 31.152 45.447−5.256 1.00 28.50 A C ATOM 2079 OG SER A 887 31.705 46.665 −5.709 1.0030.47 A O ATOM 2080 C SER A 887 29.418 43.798 −5.878 1.00 30.04 A C ATOM2081 O SER A 887 29.723 43.132 −6.866 1.00 31.26 A O ATOM 2082 N ILE A888 28.787 43.288 −4.830 1.00 30.43 A N ATOM 2083 CA ILE A 888 38.43141.882 −4.791 1.00 29.38 A C ATOM 2084 CB ILE A 888 28.158 41.410 −3.3311.00 28.67 A C ATOM 2085 CG2 ILE A 888 27.778 39.941 −3.327 1.00 29.47 AC ATOM 2086 CG1 ILE A 888 29.412 41.624 −2.475 1.00 28.02 A C ATOM 2087CD1 ILE A 888 29.475 40.765 −1.232 1.00 28.31 A C ATOM 2088 C ILE A 88827.229 41.540 −5.672 1.00 28.17 A C ATOM 2089 O ILE A 888 27.268 40.566−6.419 1.00 30.39 A O ATOM 2090 N MET A 889 26.162 42.138 −5.603 1.0026.74 A N ATOM 2091 CA MET A 889 25.013 41.983 −6.426 1.00 27.93 A CATOM 2092 CB MET A 889 23.919 43.034 −6.286 1.00 26.87 A C ATOM 2093 CGMET A 889 23.202 42.977 −4.959 1.00 26.99 A C ATOM 2094 SD MET A 88922.300 44.489 −4.574 1.00 25.48 A S ATOM 2095 CE MET A 889 23.425 45.274−3.406 1.00 25.48 A C ATOM 2096 C MET A 889 25.507 41.940 −7.851 1.0029.91 A C ATOM 2097 O MET A 889 25.178 41.027 −8.621 1.00 31.75 A O ATOM2098 N GLN A 890 26.336 42.925 −8.176 1.00 30.71 A N ATOM 2099 CA GLN A890 26.898 43.058 −9.503 1.00 31.31 A C ATOM 2100 CB GLN A 890 27.86144.236 −9.522 1.00 32.84 A C ATOM 2101 CG GLN A 890 27.196 45.516 −9.0591.00 32.34 A C ATOM 2102 CD GLN A 890 27.700 46.713 −9.802 1.00 32.17 AC ATOM 2103 OE1 GLN A 890 28.833 47.151 −9.594 1.00 32.52 A O ATOM 2104NE2 GLN A 890 26.864 47.254 −10.694 1.00 32.54 A N ATOM 2105 C GLN A 89027.596 41.794 −9.959 1.00 32.22 A C ATOM 2106 O GLN A 890 27.170 41.191−10.947 1.00 33.98 A O ATOM 2107 N ALA A 891 28.651 41.395 −9.242 1.0031.70 A N ATOM 2108 CA ALA A 891 29.424 40.182 −9.551 1.00 31.40 A CATOM 2109 CB ALA A 891 30.423 39.894 −8.429 1.00 30.54 A C ATOM 2110 CALA A 891 28.500 38.977 −9.724 1.00 32.62 A C ATOM 2111 O ALA A 89128.688 38.136 −10.620 1.00 32.37 A O ATOM 2112 N CYS A 892 27.502 38.880−8.852 1.00 32.29 A N ATOM 2113 CA CYS A 892 26.564 37.775 −8.951 1.0031.85 A C ATOM 2114 CB CYS A 892 25.541 37.836 −7.823 1.00 28.88 A CATOM 2115 SG CYS A 892 26.292 37.430 −6.235 1.00 23.34 A S ATOM 2116 CCYS A 892 25.856 37.853 −10.282 1.00 33.34 A C ATOM 2117 O CYS A 89225.528 36.826 −10.882 1.00 35.16 A O ATOM 2118 N TRP A 893 25.666 39.080−10.760 1.00 33.94 A N ATOM 2119 CA TRP A 893 24.949 39.323 −12.004 1.0033.40 A C ATOM 2120 CB TRP A 893 24.177 40.642 −11.865 1.00 33.62 A CATOM 2121 CG TRP A 893 23.203 40.625 −10.682 1.00 32.02 A C ATOM 2122CD2 TRP A 893 22.658 41.759 −9.995 1.00 30.98 A C ATOM 2123 CE2 TRP A893 21.748 41.268 −9.027 1.00 30.36 A C ATOM 2124 CE3 TRP A 893 22.84543.139 −10.105 1.00 29.71 A C ATOM 2125 CD1 TRP A 893 22.621 39.524−10.112 1.00 30.99 A C ATOM 2126 NE1 TRP A 893 21.745 39.903 −9.119 1.0029.45 A N ATOM 2127 CZ2 TRP A 893 21.031 42.107 −8.182 1.00 31.14 A CATOM 2128 CZ3 TRP A 893 22.131 43.976 −9.262 1.00 29.35 A C ATOM 2129CH2 TRP A 893 21.235 43.460 −8.314 1.00 30.37 A C ATOM 2130 C TRP A 89325.750 39.293 −13.305 1.00 32.80 A C ATOM 2131 O TRP A 893 25.241 39.670−14.366 1.00 33.26 A O ATOM 2132 N ALA A 894 26.992 38.833 −13.240 1.0031.92 A N ATOM 2133 CA ALA A 894 27.809 38.744 −14.447 1.00 32.67 A CATOM 2134 CB ALA A 894 29.161 38.152 −14.112 1.00 32.52 A C ATOM 2135 CALA A 894 27.098 37.848 −15.455 1.00 34.21 A C ATOM 2136 O ALA A 89426.756 36.703 −15.137 1.00 34.47 A O ATOM 2137 N LEU A 895 26.879 38.353−16.668 1.00 37.08 A N ATOM 2138 CA LEU A 895 26.198 35.573 −17.715 1.0037.52 A C ATOM 2139 CB LEU A 895 26.194 38.327 −19.049 1.00 37.41 A CATOM 2140 CG LEU A 895 25.198 39.479 −19.219 1.00 37.31 A C ATOM 2141CD1 LEU A 895 25.167 39.871 −20.695 1.00 38.63 A C ATOM 2142 CD2 LEU A895 23.805 39.067 −18.767 1.00 35.68 A C ATOM 2143 C LEU A 895 26.78036.179 −17.937 1.00 37.71 A C ATOM 2144 O LEU A 895 26.025 35.205−18.074 1.00 37.49 A O ATOM 2145 N GLU A 896 28.106 36.059 −17.985 1.0037.32 A N ATOM 2146 CA GLU A 896 28.657 34.727 −18.183 1.00 37.36 A CATOM 2147 CB GLU A 896 29.923 34.720 −19.038 1.00 41.29 A C ATOM 2148 CGGLU A 896 30.283 33.289 −19.467 1.00 46.94 A C ATOM 2149 CD GLU A 89631.666 33.172 −20.076 1.00 51.83 A C ATOM 2150 OE1 GLU A 896 32.66033.317 −19.315 1.00 54.87 A O ATOM 2151 OE2 GLU A 896 31.760 32.938−21.313 1.00 52.53 A O ATOM 2152 C GLU A 896 28.953 34.051 −16.863 1.0034.85 A C ATOM 2153 O GLU A 896 29.876 34.440 −16.131 1.00 33.52 A OATOM 2154 N PRO A 897 28.159 33.015 −16.551 1.00 32.98 A N ATOM 2155 CDPRO A 897 27.112 32.567 −17.491 1.00 30.01 A C ATOM 2156 CA PRO A 89728.178 32.160 −15.362 1.00 31.76 A C ATOM 2157 CB PRO A 897 27.44430.919 −15.841 1.00 31.03 A C ATOM 2158 CG PRO A 897 26.383 31.504−16.904 1.00 30.70 A C ATOM 2159 C PRO A 897 29.542 31.841 −14.757 1.0032.40 A C ATOM 2160 O PRO A 897 29.647 31.622 −13.541 1.00 31.30 A OATOM 2161 N THR A 898 30.582 31.810 −15.591 1.00 34.36 A N ATOM 2162 CATHR A 898 31.939 31.506 −15.110 1.00 35.46 A C ATOM 2163 CB THR A 89832.885 31.170 −16.257 1.00 35.24 A C ATOM 2164 OG1 THR A 898 32.26331.514 −17.510 1.00 36.79 A O ATOM 2165 CG2 THR A 898 33.240 29.692−16.215 1.00 35.03 A C ATOM 2166 C THR A 898 32.581 32.631 −14.317 1.0036.08 A C ATOM 2167 O THR A 898 33.424 32.381 −13.448 1.00 37.44 A OATOM 2168 N HIS A 899 32.191 33.871 −14.600 1.00 36.64 A N ATOM 2169 CAHIS A 899 32.766 34.985 −13.867 1.00 36.85 A C ATOM 2170 CB HIS A 89932.853 36.221 −14.758 1.00 40.74 A C ATOM 2171 CG HIS A 899 34.14436.301 −15.513 1.00 46.62 A C ATOM 2172 CD2 HIS A 899 34.550 35.681−16.649 1.00 48.81 A C ATOM 2173 ND1 HIS A 899 35.241 36.995 −15.0421.00 49.33 A N ATOM 2174 CE1 HIS A 899 36.267 36.796 −15.853 1.00 50.49A C ATOM 2175 NE2 HIS A 899 35.875 36.001 −16.835 1.00 50.88 A N ATOM2176 C HIS A 899 32.074 35.225 −12.550 1.00 34.73 A C ATOM 2177 O HIS A899 32.647 35.995 −11.714 1.00 34.91 A O ATOM 2178 N ARG A 900 30.85434.791 −12.349 1.00 32.24 A N ATOM 2179 CA ARG A 900 30.161 35.021−11.079 1.00 29.47 A C ATOM 2180 CB ARG A 900 28.801 34.338 −11.030 1.0028.72 A C ATOM 2181 CG ARG A 900 27.785 34.844 −11.981 1.00 25.86 A CATOM 2182 CD ARG A 900 26.457 34.238 −11.657 1.00 24.92 A C ATOM 2183 NEARG A 900 25.509 34.630 −12.680 1.00 26.84 A N ATOM 2184 CZ ARG A 90025.319 33.945 −13.799 1.00 27.90 A C ATOM 2185 NH1 ARG A 900 26.00032.831 −14.012 1.00 29.25 A N ATOM 2186 NH2 ARG A 900 24.483 34.392−14.718 1.00 28.21 A N ATOM 2187 C ARG A 900 31.027 34.358 −10.032 1.0027.68 A C ATOM 2188 O ARG A 900 31.747 33.409 −10.329 1.00 29.47 A OATOM 2189 N PRO A 901 30.954 34.820 −8.785 1.00 25.62 A N ATOM 2190 CDPRO A 901 30.173 35.941 −8.223 1.00 24.12 A C ATOM 2191 CA PRO A 90131.795 34.177 −7.769 1.00 24.91 A C ATOM 2192 CB PRO A 901 31.874 35.244−6.682 1.00 23.22 A C ATOM 2193 CG PRO A 901 30.475 35.839 −6.721 1.0022.97 A C ATOM 2194 C PRO A 901 31.142 32.887 −7.262 1.00 25.00 A C ATOM2195 O PRO A 901 30.260 32.305 −7.927 1.00 23.82 A O ATOM 2196 N THR A902 31.565 32.449 −6.077 1.00 24.36 A N ATOM 2197 CA THR A 902 30.98931.256 −5.455 1.00 24.43 A C ATOM 2198 CB THR A 902 32.024 30.159 −5.3001.00 23.14 A C ATOM 2199 OG THR A 902 33.224 30.721 −4.729 1.00 23.76 AO ATOM 2200 CG2 THR A 902 32.301 29.515 −6.649 1.00 21.07 A C ATOM 2201C THR A 902 30.472 31.601 −4.062 1.00 24.46 A C ATOM 2202 O THR A 90230.921 32.570 −3.440 1.00 23.55 A O ATOM 2203 N PHE A 903 29.537 30.806−3.559 1.00 25.02 A N ATOM 2204 CA PHE A 903 29.008 31.082 −2.234 1.0026.45 A C ATOM 2205 CB PHE A 903 27.949 30.048 −1.883 1.00 26.28 A CATOM 2206 CG PHE A 903 26.711 30.183 −2.720 1.00 26.42 A C ATOM 2207 CD1PHE A 903 25.952 31.351 −2.664 1.00 24.63 A C ATOM 2208 CD2 PHE A 90326.307 29.154 −3.573 1.00 25.83 A C ATOM 2209 CE1 PHE A 903 24.79631.495 −3.445 1.00 26.30 A C ATOM 2210 CE2 PHE A 903 25.158 29.284−4.358 1.00 25.43 A CREMARK c-fms (538-922, FGF chimera) complexed with 793693REMARK refinement resolution: 500.0-2.8 AREMARK starting r = 0.2645 free_r = 0.3191REMARK final = 0.2617 free_r = 0.3141CRYST1 82.210 82.210 143.440 90.00 90.00 120.00 R 3REMARK Written by CNX VERSION: 2000.12

TABLE 3 Coordinates of c-FMS (tie-2-chimera) in complex with 1183648(Arylamide) ATOM 1 CB GLN A 547 50.705 48.088 11.065 1.00 59.29 A C ATOM2 CG GLN A 547 50.108 48.650 9.788 1.00 63.33 A C ATOM 3 CD GLN A 54748.603 48.477 9.735 1.00 65.77 A C ATOM 4 OE1 GLN A 547 47.870 49.05710.538 1.00 67.17 A O ATOM 5 NE2 GLN A 547 48.134 47.667 8.790 1.0064.89 A N ATOM 6 C GLN A 547 50.754 45.684 10.330 1.00 57.19 A C ATOM 7O GLN A 547 51.326 44.642 10.662 1.00 59.65 A O ATOM 8 N GLN A 54750.739 46.267 12.745 1.00 59.16 A N ATOM 9 CA GLN A 547 50.248 46.66211.392 1.00 57.65 A C ATOM 10 N VAL A 548 50.548 46.015 9.058 1.00 49.89A N ATOM 11 CA VAL A 548 50.976 45.139 7.979 1.00 47.64 A C ATOM 12 CBVAL A 548 49.919 44.026 7.743 1.00 51.23 A C ATOM 13 CG1 VAL A 54848.733 44.574 6.957 1.00 52.01 A C ATOM 14 CG2 VAL A 548 50.551 42.8517.046 1.00 52.53 A C ATOM 15 C VAL A 548 51.222 45.909 6.678 1.00 46.21A C ATOM 16 O VAL A 548 51.047 45.373 5.582 1.00 44.14 A O ATOM 17 N ARGA 549 51.650 47.162 6.806 1.00 37.38 A N ATOM 18 CA ARG A 549 51.92448.005 5.647 1.00 30.25 A C ATOM 19 CB ARG A 549 51.137 49.311 5.7631.00 32.08 A C ATOM 20 CG ARG A 549 49.672 49.113 6.157 1.00 43.17 A CATOM 21 CD ARG A 549 48.938 50.441 6.288 1.00 55.28 A C ATOM 22 NE ARG A549 47.580 50.289 6.814 1.00 61.34 A N ATOM 23 CZ ARG A 549 46.61449.591 6.221 1.00 64.15 A C ATOM 24 NH1 ARG A 549 46.844 48.969 5.0721.00 66.91 A N ATOM 25 NH2 ARG A 549 45.413 49.517 6.779 1.00 64.80 A NATOM 26 C ARG A 549 53.420 48.320 5.535 1.00 27.01 A C ATOM 27 O ARG A549 54.156 48.272 6.525 1.00 22.12 A O ATOM 28 N TRP A 550 53.872 48.6454.327 1.00 19.84 A N ATOM 29 CA TRP A 550 55.276 48.980 4.125 1.00 21.93A C ATOM 30 CB TRP A 550 55.556 49.244 2.650 1.00 19.89 A C ATOM 31 CGTRP A 550 55.585 48.012 1.850 1.00 24.51 A C ATOM 32 CD2 TRP A 55056.193 47.837 0.567 1.00 22.47 A C ATOM 33 CE2 TRP A 550 55.994 46.4920.193 1.00 20.46 A C ATOM 34 CE3 TRP A 550 56.889 48.685 −0.298 1.0018.32 A C ATOM 35 CD1 TRP A 550 55.051 46.801 2.194 1.00 16.54 A C ATOM36 NE1 TRP A 550 55.293 45.882 1.201 1.00 20.30 A N ATOM 37 CZ2 TRP A550 56.465 45.976 −1.010 1.00 18.45 A C ATOM 38 CZ3 TRP A 550 57.35548.176 −1.489 1.00 20.72 A C ATOM 39 CH2 TRP A 550 57.142 46.830 −1.8381.00 25.45 A C ATOM 40 C TRP A 550 55.583 50.229 4.935 1.00 24.49 A CATOM 41 O TRP A 550 54.742 51.125 5.045 1.00 20.67 A O ATOM 42 N LYS A551 56.790 50.292 5.481 1.00 19.05 A N ATOM 43 CA LYS A 551 57.19151.433 6.302 1.00 23.41 A C ATOM 44 CB LYS A 551 56.747 51.202 7.7471.00 26.59 A C ATOM 45 CG LYS A 551 57.092 52.332 8.709 1.00 32.32 A CATOM 46 CD LYS A 551 56.462 52.081 10.073 1.00 45.89 A C ATOM 47 CE LYSA 551 56.653 53.267 11.008 1.00 48.10 A C ATOM 48 NZ LYS A 551 58.09153.564 11.235 1.00 51.66 A N ATOM 49 C LYS A 551 58.692 51.665 6.2851.00 23.21 A C ATOM 50 O LYS A 551 59.468 50.722 6.438 1.00 22.75 A OATOM 51 N ILE A 552 59.086 52.925 6.106 1.00 22.70 A N ATOM 52 CA ILE A552 60.490 53.315 6.116 1.00 28.63 A C ATOM 53 CB ILE A 552 60.72254.668 5.423 1.00 30.18 A C ATOM 54 CG2 ILE A 552 62.187 55.072 5.5751.00 28.32 A C ATOM 55 CG1 ILE A 552 60.295 54.594 3.952 1.00 28.75 A CATOM 56 CD1 ILE A 552 61.101 53.642 3.116 1.00 26.35 A C ATOM 57 C ILE A552 60.851 53.490 7.591 1.00 29.56 A C ATOM 58 O ILE A 552 60.209 54.2608.298 1.00 31.45 A O ATOM 59 N ILE A 553 61.870 52.773 8.048 1.00 24.52A N ATOM 60 CA ILE A 553 62.294 52.851 9.437 1.00 27.47 A C ATOM 61 CBILE A 553 62.485 51.447 10.040 1.00 34.69 A C ATOM 62 CG2 ILE A 55361.199 50.641 9.912 1.00 37.60 A C ATOM 63 CG1 ILE A 5.53 63.642 50.7369.335 1.00 32.96 A C ATOM 64 CD1 ILE A 553 63.957 49.375 9.911 1.0042.39 A C ATOM 65 C ILE A 553 63.614 53.602 9.561 1.00 29.91 A C ATOM 66O ILE A 553 64.309 53.824 8.569 1.00 25.11 A O ATOM 67 N GLU A 55463.956 53.981 10.790 1.00 37.63 A N ATOM 68 CA GLU A 554 65.196 54.70911.059 1.00 42.70 A C ATOM 69 CB GLU A 554 65.035 55.577 12.311 1.0044.36 A C ATOM 70 CG GLU A 554 64.018 56.693 12.177 1.00 55.55 A C ATOM71 CD GLU A 554 63.794 57.434 13.483 1.00 62.27 A C ATOM 72 OE1 GLU A554 63.035 58.428 13.479 1.00 65.84 A O ATOM 73 OE2 GLU A 554 64.37157.022 14.513 1.00 65.19 A O ATOM 74 C GLU A 554 66.401 53.789 11.2481.00 42.46 A C ATOM 75 O GLU A 554 66.362 52.853 12.042 1.00 44.89 A OATOM 76 N SER A 555 67.472 54.070 10.512 1.00 45.78 A N ATOM 77 CA SER A555 68.706 53.298 10.600 1.00 49.70 A C ATOM 78 CB SER A 555 68.55651.932 9.921 1.00 57.95 A C ATOM 79 OG SER A 555 67.937 50.989 10.7831.00 57.72 A O ATOM 80 C SER A 555 69.834 54.076 9.945 1.00 56.37 A CATOM 81 O SER A 555 69.588 55.025 9.195 1.00 55.73 A O ATOM 82 N TYR A556 71.070 53.673 10.231 1.00 61.77 A N ATOM 83 CA TYR A 556 72.24354.344 9.681 1.00 63.94 A C ATOM 84 CB TYR A 556 72.460 55.675 10.4041.00 68.76 A C ATOM 85 CG TYR A 556 72.226 55.605 11.894 1.00 71.33 A CATOM 86 CD1 TYR A 556 72.998 54.779 12.702 1.00 76.60 A C ATOM 87 CE1TYR A 556 72.770 54.695 14.065 1.00 76.88 A C ATOM 88 CD2 TYR A 55671.217 56.349 12.490 1.00 73.84 A C ATOM 89 CE2 TYR A 556 70.981 56.27213.850 1.00 77.97 A C ATOM 90 CZ TYR A 556 71.759 55.443 14.634 1.0077.93 A C ATOM 91 OH TYR A 556 71.519 55.359 15.988 1.00 77.63 A O ATOM92 C TYR A 556 73.507 53.495 9.777 1.00 65.66 A C ATOM 93 O TYR A 55674.618 53.999 9.592 1.00 63.62 A O ATOM 94 N ASN A 559 74.913 50.4186.858 1.00 58.03 A N ATOM 95 CA ASN A 559 74.977 50.113 5.433 1.00 55.60A C ATOM 96 CB ASN A 559 74.564 48.659 5.195 1.00 58.24 A C ATOM 97 CGASN A 559 74.936 48.165 3.813 1.00 64.11 A C ATOM 98 OD1 ASN A 55974.469 48.692 2.801 1.00 66.81 A O ATOM 99 ND2 ASN A 559 75.786 47.1413.762 1.00 63.62 A N ATOM 100 C ASN A 559 74.024 51.059 4.710 1.00 53.13A C ATOM 101 O ASN A 559 74.407 51.752 3.765 1.00 50.85 A O ATOM 102 NSER A 560 72.776 51.076 5.167 1.00 49.61 A N ATOM 103 CA SER A 56071.758 51.951 4.604 1.00 46.25 A C ATOM 104 CB SER A 560 70.430 51.2044.482 1.00 49.55 A C ATOM 105 OG SER A 560 69.445 52.027 3.883 1.0061.42 A O ATOM 106 C SER A 560 71.608 53.135 5.558 1.00 38.67 A C ATOM107 O SER A 560 71.898 53.016 6.749 1.00 36.71 A O ATOM 108 N TYR A 56171.161 54.275 5.045 1.00 35.17 A N ATOM 109 CA TYR A 561 71.006 55.4585.888 1.00 34.70 A C ATOM 110 CE TYR A 561 72.177 56.430 5.647 1.0028.11 A C ATOM 111 CG TYR A 561 72.291 57.536 6.675 1.00 30.02 A C ATOM112 CD1 TYR A 561 71.482 58.663 6.612 1.00 26.28 A C ATOM 113 CE1 TYR A561 71.554 59.648 7.577 1.00 31.92 A C ATOM 114 CD2 TYR A 561 73.18257.429 7.736 1.00 30.58 A C ATOM 115 CE2 TYR A 561 73.260 58.405 8.7061.00 23.12 A C ATOM 116 CZ TYR A 561 72.443 59.513 8.620 1.00 28.95 A CATOM 117 OH TYR A 561 72.525 60.490 9.584 1.00 31.30 A O ATOM 118 C TYRA 561 69.671 56.150 5.628 1.00 31.68 A C ATOM 119 O TYR A 561 69.32356.447 4.489 1.00 29.98 A O ATOM 120 N THR A 562 68.916 56.391 6.6921.00 32.64 A N ATOM 121 CA THR A 562 67.624 57.056 6.553 1.00 28.44 A CATOM 122 CB THR A 562 66.618 56.567 7.623 1.00 31.76 A C ATOM 123 OG1THR A 562 66.542 55.135 7.597 1.00 42.23 A 0 ATOM 124 CG2 THR A 56265.230 57.138 7.347 1.00 35.49 A C ATOM 125 C THR A 562 67.821 58.5626.717 1.00 26.81 A C ATOM 126 O THR A 562 67.944 59.059 7.837 1.00 25.47A 0 ATOM 127 N PHE A 563 67.876 59.276 5.598 1.00 18.63 A N ATOM 128 CAPHE A 563 68.033 60.724 5.606 1.00 24.24 A C ATOM 129 CB PHE A 56368.578 61.231 4.263 1.00 28.51 A C ATOM 130 CG PHE A 563 70.026 60.8974.017 1.00 26.30 A C ATOM 131 CD1 PHE A 563 70.389 59.706 3.401 1.0029.06 A C ATOM 132 CD2 PHE A 563 71.024 61.789 4.384 1.00 29.63 A C ATOM133 CE1 PHE A 563 71.722 59.413 3.152 1.00 34.72 A C ATOM 134 CE2 PHE A563 72.360 61.503 4.140 1.00 28.25 A C ATOM 135 CZ PHE A 563 72.71160.315 3.523 1.00 28.14 A C ATOM 136 C PHE A 563 66.677 61.379 5.8531.00 31.10 A C ATOM 137 O PHE A 563 66.599 62.493 6.378 1.00 24.85 A 0ATOM 138 N ILE A 564 65.608 60.692 5.460 1.00 29.30 A N ATOM 139 CA ILEA 564 64.269 61.232 5.651 1.00 28.37 A C ATOM 140 CB ILE A 564 63.99062.373 4.644 1.00 34.24 A C ATOM 141 CG2 ILE A 564 63.888 61.812 3.2271.00 29.15 A C ATOM 142 CG1 ILE A 564 62.690 63.086 5.015 1.00 38.26 A CATOM 143 CD1 ILE A 564 62.388 64.284 4.141 1.00 46.88 A C ATOM 144 C ILEA 564 63.164 60.189 5.512 1.00 30.93 A C ATOM 145 O ILE A 564 63.28559.234 4.745 1.00 34.04 A O ATOM 146 N ASP A 565 62.097 60.378 6.2801.00 32.11 A N ATOM 147 CA ASP A 565 60.932 59.508 6.234 1.00 27.33 A CATOM 148 CB ASP A 565 60.328 59.347 7.633 1.00 28.72 A C ATOM 149 CG ASPA 565 59.029 58.551 7.623 1.00 38.03 A C ATOM 150 OD1 ASP A 565 58.50358.271 8.721 1.00 37.84 A O ATOM 151 OD2 ASP A 565 58.533 58.208 6.5271.00 26.21 A O ATOM 152 C ASP A 565 59.933 60.197 5.312 1.00 30.22 A CATOM 153 O ASP A 565 59.357 61.229 5.663 1.00 33.03 A O ATOM 154 N PRO A566 59.734 59.643 4.108 1.00 33.59 A N ATOM 155 CD PRO A 566 60.35458.379 3.686 1.00 34.17 A C ATOM 156 CA PRO A 566 58.821 60.141 3.0731.00 34.98 A C ATOM 157 CB PRO A 566 58.851 59.034 2.023 1.00 35.51 A CATOM 158 CG PRO A 566 60.177 58.434 2.198 1.00 37.05 A C ATOM 159 C PROA 566 57.408 60.344 3.614 1.00 33.80 A C ATOM 160 O PRO A 566 56.65061.169 3.099 1.00 32.70 A O ATOM 161 N THR A 567 57.066 59.571 4.6451.00 32.01 A N ATOM 162 CA THR A 567 55.746 59.630 5.271 1.00 36.01 A CATOM 163 CB THR A 567 55.638 58.638 6.442 1.00 34.80 A C ATOM 164 OG1THR A 567 55.699 57.299 5.932 1.00 43.97 A O ATOM 165 CG2 THR A 56754.329 58.832 7.191 1.00 46.71 A C ATOM 166 C THR A 567 55.448 61.0315.766 1.00 41.90 A C ATOM 167 O THR A 567 54.376 61.571 5.493 1.00 46.23A O ATOM 168 N GLN A 568 56.382 61.618 6.510 1.00 43.71 A N ATOM 169 CAGLN A 568 56.190 62.984 6.964 1.00 48.14 A C ATOM 170 CB GLN A 56857.317 63.420 7.902 1.00 44.17 A C ATOM 171 CG GLN A 568 57.140 63.0129.354 1.00 50.98 A C ATOM 172 CD GLN A 568 57.166 61.513 9.562 1.0057.27 A C ATOM 173 OE1 GLN A 568 58.117 60.834 9.174 1.00 58.66 A O ATOM174 NE2 GLN A 568 56.119 60.987 10.188 1.00 59.35 A N ATOM 175 C GLN A568 56.256 63.780 5.666 1.00 51.91 A C ATOM 176 O GLN A 568 56.61763.231 4.623 1.00 55.37 A O ATOM 177 N LEU A 569 55.917 65.060 5.7191.00 55.50 A N ATOM 178 CA LEU A 569 55.948 65.895 4.522 1.00 56.69 A CATOM 179 CB LEU A 569 57.295 65.762 3.794 1.00 59.47 A C ATOM 180 CG LEUA 569 58.623 66.112 4.474 1.00 64.81 A C ATOM 181 CD1 LEU A 569 59.0065.058 5.507 1.00 65.18 A C ATOM 182 CD2 LEU A 569 59.708 66.192 3.4061.00 68.71 A C ATOM 183 C LEU A 569 54.838 65.505 3.549 1.00 55.23 A CATOM 184 O LEU A 569 54.490 64.327 3.416 1.00 50.24 A O ATOM 185 N PRO A570 54.259 66.497 2.861 1.00 53.48 A N ATOM 186 CD PRO A 570 54.36267.938 3.155 1.00 49.89 A C ATOM 187 CA PRO A 570 53.190 66.233 1.8941.00 53.48 A C ATOM 188 CB PRO A 570 52.818 67.632 1.413 1.00 51.63 A CATOM 189 CG PRO A 570 53.035 68.461 2.652 1.00 53.16 A C ATOM 190 C PROA 570 53.682 65.327 0.760 1.00 54.61 A C ATOM 191 O PRO A 570 54.75164.726 0.857 1.00 55.35 A O ATOM 192 N TYR A 571 52.903 65.246 −0.3141.00 56.06 A N ATOM 193 CA TYR A 571 53.226 64.405 −1.467 1.00 54.29 A CATOM 194 CB TYR A 571 51.949 63.676 −1.910 1.00 45.30 A C ATOM 195 CGTYR A 571 51.813 63.445 −3.397 1.00 45.06 A C ATOM 196 CD1 TYR A 57152.552 62.461 −4.049 1.00 40.56 A C ATOM 197 CE1 TYR A 571 52.414 62.250−5.411 1.00 36.51 A C ATOM 198 CD2 TYR A 571 50.935 64.212 −4.151 1.0037.84 A C ATOM 199 CE2 TYR A 571 50.792 64.011 −5.507 1.00 39.91 A CATOM 200 CZ TYR A 571 51.531 63.031 −6.133 1.00 36.18 A C ATOM 201 OHTYR A 571 51.382 62.843 −7.488 1.00 44.41 A O ATOM 202 C TYR A 57153.849 65.182 −2.636 1.00 57.33 A C ATOM 203 O TYR A 571 53.670 66.392−2.753 1.00 59.52 A O ATOM 204 N ASN A 572 54.579 64.468 −3.493 1.0060.54 A N ATOM 205 CA ASN A 572 55.257 65.046 −4.660 1.00 62.84 A C ATOM206 CB ASN A 572 56.530 64.253 −4.961 1.00 63.18 A C ATOM 207 CG ASN A572 57.515 64.277 −3.818 1.00 66.91 A C ATOM 208 OD1 ASN A 572 57.13364.151 −2.656 1.00 72.16 A O ATOM 209 ND2 ASN A 572 58.796 64.425 −4.1411.00 68.55 A N ATOM 210 C ASN A 572 54.410 65.071 −5.933 1.00 62.14 A CATOM 211 O ASN A 572 54.284 64.051 −6.609 1.00 65.57 A O ATOM 212 N GLUA 573 53.862 66.236 −6.275 1.00 59.46 A N ATOM 213 CA GLU A 573 53.03966.394 −7.480 1.00 53.77 A C ATOM 214 CB GLU A 573 52.718 67.876 −7.7031.00 53.46 A C ATOM 215 CG GLU A 573 51.653 68.444 −6.777 1.00 57.06 A CATOM 216 CD GLU A 573 50.261 67.918 −7.095 1.00 55.91 A C ATOM 217 OE1GLU A 573 49.810 68.074 −8.251 1.00 54.97 A O ATOM 218 OE2 GLU A 57349.615 67.353 −6.192 1.00 50.79 A O ATOM 219 C GLU A 573 53.722 65.837−8.729 1.00 52.29 A C ATOM 220 O GLU A 573 53.197 65.928 −9.845 1.0048.82 A O ATOM 221 N LYS A 574 54.893 65.249 −8.527 1.00 51.27 A N ATOM222 CA LYS A 574 55.685 64.682 −9.606 1.00 49.90 A C ATOM 223 CB LYS A574 57.096 64.392 −9.090 1.00 52.80 A C ATOM 224 CG LYS A 574 57.94965.633 −8.861 1.00 57.31 A C ATOM 225 CD LYS A 574 57.362 66.593 −7.8451.00 55.83 A C ATOM 226 CE LYS A 574 58.257 67.821 −7.692 1.00 57.27 A CATOM 227 NZ LYS A 574 57.701 68.832 −6.750 1.00 56.52 A N ATOM 228 C LYSA 574 55.115 63.421 −10.259 1.00 47.63 A C ATOM 229 O LYS A 574 55.64362.962 −11.271 1.00 45.25 A O ATOM 230 N TRP A 575 54.043 62.863 −9.7011.00 39.10 A N ATOM 231 CA TRP A 575 53.467 61.645 −10.268 1.00 34.70 AC ATOM 232 CE TRP A 575 53.475 60.524 −9.224 1.00 32.40 A C ATOM 233 CGTRP A 575 54.836 60.076 −8.867 1.00 24.25 A C ATOM 234 CD2 TRP A 57555.569 59.018 −9.485 1.00 25.63 A C ATOM 235 CE2 TRP A 575 56.844 58.987−8.885 1.00 29.80 A C ATOM 236 CE3 TRP A 575 55.272 58.093 −10.492 1.0031.67 A C ATOM 237 CD1 TRP A 575 55.668 60.630 −7.940 1.00 32.41 A CATOM 238 NE1 TRP A 575 56.880 59.981 −7.944 1.00 28.89 A N ATOM 239 CZ2TRP A 575 57.822 58.066 −9.260 1.00 29.83 A C ATOM 240 CZ3 TRP A 57556.244 57.183 −10.861 1.00 32.60 A C ATOM 241 CH2 TRP A 57 57.504 57.176−10.247 1.00 26.78 A C ATOM 242 C TRP A 575 52.059 61.783 −10.830 1.0035.45 A C ATOM 243 O TRP A 575 51.495 60.820 −11.355 1.00 29.00 A O ATOM244 N GLU A 576 51.499 62.981 −10.730 1.00 32.64 A N ATOM 245 CA GLU A576 50.147 63.232 −11.206 1.00 33.90 A C ATOM 246 CE GLU A 576 49.83764.724 −11.086 1.00 34.05 A C ATOM 247 CG GLU A 576 48.381 65.038−10.843 1.00 43.65 A C ATOM 248 CD GLU A 576 47.811 64.254 −9.680 1.0041.94 A C ATOM 249 OE1 GLU A 576 48.510 64.107 −8.652 1.00 46.89 A OATOM 250 OE2 GLU A 576 46.657 63.796 −9.793 1.00 46.18 A O ATOM 251 CGLU A 576 49.933 62.756 −12.642 1.00 32.44 A C ATOM 252 O GLU A 57650.771 62.976 −13.518 1.00 35.52 A O ATOM 253 N PHE A 577 48.800 62.097−12.864 1.00 32.97 A N ATOM 254 CA PHE A 577 48.430 61.560 −14.172 1.0037.81 A C ATOM 255 CB PHE A 577 48.653 60.044 −14.195 1.00 38.19 A CATOM 256 CG PHE A 577 48.255 59.385 −15.488 1.00 36.08 A C ATOM 257 CD1PHE A 577 49.061 59.483 −16.613 1.00 36.75 A C ATOM 258 CD2 PHE A 57747.077 58.658 −15.577 1.00 35.23 A C ATOM 259 CE1 PHE A 577 48.69858.866 −17.802 1.00 35.50 A C ATOM 260 CE2 PHE A 577 46.709 58.040−16.762 1.00 31.27 A C ATOM 261 CZ PHE A 577 47.522 58.145 −17.874 1.0029.63 A C ATOM 262 C PHE A 577 46.953 61.857 −14.435 1.00 39.50 A C ATOM263 O PHE A 577 46.127 61.786 −13.524 1.00 37.92 A O ATOM 264 N PRO A578 46.607 62.194 −15.689 1.00 41.54 A N ATOM 265 CD PRO A 578 47.55162.385 −16.805 1.00 43.08 A C ATOM 266 CA PRO A 578 45.240 62.510−16.112 1.00 42.13 A C ATOM 267 CE PRO A 578 45.377 62.658 −17.621 1.0046.24 A C ATOM 268 CG PRO A 578 46.745 63.228 −17.766 1.00 46.41 A CATOM 269 C PRO A 578 44.215 61.447 −15.731 1.00 42.52 A C ATOM 270 O PROA 578 44.140 60.387 −16.352 1.00 44.49 A O ATOM 271 N ARG A 579 43.42561.750 −14.709 1.00 39.50 A N ATOM 272 CA ARG A 579 42.386 60.857−14.218 1.00 42.13 A C ATOM 273 CE ARG A 579 41.571 61.593 −13.150 1.0043.43 A C ATOM 274 CG ARG A 579 40.348 60.865 −12.630 1.00 39.15 A CATOM 275 CD ARG A 579 39.582 61.775 −11.688 1.00 33.24 A C ATOM 276 NEARG A 579 40.404 62.208 −10.559 1.00 34.71 A N ATOM 277 CZ ARG A 57940.582 61.502 −9.444 1.00 37.36 A C ATOM 278 NH1 ARG A 579 39.993 60.322−9.295 1.00 31.90 A N ATOM 279 NH2 ARG A 579 41.355 61.976 −8.476 1.0038.21 A N ATOM 280 C ARG A 579 41.470 60.375 −15.348 1.00 47.76 A C ATOM281 0 ARG A 579 40.787 59.361 −15.215 1.00 52.44 A O ATOM 282 N ASN A580 41.468 61.106 −16.460 1.00 53.12 A N ATOM 283 CA ASN A 580 40.63860.771 −17.615 1.00 56.04 A C ATOM 284 CE ASN A 580 40.321 62.040−18.413 1.00 59.98 A C ATOM 285 CG ASN A 580 39.974 61.749 −19.865 1.0066.26 A C ATOM 286 OD1 ASN A 580 40.814 61.284 −20.635 1.00 71.83 A OATOM 287 ND2 ASN A 580 38.731 62.023 −20.244 1.00 7.081 A N ATOM 288 CAASN A 580 41.259 59.731 −18.543 1.00 57.00 A C ATOM 289 O ASN A 58040.558 58.862 −19.061 1.00 60.31 A O ATOM 290 N ASN A 581 42.568 59.829−18.763 1.00 54.46 A N ATOM 291 CA ASN A 581 43.274 58.898 −19.639 1.0051.93 A C ATOM 292 CB ASN A 581 44.673 59.429 −19.963 1.00 53.14 A CATOM 293 CG ASN A 581 44.638 60.753 −20.698 1.00 51.63 A C ATOM 294 OD1ASN A 581 44.053 61.721 −20.222 1.00 51.37 A O ATOM 295 ND2 ASN A 58145.271 60.800 −21.865 1.00 54.71 A N ATOM 296 C ASN A 581 43.394 57.522−18.999 1.00 53.02 A C ATOM 297 O ASN A 581 44.361 56.796 −19.240 1.0048.84 A O ATOM 298 N LEU A 582 42.400 57.168 −18.192 1.00 51.03 A N ATOM299 CA LEU A 582 42.389 55.888 −17.504 1.00 54.48 A C ATOM 300 CB LEU A582 42.708 56.111 −16.022 1.00 56.26 A C ATOM 301 CG LEU A 582 43.52255.077 −15.242 1.00 53.82 A C ATOM 302 CD1 LEU A 582 44.896 54.919−15.873 1.00 51.83 A C ATOM 303 CD2 LEU A 582 43.657 55.533 −13.797 1.0052.98 A C ATOM 304 C LEU A 582 41.009 55.245 −17.647 1.00 57.15 A C ATOM305 O LEU A 582 40.010 55.812 −17.206 1.00 59.35 A O ATOM 306 N GLN A583 40.949 54.074 −18.276 1.00 56.30 A N ATOM 307 CA GLN A 583 39.67853.371 −18.438 1.00 55.57 A C ATOM 308 CB GLN A 583 39.479 52.898−19.878 1.00 60.58 A C ATOM 309 CG GLN A 583 38.172 52.135 −20.072 1.0065.90 A C ATOM 310 CD GLN A 583 38.113 51.387 −21.387 1.00 71.23 A CATOM 311 OE1 GLN A 583 38.208 51.984 −22.460 1.00 75.78 A O ATOM 312 NE2GLN A 583 37.958 50.069 −21.312 1.00 75.45 A N ATOM 313 C GLN A 58339.668 52.160 −17.524 1.00 51.30 A C ATOM 314 O GLN A 583 40.377 51.188−17.773 1.00 48.34 A O ATOM 315 N PHE A 584 38.858 52.214 −16.473 1.0049.58 A N ATOM 316 CA PHE A 584 38.786 51.112 −15.526 1.00 50.64 A CATOM 317 CB PHE A 584 37.896 51.480 −14.335 1.00 53.40 A C ATOM 318 CGPHE A 584 38.482 52.542 −13.444 1.00 53.06 A C ATOM 319 CD1 PHE A 58439.845 52.800 −13.454 1.00 53.35 A C ATOM 320 CD2 PHE A 584 37.67453.261 −12.575 1.00 52.65 A C ATOM 321 CE1 PHE A 584 40.394 53.755−12.614 1.00 51.51 A C ATOM 322 CE2 PHE A 584 38.216 54.216 −11.731 1.0052.15 A C ATOM 323 CZ PHE A 584 39.580 54.463 −11.751 1.00 50.37 A CATOM 324 C PHE A 584 38.293 49.811 −16.140 1.00 52.87 A C ATOM 325 O PHEA 584 37.316 49.788 −16.887 1.00 52.62 A O ATOM 326 N GLY A 585 38.98748.726 −15.813 1.00 51.95 A N ATOM 327 CA GLY A 585 38.614 47.418−16.314 1.00 46.36 A C ATOM 328 C GLY A 585 38.134 46.526 −15.183 1.0042.19 A C ATOM 329 O GLY A 585 37.433 46.978 −14.277 1.00 41.40 A O ATOM330 N LYS A 586 38.525 45.258 −15.230 1.00 43.47 A N ATOM 331 CA LYS A586 38.134 44.283 −14.218 1.00 45.09 A C ATOM 332 CB LYS A 586 38.49242.874 −14.696 1.00 44.79 A C ATOM 333 CG LYS A 586 39.972 42.700−15.001 1.00 54.34 A C ATOM 334 CD LYS A 586 40.310 41.277 −15.422 1.0054.93 A C ATOM 335 CE LYS A 586 40.094 40.292 −14.287 1.00 54.08 A CATOM 336 NZ LYS A 586 40.444 38.903 −14.705 1.00 53.34 A N ATOM 337 CLYS A 586 38.790 44.532 −12.860 1.00 44.37 A C ATOM 338 O LYS A 58639.898 45.068 −12.782 1.00 39.89 A O ATOM 339 N THR A 587 38.095 44.129−11.799 1.00 42.38 A N ATOM 340 CA THR A 587 38.582 44.272 −10.430 1.0039.75 A C ATOM 341 CB THR A 587 37.417 44.270 −9.425 1.00 38.20 A C ATOM342 OG1 THR A 587 36.617 45.441 −9.612 1.00 41.55 A O ATOM 343 CG2 THR A587 37.943 44.239 −7.995 1.00 44.74 A C ATOM 344 C THR A 587 39.50943.103 −10.081 1.00 41.73 A C ATOM 345 O THR A 587 39.049 41.992 −9.8271.00 43.31 A O ATOM 346 N LEU A 588 40.812 43.359 −10.070 1.00 39.85 A NATOM 347 CA LEU A 588 41.798 42.331 −9.756 1.00 33.01 A C ATOM 348 CBLEU A 588 43.206 42.919 −9.852 1.00 35.74 A C ATOM 349 CG LEU A 58843.885 42.782 −11.217 1.00 45.14 A C ATOM 350 CD1 LEU A 588 42.84042.777 −12.326 1.00 42.62 A C ATOM 351 CD2 LEU A 588 44.901 43.907−11.390 1.00 39.42 A C ATOM 352 C LEU A 588 41.598 41.715 −8.379 1.0035.37 A C ATOM 353 O LEU A 588 41.812 40.517 8.186 1.00 36.10 A O ATOM354 N GLY A 589 41.196 42.538 −7.420 1.00 34.55 A N ATOM 355 CA GLY A589 40.980 42.049 −6.070 1.00 29.06 A C ATOM 356 C GLY A 589 40.46843.180 −5.205 1.00 30.79 A C ATOM 357 O GLY A 589 40.649 44.351 −5.5451.00 33.83 A O ATOM 358 N ALA A 590 39.837 42.856 −4.085 1.00 24.47 A NATOM 359 CA ALA A 590 39.308 43.905 −3.227 1.00 27.44 A C ATOM 360 CBALA A 590 37.853 44.213 −3.612 1.00 31.60 A C ATOM 361 C ALA A 59039.388 43.532 −1.766 1.00 24.67 A C ATOM 362 O ALA A 590 39.327 42.357−1.418 1.00 31.10 A O ATOM 363 N GLY A 591 39.517 44.543 −0.913 1.0029.82 A N ATOM 364 CA GLY A 591 39.608 44.301 0.514 1.00 39.85 A C ATOM365 C GLY A 591 38.584 45.069 1.324 1.00 45.53 A C ATOM 366 O GLY A 59137.540 45.475 0.811 1.00 43.66 A 0 ATOM 367 N ALA A 592 38.892 45.2772.599 1.00 49.91 A N ATOM 368 CA ALA A 592 37.996 45.987 3.500 1.0051.25 A C ATOM 369 CB ALA A 592 38.403 45.718 4.942 1.00 51.95 A C ATOM370 C ALA A 592 37.954 47.490 3.251 1.00 54.77 A C ATOM 371 O ALA A 59236.875 48.089 3.210 1.00 56.08 A O ATOM 372 N PHE A 593 39.127 48.0943.083 1.00 55.02 A N ATOM 373 CA PHE A 593 39.224 49.536 2.872 1.0052.35 A C ATOM 374 CB PHE A 593 40.483 50.080 3.550 1.00 57.34 A C ATOM375 CG PHE A 593 40.806 49.417 4.857 1.00 64.78 A C ATOM 376 CD1 PHE A593 39.891 49.412 5.896 1.00 68.19 A C ATOM 377 CD2 PHE A 593 42.03748.801 5.046 1.00 69.62 A C ATOM 378 CE1 PHE A 593 40.196 48.803 7.1031.00 73.09 A C ATOM 379 CE2 PHE A 593 42.349 48.190 6.250 1.00 70.39 A CATOM 380 CZ PHE A 593 41.428 48.191 7.280 1.00 73.37 A C ATOM 381 C PHEA 593 39.238 49.972 1.408 1.00 47.62 A C ATOM 382 O PHE A 593 38.88851.109 1.099 1.00 50.90 A O ATOM 383 N GLY A 594 39.647 49.086 0.5061.00 41.94 A N ATOM 384 CA GLY A 594 39.695 49.468 0.893 1.00 29.97 A CATOM 385 C GLY A 594 39.797 48.328 −1.884 1.00 32.94 A C ATOM 386 O GLYA 594 39.461 47.186 1.579 1.00 37.39 A O ATOM 387 N LYS A 595 40.27048.641 −3.083 1.00 31.08 A N ATOM 388 CA LYS A 595 40.400 47.640 4.1231.00 30.13 A C ATOM 389 CB LYS A 595 39.036 47.406 4.774 1.00 35.57 A CATOM 390 CG LYS A 595 38.360 48.696 −5.216 1.00 40.48 A C ATOM 391 CDLYS A 595 36.880 48.477 5.510 1.00 51.46 A C ATOM 392 CE LYS A 59536.132 49.801 −5.585 1.00 52.40 A C ATOM 393 NZ LYS A 595 34.655 49.603−5.611 1.00 53.83 A N ATOM 394 C LYS A 595 41.393 48.087 −5.178 1.0030.80 A C ATOM 395 O LYS A 595 41.830 49.237 5.189 1.00 29.83 A O ATOM396 N VAL A 596 41.749 47.160 −6.056 1.00 24.54 A N ATOM 397 CA VAL A596 42.671 47.435 7.143 1.00 32.04 A C ATOM 398 CB VAL A 596 44.05446.743 6.923 1.00 35.30 A C ATOM 399 CG1 VAL A 596 43.890 45.219 6.8351.00 29.59 A C ATOM 400 CG2 VAL A 596 45.006 47.123 8.053 1.00 28.30 A CATOM 401 C VAL A 596 42.013 46.915 −8.417 1.00 31.88 A C ATOM 402 O VALA 596 41.499 45.794 8.454 1.00 35.69 A O ATOM 403 N VAL A 597 42.01447.733 9.460 1.00 33.53 A N ATOM 404 CA VAL A 597 41.392 47.332 −10.7071.00 33.61 A C ATOM 405 CB VAL A 597 40.200 48.243 −11.041 1.00 37.26 AC ATOM 406 CQ1 VAL A 597 39.259 48.323 −9.849 1.00 35.70 A C ATOM 407CG2 VAL A 597 40.698 49.622 −11.415 1.00 39.07 A C ATOM 408 C VAL A 59742.374 47.393 −11.858 1.00 35.53 A C ATOM 409 O VAL A 597 43.361 48.130−11.810 1.00 30.90 A O ATOM 410 N GLU A 598 42.110 46.600 −12.887 1.0032.63 A N ATOM 411 CA GLU A 598 42.959 46.606 −14.060 1.00 36.26 A CATOM 412 CB GLU A 598 42.822 45.294 −14.832 1.00 39.08 A C ATOM 413 CGGLU A 598 43.547 45.285 −16.171 1.00 43.81 A C ATOM 414 CD GLU A 59843.638 43.896 −16.778 1.00 44.32 A C ATOM 415 OE1 GLU A 598 42.71643.084 −16.555 1.00 41.77 A O ATOM 416 OE2 GLU A 598 44.628 43.621−17.489 1.00 44.58 A O ATOM 417 C GLU A 598 42.468 47.774 −14.901 1.0037.63 A C ATOM 418 O GLU A 598 41.323 48.199 −14.764 1.00 40.80 A O ATOM419 N ALA A 599 43.328 48.306 −15.757 1.00 36.17 A N ATOM 420 CA ALA A599 42.927 49.431 −16.582 1.00 38.98 A C ATOM 421 CB ALA A 599 42.74350.677 −15.717 1.00 34.99 A C ATOM 422 C ALA A 599 43.943 49.703 −17.6671.00 39.88 A C ATOM 423 O ALA A 599 45.060 49.173 −17.657 1.00 32.51 A OATOM 424 N THR A 600 43.540 50.534 −18.616 1.00 44.21 A N ATOM 425 CATHR A 600 44.414 50.894 −19.711 1.00 47.57 A C ATOM 426 CB THR A 60043.714 50.678 −21.054 1.00 51.77 A C ATOM 427 OG1 THR A 600 42.90049.499 −20.979 1.00 51.44 A O ATOM 428 CG2 THR A 600 44.741 50.494−22.157 1.00 56.65 A C ATOM 429 C THR A 600 44.756 52.365 −19.538 1.0047.69 A C ATOM 430 O THR A 600 43.869 53.206 −19.378 1.00 51.13 A O ATOM431 N ALA A 601 46.046 52.668 −19.542 1.00 47.94 A N ATOM 432 CA ALA A601 46.507 54.036 −19.382 1.00 49.59 A C ATOM 433 CB ALA A 601 47.65654.085 −18.386 1.00 49.60 A C ATOM 434 C ALA A 601 46.957 54.566 −20.7331.00 48.79 A C ATOM 435 O ALA A 601 47.899 54.046 −21.331 1.00 45.73 A OATOM 436 N PHE A 602 46.279 55.601 −21.213 1.00 50.28 A N ATOM 437 CAPHE A 602 46.621 56.181 −22.500 1.00 52.84 A C ATOM 438 CB PHE A 60245.356 56.669 −23.209 1.00 51.88 A C ATOM 439 CG PHE A 602 44.176 55.754−23.037 1.00 51.31 A C ATOM 440 CD1 PHE A 602 43.295 55.929 −21.978 1.0048.72 A C ATOM 441 CD2 PHE A 602 43.959 54.705 −23.914 1.00 48.49 A CATOM 442 CE1 PHE A 602 42.218 55.072 −21.798 1.00 47.53 A C ATOM 443 CE2PHE A 602 42.884 53.844 −23.739 1.00 53.37 A C ATOM 444 CZ PHE A 60242.011 54.029 −22.678 1.00 46.43 A C ATOM 445 C PHE A 602 47.597 57.332−22.310 1.00 52.01 A C ATOM 446 O PHE A 602 47.279 58.332 −21.668 1.0051.47 A O ATOM 447 N GLY A 603 48.792 57.175 −22.866 1.00 51.12 A N ATOM448 CA GLY A 603 49.802 58.208 −22.752 1.00 54.60 A C ATOM 449 C GLY A603 50.385 58.299 −21.357 1.00 55.28 A C ATOM 450 O GLY A 603 50.48159.388 −20.790 1.00 57.85 A O ATOM 451 N LEU A 604 502779 57.155 −20.8041.00 55.98 A N ATOM 452 CA LEU A 604 51.352 57.119 −19.464 1.00 54.42 AC ATOM 453 CB LEU A 604 50.856 55.885 −18.707 1.00 52.63 A C ATOM 454 CGLEU A 604 50.668 56.029 −17.190 1.00 53.02 A C ATOM 455 CD1 LEU A 60450.348 54.669 −16.589 1.00 47.74 A C ATOM 456 CD2 LEU A 604 51.91456.609 −16.553 1.00 45.06 A C ATOM 457 C LEU A 604 52.869 57.085 −19.5531.00 57.25 A C ATOM 458 O LEU A 604 53.439 56.279 −20.288 1.00 59.13 A OATOM 459 N GLY A 605 53.520 57.965 −18.801 1.00 59.81 A N ATOM 460 CAGLY A 605 54.969 58.013 −18.812 1.00 61.32 A C ATOM 461 C GLY A 60555.501 58.603 −20.100 1.00 64.09 A C ATOM 462 O GLY A 605 54.742 58.858−21.037 1.00 64.12 A O ATOM 463 N LYS A 606 56.809 58.824 −20.145 1.0067.16 A N ATOM 464 CA LYS A 606 57.447 59.387 −21.325 1.00 73.06 A CATOM 465 CB LYS A 606 58.967 59.266 −21.194 1.00 74.86 A C ATOM 466 CCLYS A 606 59.499 60.029 −19.986 1.00 77.56 A C ATOM 467 CD LYS A 60660.981 59.814 −19.743 1.00 78.95 A C ATOM 468 CE LYS A 606 61.414 60.538−18.472 1.00 81.67 A C ATOM 469 NZ LYS A 606 62.860 60.359 −18.164 1.0084.93 A N ATOM 470 C LYS A 606 56.938 58.654 −22.559 1.00 75.50 A C ATOM471 O LYS A 606 56.313 59.255 −23.433 1.00 75.14 A O ATOM 472 N GLU A607 5.7.194 57.354 −22.625 1.00 78.26 A N ATOM 473 CA GLU A 607 56.71656.567 −23.749 1.00 81.93 A C ATOM 474 CB GLU A 607 57.274 55.145−23.684 1.00 84.74 A C ATOM 475 CG GLU A 607 58.744 55.084 −23.310 1.0086.75 A C ATOM 476 CD GLU A 607 59.569 56.126 −24.037 1.00 90.39 A CATOM 477 OE1 GLU A 607 59.611 56.094 −25.286 1.00 92.77 A O ATOM 478 OE2GLU A 607 60.173 56.981 −23.3.55 1.00 91.60 A O ATOM 479 C GLU A 60755.201 56.545 −23.588 1.00 83.47 A C ATOM 480 O GLU A 607 54.671 55.833−22.734 1.00 85.59 A O ATOM 481 N ASP A 608 54.510 57.339 −24.399 1.0081.98 A N ATOM 482 CA ASP A 608 53.055 57.434 −24.333 1.00 80.62 A CATOM 483 CB ASP A 608 52.560 58.507 −25.304 1.00 82.58 A C ATOM 484 CGASP A 608 53.190 59.858 −25.043 1.00 84.79 A C ATOM 485 OD1 ASP A 60854.418 59.987 −25.235 1.00 86.74 A O ATOM 486 OD2 ASP A 608 52.46060.788 −24.639 1.00 87.45 A O ATOM 487 C ASP A 608 52.336 56.121 −24.6191.00 77.60 A C ATOM 488 O ASP A 608 51.170 56.120 −25.014 1.00 78.28 A OATOM 489 N ALA A 609 53.028 55.007 −24.414 1.00 75.42 A N ATOM 490 CAALA A 609 52.443 53.694 −24.649 1.00 72.97 A C ATOM 491 CB ALA A 60953.411 52.602 −24.202 1.00 75.62 A C ATOM 492 C ALA A 609 51.120 53.559−23.905 1.00 70.13 A C ATOM 493 O ALA A 609 50.899 54.211 −22.881 1.0066.39 A O ATOM 494 N VAL A 610 50.241 52.714 −24.433 1.00 68.09 A N ATOM495 CA VAL A 610 48.934 52.477 −23.830 1.00 64.25 A C ATOM 496 CB VAL A610 47.826 52.418 −24.913 1.00 59.85 A C ATOM 497 CG1 VAL A 610 46.45552.349 −24.262 1.00 56.84 A C ATOM 498 CG2 VAL A 610 47.922 53.636−25.819 1.00 54.82 A C ATOM 499 C VAL A 610 48.983 51.148 −23.079 1.0062.29 A C ATOM 500 O VAL A 610 48.181 50.247 −23.329 1.00 63.16 A O ATOM501 N LEU A 611 49.933 51.038 −22.155 1.00 59.06 A N ATOM 502 CA LEU A611 50.108 49.821 −21.371 1.00 57.74 A C ATOM 503 CB LEU A 611 51.47549.840 −20.679 1.00 58.65 A C ATOM 504 CG LEU A 611 51.968 51.173−20.107 1.00 61.98 A C ATOM 505 CD1 LEU A 611 50.925 51.766 −19.185 1.0062.53 A C ATOM 506 CD2 LEU A 611 53.278 50.952 −19.366 1.00 62.46 A CATOM 507 C LEU A 611 49.014 49.543 −20.342 1.00 53.57 A C ATOM 508 O LEUA 611 48.339 50.452 −19.859 1.00 52.15 A O ATOM 509 N LYS A 612 48.84748.263 −20.024 1.00 54.36 A N ATOM 510 CA LYS A 612 47.859 47.821−19.049 1.00 51.58 A C ATOM 511 CB LYS A 612 47.608 46.317 −19.198 1.0054.96 A C ATOM 512 CG LYS A 612 46.371 45.809 −18.474 1.00 58.00 A CATOM 513 CD LYS A 612 45.174 45.707 −19.413 1.00 66.68 A C ATOM 514 CELYS A 612 44.813 47.046 −20.038 1.00 71.12 A C ATOM 515 NZ LYS A 61243.678 46.915 −20.996 1.00 70.54 A N ATOM 516 C LYS A 612 48.450 48.113−17.675 1.00 45.89 A C ATOM 517 O LYS A 612 49.650 47.937 −17.465 1.0042.47 A O ATOM 518 N VAL A 613 47.615 48.562 −16.743 1.00 38.49 A N ATOM519 CA VAL A 613 48.094 48.894 −15.407 1.00 34.26 A C ATOM 520 CB VAL A613 48.392 50.415 −15.269 1.00 27.93 A C ATOM 521 CG1 VAL A 613 49.34650.864 −16.363 1.00 30.91 A C ATOM 522 CG2 VAL A 613 47.101 51.215−15.330 1.00 22.94 A C ATOM 523 C VAL A 613 47.079 48.518 −14.342 1.0032.02 A C ATOM 524 O VAL A 613 45.971 48.097 −14.652 1.00 28.00 A O ATOM525 N ALA A 614 47.482 48.672 −13.084 1.00 29.17 A N ATOM 526 CA ALA A614 46.633 48.376 −11.938 1.00 29.17 A C ATOM 527 CB ALA A 614 47.33847.397 −11.005 1.00 32.26 A C ATOM 528 C ALA A 614 46.383 49.695 −11.2211.00 30.22 A C ATOM 529 O ALA A 614 47.289 50.518 −11.105 1.00 29.40 A OATOM 530 N VAL A 615 45.161 49.894 −10.736 1.00 29.87 A N ATOM 531 CAVAL A 615 44.798 51.133 −10.061 1.00 27.61 A C ATOM 532 CB VAL A 61543.761 51.936 −10.906 1.00 31.06 A C ATOM 533 CG1 VAL A 615 43.50553.297 −10.283 1.00 23.19 A C ATOM 534 CG2 VAL A 61 44.258 52.090−12.336 1.00 24.92 A C ATOM 535 C VAL A 615 44.192 50.852 −8.693 1.0029.60 A C ATOM 536 O VAL A 615 43.131 50.243 −8.596 1.00 31.31 A O ATOM537 N LYS A 616 44.862 51.290 −7.633 1.00 30.91 A N ATOM 538 CA LYS A616 44.332 51.075 −6.295 1.00 30.66 A C ATOM 539 CB LYS A 616 45.46150.781 −5.304 1.00 35.30 A C ATOM 540 CG LYS A 616 44.984 50.022 −4.0721.00 48.47 A C ATOM 541 CD LYS A 616 46.133 49.518 −3.210 1.00 53.24 A CATOM 542 CB LYS A 616 46.863 50.660 −2.540 1.00 53.43 A C ATOM 543 NZLYS A 616 45.934 51.438 −1.678 1.00 58.24 A N ATOM 544 C LYS A 61643.554 52.323 −5.870 1.00 29.05 A C ATOM 545 O LYS A 616 43.898 53.445−6.252 1.00 25.57 A O ATOM 546 N MET A 617 42.508 52.119 −5.076 1.0026.07 A N ATOM 547 CA MET A 617 41.650 53.212 −4.623 1.00 34.81 A C ATOM548 CB MET A 617 40.637 53.549 5.715 1.00 33.43 A C ATOM 549 CG MET A617 39.722 52.372 −6.037 1.00 36.82 A C ATOM 550 SD MET A 617 38.99552.461 −7.670 1.00 38.05 A S ATOM 551 CB MET A 617 40.387 51.929 −8.6801.00 39.70 A C ATOM 552 C MET A 617 40.899 52.793 −3.367 1.00 32.33 A CATOM 553 0 MET A 617 40.833 51.607 −3.043 1.00 37.05 A O ATOM 554 N LEUA 618 40.317 53.767 −2.676 1.00 35.77 A N ATOM 555 CA LEU A 618 39.57753.492 −1.449 1.00 37.88 A C ATOM 556 CB LEU A 618 39.717 54.661 −0.4761.00 35.44 A C ATOM 557 CG LEU A 618 41.125 54.928 0.049 1.00 39.79 A CATOM 558 CD1 LEU A 618 41.069 56.023 1.106 1.00 28.83 A C ATOM 559 CD2LEU A 618 41.700 53.644 0.635 1.00 39.94 A C ATOM 560 C LEU A 618 38.09453.215 −1.666 1.00 40.94 A C ATOM 561 O LEU A 618 37.575 53.373 −2.7701.00 34.19 A O ATOM 562 N LYS A 619 37.430 52.793 −0.590 1.00 44.91 A NATOM 563 CA LYS A 619 35.998 52.505 −0.593 1.00 50.05 A C ATOM 564 CBLYS A 619 35.724 51.089 −0.082 1.00 48.11 A C ATOM 565 CG LYS A 61936.012 49.976 −1.061 1.00 50.29 A C ATOM 566 CD LYS A 619 35.636 48.638−0.448 1.00 49.52 A C ATOM 567 CB LYS A 619 35.773 47.508 −1.448 1.005093 A C ATOM 568 NZ LYS A 619 35.347 46.214 −0.851 1.00 55.92 A N ATOM569 C LYS A 619 35.299 53.496 0.336 1.00 51.91 A C ATOM 570 O LYS A 61935.932 54.396 0.893 1.00 53.70 A O ATOM 571 N SER A 620 33.991 53.3180.501 1.00 51.80 A N ATOM 572 CA SER A 620 33.199 54.177 1.379 1.0051.84 A C ATOM 573 CB SER A 620 31.712 53.851 1.228 1.00 52.28 A C ATOM574 CG SER A 620 31.331 53.834 −0.137 1.00 53.43 A O ATOM 575 C SER A620 33.644 53.875 2.803 1.00 52.87 A C ATOM 576 O SER A 620 33.69154.758 3.663 1.00 50.58 A O ATOM 577 N THR A 621 33.981 52.608 3.0241.00 53.81 A N ATOM 578 CA THR A 621 34.434 52.111 4.318 1.00 60.49 A CATOM 579 CB THR A 621 34.817 50.614 4.220 1.00 61.16 A C ATOM 580 OG1THR A 621 33.704 49.867 3.714 1.00 63.62 A O ATOM 581 CG2 THR A 62135.206 50.066 5.587 1.00 66.57 A C ATOM 582 C THR A 621 35.641 52.8844.847 1.00 60.35 A C ATOM 583 O THR A 621 35.801 53.049 6.059 1.00 59.91A O ATOM 584 N ALA A 622 36.484 53.354 3.931 1.00 60.73 A N ATOM 585 CAALA A 622 37.687 54.100 4.289 1.00 59.33 A C ATOM 586 CB ALA A 62238.569 54.282 3.059 1.00 51.34 A C ATOM 587 C ALA A 622 37.380 55.4584.913 1.00 59.82 A C ATOM 588 O ALA A 622 36.583 56.235 4.384 1.00 58.89A O ATOM 589 N HIS A 623 38.026 55.739 6.040 1.00 62.90 A N ATOM 590 CAHIS A 623 37.837 56.999 6.743 1.00 65.60 A C ATOM 591 CB HIS A 62337.583 56.734 8.230 1.00 69.02 A C ATOM 592 CG HIS A 623 36.818 57.8238.915 1.00 72.93 A C ATOM 593 CD2 HIS A 623 35.694 57.783 9.670 1.0075.31 A C ATOM 594 ND1 HIS A 623 37.196 59.147 8.862 1.00 75.32 A N ATOM595 CE1 HIS A 623 36.338 59.876 9.554 1.00 74.30 A C ATOM 596 NE2 HIS A623 35.418 59.073 10.054 1.00 75.22 A N ATOM 597 C HIS A 623 39.08857.865 6.569 1.00 67.22 A C ATOM 598 O HIS A 623 39.689 57.893 5.4941.00 67.16 A O ATOM 599 N ALA A 624 39.482 58.566 7.628 1.00 67.44 A NATOM 600 CA ALA A 624 40.660 59.426 7.581 1.00 66.82 A C ATOM 601 CB ALAA 624 40.611 60.440 8.719 1.00 65.89 A C ATOM 602 C ALA A 624 41.93658.593 7.676 1.00 64.74 A C ATOM 603 O ALA A 624 42.818 58.680 6.8201.00 60.99 A O ATOM 604 N ASP A 625 42.022 57.785 8.726 1.00 61.61 A NATOM 605 CA ASP A 625 43.178 56.929 8.946 1.00 65.53 A C ATOM 606 CB ASPA 625 42.924 56.006 10.141 1.00 69.12 A C ATOM 607 CG ASP A 625 42.55656.768 11.401 1.00 75.92 A C ATOM 608 OD1 ASP A 625 42.200 56.115 12.4051.00 79.00 A O ATOM 609 OD2 ASP A 625 42.624 58.017 11.389 1.00 77.85 AO ATOM 610 C ASP A 625 43.458 56.084 7.707 1.00 65.81 A C ATOM 611 O ASPA 625 44.609 55.777 7.397 1.00 64.91 A O ATOM 612 N GLU A 626 42.39355.714 7.003 1.00 63.78 A N ATOM 613 CA GLU A 626 42.507 54.891 5.8061.00 58.91 A C ATOM 614 CB GLU A 626 41.137 54.314 5.443 1.00 65.97 A CATOM 615 CG GLU A 626 40.259 54.002 6.651 1.00 74.56 A C ATOM 616 CD GLUA 626 40.898 53.027 7.619 1.00 78.91 A C ATOM 617 OE1 GLU A 626 41.07751.849 7.247 1.00 83.56 A O ATOM 618 OE2 GLU A 626 41.222 53.440 8.7541.00 80.70 A O ATOM 619 C GLU A 626 43.055 55.704 4.636 1.00 53.87 A CATOM 620 O GLU A 626 43.876 55.212 3.859 1.00 44.64 A O ATOM 621 N LYS A627 42.595 56.946 4.510 1.00 49.35 A N ATOM 622 CA LYS A 627 43.05657.819 3.438 1.00 46.10 A C ATOM 623 CB LYS A 627 42.222 59.102 3.3951.00 52.87 A C ATOM 624 CG LYS A 627 40.921 58.974 2.611 1.00 56.92 A CATOM 625 CD LYS A 627 40.205 60.316 2.509 1.00 64.69 A C ATOM 626 CE LYSA 627 39.081 60.287 1.475 1.00 64.70 A C ATOM 627 NZ LYS A 627 38.03359.276 1.788 1.00 64.21 A N ATOM 628 C LYS A 627 44.533 58.168 3.6151.00 44.02 A C ATOM 629 O LYS A 627 45.281 58.237 2.641 1.00 37.71 A OATOM 630 N GLU A 628 44.947 58.379 4.863 1.00 41.50 A N ATOM 631 CA GLUA 628 46.335 58.712 5.164 1.00 42.46 A C ATOM 632 CB GLU A 628 46.51758.976 6.662 1.00 52.27 A C ATOM 633 CG GLU A 628 45.799 60.211 7.1891.00 60.91 A C ATOM 634 CD GLU A 628 46.106 60.477 8.654 1.00 65.87 A CATOM 635 OE1 GLU A 628 47.296 60.665 8.989 1.00 68.70 A O ATOM 636 OE2GLU A 628 45.160 60.498 9.471 1.00 70.18 A O ATOM 637 C GLU A 628 47.26457.582 4.746 1.00 41.10 A C ATOM 638 O GLU A 628 48.324 57.825 4.1661.00 36.83 A O ATOM 639 N ALA A 629 46.856 56.349 5.043 1.00 36.25 A NATOM 640 CA ALA A 629 47.646 55.167 4.715 1.00 34.22 A C ATOM 641 CB ALAA 629 46.949 53.906 5.224 1.00 32.33 A C ATOM 642 C ALA A 629 47.89855.057 3.217 1.00 33.16 A C ATOM 643 O ALA A 629 48.990 54.673 2.7911.00 34.61 A O ATOM 644 N LEU A 630 46.890 55.386 2.418 1.00 28.87 A NATOM 645 CA LEU A 630 47.040 55.325 0.968 1.00 27.43 A C ATOM 646 CE LEUA 630 45.687 55.525 0.274 1.00 30.67 A C ATOM 647 CG LEU A 630 45.74355.479 −1.259 1.00 27.79 A C ATOM 648 CD1 LEU A 630 46.375 54.182 −1.7071.00 22.09 A C ATOM 649 CD2 LEU A 630 44.349 55.606 1.838 1.00 35.18 A CATOM 650 C LEU A 630 48.039 56.392 0.509 1.00 24.01 A C ATOM 651 O LEU A630 48.923 56.118 0.309 1.00 21.58 A O ATOM 652 N MET A 631 47.89957.604 1.039 1.00 26.37 A N ATOM 653 CA MET A 631 48.811 58.696 0.6921.00 22.28 A C ATOM 654 CB MET A 631 48.381 60.004 1.362 1.00 25.47 A CATOM 655 CG MET A 631 47.214 60.727 0.688 1.00 25.79 A C ATOM 656 SD META 631 47.436 60.997 1.091 1.00 33.85 A S ATOM 657 CB MET A 631 48.91761.962 1.116 1.00 22.54 A C ATOM 658 C MET A 631 50.234 58.336 1.1261.00 23.32 A C ATOM 659 O MET A 631 51.194 58.583 0.395 1.00 25.68 A OATOM 660 N SER A 632 50.360 57.762 2.319 1.00 20.26 A N ATOM 661 CA SERA 632 51.660 57.338 2.837 1.00 25.00 A C ATOM 662 CB SER A 632 51.51856.764 4.242 1.00 22.87 A C ATOM 663 OG SER A 632 51.210 57.778 5.1721.00 29.83 A O ATOM 664 C SER A 632 52.282 56.283 1.934 1.00 22.56 A CATOM 665 O SER A 632 53.483 56.320 1.671 1.00 20.09 A O ATOM 666 N GLU A633 51.469 55.337 1.463 1.00 20.83 A N ATOM 667 CA GLU A 633 51.98154.298 0.579 1.00 26.94 A C ATOM 668 CB GLU A 633 50.885 53.301 0.1871.00 25.64 A C ATOM 669 CG GLU A 633 51.387 52.193 0.726 1.00 27.09 A CATOM 670 CD GLU A 633 50.280 51.275 1.201 1.00 27.05 A C ATOM 671 OE1GLU A 633 49.310 51.079 0.446 1.00 27.37 A O ATOM 672 OE2 GLU A 63350.385 50.738 2.325 1.00 33.08 A O ATOM 673 C GLU A 633 52.493 54.9960.666 1.00 20.38 A C ATOM 674 O GLU A 633 53.578 54.698 1.161 1.00 21.26A O ATOM 675 N LEU A 634 51.701 55.941 1.156 1.00 22.56 A N ATOM 676 CALEU A 634 52.059 56.712 2.341 1.00 25.09 A C ATOM 677 CB LEU A 63450.966 57.741 2.627 1.00 27.78 A C ATOM 678 CG LEU A 634 50.787 58.2314.066 1.00 25.35 A C ATOM 679 CD1 LEU A 634 49.949 59.512 4.052 1.0021.43 A C ATOM 680 CD2 LEU A 634 52.127 58.476 4.706 1.00 22.68 A C ATOM681 C LEU A 634 53.395 57.434 2.128 1.00 24.30 A C ATOM 682 O LEU A 63454.276 57.415 2.992 1.00 24.05 A O ATOM 683 N LYS A 635 53.538 58.0780.973 1.00 22.48 A N ATOM 684 CA LYS A 635 54.764 58.804 0.646 1.0019.32 A C ATOM 685 CB LYS A 635 54.598 59.533 0.690 1.00 19.43 A C ATOM686 CG LYS A 635 53.539 60.612 0.679 1.00 27.19 A C ATOM 687 CD LYS A635 53.358 61.183 2.073 1.00 31.64 A C ATOM 688 CB LYS A 635 52.22162.191 2.122 1.00 36.37 A C ATOM 689 NZ LYS A 635 52.063 62.721 3.5021.00 37.87 A N ATOM 690 C LYS A 635 55.960 57.857 0.570 1.00 15.22 A CATOM 691 O LYS A 635 57.061 58.190 1.018 1.00 18.34 A O ATOM 692 N ILE A636 55.754 56.680 0.012 1.00 18.18 A N ATOM 693 CA ILE A 636 56.82755.708 0.102 1.00 17.98 A C ATOM 694 CB ILE A 636 56.403 54.489 0.9411.00 19.18 A C ATOM 695 CG2 ILE A 636 57.373 53.342 0.720 1.00 25.01 A CATOM 696 CG1 ILE A 636 56.345 54.880 2.424 1.00 20.19 A C ATOM 697 CD1ILE A 636 55.901 53.764 3.335 1.00 27.49 A C ATOM 698 C ILE A 636 57.23455.240 1.298 1.00 15.24 A C ATOM 699 O ILE A 636 58.417 55.259 −1.6531.00 18.48 A O ATOM 700 N MET A 637 56.255 54.836 2.098 1.00 20.21 A NATOM 701 CA MET A 637 56.551 54.352 −3.442 1.00 17.53 A C ATOM 702 CBMET A 637 55.291 53.771 4.086 1.00 25.94 A C ATOM 703 CG MET A 63754.685 52.585 −3.324 1.00 21.02 A C ATOM 704 SD MET A 637 55.855 51.242−2.971 1.00 24.05 A S ATOM 705 CB MET A 637 56.113 50.547 −4.616 1.0018.83 A C ATOM 706 C MET A 637 57.157 55.423 −4.347 1.00 25.09 A C ATOM707 O MET A 637 57.901 55.112 −5.277 1.00 22.66 A O ATOM 708 N SER A 63856.849 56.688 −4.094 1.00 26.29 A N ATOM 709 CA SER A 638 57.421 57.733−4.933 1.00 33.24 A C ATOM 710 CB SER A 638 56.618 59.035 −4.800 1.0033.33 A C ATOM 711 OG SER A 638 56.811 59.634 −3.532 1.00 35.42 A O ATOM712 C SER A 638 58.877 57.972 −4.530 1.00 34.32 A C ATOM 713 O SER A 63859.661 58.527 −5.299 1.00 37.80 A O ATOM 714 N HIS A 639 59.231 57.519−3.328 1.00 30.10 A N ATOM 715 CA HIS A 639 60.573 57.694 −2.781 1.0034.75 A C ATOM 716 CB HIS A 639 60.451 58.134 −1.316 1.00 40.02 A C ATOM717 CG HIS A 639 61.721 58.026 −0.531 1.00 45.54 A C ATOM 718 CD2 HIS A639 62.589 58.974 −0.104 1.00 50.09 A C ATOM 719 ND1 HIS A 639 62.20756.823 −0.061 1.00 52.72 A N ATOM 720 CE1 HIS A 639 63.317 57.036 0.6231.00 54.80 A C ATOM 721 NE2 HIS A 639 63.571 58.333 0.612 1.00 54.49 A NATOM 722 C HIS A 639 61.510 56.484 −2.897 1.00 32.89 A C ATOM 723 O HISA 639 62.732 56.638 −2.874 1.00 23.77 A O ATOM 724 N LEU A 640 60.94855.288 −3.035 1.00 26.57 A N ATOM 725 CA LEU A 640 61.767 54.088 −3.1381.00 26.21 A C ATOM 726 CB LEU A 640 60.901 52.833 −2.988 1.00 24.80 A CATOM 727 CG LEU A 640 60.546 52.323 −1.591 1.00 28.55 A C ATOM 728 CD1LEU A 640 59.736 51.039 −1.739 1.00 31.89 A C ATOM 729 CD2 LEU A 64061.803 52.054 −0.785 1.00 32.23 A C ATOM 730 C LEU A 640 62.581 53.943−4.424 1.00 24.89 A C ATOM 731 O LEU A 640 63.653 53.349 −4.415 1.0022.91 A O ATOM 732 N GLY A 641 62.083 54.481 −5.528 1.00 24.86 A N ATOM733 CA GLY A 641 62.804 54.309 −6.773 1.00 28.59 A C ATOM 734 C GLY A641 62.340 52.984 −7.354 1.00 29.97 A C ATOM 735 O GLY A 641 61.72552.179 −6.647 1.00 27.41 A O ATOM 736 N GLN A 642 62.637 52.731 −8.6241.00 24.00 A N ATOM 737 CA GLN A 642 62.189 51.497 −9.261 1.00 27.01 A CATOM 738 CB GLN A 642 61.919 51.728 −10.751 1.00 29.07 A C ATOM 739 CGGLN A 642 60.775 52.683 −11.054 1.00 52.49 A C ATOM 740 CD GLN A 64260;420 52.701 −12.532 1.00 62.87 A C ATOM 741 OE1 GLN A 642 61.28752.903 −13.386 1.00 68.48 A O ATOM 742 NE2 GLN A 642 59.143 52.490−12.840 1.00 63.12 A N ATOM 743 C GLN A 642 63.133 50.311 −9.136 1.0022.61 A C ATOM 744 O GLN A 642 64.340 50.474 −8.951 1.00 21.65 A O ATOM745 N HIS A 643 62.556 49.118 −9.251 1.00 22.32 A N ATOM 746 CA HIS A643 63.302 47.868 −9.205 1.00 22.22 A C ATOM 747 CB HIS A 643 63.53647.410 −7.756 1.00 21.85 A C ATOM 748 CG HIS A 643 64.434 46.211 −7.6341.00 23.29 A C ATOM 749 CD2 HIS A 643 65.738 46.107 −7.278 1.00 25.57 AC ATOM 750 ND1 HIS A 643 64.012 44.927 −7.912 1.00 23.34 A N ATOM 751CE1 HIS A 643 65.016 44.085 −7.730 1.00 20.93 A C ATOM 752 NE2 HIS A 64366.075 44.776 −7.344 1.00 24.44 A N ATOM 753 C HIS A 643 62.499 46.825−9.987 1.00 23.97 A C ATOM 754 O HIS A 643 61.261 46.825 −9.988 1.0020.55 A O ATOM 755 N GLU A 644 63.213 45.936 −10.662 1.00 28.13 A N ATOM756 CA GLU A 644 62.587 44.903 −11.476 1.00 29.69 A C ATOM 757 CB GLU A644 63.684 44.094 −12.181 1.00 38.10 A C ATOM 758 CG GLU A 644 64.61343.353 −11.222 1.00 52.65 A C ATOM 759 CD GLU A 644 65.828 42.747−11.909 1.00 61.25 A C ATOM 760 OE1 GLU A 644 65.656 42.080 −12.953 1.0063.57 A O ATOM 761 OE2 GLU A 644 66.955 42.929 −11.396 1.00 64.44 A OATOM 762 C GLU A 644 61.642 43.948 −10.729 1.00 27.63 A C ATOM 763 O GLUA 644 60.710 43.401 −11.327 1.00 21.30 A O ATOM 764 N ASN A 645 61.86143.752 −9.429 1.00 22.24 A N ATOM 765 CA ASN A 645 61.021 42.821 −8.6741.00 25.56 A C ATOM 766 CB ASN A 645 61.901 41.809 −7.939 1.00 19.60 A CATOM 767 CC ASN A 645 62.854 41.097 −8.877 1.00 27.53 A C ATOM 768 OD1ASN A 645 64.077 41.220 −8.756 1.00 21.54 A O ATOM 769 ND2 ASN A 64562.296 40.360 −9.835 1.00 17.26 A N ATOM 770 C ASN A 645 60.050 43.469−7.701 1.00 26.56 A C ATOM 771 O ASN A 645 59.604 42.844 −6.746 1.0022.63 A O ATOM 772 N ILE A 646 59.737 44.732 −7.949 1.00 24.07 A N ATOM773 CA ILE A 646 58.792 45.463 −7.127 1.00 22.29 A C ATOM 774 CB ILE A646 59.430 46.727 −6.508 1.00 23.88 A C ATOM 775 CG2 ILE A 646 58.39347.491 −5.705 1.00 30.07 A C ATOM 776 CG1 ILE A 646 60.617 46.353 −5.6211.00 28.07 A C ATOM 777 CD1 ILE A 646 60.240 45.844 −4.249 1.00 26.14 AC ATOM 778 C ILE A 646 57.677 45.905 −8.069 1.00 23.35 A C ATOM 779 OILE A 646 57.929 46.179 −9.251 1.00 22.79 A O ATOM 780 N VAL A 64756.447 45.933 −7.566 1.00 18.17 A N ATOM 781 CA VAL A 647 55.311 46.401−8.357 1.00 23.59 A C ATOM 782 CB VAL A 647 53.970 46.004 −7.706 1.0017.76 A C ATOM 783 CG1 VAL A 647 52.816 46.598 −8.486 1.00 20.21 A CATOM 784 CG2 VAL A 647 53.846 44.484 −7.666 1.00 27.63 A C ATOM 785 CVAL A 647 55.486 47.923 −8.318 1.00 26.28 A C ATOM 786 O VAL A 64755.023 48.604 −7.396 1.00 23.39 A O ATOM 787 N ASN A 648 56.175 48.442−9.326 1.00 25.50 A N ATOM 788 CA ASN A 648 56.492 49.859 −9.393 1.0024.16 A C ATOM 789 CB ASN A 648 57.496 50.100 −10.526 1.00 26.76 A CATOM 790 CG ASN A 648 58.806 49.358 −10.310 1.00 29.70 A C ATOM 791 OD1ASN A 648 59.478 49.537 −9.292 1.00 23.12 A O ATOM 792 ND2 ASN A 64859.174 48.520 −11.267 1.00 28.39 A N ATOM 793 C ASN A 648 55.333 50.838−9.519 1.00 21.87 A C ATOM 794 O ASN A 648 54.292 50.530 −10.091 1.0023.06 A O ATOM 795 N LEU A 649 55.528 52.020 −8.945 1.00 21.70 A N ATOM796 CA LEU A 649 54.540 53.080 −9.021 1.00 20.39 A C ATOM 797 CB LEU A649 54.832 54.162 −7.978 1.00 20.12 A C ATOM 798 CG LEU A 649 53.99455.438 −8.100 1.00 22.61 A C ATOM 799 CD1 LEU A 649 52.541 55.132 −7.7791.00 17.80 A C ATOM 800 CD2 LEU A 649 54.539 56.505 −7.148 1.00 25.20 AC ATOM 801 C LEU A 649 54.705 53.664 −10.421 1.00 22.86 A C ATOM 802 OLEU A 649 55.826 53.803 −10.916 1.00 23.25 A O ATOM 803 N LEU A 65053.592 53.997 −11.058 1.00 21.92 A N ATOM 804 CA LEU A 650 53.624 54.561−12.396 1.00 24.37 A C ATOM 805 CB LEU A 650 52.854 53.647 −13.357 1.0024.72 A C ATOM 806 CG LEU A 650 53.343 52.196 −13.493 1.00 25.79 A CATOM 807 CD1 LEU A 650 52.409 51.427 −14.418 1.00 31.72 A C ATOM 808 CD2LEU A 650 54.758 52.170 −14.038 1.00 24.15 A C ATOM 809 C LEU A 65053.016 55.965 −12.404 1.00 25.19 A C ATOM 810 O LEU A 650 53.414 56.819−13.192 1.00 29.30 A O ATOM 811 N GLY A 651 52.048 56.194 −11.524 1.0025.81 A N ATOM 812 CA GLY A 651 51.410 57.494 −11.450 1.00 27.92 A CATOM 813 C GLY A 651 50.340 57.522 −10.378 1.00 29.85 A C ATOM 814 O GLYA 651 50.115 56.528 −9.688 1.00 27.19 A O ATOM 815 N ALA A 652 49.68158.667 −10.241 1.00 25.92 A N ATOM 816 CA ALA A 652 48.623 58.840 −9.2651.00 20.70 A C ATOM 817 CB ALA A 652 −49.218 59.231 −7.914 1.00 15.45 AC ATOM 818 C ALA A 652 47.657 59.923 −9.738 1.00 27.72 A C ATOM 819 OALA A 652 47.982 60.726 −10.613 1.00 28.78 A O ATOM 820 N CYS A 65346.464 59.926 −9.157 1.00 27.84 A N ATOM 821 CA CYS A 653 45.436 60.910−9.466 1.00 27.49 A C ATOM 822 CB CYS A 653 44.285 60.254 −10.230 1.0026.09 A C ATOM 823 SG CYS A 653 44.784 59.486 −11.802 1.00 34.38 A SATOM 824 C CYS A 653 44.980 61.379 −8.088 1.00 26.02 A C ATOM 825 O CYSA 653 44.175 60.728 −7.437 1.00 27.77 A O ATOM 826 N THR A 654 45.51762.507 −7.640 1.00 24.22 A N ATOM 827 CA THR A 654 45.190 63.020 −6.3211.00 26.99 A C ATOM 828 CB THR A 654 46.477 63.311 −5.515 −1.00 29.57 AC ATOM 829 OG1 THR A 654 47.257 64.304 −6.193 1.00 34.03 A O ATOM 830CG2 THR A 654 47.309 62.047 −5.368 1.00 28.82 A C ATOM 831 C THR A 65444.33 264.280 −6.350 1.00 29.01 A C ATOM 832 O THR A 654 44.098 64.896−5.312 1.00 31.97 A O ATOM 833 N HIS A 655 43.862 64.654 −7.536 1.0031.62 A N ATOM 834 CA HIS A 655 43.029 65.844 −7.687 1.00 34.93 A C ATOM835 CB HIS A 655 43.838 66.981 −8.323 1.00 31.60 A C ATOM 836 CG HIS A655 45.071 67.345 −7.559 1.00 37.08 A C ATOM 837 CD2 HIS A 655 46.38267.207 −7.865 1.00 30.91 A C ATOM 838 ND1 HIS A 655 45.029 67.894 −6.2951.00 37.45 A N ATOM 839 CE1 HIS A 655 46.261 68.076 −5.855 1.00 37.22 AC ATOM 840 NE2 HIS A 655 47.101 67.666 −6.789 1.00 33.14 A N ATOM 841 CHIS A 655 41.807 65.562 −8.551 1.00 36.19 A C ATOM 842 O HIS A 65541.804 64.629 −9.359 1.00 37.26 A O ATOM 843 N GLY A 656 40.772 66.381−8.372 1.00 36.44 A N ATOM 844 CA GLY A 656 39.554 66.239 −9.148 1.0033.74 A C ATOM 845 C GLY A 656 38.774 64.961 −8.9.14 1.00 32.51 A C ATOM846 O GLY A 656 37.958 64.566 −9.747 1.00 35.25 A O ATOM 847 N GLY A 65739.015 64.317 −7.779 1.00 31.89 A N ATOM 848 CA GLY A 657 38.319 63.083−7.467 1.00 34.11 A C ATOM 849 C GLY A 657 39.053 62.290 −6.403 1.0034.68 A C ATOM 850 O GLY A 657 40.048 62.762 −5.856 1.00 31.99 A O ATOM851 N PRO A 658 38.579 61.080 −6.079 1.00 39.26 A N ATOM 852 CD PRO A658 37.341 60.450 −6.567 1.00 43.66 A C ATOM 853 CA PRO A 658 39.22460.242 −5.062 1.00 37.22 A C ATOM 854 CB PRO A 658 38.302 59.024 −4.9811.00 39.65 A C ATOM 855 CG PRO A 658 36.963 59.575 −5.405 1.00 43.48 A CATOM 856 C PRO A 658 40.635 59.861 −5.500 1.00 33.73 A C ATOM 857 O PROA 658 40.907 59.715 −6.695 1.00 28.06 A O ATOM 858 N VAL A 659 41.52559.697 −4.528 1.00 31.88 A N ATOM 859 CA VAL A 659 42.909 59.329 −4.8041.00 31.94 A C ATOM 860 CB VAL A 659 43.736 59.269 −3.499 1.00 34.29 A CATOM 861 CG1 VAL A 659 45.165 58.823 −3.809 1.00 29.89 A C ATOM 862 CG2VAL A 659 43.734 60.626 −2.818 1.00 32.93 A C ATOM 863 C VAL A 65943.035 57.975 −5.501 1.00 24.77 A C ATOM 864 O VAL A 659 42.442 56.991−5.070 1.00 30.57 A O ATOM 865 N LEU A 660 43.813 57.932 −6.578 1.0025.76 A N ATOM 866 CA LEU A 660 44.044 56.694 −7.321 1.00 26.43 A C ATOM867 CB LEU A 660 43.426 56.772 −8.722 1.00 29.65 A C ATOM 868 CG LEU A660 41.965 57.227 −8.845 1.00 35.40 A C ATOM 869 CD1 LEU A 660 41.56157.235 −10.318 1.00 31.66 A C ATOM 870 CD2 LEU A 660 41.053 56.316−8.041 1.00 27.07 A C ATOM 871 C LEU A 660 45.552 56.496 −7.457 1.0026.44 A C ATOM 872 O LEU A 660 46.260 57.395 −7.910 1.00 27.80 A O ATOM873 N VAL A 661 46.042 55.332 −7.050 1.00 22.60 A N ATOM 874 CA VAL A661 47.464 55.023 −7.151 1.00 23.64 A C ATOM 875 CB VAL A 661 47.99854.463 −5.807 1.00 6.14 A C ATOM 876 CG1 VAL A 661 49.419 53.931 −5.9761.00 23.41 A C ATOM 877 CG2 VAL A 661 47.946 55.563 −4.744 1.00 20.58 AC ATOM 878 C VAL A 661 47.643 54.000 −8.273 1.00 23.24 A C ATOM 879 OVAL A 661 47.134 52.882 −6.206 1.00 21.85 A O ATOM 880 N ILE A 66248.361 54.405 −9.312 1.00 25.10 A N ATOM 881 CA ILE A 662 48.595 53.561−10.471 1.00 26.03 A C ATOM 882 CB ILE A 662 48.554 54.399 −11.765 1.0026.14 A C ATOM 883 CG2 ILE A 662 48.543 53.475 −12.982 1.00 28.43 A CATOM 884 CG1 ILE A 662 47.311 55.294 −11.765 1.00 30.10 A C ATOM 885 CD1ILE A 662 47.344 56.393 −12.824 1.00 23.69 A C ATOM 886 C ILE A 66249.954 52.873 −10.366 1.00 27.61 A C ATOM 887 O ILE A 662 50.968 53.531−10.260 1.01 29.04 A O ATOM 888 N THR A 663 49.942 51.547 −10.462 1.0029.00 A N ATOM 889 CA THR A 663 51.166 50.755 −10.395 1.00 28.88 A CATOM 890 CB THR A 663 51.238 49.955 −9.078 1.00 30.13 A C ATOM 891 OG1THR A 663 50.304 48.873 −9.129 1.00 25.31 A O ATOM 892 CG2 THR A 66350.878 50.841 −7.898 1.00 28.52 A C ATOM 893 C THR A 663 51.200 49.755−11.549 1.00 30.38 A C ATOM 894 O THR A 663 50.227 49.612 −12.293 1.0031.59 A O ATOM 895 N GLU A 664 52.327 49.070 −11.696 1.00 27.00 A N ATOM896 CA GLU A 664 52.466 48.068 −12.743 1.00 35.00 A C ATOM 897 CB GLU A664 53.875 47.475 −12.740 1.00 29.30 A C ATOM 898 CG GLU A 664 54.96548.469 −13.083 1.00 37.47 A C ATOM 899 CD GLU A 664 56.349 47.846−13.052 1.00 41.46 A C ATOM 900 OE1 GLU A 664 56.715 47.254 −12.017 1.0035.89 A O ATOM 901 OE2 GLU A 664 57.074 47.950 −14.064 1.00 48.46 A OATOM 902 C GLU A 664 51.445 46.957 −12.519 1.00 28.73 A C ATOM 903 O GLUA 664 51.031 46.692 −11.391 1.00 30.61 A O ATOM 904 N TYR A 665 51.04446.310 −13.604 1.00 30.70 A N ATOM 905 CA TYR A 665 50.073 45.228−13.547 1.00 29.76 A C ATOM 906 CB TYR A 665 49.030 45.438 −14.652 1.0032.72 A C ATOM 907 CG TYR A 665 48.144 44.248 −14.922 1.00 35.89 A CATOM 908 CD1 TYR A 665 47.224 43.810 −13.978 1.00 27.69 A C ATOM 909 CE1TYR A 665 46.423 42.713 −14.224 1.00 34.20 A C ATOM 910 CD2 TYR A 66548.237 43.556 −16.121 1.00 31.55 A C ATOM 911 CE2 TYR A 665 47.44142.459 −16.375 1.00 31.36 A C ATOM 912 CZ TYR A 665 46.538 42.042−15.425 1.00 28.75 A C ATOM 913 OH TYR A 665 45.753 40.944 −15.675 1.0035.96 A O ATOM 914 C TYR A 665 50.779 43.878 −13.716 1.00 28.14 A C ATOM915 O TYR A 665 51.714 43.750 −14.508 1.00 30.04 A O ATOM 916 N CYS A666 50.337 42.875 −12.964 1.00 29.53 A N ATOM 917 CA CYS A 666 50.94141.545 −13.036 1.00 28.64 A C ATOM 918 CB CYS A 666 51.411 41.124−11.638 1.00 25.70 A C ATOM 919 SG CYS A 666 52.670 42.237 −10.910 1.0026.77 A S ATOM 920 C CYS A 666 49.951 40.522 −13.625 1.00 29.12 A C ATOM921 O CYS A 666 49.122 39.952 −12.916 1.00 22.94 A O ATOM 922 N CYS A667 50.068 40.295 −14.932 1.00 30.40 A N ATOM 923 CA CYS A 667 49.18139.396 −15.672 1.00 34.47 A C ATOM 924 CB CYS A 667 49.639 39.308−17.135 1.00 36.28 A C ATOM 925 SG CYS A 667 51.310 38.651 −17.411 1.0040.31 A S ATOM 926 C CYS A 667 48.924 37.978 −15.164 1.00 35.66 A C ATOM927 O CYS A 667 47.874 37.413 −15.459 1.00 38.24 A O ATOM 928 N TYR A668 49.849 37.397 −14.405 1.00 36.54 A N ATOM 929 CA TYR A 668 49.65336.025 −13.934 1.00 32.77 A C ATOM 930 CB TYR A 668 50.959 35.238−14.074 1.00 37.24 A C ATOM 931 CG TYR A 668 51.417 35.083 −15.511 1.0033.30 A C ATOM 932 CD1 TYR A 668 52.665 35.536 −15.915 1.00 33.99 A CATOM 933 CE1 TYR A 668 53.073 35.435 −17.229 1.00 39.96 A C ATOM 934 CD2TYR A 668 50.585 34.515 −16.469 1.00 38.12 A C ATOM 935 CE2 TYR A 66850.985 34.408 −17.790 1.00 34.76 A C ATOM 936 CZ TYR A 668 52.229 34.872−18.165 1.00 39.12 A C ATOM 937 OH TYR A 668 52.629 34.790 −19.481 1.0041.65 A O ATOM 938 C TYR A 668 49.088 35.840 −12.528 1.00 34.16 A C ATOM939 O TYR A 668 48.866 34.709 −12.097 1.00 33.71 A O ATOM 940 N GLY A669 48.853 36.932 −11.809 1.00 26.49 A N ATOM 941 CA GLY A 669 48.29736.805 −10.470 1.00 28.48 A C ATOM 942 C GLY A 669 49.300 36.486 −9.3751.00 23.20 A C ATOM 943 O GLY A 669 50.515 36.592 −9.578 1.00 23.60 A OATOM 944 N ASP A 670 48.800 36.084 −8.210 1.00 24.97 A N ATOM 945 CA ASPA 670 49.685 35.787 −7.095 1.00 28.97 A C ATOM 946 CB ASP A 670 48.97135.992 −5.749 1.00 27.18 A C ATOM 947 CC ASP A 670 48.065 34.848 −5.4011.00 37.51 A C ATOM 948 OD1 ASP A 670 46.987 34.745 −6.017 1.00 42.45 AO ATOM 949 OD2 ASP A 670 48.438 34.045 −4.520 1.00 37.32 A O ATOM 950 CASP A 670 50.309 34.398 −7.140 1.00 27.49 A C ATOM 951 O ASP A 67049.713 33.415 −7.610 1.00 25.73 A O ATOM 952 N LEU A 671 51.535 34.352−6.644 1.00 26.96 A N ATOM 953 CA LEU A 671 52.346 33.149 −6.591 1.0022.40 A C ATOM 954 CB LEU A 671 53.678 33.478 −5.922 1.00 21.85 A C ATOM955 CG LEU A 671 54.595 32.293 −5.630 1.00 17.71 A C ATOM 956 CD1 LEU A671 55.022 31.646 6.933 1.00 21.96 A C ATOM 957 CD2 LEU A 671 55.79732.782 −4.852 1.00 20.20 A C ATOM 958 C LEU A 671 51.713 31.960 −5.8831.00 27.28 A C ATOM 959 O LEU A 671 51.769 30.842 −6.388 1.00 23.81 A OATOM 960 N LEU A 672 51.120 32.188 −4.712 1.00 21:.21 A N ATOM 961 CALEU A 672 50.519 31.090 −3.968 1.00 21.54 A C ATOM 962 CB LEU A 67249.776 31.605 −2.737 1.00 23.59 A C ATOM 963 CG LEU A 672 49.217 30.455−1.894 .1.00 24.90 A C ATOM 964 CD1 LEU A 672 50.355 29.528 −1.508 1.002930 A C ATOM 965 CD2 LEU A 672 48.511 30.983 −0.671 1.00 22.25 A C ATOM966 C LEU A 672 49.562 30.243 −4.805 1.00 29.90 A C ATOM 967 O LEU A 67249.611 29.010 −4.767 1.00 24.61 A O ATOM 968 N ASN A 673 48.693 30.89515.564 1.00 25.27 A N ATOM 969 CA ASN A 673 47.749 30.151 −6.383 1.0028.81 A C ATOM 970 CB ASN A 673 46.616 31.071 −6.827 1.00 35.55 A C ATOM971 CG ASN A 673 45.717 31.455 −5.670 1.00 43.59 A C ATOM 972 OD1 ASN A673 45.093 30.597 −5.046 1.00 48.83 A O ATOM 973 ND2 ASN A 673 45.66232.741 −5.362 1.00 47.05 A N ATOM 974 C ASN A 673 48.424 29.480 −7.5681.00 28.39 A C ATOM 975 O ASN A 673 47.992 28.417 −8.008 1.00 31.21 A OATOM 976 N PHE A 674 49.494 30.091 −8.071 1.00 27.12 A N ATOM 977 CA PHEA 674 50.242 29.519 −9.184 1.00 25.22 A C ATOM 978 CB PHE A 674 51.36030.465 −9.627 1.00 27.97 A C ATOM 979 CG PHE A 674 52.221 29.917 −10.7331.00 27.02 A C ATOM 980 CD1 PHE A 674 51.781 29.933 −12.049 1.00 31.40 AC ATOM 981 CD2 PHE A 674 53.470 29.374 −10.455 1.00 29.05 A C ATOM 982CE1 PHE A 674 52.571 29.415 −13.071 1.00 28.13 A C ATOM 983 CE2 PHE A674 54.264 28.856 −11.468 1.00 34.83 A C ATOM 984 CZ PHE A 674 53.81228.877 −12.781 1.00 25.40 A C ATOM 985 C PHE A 674 50.855 28.215 −8.6881.00 29.92 A C ATOM 986 O PHE A 674 50.774 27.184 −9.352 1.00 29.40 A OATOM 987 N LEU A 675 51.465 28.267 −7.509 1.00 25.02 A N ATOM 988 CA LEUA 675 52.087 27.083 −6.928 1.00 24.58 A C ATOM 989 CB LEU A 675 52.74227.429 −5.592 1.00 25.53 A C ATOM 990 CG LEU A 675 53.942 28.366 −5.6471.00 22.19 A C ATOM 991 CD1 LEU A 675 54.363 28.726 −4.223 1.00 28.72 AC ATOM 992 CD2 LEU A 675 55.072 27.697 −6.405 1.00 26.45 A C ATOM 993 CLEU A 675 51.063 25.979 −6.703 1.00 23.02 A C ATOM 994 O LEU A 67551.276 24.834 −7.090 1.00 27.30 A O ATOM 995 N ARG A 676 49.950 .26.333−6.073 1.00 21.01 A N ATOM 996 CA ARG A 676 48.910 25.370 −5.781 1.0024.79 A C ATOM 997 CB ARG A 676 47.806 26.051 −4.976 1.00 25.32 A C ATOM998 CG ARG A 676 48.312 26.448 −3.603 1.00 28.64 A C ATOM 999 CD ARG A676 47.259 27.076 −2.727 1.00 30.55 A C ATOM 1000 NE ARG A 676 47.72527.133 −1.344 1.00 18.04 A N ATOM 1001 CZ ARG A 676 46.981 27.541 −0.3261.00 27.36 A C ATOM 1002 NH1 ARG A 676 45.737 27.937 −0.539 1.00 28.80 AN ATOM 1003 NH2 ARG A 676 47.470 27.528 0.906 1.00 26.04 A N ATOM 1004 CARG A 676 48.346 24.666 −7.010 1.00 32.26 A C ATOM 1005 O ARG A 67647.958 23.503 −6.934 1.00 31.67 A O ATOM 1006 N ARG A 677 48.315 25.361−8.142 1.00 35.75 A N ATOM 1007 CA ARC A 677 47.814 24.760 −9.366 1.0035.90 A C ATOM 1008 CB ARG A 677 47.602 25.828 −10.442 1.00 43.63 A CATOM 1009 CG ARG A 677 46.526 26.829 −10.090 1.00 50.57 A C ATOM 1010 CDARG A 677 46.099 27.660 −11.286 1.00 57.17 A C ATOM 1011 NE ARG A 67745.044 28.602 −10.914 1.00 67.71 A N ATOM 1012 CZ ARG A 677 44.35229.340 −11.778 1.00 71.08 A C ATOM 1013 NH1 ARG A 677 44.596 29.248−13.080 1.00 71.07 A N ATOM 1014 NH2 ARG A 677 43.415 30.171 −11.3371.00 67.48 A N ATOM 1015 C ARG A 677 48.775 23.695 −9.883 1.00 37.85 A CATOM 1016 O ARG A 677 48.349 22.619 −10.299 1.00 35.60 A O ATOM 1017 NLYS A 678 50.071 23.994 −9.855 1.00 39.35 A N ATOM 1018 CA LYS A 67851.081 23.054 −10.333 1.00 41.87 A C ATOM 1019 CB LYS A 678 52.47423.687 −10.265 1.00 45.55 A C ATOM 1020 CG LYS A 678 52.546 25.112−10.790 1.00 52.01 A C ATOM 1021 CD LYS A 678 52.286 25.197 −12.284 1.0055.06 A C ATOM 1022 CB LYS A 678 53.410 24.564 −13.084 1.00 60.03 A CATOM 1023 NZ LYS A 678 53.232 24.817 −14.540 1.00 62.90 A N ATOM 1024 CLYS A 678 51.063 21.779 −9.492 1.00 44.37 A C ATOM 1025 O LYS A 67851.073 20.667 −10.027 1.00 40.32 A 0 ATOM 1026 N SER A 679 51.037 21.950−8.174 1.00 41.30 A N ATOM 1027 CA SER A 679 51.018 20.819 −7.254 1.0047.34 A C ATOM 1028 CB SER A 679 50.965 21.310 −5.808 1.00 47.51 A CATOM 1029 OG SER A 679 49.787 22.057 −5.574 1.00 56.35 A O ATOM 1030 CSER A 679 49.813 19.929 −7.530 1.00 46.51 A C ATOM 1031 O SER A 67949.939 18.706 −7.612 1.00 40.78 A O ATOM 1032 N ARG A 680 48.645 20.547−7.663 1.00 42.11 A N ATOM 1033 CA ARG A 680 47.433 19.798 −7.946 1.0047.66 A C ATOM 1034 CB ARG A 680 46.249 20.747 −8.141 1.00 51.99 A CATOM 1035 CG ARG A 680 44.979 20.044 −8.588 1.00 59.20 A C ATOM 1036 CDARG A 680 44.473 19.092 −7.518 1.00 60.66 A C ATOM 1037 NE ARG A 68043.610 18.056 −8.078 1.00 69.98 A N ATOM 1038 CZ ARG A 680 42.916 17.187−7.348 1.00 75.10 A C ATOM 1039 NH1 ARG A 680 42.977 17.231 −6.024 1.0077.74 A N ATOM 1040 NH2 ARG A 680 42.169 16.265 −7.940 1.00 71.58 A NATOM 1041 C ARG A 680 47.666 18.995 −9.222 1.00 49.29 A C ATOM 1042 OARG A 680 47.205 17.861 −9.353 1.00 41.73 A O ATOM 1043 N VAL A 68148.399 19.595 −10.156 1.00 49.39 A N ATOM 1044 CA VAL A 681 48.70518.951 −11.423 1.00 50.39 A C ATOM 1045 CB VAL A 681 49.300 19.952−12.427 1.00 48.40 A C ATOM 1046 CG1 VAL A 681 49.678 19.240 −13.7131.00 55.59 A C ATOM 1047 CG2 VAL A 681 48.298 21.050 −12.715 1.00 54.90A C ATOM 1048 C VAL A 681 49.690 17.801 −11.238 1.00 53.38 A C ATOM 1049O VAL A 681 49.628 16.812 −11.969 1.00 52.52 A O ATOM 1050 N LEU A 68250.595 17.931 −10.268 1.00 53.60 A N ATOM 1051 CA LEU A 682 51.57916.880 −10.009 1.00 54.50 A C ATOM 1052 CB LEU A 682 52.336 17.146−8.703 1.00 55.91 A C ATOM 1053 CG LEU A 682 53.603 18.002 −8.828 1.0051.61 A C ATOM 1054 CD1 LEU A 682 54.209 18.226 −7.466 1.00 45.39 A CATOM 1055 CD2 LEU A 682 54.607 17.304 −9.726 1.00 56.00 A C ATOM 1056 CLEU A 682 50.893 15.521 −9.956 1.00 58.22 A C ATOM 1057 O LEU A 68251.465 14.514 −10.370 1.00 60.71 A O ATOM 1058 N GLU A 683 49.670 15.487−9.436 1.00 61.1.00 A N ATOM 1059 CA GLU A 683 48.920 14.239 −9.407 1.0067.33 A C ATOM 1060 CB GLU A 683 47.752 14.315 −8.423 1.00 65.47 A CATOM 1061 CG GLU A 683 48.135 14.069 −6.969 1.00 69.77 A C ATOM 1062 CDGLU A 683 48.555 15.326 −6.236 1.00 68.58 A C ATOM 1063 OE1 GLU A 68347.734 16.262 −6.135 1.00 70.57 A O ATOM 1064 OE2 GLU A 683 49.70415.375 −5.752 1.00 71.66 A O ATOM 1065 C GLU A 683 48.393 14.072 −10.8291.00 70.81 A C ATOM 1066 O GLU A 683 47.208 13.817 −11.046 1.007 1.00 AO ATOM 1067 N THR A 684 49.307 14.233 −11.785 1.00 74.11 A N ATOM 1068CA THR A 684 49.029 14.147 −13.216 1.00 77.51 A C ATOM 1069 CB THR A 68450.337 13.995 −14.022 1.00 78.20 A C ATOM 107O OG1 THR A 684 51.39413.570 −13.151 1.00 76.25 A O ATOM 1071 CG2 THR A 684 50.709 15.311−14.687 1.00 79.78 A C ATOM 1072 C THR A 684 48.078 13.054 −13.672 1.0079.52 A C ATOM 1073 O THR A 684 47.691 12.176 −12.901 1.00 80.83 A OATOM 1074 N ASP A 685 47.711 13.126 −14.949 1.00 80.38 A N ATOM 1075 CASP A 685 46.808 12.162 −15.559 1.00 82.24 A C ATOM 1076 CB ASP A 68545.362 12.655 −15.466 1.00 82.26 A C ATOM 1077 CG ASP A 685 44.90212.844 −14.033 1.00 84.36 A C ATOM 1078 OD1 ASP A 685 45.433 13.743−13.346 1.00 83.48 A O ATOM 1079 OD2 ASP A 685 44.008 12.089 −13.5931.00 85.26 A O ATOM 1080 C ASP A 685 47.183 11.950 −17.022 1.00 84.72 AC ATOM 1081 O ASP A 685 48.259 12.357 −17.464 1.00 87.50 A O ATOM 1082 NSER A 693 53.014 22.633 −18.624 1.00 70.15 A N ATOM 1083 CA SER A 69354.049 23.336 −17.873 1.00 72.82 A C ATOM 1084 CB SER A 693 53.64924.804 −17.684 1.00 73.91 A C ATOM 1085 OG SER A 693 52359 24.918−17.105 1.00 75.91 A O ATOM 1086 C SER A 693 54.289 22.678 −16.513 1.0073.06 A C ATOM 1087 O SER A 693 53.355 22.491 −15.730 1.00 75.58 A OATOM 1088 N THR A 694 55.545 22.331 −16.239 1.00 68.76 A N ATOM 1089 CATHR A 694 55.908 21.684 −14.981 1.00 66.40 A C ATOM 1090 CB THR A 69456;243 20.197 −15.204 1.00 69.60 A C ATOM 1091 OG1 THR A 694 55.07619.509 −15.670 1.00 70.35 A O ATOM 1092 CG2 THR A 694 56.726 19.559−13.908 1.00 70.77 A C ATOM 1093 C THR A 694 57.102 22.354 −14.304 1.0060.92 A C ATOM 1094 O THR A 694 58.222 22.321 −14.816 1.00 58.71 A OATOM 1095 N ALA A 697 56.854 22.948 −13.141 1.00 55.19 A N ATOM 1096 CAALA A 697 57.895 23.639 −12.391 1.00 48.73 A C ATOM 1097 CB ALA A 69757.335 24.124 −11.052 1.00 45.94 A C ATOM 1098 C ALA A 697 59.128 22.773−12.157 1.00 47.24 A C ATOM 1099 O ALA A 697 59.028 21.579 −11.877 1.0046.79 A O ATOM 1100 N SER A 698 60.294 23.393 −12.280 1.00 44.27 A NATOM 1101 CA SER A 698 61.562 22.712 −12.070 1.00 43.79 A C ATOM 1102 CBSER A 698 62.424 22.802 −13.327 1.00 49.31 A C ATOM 1103 CG SER A 69863.692 22.204 −13.120 1.00 57.76 A O ATOM 1104 C SER A 698 62.274 23.396−10.909 1.00 42.26 A C ATOM 1105 O SER A 698 61.895 24.496 −10.504 1.0035.95 A O ATOM 1106 N THR A 699 63.305 22.751 −10.375 1.00 40.48 A NATOM 1107 CA THR A 699 64.042 23.331 −9.262 1.00 41.25 A C ATOM 1108 CBTHR A 699 65.246 22.443 −8.860 1.00 43.33 A C ATOM 1109 OG1 THR A 69965.943 23.050 −7.763 1.00 54.42 A O ATOM 1110 CG2 THR A 699 66.19922.262 −10.032 1.00 51.95 A C ATOM 1111 C THR A 699 64.525 24.735 −9.6281.00 40.03 A C ATOM 1112 O THR A 699 64.577 25.624 −8.775 1.00 33.42 A OATOM 1113 N ARG A 753 64.863 24.935 −10.900 1.00 32.66 A N ATOM 1114 CAARG A 753 65.326 26.236 −11.370 1.00 38.55 A C ATOM 1115 CB ARG A 75365.785 26.140 −12.824 1.00 42.14 A C ATOM 1116 CG ARG A 753 64.68025.707 −13.766 1.00 48.56 A C ATOM 1117 CD ARG A 753 65.162 25.606−15.202 1.00 58.62 A C ATOM 1118 NE ARG A 753 64.151 24.982 −16.050 1.0067.47 A N ATOM 1119 CZ ARG A 753 64.294 24.769 −17.353 1.00 70.46 A CATOM 1120 NH1 ARG A 753 65.412 25.132 −17.965 1.00 74.39 A N ATOM 1121NH2 ARG A 753 63.320 24.191 −18.044 1.00 73.59 A N ATOM 1122 C ARG A 75364.192 27.257 −11.269 1.00 36.15 A C ATOM 1123 O ARG A 753 64.419 28.427−10.958 1.00 31.25 A O ATOM 1124 N ASP A 754 62.975 26.804 −11.545 1.0030.98 A N ATOM 1125 CA ASP A 754 61.797 27.661 −11.492 1.00 31.57 A CATOM 1126 CB ASP A 754 60.572 26.884 −11.977 1.00 34.21 A C ATOM 1127 CGASP A 754 60.674 26.497 −13.441 1.00 33.79 A C ATOM 1128 OD1 ASP A 75460.068 25.476 −13.836 1.00 36.78 A O ATOM 1129 OD2 ASP A 754 61.35227.224 −14.199 1.00 35.61 A O ATOM 1130 C ASP A 75.4 61.557 28.168−10.074 1.00 31.79 A C ATOM 1131 O ASP A 754 61.257 29.345 −9.870 1.0028.70 A O ATOM 1132 N LEU A 755 61.699 27.277 −9.099 1.00 29.81 A N ATOM1133 CA LEU A 755 61.489 27.637 −7.699 1.00 24.86 A C ATOM 1134 CB LEU A755 61.412 26.376 −6.834 1.00 25.77 A C ATOM 1135 CG LEU A 755 60.34925.348 −7.245 1.00 23.84 A C ATOM 1136 CD1 LEU A 755 60.342 24.202−6.240 1.00 25.93 A C ATOM 1137 CD2 LEU A 755 58.984 26.001 −7.332 1.0021.61 A C ATOM 1138 C LEU A 755 62.616 28.531 −7.210 1.00 26.51 A C ATOM1139 O LEU A 755 62.401 29.426 −6.391 1.00 26.03 A O ATOM 1140 N LEU A756 63.823 28.284 −7.712 1.00 19.75 A N ATOM 1141 CA LEU A 756 64.97829.081 −7.329 1.00 25.64 A C ATOM 1142 CB LEU A 756 66.267 28.449 −7.8621.00 19.69 A C ATOM 1143 CG LEU A 756 66.699 27.143 −7.177 1.00 24.24 AC ATOM 1144 CD1 LEU A 756 67.899 26.553 −7.91.1 1.00 29.63 A C ATOM 1145CD2 LEU A 756 67.054 27.409 −5.719 1.00 25.25 A C ATOM 1146 C LEU A 75664.834 30.504 −7.848 1.00 23.89 A C ATOM 1147 O LEU A 756 65.181 31.455−7.155 1.00 21.64 A O ATOM 1148 N HIS A 757 64.312 30.649 −9.064 1.0026.01 A N ATOM 1149 CA HIS A 757 64.122 31.969 −9.658 1.00 32.21A C ATOM1150 CB HIS A 757 63.680 31.827 −11.117 1.00 30.34 A C ATOM 1151 CG HISA 757 64.748 31.276 −12.010 1.00 43.72 A C ATOM 1152 CD2 HIS A 75766.018 30.888 −11.744 1.00 47.21 A C ATOM 1153 ND1 HIS A 757 64.56131.070 −13.360 1.00 47.06 A N ATOM 1154 CE1 HIS A 757 65.668 30.580−13.888 1.00 46.10 A C ATOM 1155 NE2 HIS A 757 66.568 30.459 −12.9281.00 50.20 A N ATOM 1156 C HIS A 757 63.103 32.784 −8.861 1.00 32.11 A CATOM 1157 O HIS A 757 63.314 33.971 −8.589 1.00 28.26 A O ATOM 1158 NPHE A 758 62.000 32.146 −8.487 1.00 26.33 A N ATOM 1159 CA PHE A 75860.982 32.823 −7.696 1.00 26.92 A C ATOM 1160 CB PHE A 758 59.850 31.864−7.345 1.00 19.40 A C ATOM 1161 CG PHE A 758 58.960 31.528 −8.505 1.0032.48 A C ATOM 1162 CD1 PHE A 758 58.233 30.346 −8.519 1.00 29.63 A CATOM 1163 CD2 PHE A 758 58.834 32.402 −9.578 1.00 27.05 A C ATOM 1164CE1 PHE A 758 57.398 30.039 −9.579 1.00 30.08 A C ATOM 1165 CE2 PHE A758 57.999 32.102 −10.642 1.00 26.86 A C ATOM 1166 CZ PHE A 758 57.28230.922 −10.644 1.00 23.91 A C ATOM 1167 C PHE A 758 61.640 33.319 −6.4181.00 24.29 A C ATOM 1168 O PHE A 758 61486 34.474 −6.048 1.00 15.30 A OATOM 1169 N SER A 759 62.388 32.428 −5.771 1.00 25.71 A N ATOM 1170 CASER A 759 63.081 32.722 −4.522 1.00 23.10 A C ATOM 1171 CB SER A 75963.796 31.467 −4.011 1.00 22.51 A C ATOM 1172 OG SER A 759 62.916 30.360−3.979 1.00 17.85 A O ATOM 1173 C SER A 759 64.086 33.852 −4.682 1.0021.83 A C ATOM 1174 O SER A 759 64.210 34.707 −3.803 1.00 20.90 A O ATOM1175 N SER A 760 64.807 33.849 −5.802 1.00 15.60 A N ATOM 1176 CA SER A760 65.801 34.872 −6.096 1.00 18.74 A C ATOM 1177 CB SER A 760 66.62534.471 −7.325 1.00 20.47 A C ATOM 1178 OG SER A 760 67.693 33.625 −6.9571.00 26.56 A O ATOM 1179 C SER A 760 65.171 36.237 −6.346 1.00 18.72 A CATOM 1180 O SER A 760 65.590 37.240 −5.767 1.00 20.41 A O ATOM 1181 NGLN A 761 64.172 36.259 −7.222 1.00 16.97 A N ATOM 1182 CA GLN A 76163.459 37.477 −7.581 1.00 18.08 A C ATOM 1183 CB GLN A 761 62.336 37.132−8.554 1.00 21.99 A C ATOM 1184 CG GLN A 761 62.839 37.017 −9.991 1.0029.71 A C ATOM 1185 CD GLN A 761 62.167 35.912 −10.781 1.00 25.33 A CATOM 1186 OE1 GLN A 761 60.998 35.599 −10.568 1.00 26.00 A O ATOM 1187NE2 GLN A 761 62.905 35.327 −11.718 1.00 29.88 A N ATOM 1188 C GLN A 76162.911 38.182 −6.349 1.00 23.40 A C ATOM 1189 O GLN A 761 63.090 39.3906.183 1.00 21.31 A O ATOM 1190 N VAL A 762 62.260 37.420 −5.479 1.0020.06 A N ATOM 1191 CA VAL A 762 61.720 37.984 −4.255 1.00 20.11 A CATOM 1192 CB VAL A 762 60.819 36.956 −3.527 1.00 26.81 A C ATOM 1193 CG1VAL A 762 60.373 37.498 2.188 1.00 11.82 A C ATOM 1194 CG2 VAL A 76259.598 36.654 4.377 1.00 17.27 A C ATOM 1195 C VAL A 762 62.857 38.444−3.334 1.00 19.95 A C ATOM 1196 O VAL A 762 62.780 39.520 −2.742 1.0013.43 A O ATOM 1197 N ALA A 763 63.921 37.645 −3.232 1.00 18.45 A N ATOM1198 CA ALA A 763 65.058 37.990 −2.381 1.00 22.30 A C ATOM 1199 CB ALA A763 66.093 36.862 −2.388 1.00 18.28 A C ATOM 1200 C ALA A 763 65.68939.292 −2.861 1.00 23.40 A C ATOM 1201 O ALA A 76.3 66.188 40.082 −2.0611.00 15.76 A O ATOM 1202 N GLN A 764 65.667 39.501 −4.175 1.00 21.55 A NATOM 1203 CA GLN A 764 66.202 40.713 4.787 1.00 27.04 A C ATOM 1204 CBGLN A 764 66.286 40.548 −6.308 1.00 24.90 A C ATOM 1205 CG GLN A 76467.565 39.906 −6.810 1.00 31.00 A C ATOM 1206 CD GLN A 764 67.407 39.343−8.211 1.00 46.06 A C ATOM 1207 OE1 GLN A 764 66.908 40.019 9.113 1.0055.63 A O ATOM 1208 NE2 GN A 764 67.835 38.098 −8.400 1.00 53.80 A NATOM 1209 C GLN A 764 65.300 41.901 −4.451 1.00 20.31 A C ATOM 1210 OGLN A 764 65.786 42.977 −4.108 1.00 21.11 A O ATOM 1211 N GLY A 76563.990 41.697 −4.544 1.00 16.15 A N ATOM 1212 CA GLY A 765 63.056 42.7664.225 1.00 17.64 A C ATOM 1213 C GLY A 765 63.248 43.179 −2.772 1.0016.42 A C ATOM 1214 O GLY A 765 63.328 44.363 −2.455 1.00 19.02 A O ATOM1215 N MET A 766 63.357 42.188 −1.893 1.00 15.31 A N ATOM 1216 CA MET A766 63.550 42.437 −0.457 1.00 14.10 A C ATOM 1217 CB MET A 766 63.40941.130 0.316 1.00 16.14 A C ATOM 1218 CG MET A 766 61.983 40.573 0.3421.00 19.94 A C ATOM 1219 SD MET A 766 60.729 41.744 0.929 1.00 19.78 A SATOM 1220 CE MET A 766 61.141 41.808 2.738 1.00 13.84 A C ATOM 1221 CMET A 766 64.907 43.080 −0.166 1.00 17.88 A C ATOM 1222 O MET A 76665.044 43.905 0.743 1.00 13.94 A O ATOM 1223 N ALA A 7.67 65.916 42.701−0.940 1.00 17.98 A N ATOM 1224 CA ALA A 767 67.237 43.272 −0.770 1.0019.33 A C ATOM 1225 CB ALA A 767 68.228 42.579 −1.700 1.00 21.62 A CATOM 1226 C ALA A 767 67.135 44.766 1.109 1.00 17.05 A C ATOM 1227 O ALAA 767 67.737 45.598 −0.450 1.00 14.87 A O ATOM 1228 N PHE A 768 66.37145.090 2.148 1.00 18.04 A N ATOM 1229 CA PHE A 768 66.188 46.479 −2.5611.00 21.12 A C ATOM 1230 CB PHE A 768 65.348 46.534 −3.835 1.00 19.56 AC ATOM 1231 CG PHE A 768 65.109 47.932 −4.353 1.00 21.17 A C ATOM 1232CD1 PHE A 768 66.164 48.714 −4.793 1.00 24.80 A C ATOM 1233 CD2 PHE A768 63.828 48.461 4.393 1.00 27.04 A C ATOM 1234 CE1 PHE A 768 65.94749.998 −5.264 1.00 27.09 A C ATOM 1235 CE2 PHE A 768 63.606 49.748−4.864 1.00 25.74 A C ATOM 1236 CZ PHE A 768 64.671 50.513 −5.299 1.0022.52 A C ATOM 1237 C PHE A 768 65.500 47.271 −1.444 1.00 21.76 A C ATOM1238 O PHE A 768 65.944 48.355 −1.063 1.00 23.66 A O ATOM 1239 N LEU A769 64.419 46.716 −0.913 1.00 20.97 A N ATOM 1240 CA LEU A 769 63.68047.367 0.156 1.00 19.58 A C ATOM 1241 CB LEU A 769 62.482 46.502 0.5841.00 19.74 A C ATOM 1242 CG LEU A 769 61.328 46.311 −0.414 1.00 22.31 AC ATOM 1243 CD1 LEU A 769 60.115 45.707 0.283 1.00 16.09 A C ATOM 1244CD2 LEU A 769 60.941 47.649 −1.002 1.00 21.21 A C ATOM 1245 C LEU A 76964.593 47.621 1.350 1.00 18.68 A C ATOM 1246 O LEU A 769 64.631 48.7301.898 1.00 17.86 A O ATOM 1247 N ALA A 770 65.335 46.590 1.744 1.0020.17 A N ATOM 1248 CA ALA A 770 66.245 46.691 2.878 1.00 24.54 A C ATOM1249 CB ALA A 770 66.937 45.352 3.104 1.00 24.53 A C ATOM 1250 C ALA A770 67289 47.799 2.705 1.00 23.83 A C ATOM 1251 O ALA A 770 67.67448.455 3.678 1.00 24.25 A O ATOM 1252 N SER A 771 67.743 48.011 1.4721.00 23.09 A N ATOM 1253 CA SER A 771 68.741 49.038 1.209 1.00 25.52 A CATOM 1254 CB SER A 771 69.338 48.864 −0.193 1.00 21.60 A C ATOM 1255 OGSER A 771 68.416 49.248 −1.194 1.00 21.11 A O ATOM 1256 C SER A 77168.129 50.433 1.352 1.00 26.48 A C ATOM 1257 O SER A 771 68.843 51.4221.501 1.00 26.76 A O ATOM 1258 N LYS A 772 66.802 50.504 1.315 1.0023.57 A N ATOM 1259 CA LYS A 772 66.097 51.773 1.455 1.00 26.01 A C ATOM1260 CB LYS A 772 64.931 51.853 0.470 1.00 26.88 A C ATOM 1261 CG LYS A772 65.288 51.585 −0.985 1.00 22.86 A C ATOM 1262 CD LYS A 772 66.23252.637 −1.529 1.00 29.15 A C ATOM 1263 CE LYS A 772 66.566 52.363 −2.9831.00 35.07 A C ATOM 1264 NZ LYS A 772 67.207 53.534 −3.628 1.00 39.67 AN ATOM 1265 C LYS A 772 65.540 51.867 2.872 1.00 21.18 A C ATOM 1266 OLYS A 772 64.763 52.764 3.181 1.00 25.40 A O ATOM 1267 N ASN A 77365.942 50.931 3.725 1.00 24.24 A N ATOM 1268 CA ASN A 773 65.451 50.8805.097 1.00 22.74 A C ATOM 1269 CB ASN A 773 65.915 52.100 5.899 1.0033.02 A C ATOM 1270 CG ASN A 773 67.414 52.133 6.087 1.00 37.25 A C ATOM1271 OD1 ASN A 773 68.041 51.102 6.334 1.00 42.18 A O ATOM 1272 ND2 ASNA 773 67.999 53.322 5.984 1.00 37.80 A N ATOM 1273 C ASN A 773 63.93150.809 5.096 1.00 22.96 A C ATOM 1274 O ASN A 773 63.263 51.461 5.8921.00 24.43 A O ATOM 1275 N CYS A 774 63.384 50.007 4.189 1.00 20.83 A NATOM 1276 CA CYS A 774 61.940 49.848 4.101 1.00 20.83 A C ATOM 1277 CBCYS A 774 61.456 50.089 2.662 1.00 23.20 A C ATOM 1278 SG CYS A 77459.642 50.006 2.440 1.00 20.10 A S ATOM 1279 C CYS A 774 61.545 48.4384.527 1.00 21.51 A C ATOM 1280 O CYS A 774 62.047 47.462 3.976 1.0020.46 A O ATOM 1281 N ILE A 77Sf 60.667 48.332 5.521 1.00 19.62 A N ATOM1282 CA ILE A 775 60.203 47.022 5.950 1.00 24.15 A C ATOM 1283 CB ILE A775 60.013 46.938 7.478 1.00 23.71 A C ATOM 1284 CG2 ILE A 775 61.35647.100 8.173 1.00 33.09 A C ATOM 1285 CG1 ILE A 775 59.035 48.002 7.9531.00 25.50 A C ATOM 1286 CD1 ILE A 775 58.639 47.831 9.388 1.00 31.05 AC ATOM 1287 C ILE A 775 58.887 46.706 5.244 1.00 20.48 A C ATOM 1288 OILE A 775 58.079 47.599 4.967 1.00 20.87 A O ATOM 1289 N HIS A 77658.694 45.426 4.946 1.00 19.40 A N ATOM 1290 CA HIS A 776 57.521 44.934.233 1.00 21.94 A C ATOM 1291 CB HIS A 776 57.929 43.668 3.464 1.0020.79 A C ATOM 1292 CG HIS A 776 56.887 43.150 2.523 1.00 21.62 A C ATOM1293 CD2 HIS A 776 56.877 43.060 1.171 1.00 14.45 A C ATOM 1294 ND1 HISA 776 55.697 42.604 2.952 1.00 16.21 A N ATOM 1295 CE1 HIS A 776 54.99942.198 1.905 1.00 16.39 A C ATOM 1296 NE2 HIS A 776 55.693 42.464 0.8121.00 13.85 A N ATOM 1297 C HIS A 776 56.394 44.617 5.210 1.00 17.18 A CATOM 1298 O HIS A 776 55.285 45.137 5.092 1.00 20.21 A O ATOM 1299 N ARGA 777 56.704 43.740 6.154 1.00 19.26 A N ATOM 1300 CA ARG A 777 55.79843.313 7.214 1.00 21.85 A C ATOM 1301 CB ARG A 777 55.177 44.535 7.9021.00 25.43 A C ATOM 1302 CG ARG A 777 56.206 45.320 8.708 1.00 30.35 A CATOM 1303 CD ARG A 777 SS.569 46.314 9.665 1.00 31.32 A C ATOM 1304 NEARG A 777 54.951 47.447 8.984 1.00 31.09 A N ATOM 1305 CZ ARC A 77754.412 48.482 9.622 1.00 38.89 A C ATOM 1306 NH1 ARG A 777 54.423 48.50710.948 1.00 27.20 A N ATOM 1307 NH2 ARG A 777 53.872 49.491 8.943 1.0025.00 A N ATOM 1308 C ARG A 777 54.724 42.282 6.889 1.00 19.94 A C ATOM1309 O ARG A 777 54.049 41.814 7.792 1.00 22.92 A 0 ATOM 1310 N ASP A778 54.553 41.926 5.615 1.00 16.40 A N ATOM 1311 CA ASP A 778 53.57340.891 5.264 1.00 16.07 A C ATOM 1312 CB ASP A 778 52.256 41.502 4.7511.00 16.31 A C ATOM 1313 CG ASP A 778 51.059 40.545 4.899 1.00 19.62 A CATOM 1314 OD1 ASP A 778 49.921 40.974 4.613 1.00 17.04 A O ATOM 1315 OD2ASP A 778 51.244 39.371 5.310 1.00 14.91 A O ATOM 1316 C ASP A 77854.141 39.965 4.194 1.00 15.26 A C ATOM 1317 O ASP A 778 53.459 39.6483.218 1.00 18.58 A O ATOM 1318 N VAL A 779 55.385 39.531 4.371 1.0014.29 A N ATOM 1319 CA VAL A 779 55.993 38.631 3.403 1.00 21.63 A C ATOM1320 CB VAL A 779 57.506 38.461 3.658 1.00 20.49 A C ATOM 1321 CG1 VAL A779 58.078 37.497 2.646 1.00 8.30 A C ATOM 1322 CG2 VAL A 779 58.22339.828 3.571 1.00 20.35 A C ATOM 1323 C VAL A 779 55.291 37.266 3.4771.00 15.56 A C ATOM 1324 O VAL A 779 55.250 36.630 4.529 1.00 18.67 A OATOM 1325 N ALA A 780 54.728 36.839 2.351 1.00 11.25 A N ATOM 1326 CAALA A 780 54.005 35.575 2.252 1.00 9.85 A C ATOM 1327 CB ALA A 78052.658 35.675 2.955 1.00 16.46 A C ATOM 1328 C AJA A 780 53.793 35.3260.767 1.00 16.61 A C ATOM 1329 O ALA A 780 53.822 36.274 −0.015 1.0016.59 A O ATOM 1330 N ALA A 781 53.578 34.071 0.381 1.00 14.97 A N ATOM1331 CA ALA A 781 53.37 733.751 −1.037 1.00 18.54 A C ATOM 1332 CB ALA A781 53.252 32.221 −1.226 1.00 17.62 A C ATOM 1333 C ALA A 781 52.15534.464 −1.623 1.00 20.68 A C ATOM 1334 O ALA A 781 52.133 34.808 −2.8151.00 19.94 A O ATOM 1335 N ARG A 782 51.135 34.680 −0.794 1.00 12.58 A NATOM 1336 CA ARG A 782 49.934 35.354 −1.250 1.00 19.87 A C ATOM 1337 CBARG A 782 48.877 35.390 −0.140 1.00 17.69 A C ATOM 1338 CG ARG A 78249.346 36.096 1.115 1.00 22.13 A C ATOM 1339 CD ARG A 782 48.245 36.2672.143 1.00 18.87 A C ATOM 1340 NE ARG A 782 48.815 36.800 3.380 1.0016.17 A N ATOM 1341 CZ ARG A 782 49.432 36.055 4.287 1.00 18.05 A C ATOM1342 NH1 ARG A 782 49.538 34.746 4.098 1.00 15.44 A N ATOM 1343 NH2 ARGA 782 49.975 36.624 5.360 1.00 14.60 A N ATOM 1344 C ARG A 782 50.25936.774 −1.697 1.00 18.63 A C ATOM 1345 O ARG A 782 49.526 37.349 −2.4991.00 19.79 A O ATOM 1346 N ASN A 783 51.355 37.337 −1.180 1.00 16.35 A NATOM 1347 CA ASN A 783 51.754 38.695 −1.538 1.00 21.66 A C ATOM 1348 CBASN A 783 52.066 39.526 −0.286 1.00 17.66 A C ATOM 1349 CG ASN A 78350.825 39.861 0.510 1.00 19.83 A C ATOM 1350 OD1 ASN A 783 49.801 40.231−0.062 1.00 21.64 A O ATOM 1351 ND2 ASN A 783 50.909 39.744 1.836 1.0015.81 A N ATOM 1352 C ASN A 783 52.932 38.744 −2.500 1.00 18.05 A C ATOM1353 O ASN A 783 53.789 39.629 −2.422 1.00 18.47 A O ATOM 1354 N VAL A784 52.985 37.771 −3.402 1.00 17.31 A N ATOM 1355 CA VAL A 784 54.02137.764 4.420 1.00 16.02 A C ATOM 1356 CB VAL A 784 54.998 36.571 −4.2681.00 18.51 A C ATOM 1357 CG1 VAL A 784 56.009 36.589 −5.404 1.00 15.61 AC ATOM 1358 CG2 VAL A 784 55.734 36.654 −2.941 1.00 12.80 A C ATOM 1359C VAL A 784 53.238 37.626 −5.723 1.00 16.94 A C ATOM 1360 O VAL A 78452.490 36.677 −5.894 1.00 17.28 A O ATOM 1361 N LEU A 785 53.386 38.589−6.625 1.00 19.95 A N ATOM 1362 CA LEU A 785 52.668 38.538 −7.894 1.0022.85 A C ATOM 1363 CB LEU A 785 52.051 39.909 −8.199 1.00 24.49 A CATOM 1364 CG LEU A 785 50.659 40.206 −7.622 1.00 34.20 A C ATOM 1365 CD1LEU A 785 50.517 39.642 −6.232 1.00 27.64 A C ATOM 1366 CD2 LEU A 78550.419 41.704 −7.624 1.00 18.93 A C ATOM 1367 C LEU A 785 53.578 38.110−9.035 1.00 24.51 A C ATOM 1368 O LEU A 785 54.789 38.305 −8.980 1.0022.25 A O ATOM 1369 N LEU A 786 52.991 37.525 −10.077 1.00 24.93 A NATOM 1370 CA LEU A 786 53.781 37.082 −11.217 1.00 24.88 A C ATOM 1371 CBLEU A 786 53.562 35.589 −11.472 1.00 26.85 A C ATOM 1372 CG LEU A 78653.951 34.661 −10.321 1.00 24.52 A C ATOM 1373 CD1 LEU A 786 53.81233.206 −10.766 1.00 22.88 A C ATOM 1374 CD2 LEU A 786 55.380 34.961−9.895 1.00 21.56 A C ATOM 1375 C LEU A 786 53.406 37.879 −12.455 1.0024.87 A C ATOM 1376 O LEU A 786 52.232 37.956 −12.819 1.00 19.86 A OATOM 1377 N THR A 787 54.412 38.470 −13.096 1.00 26.67 A N ATOM 1378 CATHR A 787 54.181 39.275 −14.291 1.00 31.86 A C ATOM 1379 CB THR A 78754.774 40.697 −14.108 1.00 32.16 A C ATOM 1380 OG1 THR A 787 54.28941.556 −15.145 1.00 35.95 A O ATOM 1381 CG2 THR A 787 56.299 40.659−14.145 1.00 29.30 A C ATOM 1382 C THR A 787 54.787 38.592 −15.524 1.0033.01 A C ATOM 1383 O THR A 787 55.109 37.405 −15.485 1.00 31.90 A OATOM 1384 N ASN A 788 54.934 39.333 −16.615 1.00 36.22 A N ATOM 1385 CAASN A 788 55.486 38.774 −17.846 1.00 40.57 A C ATOM 1386 CB ASN A 78855.762 39.896 −18.844 1.00 42.89 A C ATOM 1387 CG ASN A 788 54.52740.706 −19.149 1.00 42.43 A C ATOM 1388 OD1 ASN A 788 53.576 40.206−19.749 1.00 43.79 A O ATOM 1389 ND2 ASN A 788 54.527 41.963 −18.7261.00 43.62 A N ATOM 1390 C ASN A 788 56.757 37.960 −17.622 1.00 39.75 AC ATOM 1391 O ASN A 788 57.674 38.394 −16.925 1.00 44.43 A O ATOM 1392 NGLY A 789 56.805 36.778 −18.230 1.00 41.34 A N ATOM 1393 CA GLY A 78957.960 35.915 −18.079 1.00 35.78 A C ATOM 1394 C GLY A 789 57.871 35.197−16.750 1.00 36.30 A C ATOM 1395 O GLY A 789 58.792 34.488 −16.346 1.0042.58 A O ATOM 1396 N HIS A 790 56.738 35.383 −16.080 1.00 34.24 A NATOM 1397 CA HIS A 790 56.492 34.792 −14.772 1.00 36.84 A C ATOM 1398 CBHIS A 790 56.488 33.266 −14.877 1.00 33.92 A C ATOM 1399 CG HIS A 79055.255 32.723 −15.530 1.00 39.92 A C ATOM 1400 CD2 HIS A 790 54.98932.424 −16.824 1.00 35.95 A C ATOM 1401 ND1 HIS A 790 54.081 32.509−14.839 1.00 38.27 A N ATOM 1402 CE1 HIS A 790 53.145 32.103 −15.6791.00 35.69 A C ATOM 1403 NE2 HIS A 790 53.670 32.044 −16.889 1.00 36.41A N ATOM 1404 C HIS A 790 57.527 35.287 −13.767 1.00 34.04 A C ATOM 1405O HIS A 790 57.957 34.557 −12.868 1.00 39.85 A O ATOM 1406 N VAL A 79157.926 36.544 −13.942 1.00 31.80 A N ATOM 1407 CA VAL A 791 58.88337.175 −13.049 1.00 31.97 A C ATOM 1408 CB VAL A 791 59.556 38.400−13.707 1.00 32.02 A C ATOM 1409 CG1 VAL A 791 60.527 39.051 −12.7261.00 25.13 A C ATOM 1410 CG2 VAL A 791 60.300 37.972 −14.961 1.00 31.02A C ATOM 1411 C VAL A 791 58.102 37.627 −11.818 1.00 27.71 A C ATOM 1412O VAL A 791 57.029 38.219 −11.933 1.00 32.13 A O ATOM 1413 N ALA A 79258.646 37.339 −10.642 1.00 28.53 A N ATOM 1414 CA ALA A 792 57.99637.692 −9.389 1.00 24.21 A C ATOM 1415 CB ALA A 792 58.495 36.773 −8.2811.00 23.90 A C ATOM 1416 C ALA A 792 58.214 39.150 −8.991 1.00 22.20 A CATOM 1417 O ALA A 792 59286 39.713 −9.212 1.00 24.18 A O ATOM 1418 N LYSA 793 57.187 39.749 −8.399 1.00 19.99 A N ATOM 1419 CA LYS A 793 57.24841.131 −7.932 1.00 20.74 A C ATOM 1420 CB LYS A 793 56.574 42.081 −8.9321.00 25.52 A C ATOM 1421 CG LYS A 793 53.389 42.424 −10.178 1.00 21.48 AC ATOM 1422 CD LYS A 793 56.555 43.295 −11.121 1.00 24.82 A C ATOM 1423CB LYS A 793 57.371 43.802 −12.302 1.00 25.83 A C ATOM 1424 NZ LYS A 79358.322 44.889 −11.929 1.00 21.51 A N ATOM 1425 C LYS A 793 56.533 41.258−6.580 1.00 19.38 A C ATOM 1426 O LYS A 793 55.560 40.551 −6.308 1.0020.92 A O ATOM 1427 N ILE A 794 57.008 42.168 −5.741 1.00 21.18 A N ATOM1428 CA ILE A 794 56.370 42.379 −4.452 1.00 22.72 A C ATOM 1429 CB ILE A794 57.321 42.032 −3.294 1.00 25.75 A C ATOM 1430 CG2 ILE A 794 57.60540.525 −3.304 1.00 26.33 A C ATOM 1431 CG1 ILE A 794 58.610 42.863−3.404 1.00 27.20 A C ATOM 1432 CD1 ILE A 794 59.584 42.688 −2.243 1.0023.60 A C ATOM 1433 C ILE A 794 55.924 43.833 −4.341 1.00 20.28 A C ATOM1434 O ILE A 794 56.489 44.715 −4.982 1.00 23.20 A O ATOM 1435 N ILE A795 54.894 44.068 −3.540 1.00 19.95 A N ATOM 1436 CA GLY A 795 54.38745.413 −3.357 1.00 19.70 A C ATOM 1437 C GLY A 795 53.482 45.440 −2.147.00 22.98 A C ATOM 1438 O GLY A 795 53.143 44.392 −1.596 1.00 25.68 A OATOM 1439 N ASP A 796 53.107 46.636 −1.713 1.00 22.67 A N ATOM 1440 CAASP A 796 52.213 46.769 −0.576 1.00 26.29 A C ATOM 1441 CB ASP A 79652.286 48.179 0.004 1.00 23.94 A C ATOM 1442 CG ASP A 796 51.588 48.2811.336 1.00 29.84 A C ATOM 1443 OD1 ASP A 796 50.543 47.619 1.485 1.0030.78 A O ATOM 1444 OD2 ASP A 796 52.075 49.013 2.222 1.00 24.56 A OATOM 1445 C ASP A 796 50.805 46.509 −1.113 1.00 26.30 A C ATOM 1446 OASP A 796 50.269 47.320 −1.869 1.00 24.33 A O ATOM 1447 N PHE A 79750.217 45.377 −0.741 1.00 24.34 A N ATOM 1448 CA PHE A 797 48.882 45.027−1.223 1.00 29.06 A C ATOM 1449 CB PHE A 797 48.892 43.627 −1.840 1.0021.19 A C ATOM 1450 CG PHE A 797 49.958 43.419 −2.868 1.00 23.96 A CATOM 1451 CD1 PHE A 797 50.698 42.243 −2.883 1.00 18.21 A C ATOM 1452CD2 PHE A 797 50.219 44.386 −3.825 1.00 17.68 A C ATOM 1453 CE1 PHE A797 51.678 42.034 −3.830 1.00 19.92 A C ATOM 1454 CE2 PHE A 797 51.20444.183 −4.782 1.00 19.67 A C ATOM 1455 CZ PHE A 797 51.931 43.007 −4.7831.00 21.31 A C ATOM 1456 C PHE A 797 47.815 45.062 −0.133 1.00 27.83 A CATOM 1457 O PHE A 797 46.676 44.646 −0.367 1.00 28.25 A O ATOM 1458 NGLY A 798 48.174 45.559 1.047 1.00 24.16 A N ATOM 1459 CA GLY A 79847.226 45.606 2.151 1.00 28.22 A C ATOM 1460 C GLY A 798 45.846 46.1901.866 1.00 35.83 A C ATOM 1461 O GLY A 798 44.822 45.557 2.148 1.0035.61 A O ATOM 1462 N LEU A 799 45.812 47.398 1.309 1.00 34.09 A N ATOM1463 CA LEU A 799 44.553 48.075 1.00 41.00 35.90 A C ATOM 1464 CB LEU A799 44.844 49.409 0.304 1.00 40.02 A C ATOM 1465 CG LEU A 799 43.67250.324 −0.078 1.00 48.48 A C ATOM 1466 CD1 LEU A 799 43.052 49.877−1.389 1.00 49.24 A C ATOM 1467 CD2 LEU A 799 42.650 50.333 1.047 1.0047.29 A C ATOM 1468 C LEU A 799 43.581 47.244 0.162 1.00 33.17 A C ATOM1469 O LEU A 799 42.368 47.434 0.242 1.00 35.80 A O ATOM 1470 N ALA A800 44.110 46.338 −0.652 1.00 27.34 A N ATOM 1471 CA ALA A 800 43.27245.481 −1.489 1.00 32.20 A C ATOM 1472 CB ALA A 800 43.854 45.401 −2.8951.00 28.94 A C ATOM 1473 C ALA A 800 43.151 44.075 −0.886 1.00 29.06 A CATOM 1474 O ALA A 800 42.590 43.170 −1.503 1.00 32.92 A O ATOM 1475 NARG A 801 43.682 43.907 0.322 1.00 28.46 A N ATOM 1476 CA ARG A 80143.654 42.631 1.022 1.00 28.47 A C ATOM 1477 CB ARG A 801 44.954 42.4661.821 1.00 35.65 A C ATOM 1478 CG ARG A 801 45.104 41.155 2.590 1.0042.08 A C ATOM 1479 CD ARG A 801 45.118 39.932 1.683 1.00 39.14 A C ATOM1480 NE ARG A 801 46.309 39.827 0.838 1.00 33.07 A N ATOM 1481 CZ ARG A801 46.470 38.877 −0.079 1.00 24.03 A C ATOM 1482 NH1 ARG A 801 45.52337.967 −0.257 1.00 29.78 A N ATOM 1483 NH2 ARG A 801 47.558 38.841−0.831 1.00 20.54 A N ATOM 1484 C ARG A 801 42.434 42.535 1.951 1.0033.90 A C ATOM 1485 O ARG A 801 42.241 43.367 2.839 1.00 26.76 A O ATOM1486 N ASP A 802 41.609 41.517 1.726 1.00 28.62 A N ATOM 1487 CA ASP A802 40.409 41.285 2.529 1.00 25.00 A C ATOM 1488 CB ASP A 802 39.46940.365 1.739 1.00 29.05 A C ATOM 1489 CG ASP A 802 38.216 39.987 2.5011.00 32.45 A C ATOM 1490 OD1 ASP A 802 37.783 40.754 3.389 1.00 27.77 AO ATOM 1491 OD2 ASP A 802 37.654 38.914 2.184 1.00 33.83 A O ATOM 1492 CASP A 802 40.842 40.648 3.855 1.00 23.80 A C ATOM 1493 O ASP A 80240.477 39.517 4.168 1.00 23.73 A O ATOM 1494 N ILE A 803 41.623 41.3954.631 1.00 24.15 A N ATOM 1495 CA ILE A 803 42.157 40.917 5.908 1.0025.86 A C ATOM 1496 CB ILE A 803 43.110 41.965 6.525 1.00 25.35 A C ATOM1497 CG2 ILE A 803 43.393 41.627 7.964 1.00 33.76 A C ATOM 1498 CG1 ILEA 803 44.418 42.006 5.731 1.00 30.72 A C ATOM 1499 CD1 ILE A 803 45.44242.960 6.301 1.00 39.69 A C ATOM 1500 C ILE A 803 41.161 40.494 6.9861.00 23.68 A C ATOM 1501 O ILE A 803 41.412 39.535 7.724 1.00 25.42 A OATOM 1502 N MET A 804 40.045 41.205 7.088 1.00 22.39 A N ATOM 1503 CAMET A 804 39.032 40.893 8.096 1.00 25.91 A C ATOM 1504 CB MET A 80437.892 41.916 8.031 1.00 27.18 A C ATOM 1505 CG MET A 804 38.331 43.3598.194 1.00 34.73 A C ATOM 1506 SD MET A 804 39.110 43.639 9.793 1.0034.84 A S ATOM 1507 CE MET A 804 37.688 43.389 10.885 1.00 38.16 A CATOM 1508 C MET A 804 38.438 39.494 7.939 1.00 24.53 A C ATOM 1509 O META 804 38.072 38.858 8.923 1.00 24.91 A O ATOM 1510 N ASN A 805 38.35439.013 6.702 1.00 19.70 A N ATOM 1511 CA ASN A 805 37.757 37.714 6.4361.00 20.76 A C ATOM 1512 CB ASN A 805 36.661 37.884 5.378 1.00 25.59 A CATOM 1513 CG ASN A 805 35.599 38.877 5.803 1.00 21.78 A C ATOM 1514 OD1ASN A 805 35.017 38.747 6.875 1.00 24.02 A O ATOM 1515 ND2 ASN A 80535.343 39.877 4.968 1.00 23.80 A N ATOM 1516 C ASN A 805 38.736 36.6216.010 1.00 28.45 A C ATOM 1517 O ASN A 805 38.331 35.586 5.475 1.0025.85 A O ATOM 1518 N ASP A 806 40.021 36.854 6.251 1.00 23.59 A N ATOM1519 CA ASP A 806 41.061 35.896 5.906 1.00 20.85 A C ATOM 1520 CB ASP A806 42.189 36.606 5.154 1.00 25.77 A C ATOM 1521 CC ASP A 806; 43.25035.654 4.651 1.00 20.88 A C ATOM 1522 OD1 ASP A 806 43.532 34.646 5.3351.00 22.17 A O ATOM 1523 OD2 ASP A 806 43.813 35.935 3.576 1.00 25.61 AO ATOM 1524 C ASP A 806 41.585 35.327 7.216 1.00 20.23 A C ATOM 1525 OASP A 806 42.265 36.026 7.972 1.00 23.86 A O ATOM 1526 N SER A 80741.278 34.063 7.485 1.00 21.93 A N ATOM 1527 CA SER A 807 41.701 33.4268.734 1.00 26..38 A C ATOM 1528 CB SER A 807 41.081 32.034 8.853 1.0021.67 A C ATOM 1529 CG SER A 807 41.378 31.270 7.709 1.00 26.13 A O ATOM1530 C SER A 807 43.210 33.333 8.935 1.00 25.96 A C ATOM 1531 O SER A807 43.672 32.919 10.000 1.00 28.13 A O ATOM 1532 N ASN A 808 43.97633.707 7.915 1.00 22.59 A N ATOM 1533 CA ASN A 808 45.420 33692 8.0261.00 24.20 A C ATOM 1534 CB ASN A 808 46.067 33.734 6.636 1.00 26.55 A CATOM 1535 CG ASN A 808 45.968 32.399 5.905 1.00 30.23 A C ATOM 1536 OD1ASN A 808 45.640 32.343 4.718 1.00 25.73 A O ATOM 1537 ND2 ASN A 80846.262 31.323 6.611 1.00 23.16 A N ATOM 1538 C ASN A 808 45.840 34.9078.849 1.00 2.6.53 A C ATOM 1539 O ASN A 808 46.986 35.002 9.287 1.0029.13 A O ATOM 1540 N TYR A 809 44.907 35.840 9.050 1.00 19.60 A N ATOM1541 CA TYR A 809 45.194 37.026 9.849 1.00 16.84 A C ATOM 1542 CB TYR A809 44.773 38.303 9.122 1.00 20.05 A C ATOM 1543 CG TYR A 809 45.60738.583 7.893 1.00 19.88 A C ATOM 1544 CD1 TYR A 809 45.343 37.938 6.6961.00 18.75 A C ATOM 1545 CE1 TYR A 809 46.129 38.160 5.571 1.00 15.18 AC ATOM 1546 CD2 TYR A 809 46.687 39.465 7.943 1.00 12.79 A C ATOM 1547CE2 TYR A 809 47.476 39.699 6.823 1.00 16.10 A C ATOM 1548 CZ TYR A 80947.189 39.042 5.638 1.00 13.32 A C ATOM 1549 OH TYR A 809 47.955 39.2584.512 1.00 16.28 A O ATOM 1556 C TYR A 809 44.466 36.904 11.180 1.0020.83 A C ATOM 1551 O TYR A 809 43.246 37.056 11.259 1.00 21.15 A O ATOM1552 N ILE A 810 45.247 36.621 12.218 1.00 29.90 A N ATOM 1553 CA ILE A810 44.759 36.424 13.575 1.00 32.50 A C ATOM 1554 CE ILE A 810 45.80435.650 14.405 1.00 35.70 A C ATOM 1555 CG2 ILE A 810 45.311 35.45015.826 1.00 34.48 A C ATOM 1556 CG1 ILE A 810 46.107 34.312 13.728 1.0035.73 A C ATOM 1557 CD1 ILE A 810 44.888 33.459 13.488 1.00 41.45 A CATOM 1558 C ILE A 810 44.425 37.717 14.304 1.00 35.12 A C ATOM 1559 OILE A 810 45.158 38.702 14.227 1.00 32.73 A O ATOM 1560 N VAL A 81143.316 37.697 15.031 1.00 35.36 A N ATOM 1561 CA VAL A 811 42.876 38.86315.778 1.00 40.37 A C ATOM 1562 CE VAL A 811 41.413 38.706 16.247 1.0039.63 A C ATOM 1563 CG1 VAL A 811 40.916 40.008 16.847 1.00 41.96 A CATOM 1564 CG2 VAL A 811 40.534 38.283 15.084 1.00 40.81 A C ATOM 1565 CVAL A 811 43.753 39.067 17.007 1.00 43.36 A C ATOM 1566 O VAL A 81143.971 38.141 17.788 1.00 45.36 A O ATOM 1567 N LYS A 812 44.271 40.27917.161 1.00 48.53 A N ATOM 1568 CA LYS A 812 45.098 40.619 18.312 1.0053.89 A C ATOM 1569 CE LYS A 812 46.539 40.904 17.892 1.00 57.97 A CATOM 1570 CG LYS A 812 47.449 41.242 19.064 1.00 61.64 A C ATOM 1571 CDLYS A 812 48.792 41.772 18.602 1.00 65.44 A C ATOM 1572 CE LYS A 81249.650 42.189 19.788 1.00 64.89 A C ATOM 1573 NZ LYS A 812 50.974 42.71719.360 1.00 59.14 A N ATOM 1574 C LYS A 812 44.487 41.871 18.929 1.0058.46 A C ATOM 1575 O LYS A 812 45.171 42.871 19.156 1.00 61.10 A O ATOM1576 N GLY A 813 43.183 41.806 19.183 1.00 58.36 A N ATOM 1577 CA GLY A813 42.483 42.936 19.758 1.00 55.86 A C ATOM 1578 C GLY A 813 42.27744.061 18.760 1.00 58.07 A C ATOM 1579 O GLY A 813 41.268 44.109 18.0541.00 52.41 A O ATOM 1580 N ASN A 814 43.254 44.959 18.692 1.00 62.47 A NATOM 1581 CA ASN A 814 43.193 46.113 17.801 1.00 65.67 A C ATOM 1582 CEASN A 814 43.982 47.270 18.414 1.00 68.89 A C ATOM 1583 CG ASN A 81445.456 46.945 18.573 1.00 71.72 A C ATOM 1584 OD1 ASN A 814 45.82045.950 19.203 1.00 73.23 A O ATOM 1585 ND2 ASN A 814 46.314 47.78418.000 1.00 72.88 A N ATOM 1586 C ASN A 814 43.719 45.854 16.392 1.0065.63 A C ATOM 1587 O ASN A 814 43.876 46.793 15.609 1.00 67.90 A O ATOM1588 N ALA A 815 43.991 44.598 16.054 1.00 60.23 A N ATOM 1589 CA ALA A815 44.516 44.314 14.726 1.00 52.04 A C ATOM 1590 CB ALA A 815 45.99344.690 14.676 1.00 52.74 A C ATOM 1591 C ALA A 815 44.340 42.878 14.2541.00 46.58 A C ATOM 1592 O ALA A 815 43.857 42.016 14.984 1.00 45.52 A OATOM 1593 N ARG A 816 44.739 42.649 13.009 1.00 40.22 A N ATOM 1594 CAARG A 816 44.683 41.341 12.368 1.00 34.96 A C ATOM 1595 CE ARG A 81643.739 41.368 11.168 1.00 40.08 A C ATOM 1596 CG ARG A 816 42.434 40.62911.355 1.00 52.11 A C ATOM 1597 CD ARG A 816 41.455 41.411 12.194 1.0049.21 A C ATOM 1598 NE ARG A 816 40.168 40.731 12.263 1.00 55.65 A NATOM 1599 CZ ARG A 816 39.101 41.225 12.876 1.00 61.09 A C ATOM 1600 NH1ARG A 816 39.172 42.408 13.473 1.00 67.17 A N ATOM 1601 NH2 ARG A 81637.966 40.543 12.888 1.00 64.77 A N ATOM 1602 C ARG A 816 46.100 41.10611.871 1.00 26.90 A C ATOM 1603 O ARG A 816 46.578 41.837 11.004 1.0025.06 A O ATOM 1604 N LEU A 817 46.773 40.093 12.401 1.00 23.26 A N ATOM1605 CA LEU A 817 48.147 39.841 11.987 1.00 26.71 A C ATOM 1606 CE LEU A817 49.083 40.064 13.178 1.00 34.47 A C ATOM 1607 CG LEU A 817 48.96441.429 13.869 1.00 38.57 A C ATOM 1608 CD1 LEU A 817 49869 41.454 15.0881.00 41.68 A C ATOM 1609 CD2 LEU A 817 49.341 42.543 12.897 1.00 38.27 AC ATOM 1610 C LEU A 817 48.388 38.452 11.403 1.00 23.81 A C ATOM 1611 OLEU A 817 47.781 37.471 11.826 1.00 24.13 A O ATOM 1612 N PRO A 81849.290 38.357 10.413 1.00 22.29 A N ATOM 1613 CD PRO A 818 50.001 39.4839.775 1.00 20.86 A C ATOM 1614 CA PRO A 818 49.628 37.088 9.763 1.0019.06 A C ATOM 1615 CB PRO A 818 50.242 37.541 8.446 1.00 22.27 A C ATOM1616 CG PRO A 818 51.012 38.763 8.872 1.00 27.08 A C ATOM 1617 C PRO A818 50.632 36.350 10.649 1.00 21.75 A C ATOM 1618 O PRO A 818 51.78236.156 10.269 1.00 23.01 A O ATOM 1619 N VAL A 819 50.183 35.958 11.8371.00 16.86 A N ATOM 1620 CA VAL A 819 51.030 35.281 12.818 1.00 20.67 AC ATOM 1621 CB VAL A 819 50.179 34.763 14.003 1.00 22.75 A C ATOM 1622CG1 VAL A 819 51.059 34.006 14.986 1.00 24.72 A C ATOM 1623 CG2 VAL A819 49.495 35.938 14.702 1.00 25.28 A C ATOM 1624 C VAL A 819 51.93934.139 12.35.6 1.00 23.31 A C ATOM 1625 O VAL A 819 531096 34.074 12.7681.00 21.31 A O ATOM 1626 N LYS A 820 51.433 33.234 11.519 1.00 20.99 A NATOM 1627 CA LYS A 820 52.251 32.106 11.072 1.00 23.20 A C ATOM 1628 CBLYS A 820 51.402 31.111 10.275 1.00 22.69 A C ATOM 1629 CG LYS A 82050.436 30.326 11.132 1.00 18.71 A C ATOM 1630 CD LYS A 820 49.887 29.11410.400 1.00 19.77 A C ATOM 1631 CE LYS A 820 49.054 28.248 11.334 1.0028.95 A C ATOM 1632 NZ LYS A 820 48.776 26.897 10.757 1.00 35.62 A NATOM 1633 C LYS A 820 53.473 32.504 10.249 1.00 21.07 A C ATOM 1634 OLYS A 820 54.395 31.708 10.073 1.00 18.03 A O ATOM 1635 N TRP A 82153.470 33.736 9.751 1.00 21.40 A N ATOM 1636 CA TRP A 821 54.564 34.2628.938 1.00 18.27 A C ATOM 1637 CB TRP A 821 53.997 35.041 7.750 1.0018.88 A C ATOM 1638 CG TRP A 82.1 53.492 34.162 6.661 1.00 17.63 A CATOM 1639 CD2 TRP A 821 52.204 33.534 6.593 1.00 11.44 A C ATOM 1640 CE2TRP A 821 52.187 32.742 5.419 1.00 12.15 A C ATOM 1641 CE3 TRP A 82151.063 33.562 7.408 1.00 10.74 A C ATOM 1642 CD1 TRP A 821 54.185 33.7435.556 1.00 14.77 A C ATOM 1643 NE1 TRP A 821 53.405 32.888 4.806 1.0015.37 A N ATOM 1644 CZ2 TRP A 821 51.078 31.980 5.042 1.00 11.08 A CATOM 1645 CZ3 TRP A 821 49.953 32.804 7.034 1.130 14.97 A C ATOM 1646CH2 TRP A 821 49.970 32.019 5.857 1.00 13.23 A C ATOM 1647 C TRP A 82155.482 35.195 9.724 1.00 24.23 A C ATOM 1648 O TRP A 821 56.555 35.5599.238 1.00 20.66 A O ATOM 1649 N MET A 822 55.064 35.559 10.936 1.0019.97 A N ATOM 1650 CA MET A 822 55.809 36.506 11.776 1.00 22.80 A CATOM 1651 CB MET A 822 54.818 37.297 12.635 1.00 21.76 A C ATOM 1652 CGMET A 822 53.912 38.219 11.831 1.00 22.97 A C ATOM 1653 SD MET A 82252.525 38.869 12.789 1.00 26.94 A 5 ATOM 1654 CB MET A 822 53.420 39.70814.129 1.00 24.56 A C ATOM 1655 C MET A 822 56.931 35.988 12.677 1.0021.20 A C ATOM 1656 O MET A 822 56.814 34.930 13.298 1.00 21.09 A O ATOM1657 N ALA A 823 58.019 36.760 12.7.35 1.00 20.51 A N ATOM 1658 CA ALA A823 59.173 36.446 13.571 1.00 24.19 A C ATOM 1659 CB ALA A 823 60.29837.440 13.306 1.00 28.32 A C ATOM 1660 C ALA A 823 58.716 36.558 15.0221.00 22.49 A C ATOM 1661 O ALA A 823 57.810 37.318 15.333 1.00 23.60 A OATOM 1662 N PRO A 824 59.351 35.807 15.931 1.00 28.05 A N ATOM 1663 CDPRO A 824 60.548 34.969 15.747 1.00 30.69 A C ATOM 1664 CA PRO A 82458.961 35.860 17.341 1.00 26.19 A C ATOM 1665 CB PRO A 824 59.937 34.89118.005 1.00 25.24 A C ATOM 1666 CG PRO A 824 61.147 34.969 17.131 1.0030.82 A C ATOM 1667 C PRO A 824 58.984 37.255 17.970 1.00 29.13 A C ATOM1668 O PRO A 824 58.041 37.639 18.659 1.00 35.79 A O ATOM 1669 N GLU A825 60.042 38.021 17.735 1.00 27.58 A N ATOM 1670 CA GLU A 825 60.10839.354 18.325 1.00 31.40 A C ATOM 1671 CB GLU A 825 61.429 40.052 17.9801.00 28.59 A C ATOM 1672 CG GLU A 825 61.567 40.452 16.525 1.00 29.84 AC ATOM 1673 CD GLU A 825 62.165 39.349 15.676 1.00 32.35 A C ATOM 1674OE1 GLU A 825 62.117 38.173 16.096 1.00 28.13 A O ATOM 1675 OE2 GLU A825 62.680 39.664 14.587 1.00 23.74 A O ATOM 1676 C GLU A 825 58.94440.237 17.885 1.00 33.54 A C ATOM 1677 O GLU A 825 58.487 41.076 18.6541.00 35.36 A O ATOM 1678 N SER A 826 58.459 40.054 16.656 1.00 29.58 A NATOM 1679 CA SER A 826 57.349 40.868 16.162 1.00 27.62 A C ATOM 1680 CBSER A 826 57.178 40.696 14.649 1.00 22.84 A C ATOM 1681 CG SER A 82658.327 41.142 13.950 1.00 28.90 A O ATOM 1682 C SER A 826 56.055 40.49316.869 1.00 29.24 A C ATOM 1683 0 SER A 826 55.243 41.358 17.206 1.0028.92 A O ATOM 1684 N ILE A 827 55.872 39.194 17.085 1.00 26.07 A N ATOM1685 CA ILE A 827 54.692 38.682 17.760 1.00 30.31 A C ATOM 1686 CB ILE A827 54.590 37.152 17.617 1.00 32.61 A C ATOM 1687 CG2 ILE A 827 53.45636.630 18.476 1.00 32.96 A C ATOM 1688 CG1 ILE A 827 54.379 36.76916.151 1.00 29.74 A C ATOM 1689 CD1 ILE A 827 54.374 35.272 15.915 1.0038.78 A C ATOM 1690 C ILE A 827 54.707 39.001 19.256 1.00 32.81 A C ATOM1691 O ILE A 827 53.750 39.562 19.787 1.00 38.91 A O ATOM 1692 N PHE A828 55.800 38.645 19.924 1.00 32.90 A N ATOM 1693 CA PHE A 828 55.92538.846 21.366 1.00 37.93 A C ATOM 1694 CB PHE A 828 56.894 37.815 21.9541.00 39.93 A C ATOM 1695 CG PHE A 828 56.647 36.411 21.488 1.00 44.73 AC ATOM 1696 CD1 PHE A 828 55.407 35.821 21.645 1.00 49.08 A C ATOM 1697CD2 PHE A 828 57.658 35.680 20.893 1.00 43.41 A C ATOM 1698 CE1 PHE A828 55.182 34.527 21.215 1.00 44.87 A C ATOM 1699 CE2 PHE A 828 57.43734.389 20.463 1.00 45.13 A C ATOM 1700 CZ PHE A 828 56.199 33.813 20.6251.00 45.05 A C ATOM 1701 C PHE A 828 56.365 40.231 21.832 1.00 38.36 A CATOM 1702 O PHE A 828 56.027 40.642 22.942 1.00 38.99 A O ATOM 1703 NASP A 8.29 57.119 40.949 21.008 1.00 36.74 A N ATOM 1704 CA ASP A 82957.594 42.267 21.410 1.00 39.45 A C ATOM 1705 CB ASP A 829 59.115 42.24721.550 1.00 40.14 A C ATOM 1706 CG ASP A 829 59.600 41.113 22.430 1.0047.35 A C ATOM 1707 OD1 ASP A 829 59.053 40.955 23.541 1.00 53.54 A OATOM 1708 OD2 ASP A 829 60.528 40.384 22.017 1.00 50.16 A O ATOM 1709 CASP A 829 57.192 43.399 20.474 1.00 42.30 A C ATOM 1710 O ASP A 82957.684 44.521 20.606 1.00 4220 A O ATOM 1711 N CYS A 830 56.302 43.11019.532 1.00 39.95 A N ATOM 1712 CA CYS A 830 55.854 44.127 18.587 1.0040.90 A C ATOM 1713 CB CYS A 830 55.022 45.189 19.311 1.00 43.86 A CATOM 1714 SG CYS A 830 53.438 44.586 19.941 1.00 53.73 A S ATOM 1715 CCYS A 830 57.012 44.803 17.857 1.00 39.03 A C ATOM 1716 O CYS A 83056.870 45.924 17.370 1.00 44.26 A O ATOM 1717 N VAL A 831 58.150 44.11817.780 1.00 35.38 A N ATOM 1718 CA VAL A 831 59.331 44.652 17.103 1.0033.09 A C ATOM 1719 CB VAL A 831 60.628 44.135 17.753 1.00 39.10 A CATOM 1720 CG1 VAL A 831 61.826 44.512 16.892 1.00 38.90 A C ATOM 1721CG2 VAL A 831 60.778 44.716 19.158 1.00 33.47 A C ATOM 1722 C VAL A 83159.346 44.251 15.631 1.00 35.33 A C ATOM 1723 O VAL A 831 59.261 43.07015.310 1.00 37.29 A O ATOM 1724 N TYR A 832 59.454 45.237 14.743 1.0036.20 A N ATOM 1725 CA TYR A 832 59.482 44.981 13.305 1.00 35.18 A CATOM 1726 CB TYR A 832 58.202 45.490 12.636 1.00 41.06 A C ATOM 1727 CGTYR A 832 56.925 44.829 13.119 1.00 52.01 A C ATOM 1728 CD1 TYR A 83256.442 45.059 14.402 1.00 58.36 A C ATOM 1729 CE1 TYR A 832 55.25644.489 14.835 1.00 59.61 A C ATOM 1730 CD2 TYR A 832 56.186 44.00212.278 1.00 54.33 A C ATOM 1731 CE2 TYR A 832 54.999 43.427 12.700 1.0057.69 A C ATOM 1732 CZ TYR A 832 54.539 43.676 13.980 1.00 64.02 A CATOM 1733 OH TYR A 832 53.351 43.125 14.407 1.00 69.27 A O ATOM 1734 CTYR A 832 60.687 45.646 12.647 1.00 31.90 A C ATOM 1735 O TYR A 83260.797 46.873 12.610 1.00 32.89 A O ATOM 1736 N THR A 833 61.581 44.82512.112 1.00 27.49 A N ATOM 1737 CA THR A 833 62.787 45.315 11.458 1.0025.12 A C ATOM 1738 CB THR A 833 64.014 45.053 12.320 1.00 22.61 A CATOM 1739 CG1 THR A 833 64.301 43.646 12.295 1.00 24.29 A O ATOM 1740CG2 THR A 833 63.754 45.482 13.762 1.00 23.08 A C ATOM 1741 C THR A 83362.991 44.536 10.170 1.00 25.15 A C ATOM 1742 O THR A 833 62.174 43.6839.808 1.00 22.41 A O ATOM 1743 N VAL A 834 64.098 44.819 9.492 1.0023.12 A N ATOM 1744 CA VAL A 834 64.420 44.113 8.263 1.00 22.35 A C ATOM1745 CB VAL A 834 65.685 44.707 7.599 1.00 21.25 A C ATOM 1746 CG1 VAL A834 66.148 43.819 6.445 1.00 28.11 A C ATOM 1747 CG2 VAL A 834 65.38646.105 7.094 1.00 26.74 A C ATOM 1748 C VAL A 834 64.650 42.638 8.6031.00 25.22 A C ATOM 1749 O VAL A 834 64.325 41.755 7.814 1.00 20.84 A OATOM 1750 N GLN A 835 65.187 42.365 9.792 1.00 22.83 A N ATOM 1751 CAGLN A 835 65.440 40.985 10.190 1.00 23.35 A C ATOM 1752 CB GLN A 83566.369 40.935 11.407 1.00 26.25 A C ATOM 1753 CG GLN A 835 67.793 41.41911.110 1.00 31.00 A C ATOM 1754 CD GLN A 835 68.313 40.927 9.763 1.0042.01 A C ATOM 1755 OE1 GLN A 835 68.009 41.504 8.715 1.00 45.65 A 0ATOM 1756 NE2 GLN A 835 69.086 39.849 9.784 1.00 41.70 A N ATOM 1757 CGLN A 835 64.159 40.199 10.469 1.00 21.05 A C ATOM 1758 O GLN A 83564.158 38.958 10.445 1.00 22.61 A O ATOM 1759 N SER A 836 63.079 40.92110.751 1.00 22.49 A N ATOM 1760 CA SER A 836 61.778 40.299 10.987 1.0019.30 A C ATOM 1761 CB SER A 836 60.779 41.326 11.522 1.00 17.74 A CATOM 1762 CG SER A 836 61.263 41.941 12.703 1.00 40.58 A O ATOM 1763 CSER A 836 61.310 39.824 9.613 1.00 19.26 A C ATOM 1764 O SER A 83660.798 38.716 9.469 1.00 22.39 A O ATOM 1765 N ASP A 837 61.476 40.6888.612 1.00 21.60 A N ATOM 1766 CA ASP A 837 61.086 40.342 7.2.44 1.0020.48 A C ATOM 1767 CB ASP A 837 61.348 41.499 6.277 1.00 24.93 A C ATOM1768 CG ASP A 837 60.275 42.585 6.337 1.00 24.76 A C ATOM 1769 OD1 ASP A837 59.162 42.328 6.843 1.00 22.05 A O ATOM 1770 OD2 ASP A 837 60.54543.703 5.847 1.00 19.45 A O ATOM 1771 C ASP A 837 61.844 39.111 6.7631.00 17.79 A C ATOM 1772 O ASP A 837 61.300 38.297 6.009 1.00 17.43 A OATOM 1773 N VAL A 838 63.093 38.971 7.194 1.00 18.92 A N ATOM 1774 CAVAL A 838 63.897 37.817 6.802 1.00 15.94 A C ATOM 1775 CB VAL A 83865.349 37.935 7.324 1.00 23.80 A C ATOM 1776 CG1 VAL A 838 66.088 36.6167.114 1.00 23.03 A C ATOM 1777 CG2 VAL A 838 66.074 39.072 6.582 1.0016.63 A C ATOM 1778 C VAL A 838 63.254 36.523 7.314 1.00 16.31 A C ATOM1779 O VAL A 838 63.199 35.525 6.604 1.00 13.23 A O ATOM 1780 N TRP A839 62.774 36.533 8.554 1.00 16.33 A N ATOM 1781 CA TRP A 839 62.10235.360 9.094 1.00 22.16 A C ATOM 1782 CB TRP A 839 61.590 35.641 10.5121.00 19.02 A C ATOM 1783 CG TRP A 839 60.768 34.534 11.110 1.00 23.68 AC ATOM 1784 CD2 TRP A 839 61.157 33.668 12.186 1.00 23.90 A C ATOM 1785CE2 TRP A 839 60.081 32.726 12.425 1.00 23.27 A C ATOM 1786 CE3 TRP A839 62.311 33.551 12.966 1.00 20.81 A C ATOM 1787 CD1 TRP A 839 59.50234.142 10.750 1.00 24.49 A C ATOM 1788 NE1 TRP A 839 59.084 33.10011.539 1.00 19.50 A N ATOM 1789 CZ2 TRP A 839 60.127 31.804 13.414 1.0026.78 A C ATOM 1790 CZ3 TRP A 839 62.356 32.575 13.944 1.00 20.57 A CATOM 1791 CH2 TRP A 839 61.269 31.713 14.159 1.00 22.37 A C ATOM 1792 CTRP A 839 60.915 35.015 8.192 1.00 16.87 A C ATOM 1793 O TRP A 83960.767 33.870 7.754 1.00 16.83 A O ATOM 1794 N SER A 840 60.077 36.0167.923 1.00 13.12 A N ATOM 1795 CA SER A 840 58.888 35.843 7.091 1.0015.26 A C ATOM 1796 CB SER A 840 58.155 37.182 6.913 1.00 14.60 A C ATOM1797 CG SER A 840 57.716 37.690 8.170 1.00 21.30 A O ATOM 1798 C SER A840 59.271 35.283 5.736 1.00 13.12 A C ATOM 1799 O SER A 840 58.55634.457 5.171 1.00 15.98 A O ATOM 1800 N TYR A 841 60.406 35.733 5.2211.00 15.43 A N ATOM 1801 CA TYR A 841 60.896 35.247 3.932 1.00 13.22 A CATOM 1802 CB TYR A 841 62.163 35.995 3.533 1.00 14.97 A C ATOM 1803 CGTYR A 841 62.766 35.479 2.252 1.00 14.31 A C ATOM 1804 CD1 TYR A 84162.286 35.896 1.015 1.00 18.92 A C ATOM 1805 CE1 TYR A 841 62.803 35.380−0.164 1.00 21.32 A C ATOM 1806 CD2 TYR A 841 63.784 34.528 2.274 1.0014.13 A C ATOM 1807 CE2 TYR A 841 64.304 34.002 1.098 1.00 19.05 A CATOM 1808 CZ TYR A 841 63.809 34.432 −0.115 1.00 20.07 A C ATOM 1809 OHTYR A 841 64.311 33.904 −1.287 1.00 17.54 A O ATOM 1810 C TYR A 84161.192 33.741 4.036 1.00 13.55 A C ATOM 1811 O TYR A 841 60.986 32.9943.086 1.00 12.94 A O ATOM 1812 N GLY A 842 61.687 33.306 5.191 1.0013.24 A N ATOM 1813 CA GLY A 842 61.953 31.893 5.403 1.00 14.97 A C ATOM1814 C GLY A 842 60.656 31.099 5.266 1.00 15.57 A C ATOM 1815 O GLY A842 60.627 30.025 4.645 1.00 15.63 A O ATOM 1816 N ILE A 843 59.57531.626 5.842 1.00 18.69 A N ATOM 1817 CA ILE A 843 58.278 30.966 5.7561.00 17.62 A C ATOM 1818 CB ILE A 843 57.217 31.685 6.614 1.00 12.37 A CATOM 1819 CG2 ILE A 843 55.872 30.956 6.509 1.00 18.15 A C ATOM 1820 CG1ILE A 843 57.667 31.714 8.073 1.00 16.08 A C ATOM 1821 CD1 ILE A 84357.772 30.328 8.692 1.00 17.89 A C ATOM 1822 C ILE A 843 57.830 30.9544.291 1.00 16.12 A C ATOM 1823 O ILE A 843 57.283 29.964 3.814 1.0012.81 A O ATOM 1824 N LEU A 844 58.072 32.055 3.586 1.00 17.71 A N ATOM1825 CA LEU A 844 57.706 32.135 2.172 1.00 18.20 A C ATOM 1826 CB LEU A844 58.045 33.509 1.605 1.00 14.27 A C ATOM 1827 CG LEU A 844 58.15233.554 0.077 1.00 15.77 A C ATOM 1828 CD1 LEU A 844 56.822 33.146 −0.5601.00 20.09 A C ATOM 1829 CD2 LEU A 844 58.547 34.961 −0.347 1.00 14.60 AC ATOM 1830 C LEU A 844 58.445 31.063 1.372 1.00 20.07 A C ATOM 1831 OLEU A 844 57.864 30.437 0.478 1.00 20.33 A O ATOM 1832 N LEU A 84559.724 30.864 1.687 1.00 17.72 A N ATOM 1833 CA LEU A 845 60.535 29.8511.008 1.00 24.22 A C ATOM 1834 CB LEU A 845 61.969 29.824 1.550 1.0020.44 A C ATOM 1835 CG LEU A 845 62.981 30.862 1.063 1.00 31.34 A C ATOM1836 CD1 LEU A 845 64.339 30.553 1.681 1.00 23.97 A C ATOM 1837 CD2 LEUA 845 63.076 30.838 −0.453 1.00 26.86 A C ATOM 1838 C LEU A 845 59.90028.486 1.222 1.00 19.15 A C ATOM 1839 O LEU A 845 59.817 27.677 0.3011.00 19.32 A O ATOM 1840 N TRP A 846 59.453 28.230 2.450 1.00 19.86 A NATOM 1841 CA TRP A 846 58.804 26.963 2.766 1.00 19.14 A C ATOM 1842 CBTRP A 846 58.441 26.908 4.247 1.00 18.27 A C ATOM 1843 CG TRP A 84657.915 25.577 4.683 1.00 25.24 A C ATOM 1844 CD2 TRP A 846 56.539 25.1704.728 1.00 19.58 A C ATOM 1845 CE2 TRP A 846 56.509 23.853 5.236 1.0022.36 A C ATOM 1846 CE3 TRP A 846 55.331 25.793 4.394 1.00 21.99 A CATOM 1847 CD1 TRP A 846 58.642 24.524 5.141 1.00 16.57 A C ATOM 1848 NE1TRP A 846 57.804 23.479 5.477 1.00 19.47 A N ATOM 1849 CZ2 TRP A 84655.317 23.147 5.422 1.00 17.41 A C ATOM 1850 CZ3 TRP A 846 54.143 25.0894.582 1.00 22.19 A C ATOM 1851 CH2 TRP A 846 54.150 23.781 5.092 1.0016.03 A C ATOM 1852 C TRP A 846 57.541 26.787 1.925 1.00 19.44 A C ATOM1853 O TRP A 846 57.261 25.689 1.447 1.00 23.03 A O ATOM 1854 N GLU A847 56.778 27.866 1.732 1.00 16.80 A N ATOM 1855 CA GLU A 847 55.55827.789 0.928 1.00 16.06 A C ATOM 1856 CB GLU A 847 54.789 29.111 0.9491.00 20.15 A C ATOM 1857 CG GLU A 847 54.218 29.539 2.286 1.00 15.75 A CATOM 1858 CD GLU A 847 53.465 30.845 2.159 1.00 21.10 A C ATOM 1859 OE1GLU A 847 52.267 30.806 1.800 1.00 18.17 A O ATOM 1860 OE2 GLU A 84754.083 31.911 2.398 1.00 13.77 A O ATOM 1861 C GLU A 847 55.920 27.495−0.524 1.00 18.01 A C ATOM 1862 O GLU A 847 55.259 26.698 −1.206 1.0021.11 A O ATOM 1863 N ILE A 848 56.959 28.167 −1.003 1.00 16.81 A N ATOM1864 CA ILE A 848 57.402 27.984 −2.384 1.00 17.37 A C ATOM 1865 CB ILE A848 58.626 28.869 −2.703 1.00 22.66 A C ATOM 1866 CG2 ILE A 848 59.29228.388 −3.987 1.00 22.09 A C ATOM 1867 CG1 ILE A 848 58.208 30.339−2.830 1.00 21.73 A C ATOM 1868 CD1 ILE A 848 59.361 31.273 −3.168 1.0022.82 A C ATOM 1869 C ILE A 848 57.794 26.527 −2.638 1.00 25.72 A C ATOM1870 O ILE A 848 57.289 25.885 −3.559 1.00 19.89 A O ATOM 1871 N PHE A849 58.675 26.000 −1.793 1.00 22.31 A O ATOM 1872 CA PHE A 849 59.17024.639 −1.968 1.00 23.53 A C ATOM 1873 CB PHE A 849 60.562 24.546 −1.3491.00 22.24 A C ATOM 1874 CG PHE A 849 61.619 25.243 −2.165 1.00 25.34 AC ATOM 1875 CD1 PHE A 849 62.231 24.594 −3.226 1.00 24.73 A C ATOM 1876CD2 PHE A 849 61.943 26.567 −1.920 1.00 24.47 A C ATOM 1877 CE1 PHE A849 63.142 25.250 −4.028 1.00 26.25 A C ATOM 1878 CE2 PHE A 849 62.85627.235 −2.720 1.00 25.29 A C ATOM 1879 CZ PHE A 849 63.456 26.577 −3.7771.00 30.37 A C ATOM 1880 C PHE A 849 58.287 23.478 −1.509 1.00 25.86 A CATOM 1881 O PHE A 849 58.706 22.318 −1.561 1.00 26.78 A O ATOM 1882 NSER A 850 57.072 23.793 −1.070 1.00 24.88 A N ATOM 1883 CA SER A 85056.105 22.786 −0.647 1.00 23.99 A C ATOM 1884 CB SER A 850 55.638 23.0520.788 1.00 22.00 A C ATOM 1885 CG SER A 850 54.854 24.230 0.844 1.0020.56 A O ATOM 1886 C SER A 850 54.930 22.957 −1.610 1.00 27.12 A C ATOM1887 O SER A 850 53.854 22.368 −1.441 1.00 22.91 A O ATOM 1888 N LEU A851 55.160 23.777 −2.629 1.00 20.02 A N ATOM 1889 CA LEU A 851 54.14824.089 −3.629 1.00 22.60 A C ATOM 1890 CB LEU A 851 53.879 22.878 −4.5391.00 25.67 A C ATOM 1891 CG LEU A 851 55.096 22.384 −5.339 1.00 23.14 AC ATOM 1892 CD1 LEU A 851 54.645 21.341 −6.348 1.00 26.96 A C ATOM 1893CD2 LEU A 851 55.776 23.549 −6.065 1.00 28.28 A C ATOM 1894 C LEU A 85152.837 24.618 −3.045 1.00 24.71 A C ATOM 1895 O LEU A 851 51.753 24.243−3.478 1.00 23.23 A O ATOM 1896 N GLY A 852 52.939 25.477 −2.035 1.0026.30 A N ATOM 1897 CA GLY A 852 51.746 26.092 −1.482 1.00 23.28 A CATOM 1898 C GLY A 852 50.998 25.533 −0.289 1.00 20.12 A C ATOM 1899 OGLY A 852 49.840 25.881 −0.097 1.00 22.32 A O ATOM 1900 N LEU A 85351.610 24.662 0.502 1.00 20.10 A N ATOM 1901 CA LEU A 853 50.914 24.1481.675 1.00 19.94 A C ATOM 1902 CB LEU A 853 51.711 23.022 2.336 1.0022.26 A C ATOM 1903 CG LEU A 853 51.908 21.689 1.613 1.00 27.30 A C ATOM1904 CD1 LEU A 853 52.748 20.769 2.497 1.00 24.38 A C ATOM 1905 CD2 LEUA 853 50.557 21.053 1.315 1.00 22.60 A C ATOM 1906 C LEU A 853 50.83125.310 2.649 1.00 25.16 A C ATOM 1907 O LEU A 853 51.653 26.225 2.5761.00 19.43 A O ATOM 1908 N ASN A 854 49.851 25.280 3.552 1.00 21.23 A NATOM 1909 CA ASN A 854 49.721 26.334 4.550 1.00 22.30 A C ATOM 1910 CBASN A 854 48.306 26.350 5.154 1.00 24.82 A C ATOM 1911 CG ASN A 85448.128 27.438 6.220 1.00 36.93 A C ATOM 1912 OD1 ASN A 854 48.132 27.1537.425 1.00 33.40 A O ATOM 1913 ND2 ASN A 854 47.980 28.692 5.776 1.0023.98 A N ATOM 1914 C ASN A 854 50.762 26.040 5.627 1.00 22.19 A C ATOM1915 0 ASN A 854 50.948 24.890 6.035 1.00 19.39 A O ATOM 1916 N PRO A855 51.478 27.076 6.084 1.00 21.60 A N ATOM 1917 CD PRO A 855 51.41728.469 5.608 1.00 14.78 A C ATOM 1918 CA PRO A 855 52.506 26.912 7.1141.00 16.21 A C ATOM 1919 CB PRO A 855 52.968 28.353 7.362 1.00 16.48 A CATOM 1920 CG PRO A 855 52.765 29.004 6.015 1.00 21.98 A C ATOM 1921 CPRO A 855 51.969 26.229 8.381 1.00 20.24 A C ATOM 1922 O PRO A 85550.794 26.401 8.736 1.00 16.54 A O ATOM 1923 N TYR A 856 52.825 25.4489.043 1.00 19.95 A N ATOM 1924 CA TYR A 856 52.439 24.755 10.270 1.0021.99 A C ATOM 1925 CB TYR A 856 52.247 25.779 11.385 1.00 21.67 A CATOM 1926 CG TYR A 856 53.487 26.615 11.625 1.00 24.56 A C ATOM 1927 CD1TYR A 856 54.560 26.106 12.350 1.00 20.85 A C ATOM 1928 CE1 TYR A 85655.717 26.850 12.546 1.00 17.31 A C ATOM 1929 CD2 TYR A 856 53.60027.900 11.096 1.00 21.06 A C ATOM 1930 CE2 TYR A 856 54.759 28.65711.284 1.00 16.14 A C ATOM 1931 CZ TYR A 856 55.811 28.119 12.012 1.0020.58 A C ATOM 1932 OH TYR A 856 56.965 28.834 12.199 1.00 25.68 A OATOM 1933 C TYR A 856 51.139 24.029 9.988 1.00 20.52 A C ATOM 1934 O TYRA 856 50.136 24.234 10.666 1.00 20.51 A O ATOM 1935 N PRO A 857 51.14623.166 8.963 1.00 24.39 A N ATOM 1936 CD PRO A 857 52.353 22.638 8.3031.00 21.69 A C ATOM 1937 CA PRO A 857 49.960 22.407 8.572 1.00 27.88 A CATOM 1938 CB PRO A 857 50.506 21.431 7.524 1.00 26.93 A C ATOM 1939 CGPRO A 857 51.927 21.243 7.936 1.00 34.47 A C ATOM 1940 C PRO A 85749.246 21.722 9.733 1.00 27.56 A C ATOM 1941 O PRO A 857 49.859 20.99610.516 1.00 28.31 A O ATOM 1942 N GLY A 858 47.947 21.981 9.846 1.0032.13 A N ATOM 1943 CA GLY A 858 47.158 21.374 10.906 1.00 33.96 A CATOM 1944 C GLY A 858 47.332 21.975 12.290 1.00 36.35 A C ATOM 1945 OGLY A 858 46.586 21.630 13.206 1.00 36.92 A O ATOM 1946 N ILE A 85948.311 22.862 12.454 1.00 30.52 A N ATOM 1947 CA ILE A 859 48.553 23.49313.750 1.00 29.17 A C ATOM 1948 CB ILE A 859 50.067 23.745 13.988 1.0032.04 A C ATOM 1949 CG2 ILE A 859 50.290 .24.451 15.332 1.00 24.42 A CATOM 1950 CG1 ILE A 859 50.822 22.417 13.976 1.00 30.97 A C ATOM 1951CD1 ILE A 859 52.333 22.561 14.080 1.00 28.08 A C ATOM 1952 C ILE A 85947.810 24.822 13.810 1.00 31.64 A C ATOM 1953 O ILE A 859 47.967 25.67312.938 1.00 31.76 A O ATOM 1954 N LEU A 860 46.987 24.987 14.838 1.0032.83 A N ATOM 1955 CA LEU A 860 46.214 26.208 15.007 1.00 34.46 A CATOM 1956 CR LEU A 860 44.906 25.912 15.746 1.00 36.28 A C ATOM 1957 CGLEU A 860 43.882 24.996 15.078 1.00 40.12 A C ATOM 1958 CD1 LEU A 86042.686 24.820 16.010 1.00 45.30 A C ATOM 1959 CD2 LEU A 860 43.44425.592 13.750 1.00 38.38 A C ATOM 1960 C LEU A 860 46.998 27.243 15.7961.00 32.17 A C ATOM 1961 O LEU A 860 47.837 26.900 16.632 1.00 30.67 A OATOM 1962 N VAL A 861 46.717 28.512 15.525 1.00 34.28 A N ATOM 1963 CAVAL A 861 47.376 29.601 16.230 1.00 35.56 A C ATOM 1964 CB VAL A 86147.273 30.927 15.451 1.00 36.71 A C ATOM 1965 CG1 VAL A 861 47.73732.082 16.332 1.00 37.10 A C ATOM 1966 CG2 VAL A 861 48.124 30.85514.181 1.00 28.53 A C ATOM 1967 C VAL A 861 46.699 29.773 17.587 1.0034.67 A C ATOM 1968 O VAL A 861 45.545 30.179 17.668 1.00 29.97 A O ATOM1969 N ASN A 862 47.421 29.428 18.644 1.00 38.73 A N ATOM 1970 CA ASN A862 46.917 29.552 20.004 1.00 40.27 A C ATOM 1971 CB ASN A 862 45.98228.386 20.351 1.00 36.28 A C ATOM 1972 CC ASN A 862 46.660 27.030 20.2461.00 42.13 A C ATOM 1973 OD1 ASN A 862 47.805 26.862 20.659 1.00 43.57 AO ATOM 1974 ND2 ASN A 862 45.941 26.048 19.707 1.00 46.38 A N ATOM 1975C ASN A 862 48.112 29.576 20.952 1.00 41.97 A C ATOM 1976 O ASN A 86249.248 29.774 20.517 1.00 39.05 A O ATOM 1977 N SER A 863 47.861 29.36822.240 1.00 43.20 A N ATOM 1978 CA SER A 863 48.932 29.374 23.228 1.0045.16 A C ATOM 1979 CB SER A 863 48.369 29.119 24.632 1.00 50.70 A CATOM 1980 CG SER A 863 47.541 30.191 25.057 1.00 59.52 A O ATOM 1981 CSER A 863 50.015 28.347 22.921 1.00 43.66 A C ATOM 1982 O SER A 86351.203 28.634 23.067 1.00 45.58 A O ATOM 1983 N LYS A 864 49.612 27.15122.505 1.00 37.02 A N ATOM 1984 CA LYS A 864 50.581 26.107 22.192 1.0039.18 A C ATOM 1985 CB LYS A 864 49.871 24.821 21.754 1.00 44.08 A CATOM 1986 CG LYS A 864 49.213 24.029 22.876 1.00 52.77 A C ATOM 1987 CDLYS A 864 48.090 24.810 23.538 1.00 61.47 A C ATOM 1988 CE LYS A 86447.394 23.970 24.598 1.00 61.23 A C ATOM 1989 NZ LYS A 864 46.310 24.72725.280 1.00 63.19 A N ATOM 1990 C LYS A 864 51.530 26.563 21.084 1.0039.38 A C ATOM 1991 O LYS A 864 52.750 26.424 21.200 1.00 38.74 A O ATOM1992 N PHE A 865 50.959 27.109 20.014 1.00 37.13 A N ATOM 1993 CA PHE A865 51.738 27.586 18.876 1.00 33.62 A C ATOM 1994 CB PHE A 865 50.82728.296 17.880 1.00 30.62 A C ATOM 1995 CG PHE A 865 51.551 28.837 16.6791.00 36.53 A C ATOM 1996 CD1 PHE A 865 52.060 27.983 15.719 1.00 35.76 AC ATOM 1997 CD2 PHE A 865 51.729 30.201 16.516 1.00 34.37 A C ATOM 1998CE1 PHE A 865 52.732 28.483 14.617 1.00 39.00 A C ATOM 1999 CE2 PHE A865 52.399 30.703 15.418 1.00 35.76 A C ATOM 2000 CZ PHE A 865 52.90029.845 14.469 1.00 32.47 A C ATOM 2001 C PHE A 865 52.840 28.549 19.3041.00 32.63 A C ATOM 2002 O PHE A 865 54.012 28.365 18.969 1.00 32.97 A OATOM 2003 N TYR A 866 52.453 29.587 20.036 1.00 32.73 A N ATOM 2004 CATYR A 866 53.406 30.582 20.503 1.00 33.59 A C ATOM 2005 CB TYR A 86652.689 31.614 21.368 1.00 34.61 A C ATOM 2006 CG TYR A 866 51.694 32.43020.581 1.00 30.27 A C ATOM 2007 CD1 TYR A 866 50.368 32.528 20.979 1.0025.95 A C ATOM 2008 CE1 TYR A 866 49.452 33.251 20.235 1.00 33.50 A CATOM 2009 CD2 TYR A 866 52.078 33.081 19.421 1.00 25.86 A C ATOM 2010CE2 TYR A 866 51.175 33.806 18.675 1.00 28.90 A C ATOM 2011 CZ TYR A 86649.865 33.887 19.082 1.00 31.65 A C ATOM 2012 OH TYR A 866 48.964 34.59818.325 1.00 34.85 A O ATOM 2013 C TYR A 866 54.551 29.936 21.265 1.0033.05 A C ATOM 2014 O TYR A 866 55.715 30.253 21.028 1.00 34.46 A O ATOM2015 N LYS A 867 54.221 29.019 22.168 1.00 38.38 A N ATOM 2016 CA LYS A867 55.238 28.331 22.946 1.00 38.06 A C ATOM 2017 CB LYS A 867 54.59027.376 23.949 1.00 43.78 A C ATOM 2018 CG LYS A 867 53.756 28.069 25.0151.00 49.88 A C ATOM 2019 CD LYS A 867 53.301 27.081 26.080 1.00 57.21 AC ATOM 2020 CE LYS A 867 52.597 27.781 27.235 1.00 60.27 A C ATOM 2021NZ LYS A 867 51.345 28.466 26.800 1.00 68.81 A N ATOM 2022 C LYS A 86756.163 27.558 22.019 1.00 34.75 A C ATOM 2023 O LYS A 867 57.366 27.50522.237 1.00 3457 A O ATOM 2024 N LEU A 868 55.598 26.960 20.974 1.0035.77 A N ATOM 2025 CA LEU A 868 56.403 26.206 20.021 1.00 33.34 A CATOM 2026 CB LEU A 868 55.511 25.538 18.964 1.00 31.41 A C ATOM 2027 CCLEU A 868 54.755 24.275 19.384 1.00 40.13 A C ATOM 2028 CD1 LEU A 86854.031 23.684 18.181 1.00 34.94 A C ATOM 2029 CD2 LEU A 868 55.73423.261 19.951 1.00 35.39 A C ATOM 2030 C LEU A 868 57.432 27.091 19.3251.00 31.07 A C ATOM 2031 O LEU A 868 58.632 26.807 19.366 1.00 29.07 A OATOM 2032 N VAL A 869 56.970 28.160 18.681 1.00 31.12 A N ATOM 2033 CAVAL A 869 57.885 29.053 17.976 1.00 35.29 A C ATOM 2034 CB VAL A 86957.132 30.180 17.220 1.00 33.94 A C ATOM 2035 CG1 VAL A 869 56.19929.578 16.193 1.00 31.92 A C ATOM 2036 CG2 VAL A 869 56.362 31.04318.195 1.00 41.37 A C ATOM 2037 C VAL A 869 58.856 29.683 18.956 1.0034.13 A C ATOM 2038 O VAL A 869 60.028 29.883 18.642 1.00 37.82 A O ATOM2039 N LYS A 870 58.358 29.985 20.150 1.00 37.80 A N ATOM 2040 CA LYS A870 59.174 30.587 21.192 1.00 38.82 A C ATOM 2041 CB LYS A 870 58.31230.887 22.423 1.00 42.45 A C ATOM 2042 CG LYS A 870 58.996 31.737 23.4791.00 47.58 A C ATOM 2043 CD LYS A 870 59.301 33.126 22.939 1.00 55.02 AC ATOM 2044 CB LYS A 870 59.976 34.006 23.985 1.00 62.93 A C ATOM 2045NZ LYS A 870 61.304 33.465 24.401 1.00 67.77 A N ATOM 2046 C LYS A 87060.291 29.627 21.573 1.00 38.54 A C ATOM 2047 O LYS A 870 61.433 30.04221.766 1.00 39.26 A O ATOM 2048 N ASP A 871 59.953 28.341 21.664 1.0037.70 A N ATOM 2049 CA ASP A 871 60.915 27.309 22.037 1.00 37.78 A CATOM 2050 CB ASP A 871 60.189 26.059 22.542 1.00 39.75 A C ATOM 2051 CGASP A 871 59.398 26.320 23.805 1.00 50.01 A C ATOM 2052 OD1 ASP A 87159.876 27.109 24.649 1.00 56.86 A O ATOM 2053 OD2 ASP A 871 58.30725.731 23.961 1.00 55.83 A O ATOM 2054 C ASP A 871 61.887 26.909 20.9311.00 3559 A C ATOM 2055 O ASP A 871 62.809 26.127 21.165 1.00 33.99 A OATOM 2056 N GLY A 872 61.687 27.432 19.728 1.00 32.21 A N ATOM 2057 CAGLY A 872 62.595 27.099 18.643 1.00 32.62 A C ATOM 2058 C GLY A 87262.099 26.064 17.649 1.00 30.80 A C ATOM 2059 O GLY A 872 62.877 25.54916.842 1.00 26.70 A O ATOM 2060 N TYR A 873 60.812 25.746 17.703 1.0027.97 A N ATOM 2061 CA TYR A 873 60.242 24.775 16.776 1.00 26.49 A CATOM 2062 CB TYR A 873 58.779 24.512 17.116 1.00 26.03 A C ATOM 2063 CGTYR A 873 58.060 23.675 16.084 1.00 27.78 A C ATOM 2064 CD1 TYR A 87358.084 22.287 16.146 1.00 28.59 A C ATOM 2065 CE1 TYR A 873 57.42421.519 15.206 1.00 31.38 A C ATOM 2066 CD2 TYR A 873 57.355 24.27615.042 1.00 25.17 A C ATOM 2067 CE2 TYR A 873 56.695 23.514 14.093 1.0026.66 A C ATOM 2068 CZ TYR A 873 56.731 22.138 14.182 1.00 31.90 A CATOM 2069 ON TYR A 873 56.064 21.376 13.251 1.00 31.18 A O ATOM 2070 CTYR A 873 60.322 25.321 15.352 1.00 25.24 A C ATOM 2071 O TYR A 87360.045 26.496 15.116 1.00 20.64 A O ATOM 2072 N GLN A 874 60.696 24.46614.408 1.00 26.48 A N ATOM 2073 CA GLN A 874 60.794 24.869 13.012 1.0022.55 A C ATOM 2074 CB GLN A 874 62.263 24.991 12.598 1.00 19.94 A CATOM 2075 CG GLN A 874 63.035 26.063 13.37 1.00 25.03 A C ATOM 2076 CDGLN A 874 64.453 26.241 12.854 1.00 25.93 A C ATOM 2077 OE1 GLN A 87465.183 27.147 13.282 1.00 26.23 A O ATOM 2078 NE2 GLN A 874 64.85225.376 11.931 1.00 18.93 A N ATOM 2079 C GLN A 874 60.108 23.831 12.1391.00 26.00 A C ATOM 2080 O GLN A 874 60.214 22.632 12.392 1.00 23.13 A OATOM 2081 N MET A 875 59.393 24.287 11.120 1.00 19.52 A N ATOM 2082 CAMET A 875 58.723 23.353 10.225 1.00 21.15 A C ATOM 2083 CB MET A 87558.024 24.093 9.092 1.00 19.03 A C ATOM 2084 CG MET A 875 56.716 24.7519.451 1.00 12.92 A C ATOM 2085 SD MET A 875 55.991 25.523 8.009 1.0021.85 A S ATOM 2086 CE MET A 875 56.803 27.168 8.068 1.00 23.16 A C ATOM2087 C MET A 875 59.743 22.403 9.620 1.00 24.16 A C ATOM 2088 O MET A875 60.941 22.702 9.577 1.00 22.50 A O ATOM 2089 N ALA A 876 59.25321.267 9.135 1.00 23.54 A N ATOM 2090 CA ALA A 876 60.097 20.262 8.5161.00 22.63 A C ATOM 2091 CB ALA A 876 59.389 18.910 8.536 1.00 20.96 A CATOM 2092 C ALA A 876 60.425 20.654 7.079 1.00 25.26 A C ATOM 2093 O ALAA 876 59.705 21.433 6.455 1.00 22.17 A O ATOM 2094 N GLN A 877 61.51320.097 6.561 1.00 26.64 A N ATOM 2095 CA LN A 877 61.941 20.363 5.1931.00 24.05 A C ATOM 2096 CB GLN A 877 63.182 19.528 4.880 1.00 25.58 A CATOM 2097 CG GLN A 877 63.806 19.795 3.522 1.00 25.54 A C ATOM 2098 CDGLN A 877 64.967 18.862 3.234 1.00 36.62 A C ATOM 2099 OE1 GLN A 87765.651 18.405 4.149 1.00 39.06 A O ATOM 2100 NE2 GLN A 877 65.204 18.5871.959 1.00 35.05 A N ATOM 2101 C GLN A 877 60.822 20.022 4.203 1.0029.06 A C ATOM 2102 O GLN A 877 60.254 18.932 4.251 1.00 30.62 A O ATOM2103 N PRO A 878 60.492 20.953 3.288 1.00 24.33 A N ATOM 2104 CD PRO A878 61.009 22.322 3.178 1.00 29.53 A C ATOM 2105 CA PRO A 878 5943820.725 2.297 1.00 25.39 A C ATOM 2106 CB PRO A 878 59.260 22.100 1.6471.00 30.92 A C ATOM 2107 CG PRO A 878 59.812 23.044 2.642 1.00 22.07 A CATOM 2108 C PRO A 878 59.852 19.667 1.275 1.00 25.47 A C ATOM 2109 O PROA 878 61.037 19.477 1.006 1.00 27.51 A O ATOM 2110 N ALA A 879 58.86319.000 0.695 1.00 32.83 A N ATOM 2111 CA ALA A 879 59.101 17.943 −0.2821.00 24.98 A C ATOM 2112 CB ALA A 879 57.773 17.440 −0.818 1.00 27.36 AC ATOM 2113 C ALA A 879 60.0111 8.317 −1.449 1.00 28.47 A C ATOM 2114 OALA A 879 60.806 17.495 −1.901 1.00 24.02 A O ATOM 2115 N PHE A 88059.921 19.552 −1.930 1.00 24.93 A N ATOM 2116 CA PHE A 880 60.733 19.940−3.077 1.00 23.72 A C ATOM 2117 CB PHE A 880 59.820 20.575 −4.123 1.0028.35 A C ATOM 2118 CG PHE A 880 58.640 19.726 −4.452 1.00 29.22 A CATOM 2119 CD1 PHE A 880 57.477 19.815 −3.705 1.00 28.79 A C ATOM 2120CD2 PHE A 880 58.722 18.766 −5.448 1.00 30.39 A C ATOM 2121 CE1 PHE A880 56.421 18.964 −3.939 1.00 31.65 A C ATOM 2122 CE2 PHE A 880 57.66817.910 −5.687 1.00 30.75 A C ATOM 2123 CZ PHE A 880 56.516 18.007 −4.9321.00 33.90 A C ATOM 2124 C PHE A 880 61.941 20.819 −2.806 1.00 26.90 A CATOM 2125 O PHE A 880 62.569 21.331 −3.734 1.00 28.62 A O ATOM 2126 NALA A 881 62.290 20.978 −1.536 1.00 25.14 A N ATOM 2127 CA ALA A 88163.442 21.794 −1.199 1.00 26.52 A C ATOM 2128 CB ALA A 881 63.154 22.6170.055 1.00 26.59 A C ATOM 2129 C ALA A 881 64.714 20.974 −0.992 1.0029.30 A C ATOM 2130 O ALA A 881 64.744 20.021 −0.210 1.00 18.47 A O ATOM2131 N PRO A 882 65.776 21.315 −1.729 1.00 26.57 A N ATOM 2132 CD PRO A882 65.770 22.156 −2.939 1.00 33.69 A C ATOM 2133 CA PRO A 882 67.04820.607 −1.588 1.00 29.31 A C ATOM 2134 CB PRO A 882 67.908 21.236 −2.6781.00 33.45 A C ATOM 2135 CG PRO A 882 66.910 21.579 −3.730 1.00 32.98 AC ATOM 2136 C PRO A 882 67.548 20.961 −0.186 1.00 32.98 A C ATOM 2137 OPRO A 882 67.036 21.902 0.434 1.00 27.82 A O ATOM 2138 N LYS A 88368.5352 0.232 0.321 1.00 32.48 A N ATOM 2139 CA LYS A 883 69.045 20.5231.655 1.00 34.15 A C ATOM 2140 CB LYS A 883 70.184 19.567 2.022 1.0041.49 A C ATOM 2141 CG LYS A 883 70.221 19.210 3.507 1.00 44.54 A C ATOM2142 CD LYS A 883 70.193 20.457 4.375 1.00 54.59 A C ATOM 2143 CE LYS A883 69.947 20.127 5.839 1.00 60.18 A C ATOM 2144 NZ LYS A 883 69.74221.362 6.651 1.00 55.58 A N ATOM 2145 C LYS A 883 69.535 21.968 1.7711.00 32.81 A C ATOM 2146 O LYS A 883 69.265 22.645 2.765 1.00 30.87 A OATOM 2147 N ASN A 884 70.252 22.440 0.756 1.00 30.41 A N ATOM 2148 CAASN A 884 70.776 23.798 0.770 1.00 26.43 A C ATOM 2149 CB ASN A 88471.555 24.089 −0.513 1.00 35.44 A C ATOM 2150 CG ASN A 884 72.857 23.335−0.582 1.00 39.22 A C ATOM 2151 OD1 ASN A 884 73.421 22.956 0.446 1.0045.06 A O ATQM 2152 ND2 ASN A 884 73.359 23.129 −1.794 1.00 45.29 A NATOM 2153 C ASN A 884 69.696 24.858 0.948 1.00 24.74 A C ATOM 2154 O ASNA 884 69.904 25.850 1.648 1.00 24.03 A O ATOM 2155 N ILE A 885 68.55124.654 0.308 1.00 24.09 A N ATOM 2156 CA ILE A 885 67.448 25.599 0.4061.00 24.08 A C ATOM 2157 CB .ILE A 885 66.383 25.318 −0.657 1.00 23.61 AC ATOM 2158 CG2 ILE A 885 65.220 26.284 −0.509 1.00 24.48 A C ATOM 2159CG1 ILE A 885 67.014 25.448 −2.047 1.00 20.26 A C ATOM 2160 CD1 ILE A885 67.693 26.782 −2.275 1.00 30.31 A C ATOM 2161 C ILE A 885 66.81325.545 1.793 1.00 27.14 A C ATOM 2162 O ILE A 885 66.377 26.568 2.3181.00 21.37 A O ATQM 2163 N TYR A 886 66.774 24.358 2.392 1.00 22.31 A NATOM 2164 CA TYR A 886 66.201 24.226 3.727 1.00 24.14 A C ATOM 2165 CBTYR A 886 66.046 22.749 4.098 1.00 28.51 A C ATOM 2166 CG TYR A 88665.354 22.522 5.421 1.00 24.83 A C ATOM 2167 CD1 TYR A 886 64.141 23.1395.708 1.00 21.95 A C ATOM 2168 CE1 TYR A 886 63.505 22.936 6.926 1.0023.52 A C ATOM 2169 CD2 TYR A 886 65.917 21.694 6.388 1.00 24.02 A CATOM 2170 CE2 TYR A 886 65.294 21.489 7.608 1.00 23.94 A C ATOM 2171 CZTYR A 886 64.092 22.109 7.874 1.00 26.79 A C ATOM 2172 OH TYR A 88663.485 21.913 9.095 1.00 23.83 A O ATOM 2173 C TYR A 886 67.133 24.9224.717 1.00 23.90 A C ATOM 2174 O TYR A 886 66.700 25.402 5.764 1.0025.15 A O ATOM 2175 N SER A 887 68.420 24.972 4.380 1.00 18.93 A N ATOM2176 CA SER A 887 69.403 25.628 5.236 1.00 21.81 A C ATOM 2177 CB SER A887 70.824 25.384 4.713 1.00 24.01 A C ATOM 2178 CG SER A 887 71.21924.047 4.967 1.00 38.40 A O ATOM 2179 C SER A 887 69.112 27.119 5.2781.00 16.47 A C ATOM 2180 O SER A 887 69.340 27.781 6.283 1.00 18.56 A OATOM 2181 N ILE A 888 68.605 27.651 4.174 1.00 15.19 A N ATOM 2182 CAILE A 888 68.256 29.061 4.127 1.00 18.13 A C ATOM 2183 CB ILE A 88867.841 29.484 2.706 1.00 21.17 A C ATOM 2184 CG2 ILE A 888 67.434 30.9562.698 1.00 22.33 A C ATOM 2185 CG1 ILE A 888 69.007 29.250 1.741 1.0015.22 A C ATOM 2186 CD1 ILE A 888 68.685 29.593 0.295 1.00 24.73 A CATOM 2187 C ILE A 888 67.076 29.278 5.073 1.00 18.00 A C ATOM 2188 O ILEA 888 67.071 30.207 5.892 1.00 19.02 A O ATOM 2189 N MET A 889 66.07928.405 4.961 1.00 16.44 A N ATOM 2190 CA MET A 889 64.894 28.485 5.8021.00 16.53 A C ATOM 2191 CB MET A 889 63.945 27.305 5.513 1.00 21.42 A CATOM 2192 CG MET A 889 63.110 27.446 4.249 1.00 25.07 A C ATOM 2193 SDMET A 889 62.123 25.973 3.860 1.00 19.76 A S ATOM 2194 CB MET A 88962.464 25.817 2.109 1.00 17.06 A C ATOM 2195 C MET A 889 65.314 28.4557.260 1.00 18.09 A C ATOM 2196 O MET A 889 64.887 29.293 8.057 1.0024.46 A O ATOM 2197 N GLN A 890 66.152 27.484 7.613 1.00 20.41 A N ATOM2198 CA GLN A 890 66.616 27.352 8.992 1.00 21.75 A C ATOM 2199 CB GLN A890 67.498 26.110 9.136 1.00 20.39 A C ATOM 2200 CG GLN A 890 66.79724.793 8.814 1.00 21.06 A C ATOM 2201 CD GLN A 890 67.708 23.596 9.0111.00 22.17 A C ATOM 2202 OE1 GLN A 890 68.802 23.541 8.455 1.00 27.55 AO ATOM 2203 NE2 GLN A 890 67.258 22.630 9.804 1.00 25.77 A N ATOM 2204 CGLN A 890 67.326 28.587 9.461 1.00 21.30 A C ATOM 2205 O GLN A 89067.284 28.988 10.624 1.00 22.93 A O ATOM 2206 N ALA A 891 68.159 29.1848.557 1.00 22.65 A N ATOM 2207 CA ALA A 891 68.935 30.377 8.884 1.0027.29 A C ATOM 2208 CB ALA A 891 69.895 30.718 7.739 1.00 26.81 A C ATOM2209 CA LA A 891 67.986 31.539 9.145 1.00 20.96 A C ATOM 2210 O ALA A891 68.135 32.269 10.130 1.00 24.30 A O ATOM 2211 N CYS A 892 67.00931.701 8.257 1.00 22.95 A N ATOM 2212 CA CYS A 892 66.008 32.750 8.3871.00 21.58 A C ATOM 2213 CB CYS A 892 65.021 32.711 7.220 1.00 13.34 A CATOM 2214 SG CYS A 892 65.691 33.225 5.626 1.00 22.09 A S ATOM 2215 CCYS A 892 65.217 32.598 9.679 1.00 20.66 A C ATOM 2216 O CYS A 89264.678 33.579 10.195 1.00 24.40 A O ATOM 2217 N TRP A 893 65.157 31.37510.206 1.00 17.46 A N ATOM 2218 CA TRP A 893 64.391 31.140 11.420 1.0020.68 A C ATOM 2219 CB TRP A 893 63.588 29.835 11.291 1.00 20.21 A CATOM 2220 CG TRP A 893 62.578 29.841 10.158 1.00 18.35 A C ATOM 2221 CD2TRP A 893 62.133 28.706 9.395 1.00 17.90 A C ATOM 2222 CE2 TRP A 89361.182 29.175 8.461 1.00 15.78 A C ATOM 2223 CE3 TRP A 893 62.445 27.3419.412 1.00 17.88 A C ATOM 2224 CD1 TRP A 893 61.887 30.925 9.666 1.0019.60 A C ATOM 2225 NE1 TRP A 893 61.049 30.527 8.645 1.00 16.99 A NATOM 2226 CZ2 TRP A 893 60.542 28.324 7.552 1.00 21.52 A C ATOM 2227 CZ3TRP A 893 61.806 26.499 8.507 1.00 21.93 A C ATOM 2228 CH2 TRP A 89360.866 26.998 7.592 1.00 19.19 A C ATOM 2229 C TRP A 893 65.201 31.14812.718 1.00 20.92 A C ATOM 2230 O TRP A 893 64.775 30.583 13.722 1.0022.06 A O ATOM 2231 N ALA A 894 66.367 31.787 12.702 1.00 24.33 A N ATOM223.2 CA ALA A 894 67.177 31.872 13.917 1.00 26.66 A C ATOM 2233 CB ALAA 894 68.540 32.503 13.611 1.00 24.78 A C ATOM 2234 C ALA A 894 66.38832.753 14.886 1.00 25.66 A C ATOM 2235 O ALA A 894 65.899 33.817 14.5021.00 26.27 A O ATOM 2236 N LEU A 895 66.245 32.307 16.131 1.00 23.03 A NATOM 2237 CA LEU A 895 65.500 33.070 17.132 1.00 28.23 A C ATOM 2238 CBLEU A 895 65.464 32.307 18.468 1.00 25.33 A C ATOM 2239 CG LEU A 89564.609 31.032 18.492 1.00 30.95 A C ATOM 2240 CD1 LEU A 895 64.63330.425 19.888 1.00 35.97 A C ATOM 2241 CD2 LEU A 895 63.179 31.36018.098 1.00 31.53 A C ATOM 2242 C LEU A 895 66.093 34.467 17.345 1.0023.03 A C ATOM 2243 O LEU A 895 65.367 35.441 17.542 1.00 24.63 A O ATOM2244 N GLU A 896 67.415 34.555 17.313 1.00 29.69 A N ATOM 2245 CA GLU A896 68.075 35.838 17.493 1.00 35.78 A C ATOM 2246 CB GLU A 896 69.44935.644 18.126 1.00 44.42 A C ATOM 2247 CG GLU A 896 69.366 35.160 19.5631.00 57.44 A C ATOM 2248 CD GLU A 896 68.435 36.018 20.402 1.00 66.55 AC ATOM 2249 OE1 GLU A 896 68.668 37.245 20.486 1.00 69.03 A O ATOM 2250OE2 GLU A 896 67.468 35.467 20.976 1.00 70.06 A O ATOM 2251 C GLU A 89668.200 36.510 16.142 1.00 29.82 A C ATOM 2252 O GLU A 89.6 68.920 36.03715.265 1.00 32.92 A O ATOM 2253 N PRO A 897 67.483 37.626 15.960 1.0028.03 A N ATOM 2254 CD PRO A 897 66.658 38.2.49 17.007 1.00 28.24 A CATOM 2255 CA PRO A 897 67.453 38.426 14.734 1.00 28.53 A C ATOM 2256 CBPRO A 897 66.733 39.698 15.173 1.00 26.92 A C ATOM 2257 CG PRO A 89765.786 39.196 16.203 1.00 33.03 A C ATOM 2258 C PRO A 897 68.828 38.71114.149 1.00 30.00 A C ATOM 2259 O PRO A 897 69.014 38.656 12.933 1.0028.91 A O ATOM 2260 N THR A 898 69.791 39.007 15.019 1.00 32.64 A N ATOM2261 CA THR A 898 71.149 39.315 14.582 1.00 36.97 A C ATOM 2262 CB THR A898 72.000 39.861 15.749 1.00 36.00 A C ATOM 2263 CG1 THR A 898 71.98238.931 16.838 1.00 42.94 A C ATOM 2264 CG2 THR A 898 71.444 41.19316.225 1.00 38.53 A C ATOM 2265 C THR A 898 71.879 38.135 13.951 1.0030.91 A C ATOM 2266 O THR A 898 72.833 38.329 13.199 1.00 35.82 A O ATOM2267 N HIS A 899 71.429 36.916 14.240 1.00 31.62 A N ATOM 2268 CA HIS A899 72.066 35.733 13.670 1.00 32.45 A C ATOM 2269 CB HIS A 899 72.05234.576 14.673 1.00 43.09 A C ATOM 2270 CG HIS A 899 72.879 34.830 15.8951.00 51.76 A C ATOM 2271 CD2 HIS A 899 72.623 34.614 17.208 1.00 56.72 AC ATOM 2272 NE2 HIS A 899 74.149 35.363 15.836 1.00 56.95 A N ATOM 2273CE1 HIS A 899 74.639 35.466 17.059 1.00 57.24 A C ATOM 2274 NE2 HIS A899 73.733 35.018 17.909 1.00 58.83 A N ATOM 2275 C HIS A 899 71.43935.284 12.351 1.00 33.51 A C ATOM 2276 O HIS A 899 71.893 34.317 11.7441.00 30.89 A O ATOM 2277 N ARG A 900 70.393 35.981 11.910 1.00 31.73 A NATOM 2278 CA ARG A 900 69.750 35.650 10.637 1.00 24.76 A C ATOM 2279 CBARG A 900 68.322 36.192 10.594 1.00 22.49 A C ATOM 2280 CG ARG A 90067.396 35.574 11.608 1.00 18.10 A C ATOM 2281 CD ARG A 900 66.068 36.29911.652 1.00 15.39 A C ATOM 2282 NE ARG A 900 65.331 35.940 12.862 1.0017.02 A N ATOM 2283 CZ ARG A 900 64.385 36.685 13.411 1.00 14.21 A CATOM 2284 NH1 ARG A 900 64.038 37.843 12.860 1.00 20.08 A N ATOM 2285NH2 ARG A 900 63.816 36.291 14.548 1.00 23.01 A N ATOM 2286 C ARG A 90070.560 36.300 9.522 1.00 26.28 A C ATOM 2287 O ARG A 900 71.245 37.3019.745 1.00 23.51 A O ATOM 2288 N PRO A 901 70.501 35.737 8.305 1.0019.50 A N ATOM 2289 CD PRO A 901 69.761 34.530 7.884 1.00 23.56 A C ATOM2290 CA PRO A 901 71.251 36.313 7.189 1.00 22.08 A C ATOM 2291 CB PRO A901 71.229 35.198 6.146 1.00 17.81 A C ATOM 2292 CG PRO A 901 69.839.34.609 6.348 1.00 18.30 A C ATOM 2293 C PRO A 901 70.537 37.554 6.6731.00 26.53 A C ATOM 2294 O PRO A 901 69.357 37.763 6.952 1.00 21.69 A 0ATOM 2295 N THR A 902 71.251 38.370 5.911 1.00 26.52 A N ATOM 2296 CATHR A 902 70.649 39.555 5.329 1.00 23.53 A C ATOM 2297 CB THR A 90271.676 40.674 5.146 1.00 22.25 A C ATOM 2298 CG1 THR A 902 72.687 40.2414.233 1.00 20.06 A O ATOM 2299 CG2 THR A 902 72.314 41.028 6.476 1.0024.06 A C ATOM 2300 C THR A 902 70.130 39.122 3.959 1.00 28.03 A C ATOM2301 O THR A 902 70.529 38.081 3.438 1.00 25.18 A O ATOM 2302 N PHE A903 69.242 39.911 3.373 1.00 20.94 A N ATOM 2303 CA PHE A 903 68.70339.555 2.075 1.00 22.60 A C ATOM 2304 CB PHE A 903 67.600 40.538 1.6841.00 23.15 A C ATOM 2305 CG PHE A 903 66.300 40.293 2.405 1.00 15.14 A CATOM 2306 CD1 PHE A 903 65.566 39.140 2.156 1.00 12.08 A C ATOM 2307 CD2PHE A 903 65.818 41.201 3.325 1.00 13.93 A C ATOM 2308 CE1 PHE A 90364.358 38.893 2.817 1.00 14.36 A C ATOM 2309 CE2 PHE A 903 64.617 40.9673.991 1.00 15.17 A C ATOM 2310 CZ PHE A 903 63.883 39.804 3.734 1.0011.14 A C ATOM 2311 C PHE A 903 69.773 39.471 0.996 1.00 20.02 A C ATOM2312 O PHE A 903 69.627 38.713 0.040 1.00 20.39 A O ATOM 2313 N GLN A904 70.844 40.247 1.133 1.00 18.06 A N ATOM 2314 CA GLN A 904 71.92040.190 0.146 1.00 20.60 A C ATOM 2315 CB GLN A 904 72.901 41.344 0.3371.00 23.18 A C ATOM 2316 CG GLN A 904 73.933 41.425 −0.769 1.00 31.27 AC ATOM 2317 CD GLN A 904 73.303 41.351 −2.149 1.00 34.56 A C ATOM 2318OE1 GLN A 904 72.426 42.145 −2.486 1.00 41.92 A O ATOM 2319 NE2 GLN A904 73.750 40.395 −2.955 1.00 39.47 A N ATOM 2320 C GLN A 904 72.65038.850 0.292 1.00 19.48 A C ATOM 2321 O GLN A 904 72.987 38.201 −0.7041.00 21.02 A O ATOM 2322 N GLN A 905 72.882 38.435 1.536 1.00 20.89 A NATOM 2323 CA GLN A 905 73.538 37.157 1.787 1.00 20.41 A C ATOM 2324 CBGLN A 905 73.778 36.967 3.296 1.00 22.32 A C ATOM 2325 CG GLN A 90575.035 37.712 3.795 1.00 20.28 A C ATOM 2326 CD GLN A 905 75.141 37.8185.311 1.00 2.50 A C ATOM 2327 OE1 GLN A 905 76.192 38.182 5.846 1.0030.15 A O ATOM 2328 NE2 CLN A 905 74.056 37.521 6.006 1.00 17.48 A NATOM 2329 C GLN A 905 72.663 36.044 1.204 1.00 18.45 A C ATOM 2330 O GLNA 905 73.173 35.088 0.632 1.00 18.96 A O ATOM 2331 N ILE A 906 71.34136.180 1.330 1.00 17.57 A N ATOM 2332 CA ILE A 906 70.419 35.191 0.7701.00 20.69 A C ATOM 2333 CB ILE A 906 68.950 35.474 1.195 1.00 20.42 A CATOM 2334 CG2 ILE A 906 67.990 34.605 0.393 1.00 20.54 A C ATOM 2335 CG1ILE A 906 68.773 35.175 2.686 1.00 19.95 A C ATOM 2336 CD1 ILE A 90667.381 35.444 3.186 1.00 21.43 A C ATOM 2337 C ILE A 906 70.490 35.213−0.761 1.00 18.82 A C ATOM 2338 O ILE A 906 70.456 34.164 −1.415 1.0019.10 A O ATOM 2339 N CYS A 907 70.564 36.415 −1.328 1.00 24.30 A N ATOM2340 CA CYS A 907 70.648 36.584 −2.780 1.00 25.00 A C ATOM 2341 CB CYS A907 70.660 38.072 −3.157 1.00 23.83 A C ATOM 2342 SG CYS A 907 69.07238.922 −3.168 1.00 24.06 A S ATOM 2343 C CYS A 907 71.911 35.941 −3.3521.00 24.79 A C ATOM 2344 O CYS A 907 71.875 35.273 −4.390 1.00 22.55 A OATOM 2345 N SER A 908 73.036 36.169 −2.692 1.00 23.07 A N ATOM 2346 CASER A 908 74.295 35.607 −3.164 1.00 28.61 A C ATOM 2347 CB SER A 90875.476 36.230 −2.411 1.00 27.95 A C ATOM 2348 CG SER A 908 75.502 35.820−1.055 1.00 40.68 A O ATOM 2349 C SER A 908 74.316 34.081 −3.026 1.0026.67 A C ATOM 2350 O SER A 908 74.821 33.386 −3.906 1.00 31.03 A O ATOM2351 N PHE A 909 73.765 33.550 −1.935 1.00 29.53 A N ATOM 2352 CA PHE A909 73.748 32.097 −1.767 1.00 27.45 A C ATOM 2353 CB PHE A 909 73.27331.695 −0.367 1.00 26.40 A C ATOM 2354 CG PHE A 909 73.358 30.212 −0.1071.00 27.39 A C ATOM 2355 CD1 PHE A 909 74.572 29.544 −0.207 1.00 22.67 AC ATOM 2356 CD2 PHE A 909 72.224 29.484 0.231 1.00 27.87 A C ATOM 2357CE1 PHE A 909 74.657 28.169 0.027 1.00 .29.86 A C ATOM 2358 CE2 PHE A909 72.299 28.115 0.466 1.00 30.67 A C ATOM 2359 CZ PHE A 909 73.52127.457 0.364 1.00 31.58 A C ATOM 2360 C PHE A 909 72.827 31.477 −2.8091.00 30.35 A C ATOM 2361 O PHE A 909 73.167 30.463 −3.424 1.00 29.83 A OATOM 2362 N LEU A 910 71.660 32.084 −3.013 1.00 24.69 A N ATOM 2363 CALEU A 910 70.719 31.569 −3.998 1.00 21.53 A C ATOM 2364 CB LEU A 91069.422 32.394 −4.013 1.00 20.17 A C ATOM 2365 CG LEU A 910 68.373 32.080−2.933 1.00 18.50 A C ATOM 2366 CD1 LEU A 910 67.222 33.113 −3.013 1.0015.08 A C ATOM 2367 CD2 LEU A 910 67.836 30.658 −3.119 1.00 15.80 A CATOM 2368 C LEU A 910 71.364 31.576 −5.380 1.00 26.90 A C ATOM 2369 OLEU A 910 71.176 30.641 −6.156 1.OO 26.84 A O ATOM 2370 N GLN A 91172.129 32.621 −5.682 1.00 29.21 A N ATOM 2371 CA GLN A 911 72.807 32.710−6.976 1.00 32.16 A C ATOM 2372 CB GLN A 911 73.598 34.024 −7.075 1.0038.41 A C ATOM 2373 CG GLN A 911 74.387 34.175 −8.374 1.00 47.02 A CATOM 2374 CD GLN A 911 73.501 34.157 −9.618 1.00 55.28 A C ATOM 2375 OE1GLN A 911 73.993 34.044 −10.742 1.00 60.36 A O ATOM 2376 NE2 GLN A 91172.192 34.277 −9.420 1.00 59.73 A N ATOM 2377 C GLN A 911 73L747 31.507−7.157 1.00 30.03 A C ATOM 2378 O GLN A 911 73.818 30.918 −8.237 1.0028.94 A O ATOM 2379 N GLU A 912 74.461 31.149 −6.092 1.00 26.11 A N ATOM2380 CA GLU A 912 75.372 30.007 −6.113 1.00 28.96 A C ATOM 2381 CB GLU A912 76.086 29.866 −4.767 1.00 28.25 A C ATOM 2382 CG GLU A 912 77.03630.994 −4.412 1.00 31.08 A C ATOM 2383 CD GLU A 912 77.516 30.885 −2.9751.00 43.69 A C ATOM 2384 OE1 GLU A 912 77.869 29.764 −2.554 1.00 50.89 AO ATOM 2385 OE2 GLU A 912 77.544 31.915 −2.267 1.00 51.82 A O ATOM 2386C GLU A 912 74.621 28.706 −6.397 1.00 31.42 A C ATOM 2387 O GLU A 91275.142 27.820 −7.071 1.00 30.82 A O ATOM 2388 N GLN A 913 73.407 28.583−5.866 1.00 30.72 A N ATOM 2389 CA GLN A 913 72.614 27.379 −6.079 1.0032.61 A C ATOM 2390 CB GLN A 913 71.418 27.342 −5.12 41.00 25.51 A CATOM 2391 CG GLN A 913 71.805 27.556 −3.675 1.00 30.21 A C ATOM 2392 CDGLN A 913 72.853 26.570 −3.196 1.00 34.13 A C ATOM 2393 OE1 GLN A 91373.779 26.944 −2.479 1.00 44.34 A O ATOM 2394 NE2 GLN A 913 72.70725.303 −3.576 1.00 32.80 A N ATOM 2395 C GLN A 913 72.124 27.322 −7.5211.00 33.43 A C ATOM 2396 O GLN A 913 71.953 26.240 −8.082 1.00 33.14 A OATOM 2397 N ALA A 914 71.899 28.492 −8.111 1.00 34.61 A N ATOM 2398 CAALA A 914 71.433 28.577 −9.492 1.00 38.93 A C ATOM 2399 CB ALA A 91470.892 29.979 −9.782 1.00 37.54 A C ATOM 2400 C ALA A 914 72.580 28.242−10.448 1.00 42.12 A C ATOM 2401 O ALA A 914 72.363 27.660 −11.513 1.0041.51 A O ATOM 2402 N GLN A 915 73.799 28.610 −10.058 1.00 39.90 A NATOM 2403 CA GLN A 915 74.981 28.337 −10.870 1.00 43.18 A C ATOM 2404 CBGLN A 915 76.193 29.102 −10.329 1.00 48.56 A C ATOM 2405 CG GLN A 91576.102 30.611 −10.494 1.00 57.09 A C ATOM 2406 CD GLN A 915 77.32231.335 −9.952 1.00 60.30 A C ATOM 2407 OE1 GLN A 915 78.452 31.057−10.356 1.00 62.53 A O ATOM 2408 NE2 GLN A 915 77.098 32.272 −9.036 1.0061.37 A N ATOM 2409 C GLN A 915 75.282 26.844 −10.874 1.00 40.29 A CATOM 2410 O GLN A 915 75.507 26.249 −11.930 1.00 33.88 A O ATOM 2411 NGLU A 916 75.288 26.244 −9.686 1.00 40.59 A N ATOM 2412 CA GLU A 91675.552 24.816 −9.557 1.00 44.31 A C ATOM 2413 CB GLU A 916 75.610 24.421−8.076 1.00 43.19 A C ATOM 2414 CG GLU A 916 75.729 22.920 −7.804 1.0049.74 A C ATOM 2415 CD GLU A 916 76.835 22.240 −8.604 1.00 51.06 A CATOM 2416 OE1 GLU A 916 77.945 22.807 −8.710 1.00 46.82 A O ATOM 2417OE2 GLU A 916 76.592 21.125 −9.116 1.00 41.94 A O ATOM 2418 C GLU A 91674.466 24.024 −10.281 1.00 46.65 A C ATOM 2419 O GLU A 916 74.757 23.044−10.969 1.00 50.03 A O ATOM 2420 N ASP A 917 73.215 24.451 −10.140 1.0043.74 A N ATOM 2421 CA ASP A 917 72.127 23.755 −10.814 1.00 47.62 A CATOM 2422 CB ASP A 917 70.777 24.401 −10.502 1.00 46.73 A C ATOM 2423 CGASP A 917 69.620 23.655 −11.143 1.00 48.25 A C ATOM 2424 OD1 ASP A 91769.309 22.533 −10.687 1.00 46.40 A O ATOM 2425 OD2 ASP A 917 69.03224.183 −12.109 1.00 46.68 A O ATOM 2426 C ASP A 917 72.358 23.792−12.321 1.00 48.61 A C ATOM 2427 O ASP A 917 72.116 22.809 −13.020 1.0046.71 A O ATOM 2428 N ARG A 918 72.826 24.933 −12.817 1.00 49.75 A NATOM 2429 CA ARG A 918 73.085 25.081 −14.241 1.00 52.53 A C ATOM 2430 CBARG A 918 73.283 26.553 −14.603 1.00 55.45 A C ATOM 2431 CG ARG A 91873.549 26.770 −16.080 1.00 64.49 A C ATOM 2432 CD ARG A 918 73.68528.240 −16.424 1.00 70.23 A C ATOM 2433 NE ARG A 918 73.998 28.427−17.838 1.00 75.64 A N ATOM 2434 CZ ARG A 918 74.182 29.610 −18.414 1.0077.62 A C ATOM 2435 NH1 ARG A 918 74.084 30.722 −17.696 1.00 76.49 A NATOM 2436 NH2 ARG A 918 74.467 29.682 −19.707 1.00 76.87 A N ATOM 2437 CARG A 918 74.319 24.282 −14.650 1.00 52.64 A C ATOM 2438 0 ARG A 91874.352 23.690 −15.728 1.00 51.91 A O ATOM 2439 N ARG A 919 75.333 24.273−13.790 1.00 51.34 A N ATOM 2440 CA ARG A 919 76.558 23.530 −14.068 1.0049.04 A C ATOM 2441 CB ARG A 919 77.519 23.626 −12.886 1.00 47.65 A CATOM 2442 CG ARG A 919 78.862 22.955 −13.121 1.00 46.84 A C ATOM 2443 CDARG A 919 79.589 22.724 −11.806 1.00 50.42 A C ATOM 2444 NE ARG A 91978.954 21.671 −11.016 1.00 49.33 A N ATOM 2445 CZ ARG A 919 79.01720.374 −11.305 1.00 47.25 A C ATOM 2446 NH1 ARG A 919 79.691 19.957−12.370 1.00 51.03 A N ATOM 2447 NH2 ARC A 919 78.406 19.489 −10.5281.00 46.36 A N ATOM 2448 C ARG A 919 76.180 22.074 −14.286 1.00 48.85 AC ATOM 2449 O ARG A 919 76.800 21.363 −15.078 1.00 48.37 A O ATOM 2450 NGLU A 920 75.150 21.644 −13.568 1.00 48.46 A N ATOM 2451 CA GLU A 92074.652 20.280 −13.653 1.00 54.97 A C ATOM 2452 CB GLU A 920 73.79819.970 −12.423 1.00 52.09 A C ATOM 2453 CG GLU A 920 74.586 19.894−11.127 1.00 50.44 A C ATOM 2454 CD GLU A 920 73.694 19.801 −9.902 1.0053.30 A C ATOM 2455 OE1 GLU A 920 72.618 19.171 −9.992 1.00 51.23 A OATOM 2456 OE2 GLU A 920 74.078 20.343 −8.843 1.00 51.50 A O ATOM 2457 CGLU A 920 73.830 20.067 −14.922 1.00 59.57 A C ATOM 2458 O GLU A 92073.985 19.056 −15.606 1.00 60.63 A O ATOM 2459 N ARG A 921 72.966 21.030−15.232 1.00 63.36 A N ATOM 2460 CA ARG A 921 72.108 20.957 −16.409 1.0069.94 A C ATOM 2461 CB ARG A 921 72.951 20.936 −17.687 1.00 69.61 A CATOM 2462 CD ARG A 921 73.560 22.280 −18.038 1.00 73.73 A C ATOM 2463 CDARG A 921 74.383 22.210 −19.309 1.00 75.05 A C ATOM 2464 NE ARG A 92174.817 23.535 −19.741 1.00 77.28 A N ATOM 2465 CZ ARG A 921 75.55223.764 −20.824 1.00 80.16 A C ATOM 2466 NH1 ARG A 921 75.941 22.751−21.588 1.00 80.62 A N ATOM 2467 NH2 ARG A 921 75.895 25.005 21.147 1.0078.40 A N ATOM 2468 C ARG A 921 71.208 19.727 −16.371 1.00 74.48 A CATOM 2469 O ARG A 921 69.985 19.904 −16.178 1.00 76.69 A O ATOM 2470 OXTARG A 921 71.736 18.605 16.526 1.00 78.73 A O ATOM 2471 O HOH W 1 53.13037.517 6.388 1.00 16.78 W O ATOM 2472 O HOH W 2 50.953 33.166 1.385 1.0017.47 W O ATOM 2473 O HOH W 3 51.687 43.318 0.792 1.00 16.68 W O ATOM2474 O HOH W 4 48.643 33.073 10.645 1.00 17.59 W O ATOM 2475 O HOH W 554.317 41.896 −1.461 1.00 13.04 W O ATOM 2476 O HOH W 6 34.251 38.6149.379 1.00 20.36 W O ATOM 2477 O HOH W 7 40.992 38.104 10.054 1.00 30.20W O ATOM 2478 O HOH W 8 56.506 31.667 11.688 1.00 20.92 W O ATOM 2479 OHOH W 9 48.238 32.734 2.554 1.00 20.74 W O ATOM 2480 O HOH W 10 57.03740.385 6.611 1.00 16.42 W O ATOM 2481 O HOH W 11 49.789 22.594 2.8651.00 33.34 W O ATOM 2482 0 HOH W 12 59.302 27.150 10.742 1.00 20.79 W OATOM 2483 0 HOH W 13 52.161 47.340 −16.089 1.00 34.97 W O ATOM 2484 0HOH W 14 64.991 22.905 11.274 1.00 26.90 W O ATOM 2485 O HOH W 15 50.43728.565 1.830 1.00 16.99 W O ATOM 2486 O HOH W 16 68.264 44.038 −4.8951.00 23.21 W O ATOM 2487 O HOH W 17 35.950 39.681 11.160 1.00 31.94 W OATOM 2488 O HOH W 18 63.623 28.974 15.625 1.00 27.40 W O ATOM 2489 O HOHW 19 54.941 22.104 11.106 1.00 25.95 W O ATOM 2490 O HOH W 20 48.03748.633 −0.256 1.00 25.98 W O ATOM 2491 O HOH W 21 47.589 22.350 −4.5451.00 34.50 W O ATOM 2492 O HOH W 22 52.889 51.815 2.909 1.00 24.83 W OATOM 2493 O HOH W 23 50.553 52.673 4.230 1.00 29.70 W O ATOM 2494 O HOHW 24 75.044 41.575 3.838 1.00 24.92 W O ATOM 2495 O HOH W 25 66.11246.295 −10.986 1.00 37.12 W O ATOM 2496 O HOH W 26 48.836 49.210 −3.9721.00 37.07 W O ATOM 2497 O HOH W 27 61.150 28.769 16.260 1.00 33.38 W OATOM 2498 O HOH W 28 67.373 24.652 13.301 1.00 40.73 W O ATOM 2499 O HOHW 29 55.269 32.755 13.628 1.00 25.27 W O ATOM 2500 O HOH W 30 48.44929.899 3.455 1.00 21.82 W O ATOM 2501 O HOH W 31 58.963 60.604 −2.1661.00 42.15 W O ATOM 2502 O HOH W 32 52.514 20.260 11.002 1.00 28.92 W OATOM 2503 O HOH W 33 78.761 30.605 0.100 1.00 48.74 W O ATOM 2504 O HOHW 34 68.828 42.458 4.407 1.00 25.24 W O ATOM 2505 O HOH W 35 65.86446.954 10.187 1.00 31.87 W O ATOM 2506 O HOH W 36 59.292 46.495 −14.1291.00 33.18 W O ATOM 2507 O HOH W 37 57.824 39.200 10.857 1.00 28.93 W OATOM 2508 O HOH W 38 48.065 66.296 −4.237 1.00 43.48 W O ATOM 2509 O HOHW 39 63.145 44.635 4.471 1.00 22.44 W O ATOM 2510 O HOH W 40 48.08119.950 14.820 1.00 45.94 W O ATOM 2511 O HOH W 41 46.013 36.945 −2.6061.00 36.92 W O ATOM 2512 O HOH W 42 40.615 56.622 −3.324 1.00 26.45 W OATOM 2513 O HOH W 43 70.704 43.006 2.464 1.00 24.18 W O ATOM 2514 O HOHW 44 48.568 24.926 18.378 1.00 38.86 W O ATOM 2515 O HOH W 45 41.88539.526 −0.221 1.00 42.04 W O ATOM 2516 O HOH W 47 53.710 63.428 −13.1741.00 35.51 W O ATOM 2517 O HOH W 48 68.350 28.106 13.242 1.00 40.78 W OATOM 2518 O HOH W 49 53.661 24.198 22.697 1.00 48.28 W O ATOM 2519 O HOHW 50 56.511 63.081 1.177 1.00 38.76 W O ATOM 2520 O HOH W 51 64.19642.225 14.363 1.00 31.79 W O ATOM 2521 O HOH W 52 52.009 42.073 −16.6971.00 35.92 W O ATOM 2522 O HOH W 53 73.866 38.527 8.774 1.00 36.41 W OATOM 2523 O HOH W 54 41.590 64.060 −16.394 1.00 45.45 W O ATOM 2524 OHOH W 55 61.088 36.665 20.070 1.00 46.38 W O ATOM 2525 O HOH W 56 86.56724.345 −7.738 1.00 33.70 W O ATOM 2526 O HOH W 57 38.680 36.279 9.4561.00 32.71 W O ATOM 2527 O HOH W 58 60.903 33.476 −13.064 1.00 36.11 W OATOM 2528 O HOH W 59 64.147 39.403 −11.899 1.00 33.79 W O ATOM 2529 OHOH W 60 67.949 32.224 21.171 1.00 48.72 W O ATOM 2530 O HOH W 61 42.52032.758 3.413 1.00 32.41 W O ATOM 2531 O HOH W 62 52.963 44.524 3.0431.00 17.47 W O ATOM 2532 O HOH W 63 61.766 21.908 15.088 1.00 36.99 W OATOM 2533 O HOH W 64 55.717 18.349 14.664 1.00 55.46 W O ATOM 2534 O HOHW 65 67.426 30.120 17.075 1.00 37.50 W O ATOM 2535 O HOH W 67 69.91735.615 −5.993 1.00 36.41 W O ATOM 2536 O HOH W 68 54.496 38.583 8.1801.00 21.17 W O ATOM 2537 O HOH W 69 71.247 21.615 −3.361 1.00 47.18 W OATOM 2538 O HOH W 70 54.227 59.657 −15.054 1.00 48.41 W O ATOM 2539 OHOH W 72 40.518 35.620 11.660 1.00 38.50 W O ATOM 2540 O HOH W 73 50.22420.085 −1.802 1.00 35.93 W O ATOM 2541 O HOH W 74 35.301 38.742 1.2931.00 27.86 W O ATOM 2542 O HOH W 75 69.301 45.907 −7.120 1.00 45.66 W OATOM 2543 O HOH W 76 63.459 41.059 −14.066 1.00 44.45 W O ATOM 2544 OHOH W 77 58.399 42.178 9.822 1.00 41.04 W O ATOM 2545 O HOH W 78 62.93432.029 25.719 1.00 57.82 W O ATOM 2546 O HOH W 79 49.343 18.458 −3.6661.00 39.29 W O ATOM 2547 O HOH W 80 52.614 18.818 13.004 1.00 30.64 W OATOM 2548 O HOH W 81 53.030 18.358 −3.594 1.00 55.10 W O ATOM 2549 O HOHW 82 65.512 43.135 16.549 1.00 31.93 W O ATOM 2550 O HOH W 84 37.92561.497 −16.034 1.00 43.12 W O ATOM 2551 O HOH W 85 59.955 48.188 16.1631.00 55.43 W O ATOM 2552 O HOH W 86 34.410 45.858 −4.473 1.00 33.23 W OATOM 2553 O HOH W 87 59.904 70.813 −7.124 1.00 41.09 W O ATOM 2554 O HOHW 88 50.889 60.579 4.573 1.00 45.40 W O ATOM 2555 O HOH W 89 64.44421.664 13.862 1.00 54.06 W O ATOM 2556 O HOH W 90 46.251 33.776 −2.1741.00 33.07 W O ATOM 2557 O HOH W 91 46.129 44.410 10.199 1.00 43.98 W OATOM 2558 O HOH W 92 39.709 44.441 −17.565 1.00 42.46 W O ATOM 2559 OHOH W 93 45.261 29.526 12.722 1.00 32.17 W O ATOM 2560 O HOH W 94 42.52035.689 18.354 1.00 46.76 W O ATOM 2561 O HOH W 97 54.260 70.596 0.3561.00 46.35 W O ATOM 2562 O HOH W 98 49.388 43.122 3.337 1.00 36.21 W OATOM 2563 O HOH W 99 67.754 32.093 −9.558 1.00 42.69 W O ATOM 2564 O HOHW 100 66.909 43.021 13.592 1.00 54.19 W O ATOM 2565 O HOH W 101 46.08633.428 0.323 1.00 32.34 W O ATOM 2566 O HOH W 102 55.031 18.523 18.0011.00 54.57 W O ATOM 2567 O HOH W 103 52.486 42.478 17.047 1.00 43.11 W OATOM 2568 O HOH W 104 41.204 63.742 −3.408 1.00 40.39 W O ATOM 2569 OHOH W 105 48.004 61.755 4.399 1.00 43.45 W O ATOM 2576 O HOH W 10657.334 23.320 22.386 1.00 53.88 W O ATOM 2571 O HOH W 107 46.410 22.73316.519 1.00 42.34 W O ATOM 2572 O HOH W 108 45.448 25.098 3.981 1.0053.09 W O ATOM 2573 O HOH W 109 48.602 32.712 −10.241 1.00 37.44 W OATOM 2574 O HOH W 110 70.149 20.304 −5.269 1.00 52.07 W O ATOM 2575 OHOH W 111 69.497 46.132 −4.008 1.00 46.09 W O ATOM 2576 O HOH W 11260.089 24.441 −16.513 1.00 46.40 W O ATOM 2577 O HOH W 114 55.073 36.156−21.044 1.00 37.67 W O ATOM 2578 O HOH W 115 68.264 63.998 8.098 1.0031.90 W O ATOM 2579 O HOH W 116 61.712 62.385 8.248 1.00 33.65 W O ATOM2580 O HOH W 117 51.057 67.571 −1.805 1.00 35.85 W O ATOM 2581 O HOH W118 34.380 56.720 7.004 1.00 44.22 W O ATOM 2582 O HOH W 119 47.63451.389 1.983 1.00 38.05 W O ATOM 2583 O HOH W 120 60.173 56.055 −6.9631.00 39.76 W O ATOM 2584 O HOH W 121 60.586 42.693 −14.171 1.00 42.46 WO ATOM 2585 O HOH W 122 53.065 48.717 −5.634 1.00 31.80 W O ATOM 2586 OHOH W 123 53.276 49.304 −2.592 1.00 37.09 W O ATOM 2587 O HOH W 12448.023 23.550 −0.097 1.00 41.97 W O ATOM 2588 O HOH W 125 58.569 20.629−8.697 1.00 46.50 W O ATOM 2589 O HOH W 126 62.960 21.885 −15.994 1.0039.18 W O ATOM 2590 O HOH W 127 61.522 26.664 −16.740 1.00 54.79 W OATOM 2591 O HOH W 128 62.573 29.843 −14.065 1.00 51.60 W O ATOM 2592 OHOH W 129 68.436 42.941 −8.574 1.00 38.26 W O ATOM 2593 O HOH W 13070.619 38.577 −10.230 1.00 43.17 W O ATOM 2594 O HOH W 131 68.700 39.175−13.625 1.00 49.45 W O ATOM 2595 O NOH W 132 66.629 35.031 −10.564 1.0057.28 W O ATOM 2596 O NOH W 133 70.343 44.945 0.851 1.00 27.47 W O ATOM2597 O HOH W 134 71.454 47.029 2.043 1.00 32.04 W O ATOM 2598 O HOH W135 50.581 45.877 3.288 1.00 35.96 W O ATOM 2599 O HOH W 136 63.04318.511 8.678 1.00 25.84 W O ATOM 2600 O HOH W 137 60.187 16.741 5.4801.00 27.83 W O ATOM 2601 O HOH W 138 71.493 20.508 −1.148 1.00 37.36 W OATOM 2602 O HOH W 140 69.236 19.813 9.718 1.00 51.17 W O ATOM 2603 O HOHW 141 48.893 48.830 3.386 1.00 31.72 W O ATOM 2604 O HOH W 142 53.75753.057 7.181 1.00 38.75 W O ATOM 2605 O HOH W 143 52.957 52.603 10.7101.00 45.21 W O ATOM 2606 O HOH W 144 57.295 55.219 6.489 1.00 28.18 W OATOM 2607 O HOH W 145 47.242 19.725 −4.341 1.00 39.04 W O ATOM 2608 OHOH W 146 51.096 17.612 −5.348 1.00 33.80 W O ATOM 2609 O HOH W 14745.841 22.498 −11.215 1.00 41.64 W O ATOM 2610 O HOH W 148 52.557 20.540−12.172 1.00 35.37 W O ATOM 2611 O HOH W 149 50.830 28.325 −16.387 1.0048.81 W O ATOM 2612 O HOH W 150 50.973 47.523 −5.037 1.00 33.85 W O ATOM2613 O HOH W 151 79.855 24.442 −8.033 1.00 34.88 W O ATOM 2614 O HOH W152 74.432 23.710 −5.162 1.00 40.89 W O ATOM 2615 O HOH W 153 50.05165.010 0.979 1.00 33.32 W O ATOM 2616 O HOH W 154 38.623 33.179 4.6581.00 32.85 W O ATOM 2617 O HOH W 155 69.899 38.414 18.457 1.00 42.55 W OATOM 2618 O HOH W 156 65.325 45.942 17.414 1.00 40.36 W O ATOM 2619 OHOH W 157 69.467 32.282 17.501 1.00 37.72 W O ATOM 2620 O HOH W 15858.000 50.791 −14.533 1.00 45.67 W O ATOM 2621 O HOH W 159 69.300 53.8821.823 1.00 39.21 W O ATOM 2622 O HOH W 160 46.458 34.361 19.260 1.0039.17 W O ATOM 2623 O HOH W 161 50.935 53.555 6.466 1.00 40.79 W O ATOM2624 O HOH W 162 59.656 19.798 12.641 1.00 41.51 W O ATOM 2625 O HOH W163 34.964 45.762 2.282 1.00 37.11 W O ATOM 2626 O HOH W 164 55.61421.617 −11.244 1.00 44.43 W O ATOM 2627 O HOH W 165 40.312 33.555 2.1561.00 40.12 W O ATOM 2628 O HOH W 166 73.397 43.749 3.369 1.00 29.96 W OATOM 2629 O HOH W 167 71.531 44.662 −1.725 1.00 35.10 W O ATOM 2630 ONOH W 168 49.054 18.937 11.992 1.00 35.78 W O ATOM 2631 O NOH W 16966.761 18.426 6.769 1.00 32.23 W O ATOM 2632 O HOH W 170 43.495 50.9997.967 1.00 51.70 W O ATOM 2633 O HOH W 171 87.329 26.319 −6.519 1.0035.59 W O ATOM 2634 O NOH W 172 76.577 26.317 −2.779 1.00 41.90 W O ATOM2635 O HOH W 173 37.878 56.033 −4.242 1.00 33.32 W O ATOM 2636 O HOH W174 52.737 50.685 12.709 1.00 46.74 W O ATOM 2637 O HOH W 175 53.27541.894 21.149 1.00 44.72 W O ATOM 2638 O HOH W 176 62.060 15.782 6.8901.00 38.60 W O ATOM 2639 O HOH W 177 45.643 66.526 −12.547 1.00 47.05 WO ATOM 2640 O HOH W 178 49.253 64.019 3.022 1.00 40.35 W O ATOM 2641 OHOH W 179 50.188 67.986 −4.184 1.00 35.76 W O ATOM 2642 O HOH W 18076.840 34.206 −5.474 1.00 44.64 W O ATOM 2643 O HOH W 181 76.534 38.632−0.025 1.00 33.48 W O ATOM 2644 O HOH W 182 67.088 22.108 13.527 1.0042.45 W O ATOM 2645 O HOH W 183 42.575 45.889 4.026 1.00 32.36 W O ATOM2646 O HOH W 184 38.466 42.501 4.663 1.00 33.28 W O ATOM 2647 C1 INHI1000 45.826 40.299 −8.534 1.00 31.13 I C ATOM 2648 C2 INH I1000 45.17039.086 −8.952 1.00 29.33 I C ATOM 2649 C3 INH I1000 45.271 38.614−10.286 1.00 30.96 I C ATOM 2650 C4 INH I1000 46.030 39.339 −11.250 1.0031.71 I C ATOM 2651 C5 INH I1000 46.683 40.SS4 −10.853 1.00 32.74 I CATOM 2652 C6 INH I1000 46.586 41.046 −9.505 1.00 29.47 I C ATOM 2653 C7INH I1000 46.945 41.023 −4.949 1.00 31.41 I C ATOM 2654 C8 INH I100046.9S4 40.327 −6.323 1.00 40.73 I C ATOM 2655 N1 INH I1000 45.765 40.654−7.172 1.00 34.83 I N ATOM 2656 C9 INH I1000 44.449 41.053 −6.597 1.0031.83 I C ATOM 2657 C10 INH I1000 44.553 41.687 −5.196 1.00 37.27 I CATOM 2658 C11 INH I1000 45.565 40.971 −4.294 1.00 33.47 I C ATOM 2659C12 INH I1000 45.615 41.649 −2.925 1.00 22.65 I C ATOM 2660 C13 INHI1000 46.168 38.824 −12.660 1.00 30.80 I C ATOM 2661 O1 INH I1000 45.13439.389 −13.461 1.00 36.39 I O ATOM 2662 C14 INH I1000 48.036 43.176−9.627 1.00 24.58 I C ATOM 2663 N2 INH I1000 47.164 42.271 −9.050 1.0025.04 I N ATOM 2664 O2 INH I1000 48.530 43.082 −10.759 1.00 34.12 I OATOM 2665 C15 INH I1000 48.330 44.304 −8.735 1.00 22.66 I C ATOM 2666C16 INH I1000 49.194 45.378 −8.874 1.00 22.73 I C ATOM 2667 C17 INHI1000 49.071 46.171 −7.701 1.00 17.57 I C ATOM 2668 C18 INH I1000 48.13745.548 −6.918 1.00 21.6S I C ATOM 2669 O3 INH I1000 47.673 44.412 −7.5271.00 23.98 I O ATOM 2670 C19 INH I1000 47.610 45.887 −5.642 1.00 20.98 IC ATOM 2671 N3 INH I1000 47.190 46.175 −4.595 1.00 22.49 I N ENDREMARK c-fms (538-922 tie2 chimera) complexed with 1183648REMARK refinement resolution: 500.0-1.8 AREMARK starting r = 0.2383 free_r = 0.2832REMARK final r = 0.2367 free_r = 0.2811CRYST1 80.440 80.440 143.760 90.00 90.00 120.00 R 3REMARK Written by CNX VERSION:2002

REFERENCES

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Although the present invention has been described in detail withreference to examples above, it is understood that various modificationscan be made without departing from the spirit of the invention. Allcited patents, published patent applications, publications and otherdocuments cited in this application are herein incorporated by referencein their entirety.

1. An isolated chimeric kinase receptor polypeptide, wherein saidpolypeptide comprises an ATP binding pocket linked to a substratebinding pocket by a kinase insert domain (KID), wherein said domain isheterologous to the ATP binding pocket or the substrate binding pocket.2. The polypeptide of claim 1, wherein said ATP binding pocket andsubstrate binding pocket are c-fms.
 3. The polypeptide of claim 1,wherein said heterologous KID is selected from the group consisting ofFGFR1, tie2 and IRK.
 4. The isolated chimeric kinase receptorpolypeptide of claim 1, wherein said chimeric polypeptide comprises anamino acid sequence beginning at c-fms amino acid position 538 andcontinuing through c-fms amino acid position 922 wherein thenative-c-fms KID is replaced with a KID sequence comprising aheterologous KID amino acid sequence beginning at c-fms amino acidpositions 672-688.
 5. The chimeric polypeptide of claim 4, wherein saidheterologous KID is selected from the group consisting of FGFR1, tie2and IRK.
 6. The chimeric polypeptide of claim 4, wherein saidpolypeptide has an amino acid sequence having at least 95% amino acidsequence identity to a sequence selected from the group consisting ofSEQ ID NO. 2 (FMS/FGFR1 chimera); SEQ ID NO. 4 (FMS/tie chimera) andSEQ. ID NO: 6 (FMS/irk chimera).
 7. The chimeric polypeptide of claim 4in crystalline form.
 8. A crystal comprising a polypeptide of claim 4,or a fragment thereof.
 9. The crystal of claim 8, comprising a crystalstructure defined by one or more structure coordinates of c-fms aminoacid residues Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596, Glu598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646, Val647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782, Asn783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799, Ala800, Arg 801, Asp 802 according to Tables 1, 2 or 3 or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 1.5 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or
 3. 10. The crystal of claim 9, comprising a crystalstructure defined by one or more structure coordinates of c-fms aminoacid residues Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596, Glu598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646, Val647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782, Asn783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799, Ala800, Arg 801, Asp 802 according to Tables 1, 2 or 3 or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 0.75 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or
 3. 11. The crystal of claim 8, comprising a crystalstructure defined by one or more structure coordinates of c-fms aminoacid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 or similarstructure coordinates for said amino acids comprising a root mean squaredeviation of non-hydrogen atoms of less than about 1.5 Å whensuperimposed on the non-hydrogen atom positions of the correspondingatomic coordinates of Tables 1, 2 or
 3. 12. The crystal of claim 11,comprising a crystal structure defined by one or more structurecoordinates of c-fms amino acid residues Lys 586, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802 according toTables 1, 2 or 3 or similar structure coordinates for said amino acidscomprising a root mean square deviation of non-hydrogen atoms of lessthan about 0.75 Å when superimposed on the non-hydrogen atom positionsof the corresponding atomic coordinates of Tables 1, 2 or
 3. 13. Thecrystal of claim 8, comprising a crystal structure defined by structurecoordinates of c-fms amino acid residues Lys 586, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp796, Phe 797, Leu 799, Ala 800, Arg 801 according to Tables 1, 2 or 3 orsimilar structure coordinates for said amino acids comprising a rootmean square deviation of non-hydrogen atoms of less than about 1.5 Åwhen superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or
 3. 14. The crystal ofclaim 13, comprising a crystal structure defined by structurecoordinates of c-fms amino acid residues Lys 586, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp796, Phe 797, Leu 799, Ala 800, Arg 801 according to Tables 1, 2 or 3 orsimilar structure coordinates for said amino acids comprising a rootmean square deviation of non-hydrogen atoms of less than about 0.75 Åwhen superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or
 3. 15. The crystal ofclaim 8, further comprising a ligand, wherein said ligand is anATP-binding pocket ligand.
 16. The crystal of claim 15, wherein saidATP-binding pocket ligand is a small molecule inhibitor.
 17. The crystalof claim 16, wherein said small molecule inhibitor is an arylamidecompound or a derivative thereof.
 18. The crystal of claim 16, whereinsaid small molecule inhibitor is a quinolone compound or a derivativethereof.
 19. The crystal of claim 17, wherein said arylamide compound is5-cyano-furan-2-carboxylic acid[5-hydroxymethyl-2-(4-methyl-piperidine-1-yl)-phenyl]-amide orderivative thereof.
 20. The crystal of claim 18, wherein said quinolonecompound is6-Chloro-3-(3-methyl-isoxazol-5-yl)-4-phenyl-1H-quinolin-2-one or aderivative thereof.
 21. The crystal of claim 16, wherein saidcrystal-ligand complex has a space group of R3. (Form I)
 22. The crystalof claim 16, wherein said crystal-ligand complex has a space group ofP2₁2₁2₁. (Form II)
 23. The crystal of claim 21, wherein the crystaleffectively diffracts X-rays for determination of atomic coordinates toa resolution of at least about 1.9 Å (Form I).
 24. The crystal of claim22, wherein the crystal effectively diffracts X-rays for determinationof atomic coordinates to a resolution of at least about 3.0 Å (Form II).25. The crystal of claim 23, comprising a unit cell having dimensionsconsisting of: a=81.07; b=81.07; c=144.67; alpha=90; beta=90; gamma=120.26. The crystal of claim 24 comprising a unit cell having dimensionsconsisting of a 53.1; b=72.4; c=91.7; alpha=90; beta=90; gamma=90. 27.The crystal of claim 8, wherein said polypeptide comprises a peptidehaving at least 95% amino acid sequence identity to SEQ ID NO. 2(FMS/FGFR1 chimera); SEQ ID NO. 4 (FMS/tie chimera) or SEQ ID NO: 6(FMS/irk chimera).
 28. The crystal of claim 27 wherein said crystalcomprises a peptide having at least 95% sequence identity to SEQ ID NO.2.
 29. A crystal comprising SEQ ID NO: 2 comprising an atomic structurecharacterized by the coordinates of Tables 1, 2 or
 3. 30. An isolatednucleic acid molecule encoding a polypeptide of claim
 4. 31. A vectorcomprising a nucleic acid molecule of claim
 30. 32. A host cellcomprising a vector of claim
 31. 33. A method of producing apolypeptide, comprising culturing the host cell of claim 32 underconditions in which the polypeptide is expressed.
 34. A computer systemcomprising: (a) a database containing information on the threedimensional structure of a crystal comprising a c-fms chimera, or afragment or a target structural motif or derivative thereof, and aligand, wherein said ligand is a small molecule inhibitor, stored on acomputer readable storage medium; and, (b) a user interface to view theinformation.
 35. The computer system of claim 34, wherein theinformation comprises diffraction data obtained from a crystalcomprising SEQ ID NO: 2, 4 or
 6. 36. The computer system of claim 34,wherein the information comprises an electron density map of a crystalform comprising SEQ ID NO: 2, 4 or
 6. 37. The computer system of claim34, wherein the information comprises the structure coordinates ofTables 1, 2 or 3 or homologous structure coordinates for the amino acidsof SEQ ID NO: 2 comprising a root mean square deviation of non-hydrogenatoms of less than about 1.5 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3.
 38. The computer system of claim 37, wherein the informationcomprises structure coordinates for amino acid residues of SEQ ID NO: 2comprising a root mean square deviation of non-hydrogen atoms of lessthan about 0.75 Å when superimposed on the non-hydrogen atom positionsof the corresponding atomic coordinates of Tables 1, 2 or
 3. 39. Thecomputer system of claim 34, wherein the information comprises thestructure coordinates for one or more amino acid residues Trp 550, Lys586, Thr 587, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys616, Glu 633, Met 637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg677, Cys 774, Ile 775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly795, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802according to Tables 1, 2 or 3 or similar structure coordinates for saidamino acids comprising a root mean square deviation of non-hydrogenatoms of less than about 1.5 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3.
 40. The computer system of claim 39, wherein the information furthercomprises the structure coordinates for one or more amino acid residuesTrp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596, Glu 598, Ala 614,Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646, Val 647, Val 661,Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670,Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782, Asn 783, Leu 785,Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801,Asp 802 according to Tables 1, 2 or 3 or similar structure coordinatesfor said amino acids comprising a root mean square deviation ofnon-hydrogen atoms of less than about 0.75 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or
 3. 41. The computer system of claim 34, comprising acrystal structure defined by structure coordinates of one or more c-fmsamino acid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe 797, Gly798, Leu 799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 orsimilar structure coordinates for said amino acids comprising a rootmean square deviation of non-hydrogen atoms of less than about 1.5 Åwhen superimposed on the non-hydrogen atom positions of thecorresponding atomic coordinates of Tables 1, 2 or
 3. 42. The computersystem of claim 41, comprising a crystal structure defined by structurecoordinates of one or more c-fms amino acid residues Lys 586, Leu 588,Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664,Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782,Leu 785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802according to Tables 1, 2 or 3 or similar structure coordinates for saidamino acids comprising a root mean square deviation of non-hydrogenatoms of less than about 0.75 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3.
 43. The computer system of claim 34, comprising a crystal structuredefined by structure coordinates of c-fms amino acid residues Lys 586,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663,Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782,Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 accordingto Tables 1, 2 or 3: or similar structure coordinates for said aminoacids comprising a root mean square deviation of non-hydrogen atoms ofless than about 1.5 Å when superimposed on the non-hydrogen atompositions of the corresponding atomic coordinates of Tables 1, 2 or 3.44. The computer system of claim 43, comprising a crystal structuredefined by structure coordinates of c-fms amino acid residues Lys 586,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663,Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782,Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 accordingto Tables 1, 2 or 3 or similar structure coordinates for said aminoacids comprising a root mean square deviation of non-hydrogen atoms ofless than about 0.75 Å when superimposed on the non-hydrogen atompositions of the corresponding atomic coordinates of Tables 1, 2 or 3.45. A method of evaluating the potential of an agent to associate withc-fms chimeric polypeptides comprising: (a) exposing the c-fms chimerato the agent; and (b) detecting the association of said agent to one ormore c-fms amino acid residues selected from the group consisting of (i)Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val 596, Glu 598, Ala 614,Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile 646, Val 647, Val 661,Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670,Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg 782, Asn 783, Leu 785,Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801,Asp 802; (ii) Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu799, Ala 800, Arg 801, Asp 802; and, (iii) Lys 586, Leu 588, Gly 589,Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665,Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785,Asp 796, Phe 797, Leu 799, Ala 800, Arg 801 thereby evaluating thepotential.
 46. The method of claim 45, wherein the agent is a virtualcompound.
 47. A method of evaluating the potential of an agent toassociate with a polypeptide of claim 1, comprising: (a) exposing thepolypeptide to the agent; and (b) detecting the level of association ofthe agent to the polypeptide, thereby evaluating the potential of theagent to associate with the polypeptide.
 48. The method of claim 47,wherein the agent is a virtual compound.
 49. The method of claim 47,wherein step (a) comprises comparing the atomic structure of thecompound to the three dimensional structure of a c-fms chimericpolypeptide.
 50. The method of claim 49, wherein the comparing comprisesemploying a computational means to perform a fitting operation betweenthe compound and at least one binding site of a c-fms chimera.
 51. Themethod of claim 50, wherein the binding site is defined by one or morestructure coordinates for amino acids Trp 550, Lys 586, Thr 587, Leu588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802 according to Tables 1,2 or 3 or similar structure coordinates for said amino acids of a c-fmschimera comprising a root mean square deviation of non-hydrogen atoms ofless than about 1.5 Å when superimposed on the non-hydrogen atompositions of the corresponding atomic coordinates of Tables 1, 2 or 3.52. The method of claim 51, wherein the binding site is defined by oneor more structure coordinates for amino acids Trp 550, Lys 586, Thr 587,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633,Met 637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665,Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774,Ile 775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796,Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802 according to Tables1, 2 or 3 or similar structure coordinates for said amino acids of ac-fms chimera comprising a root mean square deviation of non-hydrogenatoms of less than about 0.75 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3.
 53. The method of claim 50, comprising a crystal structure defined byone or more structure coordinates of c-fms amino acid residues Lys 586,Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663,Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677,Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801,Asp 802 according to Tables 1, 2 or 3 or similar structure coordinatesfor said amino acids comprising a root mean square deviation ofnon-hydrogen atoms of less than about 1.5 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or
 3. 54. The method of claim 53, comprising a crystalstructure defined by one or more structure coordinates of c-fms aminoacid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796, Phe 797, Gly 798, Leu799, Ala 800, Arg 801, Asp 802 according to Tables 1, 2 or 3 or similarstructure coordinates for said amino acids comprising a root mean squaredeviation of non-hydrogen atoms of less than about 0.75 Å whensuperimposed on the non-hydrogen atom positions of the correspondingatomic coordinates of Tables 1, 2 or
 3. 55. The method of claim 50,comprising a crystal structure defined by structure coordinates of c-fmsamino acid residues Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu799, Ala 800, Arg 801 according to Tables 1, 2 or 3 or similar structurecoordinates for said amino acids comprising a root mean square deviationof non-hydrogen atoms of less than about 1.5 Å when superimposed on thenon-hydrogen atom positions of the corresponding atomic coordinates ofTables 1, 2 or
 3. 56. The method of claim 55, comprising a crystalstructure defined by structure coordinates of c-fms amino acid residuesLys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647,Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670,Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg 801according to Tables 1, 2 or 3 or similar structure coordinates for saidamino acids comprising a root mean square deviation of non-hydrogenatoms of less than about 0.75 Å when superimposed on the non-hydrogenatom positions of the corresponding atomic coordinates of Tables 1, 2 or3.
 57. The method of claim 47, wherein the agent is exposed to acrystalline c-fms chimera and the detecting of step (b) comprisesdetermining the three dimensional structure of the agent-c-fms chimeracomplex.
 58. A method of identifying a potential agonist or antagonistagainst a c-fms chimera comprising: (a) employing the three dimensionalstructure of the c-fms chimera cocrystallized with a small moleculeinhibitor to design or select said potential agonist or antagonist. 59.The method of claim 58, wherein the three dimensional structurecorresponds to the atomic structure characterized by the coordinates ofTables 1, 2 or 3 or similar structure coordinates for said c-fms chimeracomprising a root mean square deviation of non-hydrogen atoms of lessthan about 1.5 Å when superimposed on the non-hydrogen atom positions ofthe corresponding atomic coordinates of Tables 1, 2 or
 3. 60. The methodof claim 59, further comprising the steps of: (b) synthesizing thepotential agonist or antagonist; and (c) contacting the potentialagonist or antagonist with a chimeric c-fms polypeptide.
 61. A method oflocating the attachment site of an inhibitor to a c-fms chimericpolypeptide, comprising: (a) obtaining X-ray diffraction data for acrystal of a chimeric c-fms polypeptide; (b) obtaining X-ray diffractiondata for a complex of a chimeric c-fms polypeptide and the inhibitor;(c) subtracting the X-ray diffraction data obtained in step (a) from theX-ray diffraction data obtained in step (b) to obtain the difference inthe X-ray diffraction data; (d) obtaining phases that correspond toX-ray diffraction data obtained in step (a); (e) utilizing the phasesobtained in step (d) and the difference in the X-ray diffraction dataobtained in step (c) to compute a difference Fourier image of theinhibitor; and, (f) locating the attachment site of the inhibitor basedon the computations obtained in step (e).
 62. A method of obtaining amodified inhibitor comprising: (a) obtaining a crystal comprising achimeric c-fms polypeptide and an inhibitor; (b) obtaining the atomiccoordinates of the crystal; (c) using the atomic coordinates and one ormore molecular modeling techniques to determine how to modify theinteraction of the inhibitor with the chimeric c-fms polypeptide; and(d) modifying the inhibitor based on the determinations obtained in step(c) to produce a modified inhibitor.
 63. The method of claim 62, whereinsaid crystal comprises a peptide selected from the group consisting of:a peptide having SEQ ID NO: 2; a peptide having SEQ ID NO: 4 and apeptide having SEQ ID NO:
 6. 64. A method of claim 62, wherein the oneor more molecular modeling techniques are selected from the groupconsisting of graphic molecular modeling and computational chemistry.65. The method of claim 62, wherein step (b) comprises detecting theinteraction of the inhibitor to one or more amino acid residues selectedfrom the group consisting of (i) Trp 550, Lys 586, Thr 587, Leu 588, Gly589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly798, Leu 799, Ala 800, Arg 801, Asp 802; (ii) Lys 586, Leu 588, Gly 589,Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665,Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785,Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802; and,(iii) Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp670, Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg801.
 66. An inhibitor of a chimeric c-fms polypeptide identified by themethod of claim
 62. 67. An isolated protein fragment comprising abinding pocket or active site defined by one or more structurecoordinates of chimeric c-fms amino acid-residues selected from thegroup consisting of (i) Trp 550, Lys 586, Thr 587, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met 637, Leu 640, Ile646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile 775, His 776, Arg782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe 797, Gly 798, Leu799, Ala 800, Arg 801, Asp 802; (ii) Lys 586, Leu 588, Gly 589, Val 596,Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666,Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782, Leu 785, Asp 796,Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802; and, (iii) Lys586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg782, Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala 800, Arg
 801. 68.An isolated fragment of claim 67 linked to a solid support.
 69. Anisolated nucleic acid molecule encoding the fragment of claim
 68. 70. Avector comprising a nucleic acid molecule of claim
 69. 71. A host cellcomprising the vector of claim
 70. 72. A method of producing a proteinfragment, comprising culturing the host cell of claim 71 underconditions in which the fragment is expressed.
 73. A method of screeningfor an agent that associates with a chimeric c-fms polypeptide,comprising: (a) exposing a protein molecule fragment of claim 67 to theagent; and (b) detecting the level of association of the agent to thefragment.
 74. A kit comprising a protein molecule fragment of claim 67.75. A method for the production of a crystal complex comprising achimeric c-fms chimeric polypeptide-ligand comprising: (a) contactingthe chimeric c-fms polypeptide with said ligand in a suitable solutionand, (b) crystallizing said resulting complex of chimeric c-fmspolypeptide-ligand from said solution.
 76. The method of claim 75,wherein said polypeptide is a polypeptide having SEQ ID NO: 2, 4 or 6.77. The method of claim 75, further comprising contacting thecrystalline chimeric c-fms polypeptide-ligand complex with anotherligand in a suitable solution to replace the bound ligand.
 78. A methodfor the production of a crystal of claim 1 comprising crystallizing apeptide comprising a sequence selected from the group consisting of SEQID NO: 2, 4 or 6 with a potential inhibitor.
 79. A method foridentifying a potential inhibitor of a chimeric c-fms polypeptidecomprising: (a) using a three dimensional structure of a chimeric c-fmspolypeptide as defined by atomic coordinates according to Tables 1, 2 or3 or similar structure coordinates for said amino acids of a c-fmschimera comprising a root mean square deviation of non-hydrogen atoms ofless than about 1.5 Å when superimposed on the non-hydrogen atompositions of the corresponding atomic coordinates of Tables 1, 2 or 3;(b) replacing one or more chimeric c-fms polypeptide amino acidsselected from the group consisting of (i) Trp 550, Lys 586, Thr 587, Leu588, Gly 589, Val 596, Glu 598, Ala 614, Val 615, Lys 616, Glu 633, Met637, Leu 640, Ile 646, Val 647, Val 661, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Asn 673, Arg 677, Cys 774, Ile775, His 776, Arg 782, Asn 783, Leu 785, Ile 794, Gly 795, Asp 796, Phe797, Gly 798, Lei 799, Ala 800, Arg 801, Asp 802; (ii) Lys 586, Leu 588,Gly 589, Val 596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664,Tyr 665, Cys 666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 677, Arg 782,Leu 785, Asp 796, Phe 797, Gly 798, Leu 799, Ala 800, Arg 801, Asp 802;and, (iii) Lys 586, Leu 588, Gly 589, Val 596, Glu 598, Ala 614, Lys616, Val 647, Thr 663, Glu 664, Tyr 665, Cys 666, Cys 667, Tyr 668, Gly669, Asp 670, Arg 782, Asn 783, Leu 785, Asp 796, Phe 797, Leu 799, Ala800, Arg 801 in said three-dimensional structure with a different aminoacid to produce a modified three-dimensional structure; and, (c) usingsaid modified three-dimensional structure to design or select saidpotential inhibitor.
 80. The method of claim 79, further comprising d)synthesizing said potential inhibitor.
 81. The method of claim 79,further comprising e) contacting said potential inhibitor with saidmodified chimeric c-fms polypeptide in the presence of a ligand to testthe ability of said potential inhibitor to inhibit a chimeric c-fmspolypeptide or said modified chimeric c-fms polypeptide.
 82. The methodof claim 79 wherein said replacing one or more amino acidresidues-further comprises replacing SEQ ID NO: 2 amino acid residuesselected from the group consisting of Lys 586, Leu 588, Gly 589, Val596, Glu 598, Ala 614, Lys 616, Val 647, Thr 663, Glu 664, Tyr 665, Cys666, Cys 667, Tyr 668, Gly 669, Asp 670, Arg 782, Asn 783, Leu 785, Asp796, Phe 797, Leu 799, Ala 800, Arg
 801. 83. The method of claim 79,wherein said potential inhibitor is selected from a database.
 84. Themethod of claim 79, wherein said potential inhibitor is designed denovo.
 85. The method of claim 79, wherein said potential inhibitor isdesigned from a known inhibitor.
 86. The method of claim 79, whereinsaid step of employing said modified three-dimensional structure todesign or select said potential inhibitor comprises the steps of: (a)identifying chemical entities or fragments capable of associating with amodified chimeric c-fms polypeptide; and (b) assembling the identifiedchemical entities or fragments into a single molecule to provide thestructure of said potential inhibitor.
 87. The method of claim 79,wherein the potential inhibitor is a competitive inhibitor.
 88. Themethod of claim 79, wherein said potential inhibitor is anon-competitive or uncompetitive inhibitor.
 89. The method of claim 79,wherein said potential inhibitor is an irreversible inhibitor.
 90. Theinhibitor identified by the method of claim 79.